CY2384B1 - Pellets having a core coated with an antifungal and a polymer. - Google Patents

Pellets having a core coated with an antifungal and a polymer.

Info

Publication number
CY2384B1
CY2384B1 CY0300079A CY0300079A CY2384B1 CY 2384 B1 CY2384 B1 CY 2384B1 CY 0300079 A CY0300079 A CY 0300079A CY 0300079 A CY0300079 A CY 0300079A CY 2384 B1 CY2384 B1 CY 2384B1
Authority
CY
Cyprus
Prior art keywords
antifungal
pellets
polymer
core coated
coated
Prior art date
Application number
CY0300079A
Other languages
English (en)
Inventor
Roger Petrus Gereber Vndecruys
De Valentin Florent Vict Conde
Paul Marie Victor Gilis
Josef Peeters
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CY2384B1 publication Critical patent/CY2384B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CY0300079A 1997-03-26 2003-11-04 Pellets having a core coated with an antifungal and a polymer. CY2384B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97200914 1997-03-26

Publications (1)

Publication Number Publication Date
CY2384B1 true CY2384B1 (en) 2004-06-04

Family

ID=8228147

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0300079A CY2384B1 (en) 1997-03-26 2003-11-04 Pellets having a core coated with an antifungal and a polymer.

Country Status (31)

Country Link
EP (1) EP0969821B1 (pt)
JP (1) JP3608800B2 (pt)
KR (1) KR100520936B1 (pt)
CN (1) CN1206984C (pt)
AP (1) AP1227A (pt)
AT (1) ATE241969T1 (pt)
AU (1) AU734248B2 (pt)
BG (1) BG64434B1 (pt)
BR (1) BR9806174A (pt)
CA (1) CA2269501C (pt)
CY (1) CY2384B1 (pt)
CZ (1) CZ295502B6 (pt)
DE (1) DE69815316T2 (pt)
DK (1) DK0969821T3 (pt)
EE (1) EE03904B1 (pt)
ES (1) ES2201485T3 (pt)
HK (1) HK1022840A1 (pt)
HU (1) HU224217B1 (pt)
ID (1) ID21477A (pt)
IL (1) IL129575A (pt)
NO (1) NO325102B1 (pt)
NZ (1) NZ335364A (pt)
OA (1) OA11162A (pt)
PL (1) PL190566B1 (pt)
PT (1) PT969821E (pt)
RU (1) RU2218153C2 (pt)
SI (1) SI0969821T1 (pt)
SK (1) SK284813B6 (pt)
TR (1) TR199900990T2 (pt)
UA (1) UA60318C2 (pt)
WO (1) WO1998042318A1 (pt)

