DK0942983T4 - Streptococcus pneumoniae-antigener og -vacciner - Google Patents
Streptococcus pneumoniae-antigener og -vacciner Download PDFInfo
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- DK0942983T4 DK0942983T4 DK97946850.1T DK97946850T DK0942983T4 DK 0942983 T4 DK0942983 T4 DK 0942983T4 DK 97946850 T DK97946850 T DK 97946850T DK 0942983 T4 DK0942983 T4 DK 0942983T4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2996096P | 1996-10-31 | 1996-10-31 | |
PCT/US1997/019422 WO1998018930A2 (en) | 1996-10-31 | 1997-10-30 | Streptococcus pneumoniae antigens and vaccines |
Publications (2)
Publication Number | Publication Date |
---|---|
DK0942983T3 DK0942983T3 (da) | 2007-04-30 |
DK0942983T4 true DK0942983T4 (da) | 2014-12-01 |
Family
ID=21851789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97946850.1T DK0942983T4 (da) | 1996-10-31 | 1997-10-30 | Streptococcus pneumoniae-antigener og -vacciner |
Country Status (11)
Country | Link |
---|---|
US (9) | US6420135B1 (da) |
EP (4) | EP1770164B1 (da) |
JP (6) | JP4469026B2 (da) |
AT (2) | ATE348887T1 (da) |
AU (6) | AU6909098A (da) |
CA (2) | CA2271720A1 (da) |
DE (2) | DE69737125T3 (da) |
DK (1) | DK0942983T4 (da) |
ES (2) | ES2350491T3 (da) |
PT (1) | PT942983E (da) |
WO (2) | WO1998018931A2 (da) |
Families Citing this family (335)
Publication number | Priority date | Publication date | Assignee | Title |
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US7078042B2 (en) * | 1995-09-15 | 2006-07-18 | Uab Research Foundation | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
JP2000506385A (ja) * | 1996-02-20 | 2000-05-30 | スミスクライン・ビーチャム・コーポレイション | 新規era |
GB9607991D0 (en) * | 1996-04-18 | 1996-06-19 | Smithkline Beecham Plc | Novel compounds |
US5834276A (en) * | 1996-04-18 | 1998-11-10 | Smithkline Beecham Corporation | Asparaginyl TRNA synthetase polynucleotides of streptococcus |
US5795758A (en) * | 1997-04-18 | 1998-08-18 | Smithkline Beecham Corporation | DNA encoding histidyl tRNA synthetase variant from Streptococcus pneumoniae |
US5968777A (en) * | 1996-04-18 | 1999-10-19 | Smithkline Beecham Corporation | DNA encoding seryl t-RNA synthetase |
GB9608000D0 (en) * | 1996-04-18 | 1996-06-19 | Smithkline Beecham Plc | Novel compounds |
GB9607993D0 (en) * | 1996-04-18 | 1996-06-19 | Smithkline Beecham Plc | Novel compounds |
US6270999B1 (en) | 1997-04-10 | 2001-08-07 | Smithkline Beecham Corporation | Compounds |
JP2000509984A (ja) * | 1996-05-01 | 2000-08-08 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
US6294661B1 (en) * | 1996-05-14 | 2001-09-25 | Smithkline Beecham Corporation | Compounds |
US6165989A (en) | 1996-05-14 | 2000-12-26 | Smithkline Beecham Corporation | Era of Streptococcus pneumoniae |
US5712108A (en) * | 1996-05-29 | 1998-01-27 | Eli Lilly And Company | Peptidoglycan biosynthetic mure protein from streptocuccus pneumoniae |
US5681694A (en) * | 1996-06-18 | 1997-10-28 | Eli Lilly And Company | Murd protein method and kit for identification of inhibitors |
EP0816502A3 (en) * | 1996-07-03 | 1999-10-20 | Smithkline Beecham Corporation | Mur A-1, an UDP-N-acetylglucosamine enolpyruvyl-transferase from Streptococcus pneumoniae |
GB9613907D0 (en) | 1996-07-03 | 1996-09-04 | Smithkline Beecham Plc | Novel compounds |
US5776733A (en) * | 1996-07-25 | 1998-07-07 | Eli Lilly And Company | Biosynthetic gene DD1 from Streptococcus pneumoniae |
US5691161A (en) * | 1996-08-01 | 1997-11-25 | Eli Lilly And Company | Peptidoglycan biosynthetic mura protein from Streptococcus pneumoniae |
US6284878B1 (en) | 1996-08-16 | 2001-09-04 | Smithkline Beecham Corporation | def1 |
US6165762A (en) * | 1996-08-16 | 2000-12-26 | Smithkline Beecham Corporation | DNA encoding adenine phosphoribosyltransferase from Streptococcus pneumoniae |
EP0956289A4 (en) * | 1996-08-16 | 2004-10-13 | Smithkline Beecham Corp | NOVEL PROKARYOTA POLYNUCLEOTIDES AND POLYPEPTIDES AND USES THEREOF |
US5858718A (en) * | 1997-07-08 | 1999-01-12 | Smithkline Beecham Corporation | Pcr a |
GB9619071D0 (en) | 1996-09-12 | 1996-10-23 | Smithkline Beecham Plc | Novel compounds |
US5928895A (en) * | 1996-09-24 | 1999-07-27 | Smithkline Beecham Corporation | IgA Fc binding protein |
US5882871A (en) * | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | Saliva binding protein |
US5882896A (en) | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | M protein |
US6225083B1 (en) * | 1996-10-01 | 2001-05-01 | Smithkline Beecham Corporation | FtsL from Streptococcus pneumoniae |
US5910414A (en) * | 1996-10-15 | 1999-06-08 | Smithkline Beecham Corporation | Topoisomerase I of streptococcus pneumoniae |
US5789202A (en) * | 1996-10-17 | 1998-08-04 | Eli Lilly And Company | DNA encoding a novel penicillin binding protein from streptococcus pneumoniae |
US6096518A (en) * | 1996-10-24 | 2000-08-01 | Smithkline Beecham Corporation | DNA encoding SPO/REL polypeptides of streptococcus |
US6022710A (en) * | 1996-10-25 | 2000-02-08 | Smithkline Beecham Corporation | Nucleic acid encoding greA from Streptococcus pneumoniae |
US6887663B1 (en) * | 1996-10-31 | 2005-05-03 | Human Genome Sciences, Inc. | Streptococcus pneumoniae SP036 polynucleotides |
DE69737125T3 (de) | 1996-10-31 | 2015-02-26 | Human Genome Sciences, Inc. | Streptococcus pneumoniae-Antigene und Impfstoffe |
US5821335A (en) * | 1996-11-19 | 1998-10-13 | Eli Lilly And Company | Biosynthetic gene murg from streptococcus pneumoniae |
US5786197A (en) * | 1996-11-25 | 1998-07-28 | Smithkline Beecham Corporation | lep |
US6287803B1 (en) * | 1996-11-27 | 2001-09-11 | Smithkline Beecham Corporation | Polynucleotides encoding a novel era polypeptide |
US5948645A (en) * | 1996-12-04 | 1999-09-07 | Eli Lilly And Company | Biosynthetic gene muri from Streptococcus pneumoniae |
CA2220850A1 (en) * | 1997-01-21 | 1998-07-21 | Smithkline Beecham Corporation | Novel aroe |
EP0863152A3 (en) * | 1997-02-10 | 2000-04-19 | Smithkline Beecham Corporation | Streptococcus pneumoniae Def1 protein |
EP0863205A1 (en) * | 1997-02-10 | 1998-09-09 | Smithkline Beecham Corporation | Def2 protein from Streptococcus pneumoniae |
US6110899A (en) | 1997-02-28 | 2000-08-29 | Smithkline Beecham Corporation | LICC of Streptococcus pneumoniae |
US6228838B1 (en) | 1997-02-28 | 2001-05-08 | Smithkline Beecham Corporation | LicD1 polypeptides |
CA2230497A1 (en) * | 1997-02-28 | 1998-08-28 | Smithkline Beecham Corporation | Novel lica |
US5962295A (en) * | 1997-02-28 | 1999-10-05 | Smithkline Beecham Corporation | LicB polypeptides from Streptococcus pneumoniae |
DE19708537A1 (de) * | 1997-03-03 | 1998-09-10 | Biotechnolog Forschung Gmbh | Neues Oberflächenprotein (SpsA-Protein) von Streptococcus pneumoniae etc. |
US6210940B1 (en) | 1997-04-18 | 2001-04-03 | Smithkline Beecham Corporation | Compounds |
US6074858A (en) * | 1997-04-18 | 2000-06-13 | Smithkline Beecham Corporation | Cysteinyl TRNA synthetase from Streptococcus pneumoniae |
WO1998048022A1 (en) * | 1997-04-24 | 1998-10-29 | Regents Of The University Of Minnesota | HUMAN COMPLEMENT C3-DEGRADING PROTEINASE FROM $i(STREPTOCOCCUS PNEUMONIAE) |
US6676943B1 (en) | 1997-04-24 | 2004-01-13 | Regents Of The University Of Minnesota | Human complement C3-degrading protein from Streptococcus pneumoniae |
US5919664A (en) * | 1997-05-29 | 1999-07-06 | Smithkline Beecham Corporation | Peptide release factor, prfC (RF-3), a GTP-Binding protein |
US6287836B1 (en) | 1997-05-30 | 2001-09-11 | Smithkline Beecham Corporation | Histidine kinase from Streptococcus pneumoniae and compositions therecontaining |
CA2233577A1 (en) * | 1997-05-30 | 1998-11-30 | Smithkline Beecham Corporation | Histidine kinase |
US6165991A (en) * | 1997-05-30 | 2000-12-26 | Smithkline Beecham Corporation | Sensor histidine kinase of Streptococcus pneumoniae |
US6165992A (en) * | 1997-05-30 | 2000-12-26 | Smithkline Beecham Corporation | Histidine kinase |
US5866365A (en) * | 1997-06-05 | 1999-02-02 | Smithkline Beecham Corporation | RNC polynucleotides |
US5882889A (en) * | 1997-06-13 | 1999-03-16 | Smithkline Beecham Corporation | Response regulator in a two component signal transduction system |
EP0885965A3 (en) * | 1997-06-20 | 2000-01-12 | Smithkline Beecham Corporation | Histidine kinase polypeptides |
EP0885963A3 (en) * | 1997-06-20 | 1999-12-29 | Smithkline Beecham Corporation | Compounds comprising polypeptides and polynucleotides of Streptococcus pneumoniae,said polypeptides being related by amino acid sequence homology to SapR from Streptococcus mutans polypeptide |
US6270991B1 (en) | 1997-06-20 | 2001-08-07 | Smithkline Beecham Corporation | Histidine kinase |
EP0885903A3 (en) * | 1997-06-20 | 2000-01-19 | Smithkline Beecham Corporation | Nucleic acid encoding streptococcus pheumoniae response regulator |
EP0891984A3 (en) | 1997-06-20 | 2000-01-19 | Smithkline Beecham Corporation | Nucleic acid encoding streptococcus pneumoniae response regulator |
EP0885966A3 (en) * | 1997-06-20 | 1999-12-29 | Smithkline Beecham Corporation | Novel compouds |
US6268172B1 (en) * | 1997-06-20 | 2001-07-31 | Smithkline Beecham Corporation | Compounds |
US6140061A (en) * | 1997-06-20 | 2000-10-31 | Smithkline Beecham Corporation | Response regulator |
CA2236441A1 (en) * | 1997-07-01 | 1999-01-01 | Smithkline Beecham Corporation | Gida2 |
US5866366A (en) * | 1997-07-01 | 1999-02-02 | Smithkline Beecham Corporation | gidB |
US6238882B1 (en) * | 1997-07-01 | 2001-05-29 | Smithkline Beecham Corporation | GidA1 |
US7153952B1 (en) | 1997-07-02 | 2006-12-26 | sanofi pasteur limited/sanofi pasteur limitée | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
US6800744B1 (en) | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
EP0890641A1 (en) * | 1997-07-10 | 1999-01-13 | Smithkline Beecham Corporation | Novel IspA |
EP0915159A1 (en) * | 1997-07-17 | 1999-05-12 | Smithkline Beecham Corporation | Novel xanthine phosphoribosyl transferase |
US5994101A (en) * | 1997-07-18 | 1999-11-30 | Smithkline Beecham Corporation | DNA encoding gidA1 polypeptides |
CA2237043A1 (en) * | 1997-07-18 | 1999-01-18 | Smithkline Beecham Corporation | Response regulator |
EP0894857A3 (en) * | 1997-08-01 | 2001-09-26 | Smithkline Beecham Corporation | SecA gene from Streptococcus pneumoniae |
US5840538A (en) * | 1997-08-06 | 1998-11-24 | Smithkline Beecham Corporation | Lgt |
EP0896061A3 (en) * | 1997-08-08 | 2000-07-26 | Smithkline Beecham Corporation | RpoA gene from Staphylococcus aureus |
US5929045A (en) | 1997-08-12 | 1999-07-27 | Smithkline Beecham Corporation | Recombinant expression of polynucleotides encoding the UDP-N-acetylmuramoylalanine:D-glutamate ligase (MurD) of Streptococcus pneumoniae |
US6197300B1 (en) * | 1997-08-12 | 2001-03-06 | Smithkline Beecham Corporation | ftsZ |
US5888770A (en) * | 1997-08-26 | 1999-03-30 | Smithkline Beecham Corporation | Spoiiie |
US6072032A (en) * | 1997-08-29 | 2000-06-06 | Smithkline Beecham Corporation | FtsY polypeptides from Streptococcus pneumoniae |