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KR100549095B1 (ko) * 1998-07-17 2006-02-06 얀센 파마슈티카 엔.브이. 항진균제 및 중합체로 코팅된 코어를 갖는 펠릿
ES2157731B1 (es) * 1998-07-21 2002-05-01 Liconsa Liberacion Controlada Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
US6497905B1 (en) 1999-03-24 2002-12-24 R.P. Scherer Technologies, Inc. Aqueous solubility pharmaceutical formulations
KR100432949B1 (ko) * 2000-06-13 2004-05-31 코오롱제약주식회사 생체이용율이 향상된 이트라코나졸의 분립체 조성물과이를 이용한 이트라코나졸 제제 및 그 제조방법
US6663897B2 (en) * 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
BR0207862A (pt) 2001-02-14 2004-06-22 Tibotec Pharm Ltd Inibidores de protease de hiv 2-(amino-substituìda)-benzotiazol-sulfonamida de amplo espectro
CZ303139B6 (cs) 2001-04-09 2012-04-25 Tibotec Pharmaceuticals Ltd. 2-(substituovaný amino)-benzoxazolsulfonamidový derivát, farmaceutická kompozice s jeho obsahem a zpusob in vitro inhibice retrovirové replikace
AR035970A1 (es) 2001-05-11 2004-07-28 Tibotec Pharm Ltd 2-amino-benzoxazol sulfonamidas inhibidoras de amplio espectro de la hiv proteasa, composicion farmaceutica, metodo "in vitro" para inhibir la replicacion retroviral, y utilizacion de estos compuestos en la manufactura de medicamentos
AU2002317063A (en) * 2001-06-12 2002-12-23 Smartrix Technologies Inc Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
US8071133B2 (en) 2001-08-20 2011-12-06 Stiefel Laboratories, Inc. Oral dosage forms of water insoluble drugs and methods of making the same
AU2002361235B2 (en) 2001-12-21 2008-07-24 Tibotec Pharmaceuticals Ltd. Broadspectrum heterocyclic substituted phenyl containing sulfonamide HIV protease inhibitors
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
SI1517899T1 (sl) 2002-05-17 2008-02-29 Tibotec Pharm Ltd Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji
WO2004016619A1 (en) 2002-08-14 2004-02-26 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted oxindole sulfonamide hiv protease inhibitors
KR100557680B1 (ko) * 2002-11-23 2006-03-07 한국유나이티드제약 주식회사 이트라코나졸의 용해도 개선을 위한 펠렛제제 및 그제조방법
DE60312635T3 (de) * 2003-01-14 2013-05-08 Cimex Pharma Ag Zusammensetzung in Form eines festen Dispersion enthaltend Itraconazol und ein hydrophilisches Polymer mit einer verbesserten Bioverfügbarkeit
PT1438961E (pt) * 2003-01-14 2007-05-31 Cimex Pharma Ag Composição bioquivalente de itraconazol disperso num polímero hidrofílico.
MXPA06001401A (es) 2003-08-06 2006-05-19 Nirmal Mulye Composicion farmaceutica que contiene farmaco soluble en agua.
JP4823063B2 (ja) 2003-09-11 2011-11-24 テイボテク・フアーマシユーチカルズ・リミテツド Ｈｉｖウイルス侵入阻害剤
EP1568369A1 (en) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the treatment of respiratory diseases in pigs
AR048650A1 (es) 2004-05-04 2006-05-10 Tibotec Pharm Ltd Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
EP2422781A1 (en) 2004-05-07 2012-02-29 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
TW200607503A (en) 2004-05-17 2006-03-01 Tibotec Pharm Ltd 1-heterocyclyl-1, 5-dihydro-pyrido[3, 2-b]indol-2-ones
BRPI0511267A (pt) 2004-05-17 2007-11-27 Tibotec Pharm Ltd 1,5-diidropirido[3,2-b]indol-2-onas 4-substituìdas
MXPA06013313A (es) 2004-05-17 2007-02-02 Tibotec Pharm Ltd 1-fenil-1,5-dihidro-pirido[3,2-b]indol-2-onas sustituidas en las posiciones 6,7,8,9 utiles como agentes farmaceuticos anti-infecciosos.
BRPI0709940A2 (pt) 2006-04-03 2011-08-02 Tibotec Pharm Ltd 3,4-diidro-imidazo[4,5-b]piridin-5-onas para inibição do hiv
RU2420268C2 (ru) * 2006-09-04 2011-06-10 Панацея Биотек Лимитед Способ программируемой плавучей доставки
KR100809903B1 (ko) * 2006-09-05 2008-03-06 주식회사유한양행 안정화된 클로피도그렐-함유 입자, 그의 제조방법, 및 이를포함하는 약학 조성물
CN101283984B (zh) * 2007-04-12 2010-05-26 永胜药品工业股份有限公司 高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物
JP2008280254A (ja) * 2007-05-08 2008-11-20 Everest Pharm Industrial Co Ltd 生体に使用される比率が高い、殺菌剤と重合物を塗粧してる核心微粒状物
US8313527B2 (en) 2007-11-05 2012-11-20 Allergan, Inc. Soft prosthesis shell texturing method
US8569364B2 (en) 2007-11-28 2013-10-29 Sequoia Pharmaceuticals, Inc. 5-substituted benzofurans as inhibitors of cytochrome P450 2D6
US8906647B2 (en) 2008-02-21 2014-12-09 Sequoia Pharmaceuticals, Inc. Diamide inhibitors of cytochrome P450
US9050184B2 (en) 2008-08-13 2015-06-09 Allergan, Inc. Dual plane breast implant
US8877822B2 (en) 2010-09-28 2014-11-04 Allergan, Inc. Porogen compositions, methods of making and uses
US9205577B2 (en) 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
US9138309B2 (en) 2010-02-05 2015-09-22 Allergan, Inc. Porous materials, methods of making and uses
GB2479213B (en) 2010-04-01 2013-07-10 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
CN102971018B (zh) * 2010-05-11 2016-02-03 阿勒根公司 致孔剂组合物、制备方法及用途
US11202853B2 (en) 2010-05-11 2021-12-21 Allergan, Inc. Porogen compositions, methods of making and uses
US8679279B2 (en) 2010-11-16 2014-03-25 Allergan, Inc. Methods for creating foam-like texture
CN102100678B (zh) * 2011-02-18 2012-10-17 天津力生制药股份有限公司 伊曲康唑硫酸盐微丸及其制备方法
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US10092392B2 (en) 2014-05-16 2018-10-09 Allergan, Inc. Textured breast implant and methods of making same
JP6841834B2 (ja) 2016-01-20 2021-03-10 テラヴィダ, インコーポレイテッドTheraVida, Inc. 多汗症の処置のための方法および組成物
HRP20240529T1 (hr) * 2018-04-16 2024-07-05 Bristol-Myers Squibb Company Formulacije apiksabana
CN114767636B (zh) * 2022-04-11 2023-11-07 苏州中化药品工业有限公司 伊曲康唑微丸、制备方法及伊曲康唑微丸胶囊