US5882898A (en) * | 1997-08-29 | 1999-03-16 | Smithkline Beecham Corporation | Streptococcus pneumoniae polynucleotides which encode folyl-polyglutamate synthetase (FPGS) polypeptides |
US6225087B1 (en) * | 1997-09-09 | 2001-05-01 | Smithkline Beecham Corporation | Response regulator |
EP0902087A3 (en) * | 1997-09-10 | 2000-03-15 | SmithKline Beecham Corporation | Histidine kinase |
EP0913478A3 (en) * | 1997-09-17 | 1999-12-29 | Smithkline Beecham Corporation | Histidine kinase from Streptococcus pneumoniae 0100993 |
US5866369A (en) * | 1997-09-18 | 1999-02-02 | Smithkline Beecham Corporation | Amps |
US5885804A (en) * | 1997-09-18 | 1999-03-23 | Smithkline Beecham Corporation | PhoH |
JP2001517449A (ja) * | 1997-09-24 | 2001-10-09 | リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミネソタ | ストレプトコッカス・ニューモニア由来のヒト補体c3分解プロテイナーゼ |
CA2244954A1 (en) * | 1997-09-25 | 1999-03-25 | Smithkline Beecham Corporation | Murf |
US6194170B1 (en) | 1997-09-25 | 2001-02-27 | Smithkline Beecham Corporation | MurF of Streptococcus pneumoniae |
EP0905249A3 (en) * | 1997-09-25 | 1999-08-04 | Smithkline Beecham Corporation | Alcohol dehydrogenase |
US6121028A (en) * | 1997-10-10 | 2000-09-19 | Smithkline Beecham Corporation | MurE |
US6331411B1 (en) * | 1997-10-14 | 2001-12-18 | Smithkline Beecham Corporation | TopA |
EP0913479A3 (en) * | 1997-10-27 | 2000-10-25 | Smithkline Beecham Corporation | Adenine glycosylase |
US6165763A (en) * | 1997-10-30 | 2000-12-26 | Smithkline Beecham Corporation | Ornithine carbamoyltransferase |
US5861281A (en) | 1997-10-30 | 1999-01-19 | Smithkline Beecham Corporation | Lacc |
EP0913480A3 (en) * | 1997-11-03 | 2001-07-11 | Smithkline Beecham Corporation | Chorismate synthase |
EP0964921A4 (en) * | 1997-11-05 | 2002-01-23 | Smithkline Beecham Corp | NEW ERS FROM STREPTOCOCCUS |
US20020058799A1 (en) * | 1998-05-18 | 2002-05-16 | Sanjoy Biswas | Novel pth |
JP2002508156A (ja) * | 1997-12-31 | 2002-03-19 | ストレスジェン バイオテクノロジーズ コーポレイション | Hsp60ファミリーのStreptococcus熱ショックタンパク質 |
JP2002504314A (ja) * | 1997-12-31 | 2002-02-12 | ミレニアム ファーマシューティカルズ インク. | 必須細菌遺伝子およびその使用 |
TR200002437T2 (tr) * | 1998-02-20 | 2000-11-21 | Biochem Pharma Inc. | B grubu streptococcus antijenleri. |
US6858706B2 (en) * | 1998-04-07 | 2005-02-22 | St. Jude Children's Research Hospital | Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
KR100638503B1 (ko) * | 1998-04-07 | 2006-10-26 | 세인트 쥬드 칠드런즈 리써치 호스피탈 | N-말단 콜린 결합 단백질 a 절두물의 아미노산을 포함하는 폴리펩티드, 이로부터 유도된 백신 및 이를 포함하는 약제학적 조성물 |
KR20060126844A (ko) * | 1998-04-07 | 2006-12-08 | 메디뮨 인코포레이티드 | 백신용 폐렴 구균의 콜린 결합성 단백질의 유도체 |
GB9808363D0 (en) * | 1998-04-22 | 1998-06-17 | Glaxo Group Ltd | Bacterial polypeptide family |
GB9808350D0 (en) * | 1998-04-22 | 1998-06-17 | Glaxo Group Ltd | Bacterial polypeptide family |
US20010016200A1 (en) * | 1998-04-23 | 2001-08-23 | Briles David E. | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
JP2002515240A (ja) * | 1998-05-18 | 2002-05-28 | スミスクライン・ビーチャム・コーポレイション | ストレプトコッカス・ニュモニエのclpX |
WO1999061452A2 (en) * | 1998-05-28 | 1999-12-02 | Smithkline Beecham Corporation | acpS |
US6660520B2 (en) * | 1998-06-05 | 2003-12-09 | Smithkline Beecham Corporation | Nrde |
US6190881B1 (en) * | 1998-06-05 | 2001-02-20 | Smithkline Beecham Corporation | Ribonucleotide diphosphate reductase, nrdF, of streptococcus pneumoniae |
WO1999064610A1 (en) * | 1998-06-11 | 1999-12-16 | St. Jude Children's Research Hospital | ZmpB, A NEW DETERMINANT OF VIRULENCE FOR STREPTOCOCCUS PNEUMONIAE, VACCINE DERIVED THEREFROM AND USES THEREOF |
JP2002519055A (ja) * | 1998-07-02 | 2002-07-02 | スミスクライン・ビーチャム・コーポレイション | Ftsz多量体蛋白およびその使用 |
JP2002521026A (ja) * | 1998-07-24 | 2002-07-16 | スミスクライン・ビーチャム・コーポレイション | ニュモコッカスnrdg蛋白 |
EP1100920A2 (en) * | 1998-07-27 | 2001-05-23 | Microbial Technics Limited | Nucleic acids and proteins from group b streptococcus |
CN1318103A (zh) * | 1998-07-27 | 2001-10-17 | 微生物技术有限公司 | 肺炎链球菌的核酸和蛋白质 |
EP1624064A3 (en) * | 1998-07-27 | 2006-05-10 | Microbial Technics Limited | Nucleic acids and proteins from streptococcus pneumoniae |
EP1785486A3 (en) * | 1998-07-27 | 2007-08-08 | Sanofi Pasteur Limited | Streptococcus pneumoniae proteins and nucleic acid molecules |
US7098182B2 (en) | 1998-07-27 | 2006-08-29 | Microbial Technics Limited | Nucleic acids and proteins from group B streptococcus |
JP2002531055A (ja) * | 1998-07-27 | 2002-09-24 | マイクロビアル テクニクス リミティッド | 肺炎連鎖球菌のタンパク質及び核酸分子 |
US6936252B2 (en) | 1998-07-27 | 2005-08-30 | Microbial Technics Limited | Streptococcus pneumoniae proteins and nucleic acid molecules |
EP1801218A3 (en) * | 1998-07-27 | 2007-10-10 | Sanofi Pasteur Limited | Nucleic acids and proteins from streptococcus pneumoniae |
US20030134407A1 (en) | 1998-07-27 | 2003-07-17 | Le Page Richard William Falla | Nucleic acids and proteins from Streptococcus pneumoniae |
JP2002524069A (ja) * | 1998-09-09 | 2002-08-06 | ミレニアム ファーマシューティカルズ インク. | 必須細菌遺伝子およびその使用 |
US6268177B1 (en) | 1998-09-22 | 2001-07-31 | Smithkline Beecham Corporation | Isolated nucleic acid encoding nucleotide pyrophosphorylase |
US6225457B1 (en) | 1998-09-23 | 2001-05-01 | Smithkline Beecham Corporation | murF2 |
IL142017A0 (en) * | 1998-09-24 | 2002-03-10 | Univ Minnesota | Human complement c3-degrading polypeptide from streptococcus pneumoniae |
JP2002525101A (ja) * | 1998-09-28 | 2002-08-13 | スミスクライン・ビーチャム・コーポレイション | Map |
US20030082614A1 (en) * | 2001-05-29 | 2003-05-01 | Sanjoy Biswas | Map |
US6515119B1 (en) * | 1998-09-30 | 2003-02-04 | Millennium Pharmaceuticals, Inc. | Use of S-ydcB and B-ydcB, essential bacterial genes |
US6537774B1 (en) * | 1998-10-14 | 2003-03-25 | Smithkline Beecham Corporation | UPS (undecaprenyl diphosphate synthase |
US6255075B1 (en) | 1998-10-20 | 2001-07-03 | Smithkline Beecham Corporation | Bira |
US6110685A (en) * | 1998-10-28 | 2000-08-29 | Smithkline Beecham Corporation | infB |
US6228625B1 (en) * | 1998-11-03 | 2001-05-08 | Smithkline Beecham Corporation | metK from Streptococcus pneumoniae |
WO2000026359A1 (en) * | 1998-11-04 | 2000-05-11 | Smithkline Beecham Corporation | ftsX |
US6165764A (en) | 1998-11-09 | 2000-12-26 | Smithkline Beecham Corporation | Polynucleotides encoding tRNA methyl transferases from Streptococcus pneumoniae |
AU2027400A (en) * | 1998-11-19 | 2000-06-05 | St. Jude Children's Research Hospital | Identification and characterization of novel pneumococcal choline binding proteins, cbpg and cbpd, and diagnostic and therapeutic uses thereof |
US6277595B1 (en) * | 1998-11-19 | 2001-08-21 | Smithkline Beecham Corporation | FabZ |
US6495139B2 (en) * | 1998-11-19 | 2002-12-17 | St. Jude Children's Research Hospital | Identification and characterization of novel pneumococcal choline binding protein, CBPG, and diagnostic and therapeutic uses thereof |
DK1140157T3 (da) * | 1998-12-21 | 2009-06-08 | Medimmune Inc | Streptococcus pneumoniae-proteiner og immunogene fragmenter til vacciner |
AU2004242430C1 (en) * | 1998-12-21 | 2008-06-05 | Med Immune, Inc. | Streptococcus pneumoniae proteins and immunogenic fragments for vaccines |
US7217415B1 (en) * | 1998-12-22 | 2007-05-15 | Emergent Product Development Uk Limited | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase for therapeutic use |
PT1141308E (pt) | 1998-12-22 | 2007-05-31 | Microscience Ltd | Ptroteínas de streptococcus do grupo b e sua utilização |
AU2005209689B2 (en) * | 1998-12-23 | 2008-07-17 | Id Biomedical Corporation Of Quebec | Novel streptococcus antigens |
EP1950302B1 (en) | 1998-12-23 | 2012-12-05 | ID Biomedical Corporation of Quebec | Streptococcus antigens |
WO2000039299A2 (en) * | 1998-12-23 | 2000-07-06 | Shire Biochem Inc. | Streptococcus antigens |
US7128918B1 (en) | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
US6340564B1 (en) | 1999-01-26 | 2002-01-22 | Smithkline Beecham Corporation | yhxB |
WO2000044764A1 (en) * | 1999-01-28 | 2000-08-03 | Smithkline Beecham Corporation | Mvd |
US6346396B1 (en) * | 1999-01-29 | 2002-02-12 | Jianzhong Huang | MurA |
US6306633B1 (en) | 1999-02-01 | 2001-10-23 | Smithkline Beecham Corporation | Polynucleotides encoding mevalonate kinase from Streptococcus pneumoniae |
WO2000049033A1 (en) * | 1999-02-17 | 2000-08-24 | Smithkline Beecham Corporation | yybQ |
US6270762B1 (en) * | 1999-02-26 | 2001-08-07 | Smithkline Beecham Corporation | tdk |
GB9906437D0 (en) * | 1999-03-19 | 1999-05-12 | Smithkline Beecham Biolog | Vaccine |
US6130069A (en) * | 1999-03-24 | 2000-10-10 | Smithkline Beecham Corporation | IspA from Streptococcus pneumoniae |
WO2000056884A1 (en) * | 1999-03-24 | 2000-09-28 | Smithkline Beecham Corporation | pksG |
WO2000056873A1 (en) * | 1999-03-25 | 2000-09-28 | Smithkline Beecham Corporation | mvaA |
EP1165795A2 (en) * | 1999-03-26 | 2002-01-02 | Provalis UK Limited | Streptococcus pneumoniae antigens |
WO2000059514A1 (en) * | 1999-04-02 | 2000-10-12 | Smithkline Beecham Corporation | Yeaz |
US7101692B2 (en) | 1999-04-15 | 2006-09-05 | The Regents Of The University Of California | Identification of sortase gene |
WO2000062804A2 (en) * | 1999-04-15 | 2000-10-26 | The Regents Of The University Of California | Identification of sortase gene |
US6326167B1 (en) * | 1999-04-23 | 2001-12-04 | Smithkline Beecham Corp. | TktA from Streptococcus pneumoniae |
WO2000065026A2 (en) * | 1999-04-28 | 2000-11-02 | Smithkline Beecham Corporation | YycG |
US6245542B1 (en) * | 1999-05-06 | 2001-06-12 | Smithkline Beecham Corporation | tRNA methyltransferase from Streptococcus pneumoniae |
WO2000070075A1 (en) * | 1999-05-17 | 2000-11-23 | Smithkline Beecham Corporation | STREPTOCOCCUS PNEUMONIAE yerS |
DK2270173T3 (da) | 1999-05-19 | 2016-03-07 | Glaxosmithkline Biolog Sa | Neisseriale kombinationssammensætninger |
US6177269B1 (en) * | 1999-06-04 | 2001-01-23 | Smithkline Beecham Corporation, | aroA |
US6887480B1 (en) * | 1999-06-10 | 2005-05-03 | Medimmune, Inc. | Streptococcus pneumoniae proteins and vaccines |
ATE500843T1 (de) * | 1999-06-10 | 2011-03-15 | Medimmune Llc | Streptococcus pneumoniae proteine und impfstoffe |
US6869767B1 (en) * | 1999-06-11 | 2005-03-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Detection of Streptococcus pneumoniae and immunization against Streptococcus pneumoniae infection |
WO2000078785A1 (en) * | 1999-06-22 | 2000-12-28 | Smithkline Beecham Corporation | lacA |
US6511839B1 (en) * | 1999-06-22 | 2003-01-28 | Pan Fong Chan | Fucose kinase |
US6291230B1 (en) * | 1999-06-23 | 2001-09-18 | Smithkline Beecham Corporation | Galk promoter |
WO2000078784A1 (en) * | 1999-06-23 | 2000-12-28 | Smithkline Beecham Corporation | treP |
PL359501A1 (en) * | 1999-07-01 | 2004-08-23 | Basf Aktiengesellschaft | Orynebacterium glutamicum |
US6884614B1 (en) | 1999-07-01 | 2005-04-26 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins |
WO2001007463A1 (en) * | 1999-07-22 | 2001-02-01 | Smithkline Beecham Corporation | Trer |
WO2001007460A1 (en) * | 1999-07-22 | 2001-02-01 | Smithkline Beecham Corporation | FucR |