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DE3346123A1 (de) * 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
GB8506792D0 (en) * 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
TR199802718T2 (xx) * 1996-06-28 1999-03-22 Schering Corporation Bir triazol mantara kar�� bile�i�ini i�eren a��zdan al�nan bile�im.

Also Published As

Publication number Publication date
EP0969821B1 (en) 2003-06-04
BG64434B1 (en) 2005-02-28
EE9900453A (et) 2000-04-17
RU2218153C2 (ru) 2003-12-10
HU224217B1 (hu) 2005-06-28
KR20000052971A (ko) 2000-08-25
NZ335364A (en) 2000-08-25
PL190566B1 (pl) 2005-12-30
SK284813B6 (sk) 2005-12-01
JP3608800B2 (ja) 2005-01-12
PL335542A1 (en) 2000-04-25
CN1206984C (zh) 2005-06-22
SK54499A3 (en) 2000-01-18
IL129575A (en) 2004-06-20
CA2269501A1 (en) 1998-10-01
CA2269501C (en) 2005-11-08
OA11162A (en) 2003-04-16
IL129575A0 (en) 2000-02-29
HUP0002056A2 (hu) 2000-12-28
NO992114D0 (no) 1999-04-30
EP0969821A1 (en) 2000-01-12
DK0969821T3 (da) 2003-09-15
ID21477A (id) 1999-06-17
CZ295502B6 (cs) 2005-08-17
DE69815316D1 (de) 2003-07-10
TR199900990T2 (xx) 1999-10-21
CZ139899A3 (cs) 1999-10-13
PT969821E (pt) 2003-10-31
DE69815316T2 (de) 2004-04-29
EE03904B1 (et) 2002-12-16
SI0969821T1 (en) 2003-10-31
JP2001520663A (ja) 2001-10-30
UA60318C2 (uk) 2003-10-15
HUP0002056A3 (en) 2001-01-29
WO1998042318A1 (en) 1998-10-01
KR100520936B1 (ko) 2005-10-17
ES2201485T3 (es) 2004-03-16
NO325102B1 (no) 2008-02-04
BG103356A (en) 2000-03-31
NO992114L (no) 1999-08-26
ATE241969T1 (de) 2003-06-15
BR9806174A (pt) 1999-10-19
CN1244796A (zh) 2000-02-16
HK1022840A1 (en) 2000-08-25
AP1227A (en) 2003-11-24
AP9901516A0 (en) 1999-06-30
AU734248B2 (en) 2001-06-07
AU7210798A (en) 1998-10-20

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