US6277597B1 (en) * | 1999-08-03 | 2001-08-21 | Smithkline Beecham Corporation | kdtB |
GB9918319D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
EP1075841A1 (en) * | 1999-08-13 | 2001-02-14 | Erasmus Universiteit Rotterdam | Pneumococcal vaccines |
US6168797B1 (en) * | 1999-08-18 | 2001-01-02 | Smithkline Beecham Corporation | FabF |
WO2001012649A1 (en) * | 1999-08-18 | 2001-02-22 | Smithkline Beecham Corporation | Aga |
US6833356B1 (en) | 1999-08-25 | 2004-12-21 | Medimmune, Inc. | Pneumococcal protein homologs and fragments for vaccines |
CA2382795A1 (en) * | 1999-08-25 | 2001-03-01 | Medimmune, Inc. | Homologs of a pneumococcal protein and fragments for vaccines |
WO2001023403A1 (en) * | 1999-09-27 | 2001-04-05 | Smithkline Beecham Corporation | ypga CLADE GENES |
EP1246935B1 (en) * | 1999-09-28 | 2013-08-14 | Geneohm Sciences Canada Inc. | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
WO2001023599A1 (en) * | 1999-09-28 | 2001-04-05 | Smithkline Beecham Corporation | Streptococcus pneumoniae ykqc |
US6861516B1 (en) | 1999-10-04 | 2005-03-01 | Merck & Co., Inc. | MraY gene and enzyme of pseudomonas aeruginosa |
US6951729B1 (en) | 1999-10-27 | 2005-10-04 | Affinium Pharmaceuticals, Inc. | High throughput screening method for biological agents affecting fatty acid biosynthesis |
CA2397710A1 (en) * | 1999-12-23 | 2001-07-05 | Vmax Limited | Streptococcus pyogenes virulence genes and proteins and their use |
WO2001049721A2 (en) * | 1999-12-30 | 2001-07-12 | Bristol-Myers Squibb Company | Bacterial genes and proteins that are essential for cell viability and their uses |
CA2335389A1 (en) * | 2000-03-01 | 2001-09-01 | Message Pharmaceuticals, Inc. | Novel bacterial rnase p proteins and their use in identifying antibacterial compounds |
FR2807764B1 (fr) * | 2000-04-18 | 2004-09-10 | Agronomique Inst Nat Rech | Mutants de bacteries lactiques surproducteurs d'exopolysaccharides |
AU5577201A (en) * | 2000-04-27 | 2001-11-07 | Med Immune Inc | Immunogenic pneumococcal protein and vaccine compositions thereof |
US6866855B2 (en) | 2000-06-12 | 2005-03-15 | University Of Saskatchewan | Immunization of dairy cattle with GapC protein against Streptococcus infection |
US6833134B2 (en) | 2000-06-12 | 2004-12-21 | University Of Saskacthewan | Immunization of dairy cattle with GapC protein against Streptococcus infection |
EP1734050A3 (en) * | 2000-06-12 | 2012-12-05 | University Of Saskatchewan | Immunization of dairy cattle with GapC protein against streptococcus infection |
US6660270B2 (en) | 2000-06-12 | 2003-12-09 | University Of Saskatchewan | Immunization of dairy cattle with chimeric GapC protein against Streptococcus infection |
ATE343593T1 (de) * | 2000-06-12 | 2006-11-15 | Univ Saskatchewan | Immunisation von milchvieh mit gapc protein gegen streptococcus infektion |
KR100927767B1 (ko) * | 2000-06-20 | 2009-11-20 | 아이디 바이오메디칼 코포레이션 | 스트렙토코커스 항원 |
US7074415B2 (en) | 2000-06-20 | 2006-07-11 | Id Biomedical Corporation | Streptococcus antigens |
AU2001269527A1 (en) * | 2000-07-18 | 2002-01-30 | Center For Advanced Science And Technology Incubation, Ltd. | Isopentenyl pyrophosphate isomerase |
GB0022742D0 (en) * | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
US7033795B2 (en) | 2000-10-06 | 2006-04-25 | Affinium Pharmaceuticals, Inc. | FabK variant |
US7048926B2 (en) | 2000-10-06 | 2006-05-23 | Affinium Pharmaceuticals, Inc. | Methods of agonizing and antagonizing FabK |
US6821746B2 (en) | 2000-10-06 | 2004-11-23 | Affinium Pharmaceuticals, Inc. | Methods of screening for FabK antagonists and agonists |
US7056697B2 (en) | 2000-10-06 | 2006-06-06 | Affinium Pharmaceuticals, Inc. | FabK variant |
CA2426738A1 (en) * | 2000-10-26 | 2002-05-02 | David William Holden | Streptococcal genes |
MXPA03003690A (es) | 2000-10-27 | 2004-05-05 | Chiron Spa | Acidos nucleicos y proteinas de los grupos a y b de estreptococos. |
AU2002227450B2 (en) | 2000-12-28 | 2008-02-28 | Wyeth | Recombinant protective protein from $I(streptococcus pneumoniae) |
EP1227152A1 (en) * | 2001-01-30 | 2002-07-31 | Société des Produits Nestlé S.A. | Bacterial strain and genome of bifidobacterium |
GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
GB0107658D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
WO2002083855A2 (en) * | 2001-04-16 | 2002-10-24 | Wyeth Holdings Corporation | Novel streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof |
WO2003054007A2 (en) * | 2001-12-20 | 2003-07-03 | Shire Biochem Inc. | Streptococcus antigens |
US20030211470A1 (en) * | 2002-03-15 | 2003-11-13 | Olson William C. | CD4-IgG2-based salvage therapy of HIV-1 infection |
US20030199603A1 (en) * | 2002-04-04 | 2003-10-23 | 3M Innovative Properties Company | Cured compositions transparent to ultraviolet radiation |
PT2255826E (pt) | 2002-08-02 | 2016-06-08 | Glaxosmithkline Biologicals Sa | Composições de vacina de neisseria compreendendo uma combinação de antigénios |
WO2004020609A2 (en) * | 2002-08-30 | 2004-03-11 | Tufts University | Streptococcus pneumoniae antigens for diagnosis, treatment and prevention of active infection |
US7615616B2 (en) * | 2002-09-13 | 2009-11-10 | The Texas A&M University System | Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby |
DK2395073T3 (da) | 2002-11-01 | 2017-10-23 | Glaxosmithkline Biologicals Sa | Fremgangsmåde til tørring. |
FR2846668B1 (fr) * | 2002-11-05 | 2007-12-21 | Univ Aix Marseille Ii | Identification moleculaire des bacteries du genre streptococcus et genres apparentes |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
AU2003286056A1 (en) * | 2002-11-26 | 2004-06-18 | Id Biomedical Corporation | Streptococcus pneumoniae surface polypeptides |
GB0302699D0 (en) * | 2003-02-06 | 2003-03-12 | Univ Bradford | Immunoglobulin |
EP2314719A1 (en) * | 2003-04-15 | 2011-04-27 | Intercell AG | S. pneumoniae antigens |
EP1648500B1 (en) | 2003-07-31 | 2014-07-09 | Novartis Vaccines and Diagnostics, Inc. | Immunogenic compositions for streptococcus pyogenes |
US8945589B2 (en) | 2003-09-15 | 2015-02-03 | Novartis Vaccines And Diagnostics, Srl | Immunogenic compositions for Streptococcus agalactiae |
ES2346314T3 (es) | 2003-10-02 | 2010-10-14 | Glaxosmithkline Biolog Sa | Antigenos de b. pertussis y uso de los mismos en vacunacion. |
CN102861325A (zh) | 2003-11-10 | 2013-01-09 | Uab研究基金会 | 减少细菌携带和中枢神经系统侵害的组合物及其使用方法 |
CN1942577A (zh) * | 2003-11-26 | 2007-04-04 | 比纳克斯公司 | 预测传染病状态的方法和试剂盒 |
EP1607485A1 (en) * | 2004-06-14 | 2005-12-21 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for quantifying VEGF121 isoform in a biological sample |
EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
JP2008504292A (ja) | 2004-06-24 | 2008-02-14 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | 免疫増強用の化合物 |
EP1784211A4 (en) | 2004-07-29 | 2010-06-30 | Novartis Vaccines & Diagnostic | IMMUNOGENIC COMPOSITIONS FOR GRAMPOSITIVE BACTERIA SUCH AS STREPTOCOCCUS AGALACTIAE |
EP1807446A2 (en) | 2004-10-08 | 2007-07-18 | Novartis Vaccines and Diagnostics, Inc. | Immunogenic and therapeutic compositions for streptococcus pyogenes |
WO2006048753A2 (en) * | 2004-11-05 | 2006-05-11 | Pharmacia & Upjohn Company Llc | Anti-bacterial vaccine compositions |
JP2006223194A (ja) * | 2005-02-17 | 2006-08-31 | Tosoh Corp | スタニオカルシン1(STC1)mRNAの測定方法 |
ES2546484T3 (es) | 2005-03-18 | 2015-09-24 | Dsm Ip Assets B.V. | Producción de carotenoides en levadura y hongos oleaginosos |
GB0505996D0 (en) | 2005-03-23 | 2005-04-27 | Glaxosmithkline Biolog Sa | Fermentation process |
US7476733B2 (en) * | 2005-03-25 | 2009-01-13 | The United States Of America As Represented By The Department Of Health And Human Services | Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease |
CA2611960C (en) | 2005-06-27 | 2015-05-05 | Glaxosmithkline Biologicals S.A. | Immunogenic compositions comprising n.meningitidis capsular saccharide conjugates |
US20070059716A1 (en) * | 2005-09-15 | 2007-03-15 | Ulysses Balis | Methods for detecting fetal abnormality |
JP2009511636A (ja) | 2005-10-18 | 2009-03-19 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | アルファウイルスレプリコン粒子による粘膜免疫および全身免疫 |
JP5215865B2 (ja) | 2005-11-22 | 2013-06-19 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | ノロウイルス抗原およびサポウイルス抗原 |
TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
AR058707A1 (es) | 2005-12-22 | 2008-02-20 | Glaxosmithkline Biolog Sa | Vacuna, procedimiento para fabricarla y su uso |
BRPI0707154B8 (pt) | 2006-01-17 | 2022-12-20 | Forsgren Arne | composição de vacina |
US20090317421A1 (en) | 2006-01-18 | 2009-12-24 | Dominique Missiakas | Compositions and methods related to staphylococcal bacterium proteins |
CA2646539A1 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Imidazoquinoxaline compounds as immunomodulators |
WO2008051285A2 (en) | 2006-04-01 | 2008-05-02 | Medical Service Consultation International, Llc | Methods and compositions for detecting fungi and mycotoxins |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
CA2661210A1 (en) * | 2006-08-17 | 2008-02-21 | The Uab Research Foundation | Diagnosing pneumococcal pneumonia |
WO2008042338A2 (en) | 2006-09-28 | 2008-04-10 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
EP1923069A1 (en) * | 2006-11-20 | 2008-05-21 | Intercell AG | Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto |
WO2008127094A2 (en) | 2007-04-12 | 2008-10-23 | Stichting Katholieke Universiteit, More Particularly The Radboud University Nijmegen Medical Center | New virulence factors of streptococcus pnuemoniae |
WO2008143676A1 (en) | 2007-05-23 | 2008-11-27 | The Uab Research Foundation | Detoxified pneumococcal neuraminidase and uses thereof |
EA200901578A1 (ru) | 2007-06-26 | 2010-08-30 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина, содержащая конъюгаты капсульных полисахаридов streptococcus pneumoniae |
GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
RU2471497C2 (ru) | 2007-09-12 | 2013-01-10 | Новартис Аг | Мутантные антигены gas57 и антитела против gas57 |
WO2009081274A2 (en) | 2007-12-21 | 2009-07-02 | Novartis Ag | Mutant forms of streptolysin o |
CA2716212A1 (en) | 2008-02-21 | 2009-08-27 | Novartis Ag | Meningococcal fhbp polypeptides |
US8466167B2 (en) | 2008-03-03 | 2013-06-18 | Irm Llc | Compounds and compositions as TLR activity modulators |
WO2009127676A1 (en) | 2008-04-16 | 2009-10-22 | Glaxosmithkline Biologicals S.A. | Vaccine |
US20100068718A1 (en) | 2008-08-22 | 2010-03-18 | Hooper Dennis G | Methods and Compositions for Identifying Yeast |
EP2174664A1 (en) | 2008-10-07 | 2010-04-14 | Stichting Katholieke Universiteit, more particularly the Radboud University Nijmegen Medical Centre | New virulence factors of Streptococcus pneumoniae |
CA2749367A1 (en) | 2009-01-12 | 2010-07-15 | Novartis Ag | Cna_b domain antigens in vaccines against gram positive bacteria |
ES2556771T3 (es) * | 2009-01-19 | 2016-01-20 | bioMérieux S.A. | Procedimientos para determinar la susceptibilidad de contraer una infección nosocomial en un paciente y para establecer un pronóstico de evolución de un síndrome séptico |
AU2010227219B2 (en) | 2009-03-24 | 2014-02-27 | Glaxosmithkline Biologicals S.A. | Adjuvanting meningococcal factor H binding protein |
JP5668049B2 (ja) | 2009-03-24 | 2015-02-12 | ノバルティス アーゲー | 髄膜炎菌h因子結合タンパク質および肺炎球菌糖結合体の組み合わせ |
ITMI20090946A1 (it) | 2009-05-28 | 2010-11-29 | Novartis Ag | Espressione di proteine ricombinanti |
CA2765112A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
EP2443250B8 (en) | 2009-06-16 | 2016-09-21 | GlaxoSmithKline Biologicals SA | High-throughput complement-mediated antibody-dependent and opsonic bactericidal assays |
JP5931724B2 (ja) * | 2009-06-29 | 2016-06-08 | ジェノセア バイオサイエンシーズ, インコーポレイテッド | StreptococcusPneumoniaeに対するワクチンおよび組成物 |
US8877356B2 (en) | 2009-07-22 | 2014-11-04 | Global Oled Technology Llc | OLED device with stabilized yellow light-emitting layer |
ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
BR112012008338A2 (pt) | 2009-09-10 | 2019-09-24 | Novartis Ag | combinação de vacinas contra doenças do trato respiratório. |
US8962251B2 (en) | 2009-10-08 | 2015-02-24 | Medical Service Consultation International, Llc | Methods and compositions for identifying sulfur and iron modifying bacteria |
CN102648003B (zh) * | 2009-10-09 | 2016-01-13 | 儿童医疗中心有限公司 | 选择性裂解的全细胞疫苗 |
WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
US9241987B2 (en) | 2009-11-20 | 2016-01-26 | The University Of Chicago | Methods and compositions related to immunogenic fibrils |
US9408907B2 (en) | 2009-12-15 | 2016-08-09 | Glaxosmithkline Biologicals Sa | Homogenous suspension of immunopotentiating compounds and uses thereof |
WO2011080595A2 (en) | 2009-12-30 | 2011-07-07 | Novartis Ag | Polysaccharide immunogens conjugated to e. coli carrier proteins |
CA2814762A1 (en) * | 2010-02-11 | 2011-08-18 | Intelligent Medical Devices, Inc. | Oligonucleotides relating to clostridium difficile genes encoding toxin b, toxin a, or binary toxin |
DK2538971T3 (da) | 2010-02-23 | 2016-01-04 | Stichting Katholieke Univ | Kombinationsvaccine til streptococcus |
US10113206B2 (en) * | 2010-02-24 | 2018-10-30 | Grifols Therapeutics Inc. | Methods, compositions, and kits for determining human immunodeficiency virus (HIV) |
GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
GB201003920D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Method of treatment |
GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
JP2013521327A (ja) | 2010-03-10 | 2013-06-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
EP2549990A1 (en) | 2010-03-23 | 2013-01-30 | Irm Llc | Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc. |
WO2011137368A2 (en) | 2010-04-30 | 2011-11-03 | Life Technologies Corporation | Systems and methods for analyzing nucleic acid sequences |
CN102933267B (zh) | 2010-05-28 | 2015-05-27 | 泰特里斯在线公司 | 交互式混合异步计算机游戏基础结构 |
US9268903B2 (en) | 2010-07-06 | 2016-02-23 | Life Technologies Corporation | Systems and methods for sequence data alignment quality assessment |
GB201015132D0 (en) | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
US9127321B2 (en) * | 2010-10-06 | 2015-09-08 | The Translational Genomics Research Institute | Method of detecting Coccidioides species |
WO2012072769A1 (en) | 2010-12-01 | 2012-06-07 | Novartis Ag | Pneumococcal rrgb epitopes and clade combinations |
EP2665490B1 (en) | 2011-01-20 | 2020-03-04 | Genocea Biosciences, Inc. | Vaccines and compositions against streptococcus pneumoniae |
GB201103836D0 (en) | 2011-03-07 | 2011-04-20 | Glaxosmithkline Biolog Sa | Conjugation process |
WO2012138470A2 (en) | 2011-04-04 | 2012-10-11 | Intelligent Medical Devices, Inc. | Optimized oligonucleotides and methods of using same for the detection, isolation, amplification, quantitation, monitoring, screening, and sequencing of group b streptococcus |
EP2709603B1 (en) | 2011-05-11 | 2021-03-24 | Children's Medical Center Corporation | Modified biotin-binding protein, fusion proteins thereof and applications |
AR086405A1 (es) | 2011-05-17 | 2013-12-11 | Glaxosmithkline Biolog Sa | Vacuna de streptococcus pneumoniae |
EP2822586A1 (en) | 2012-03-07 | 2015-01-14 | Novartis AG | Adjuvanted formulations of streptococcus pneumoniae antigens |
NZ630133A (en) | 2012-06-14 | 2016-10-28 | Novartis Ag | Vaccines for serogroup x meningococcus |
CN105307684A (zh) | 2012-10-02 | 2016-02-03 | 葛兰素史密丝克莱恩生物有限公司 | 非直链糖缀合物 |
CN105188747A (zh) | 2013-02-01 | 2015-12-23 | 葛兰素史密斯克莱生物公司 | 包含toll样受体激动剂的免疫组合物的皮内递送 |
US11576958B2 (en) | 2013-02-07 | 2023-02-14 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
WO2015188899A1 (en) * | 2014-06-12 | 2015-12-17 | Deutsches Krebsforschungszentrum | Novel ttv mirna sequences as an early marker for the future development of cancer and as a target for cancer treatment and prevention |
CA2931570A1 (en) | 2013-12-03 | 2015-06-11 | Virometix Ag | Proline-rich peptides protective against s. pneumoniae |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
EP3207055A1 (en) * | 2014-10-15 | 2017-08-23 | Xenothera | Composition with reduced immunogenicity |
US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
JP6399589B2 (ja) * | 2014-10-28 | 2018-10-03 | 国立大学法人山口大学 | 肺炎球菌における発現プロモーター |
WO2017023855A1 (en) * | 2015-07-31 | 2017-02-09 | The General Hospital Corporation | Protein prostheses for mitochondrial diseases or conditions |
GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
BR112018010705A8 (pt) | 2015-12-04 | 2019-02-26 | Dana Farber Cancer Inst Inc | vacinação com o domínio mica/b alfa 3 para o tratamento de câncer |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
CN110730670A (zh) | 2017-03-28 | 2020-01-24 | 儿童医疗中心有限公司 | 基于多抗原提呈系统(maps)的金黄色葡萄球菌疫苗、免疫原性组合物以及它们的用途 |
WO2018183666A1 (en) * | 2017-03-31 | 2018-10-04 | Boston Medical Center Corporation | Methods and compositions using highly converved pneumococcal surface proteins |
EP3641828B1 (en) | 2017-06-23 | 2023-11-22 | Affinivax, Inc. | Immunogenic compositions |
CN111683678B (zh) | 2017-12-06 | 2024-01-26 | 默沙东有限责任公司 | 包含肺炎链球菌多糖蛋白缀合物的组合物及其使用方法 |
US11458151B2 (en) | 2018-02-12 | 2022-10-04 | Inimmune Corporation | Toll-like receptor ligands |
MX2021000548A (es) | 2018-07-19 | 2021-07-02 | Glaxosmithkline Biologicals Sa | Procesos para preparar polisacáridos en seco. |
KR20210093854A (ko) | 2018-09-12 | 2021-07-28 | 아피니백스, 인크. | 다가 폐렴구균 백신 |
TWI788610B (zh) | 2018-12-19 | 2023-01-01 | 美商默沙東有限責任公司 | 包含肺炎鏈球菌多醣-蛋白質結合物之組合物及其使用方法 |
BR112022008761A2 (pt) | 2019-11-22 | 2022-07-26 | Glaxosmithkline Biologicals Sa | Dosagem e administração de uma vacina de glicoconjugado de sacarídeo |
CA3198924A1 (en) | 2020-11-04 | 2022-05-12 | Eligo Bioscience | Phage-derived particles for in situ delivery of dna payload into c. acnes population |
WO2023006825A1 (en) * | 2021-07-29 | 2023-02-02 | Université de Lausanne | Novel pneumococcal polypeptide antigens |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4433092A (en) | 1981-03-09 | 1984-02-21 | Champion Spark Plug Company | Green ceramic of lead-free glass, conductive carbon, silicone resin and AlPO4, useful, after firing, as an electrical resistor |
JPH07119760B2 (ja) | 1984-07-24 | 1995-12-20 | コモンウエルス・セ−ラム・ラボラトリ−ズ・コミッション | ミモトープを検出または決定する方法 |
US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
LU86128A1 (fr) | 1985-10-18 | 1987-06-02 | Vander Poorten Henri | Procede permettant l'impression ou le revetement de ceramique simultanement a son electroformage et conduisant en monocuisson a des produits decoratifs ou techniques |
GB8904762D0 (en) * | 1989-03-02 | 1989-04-12 | Glaxo Group Ltd | Biological process |
EP0394827A1 (en) | 1989-04-26 | 1990-10-31 | F. Hoffmann-La Roche Ag | Chimaeric CD4-immunoglobulin polypeptides |
US6251581B1 (en) * | 1991-05-22 | 2001-06-26 | Dade Behring Marburg Gmbh | Assay method utilizing induced luminescence |
WO1993010238A1 (en) * | 1991-11-14 | 1993-05-27 | The Government Of The United States Of America As Represented By The Department Of Health And Human Services | Pneumococcal fimbrial protein a vaccines |
WO1994017087A1 (en) * | 1993-01-28 | 1994-08-04 | The Regents Of The University Of California | Tata-binding protein associated factors, nucleic acids encoding tafs, and methods of use |
CA2116261A1 (en) * | 1993-04-20 | 1994-10-21 | David E. Briles | Epitopic regions of pneumococcal surface protein a |
US5480971A (en) | 1993-06-17 | 1996-01-02 | Houghten Pharmaceuticals, Inc. | Peralkylated oligopeptide mixtures |
US5928900A (en) * | 1993-09-01 | 1999-07-27 | The Rockefeller University | Bacterial exported proteins and acellular vaccines based thereon |
US5474905A (en) | 1993-11-24 | 1995-12-12 | Research Corporation Technologies | Antibodies specific for streptococcus pneumoniae hemin/hemoglobin-binding antigens |
WO1995016711A1 (es) * | 1993-12-17 | 1995-06-22 | Universidad De Oviedo | Anticuerpos contra la neumolisina y sus aplicaciones |
AU2638595A (en) | 1994-05-16 | 1995-12-05 | Uab Research Foundation, The | (streptococcus pneumoniae) capsular polysaccharide genes and flanking regions |
SE9404072D0 (sv) | 1994-11-24 | 1994-11-24 | Astra Ab | Novel polypeptides |
US5620190A (en) | 1994-08-18 | 1997-04-15 | Fisher-Price, Inc. | In-line skate |
US5565204A (en) | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
US6001564A (en) * | 1994-09-12 | 1999-12-14 | Infectio Diagnostic, Inc. | Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
JPH08116973A (ja) | 1994-10-25 | 1996-05-14 | Yotsuba Nyugyo Kk | 新規アミノペプチダーゼとそれをコードするアミノペプチダーゼ遺伝子 |
JPH11501520A (ja) | 1995-04-21 | 1999-02-09 | ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド | インフルエンザ菌Rdゲノムのヌクレオチド配列、そのフラグメント及びその使用 |
US6294661B1 (en) | 1996-05-14 | 2001-09-25 | Smithkline Beecham Corporation | Compounds |
DE69737125T3 (de) * | 1996-10-31 | 2015-02-26 | Human Genome Sciences, Inc. | Streptococcus pneumoniae-Antigene und Impfstoffe |
US5958730A (en) | 1996-12-13 | 1999-09-28 | Eli Lilly And Company | Streptococcus pneumoniae gene sequence FtsY |
US6800744B1 (en) * | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
US7153952B1 (en) * | 1997-07-02 | 2006-12-26 | sanofi pasteur limited/sanofi pasteur limitée | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
JP2001517449A (ja) * | 1997-09-24 | 2001-10-09 | リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミネソタ | ストレプトコッカス・ニューモニア由来のヒト補体c3分解プロテイナーゼ |
US6251588B1 (en) * | 1998-02-10 | 2001-06-26 | Agilent Technologies, Inc. | Method for evaluating oligonucleotide probe sequences |
IL142017A0 (en) * | 1998-09-24 | 2002-03-10 | Univ Minnesota | Human complement c3-degrading polypeptide from streptococcus pneumoniae |
DK1140157T3 (da) * | 1998-12-21 | 2009-06-08 | Medimmune Inc | Streptococcus pneumoniae-proteiner og immunogene fragmenter til vacciner |
-
1997
- 1997-10-30 DE DE69737125.5T patent/DE69737125T3/de not_active Expired - Lifetime
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