HUP0203880A2 - Virulencia gének, proteinek és alkalmazásuk - Google Patents
Virulencia gének, proteinek és alkalmazásukInfo
- Publication number
- HUP0203880A2 HUP0203880A2 HU0203880A HUP0203880A HUP0203880A2 HU P0203880 A2 HUP0203880 A2 HU P0203880A2 HU 0203880 A HU0203880 A HU 0203880A HU P0203880 A HUP0203880 A HU P0203880A HU P0203880 A2 HUP0203880 A2 HU P0203880A2
- Authority
- HU
- Hungary
- Prior art keywords
- proteins
- subject
- pyogenes
- peptide
- virulence genes
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 241000193996 Streptococcus pyogenes Species 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 230000001018 virulence Effects 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241001505901 Streptococcus sp. 'group A' Species 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Abstract
A találmány tárgyát virulencia gének, proteinek és ezek alkalmazásaképezi. Közelebbről: a találmány tárgyát a Streptococcus pyogenes-bőlkapott gének és fehérjék/peptidek képezik, valamint ezek alkalmazása aterápiában és gyógyhatású anyagok szkrínelésében. A találmány azon afelismerésen alapul, hogy a S. pyogenesben virulencia gének vannakjelen. A találmány egyik tárgyát egy operon által kódolt peptidterápiás vagy diagnosztikus alkalmazása képezi, amely a S. pyogenesvagy egy Gram pozitív baktériumban jelen levő homológja vagyfunkcionális fragmentuma valamelyik nukleotid szekvenciáját /SEQ IDNo. 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35,37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59 és 61/ tartalmazza. Apeptidek többféle terápiás alkalmazási lehetőséget képviselnek Acsoportbeli Streptococcus fertőzések esetében, ideértve aprofilaktikus alkalmazást is vakcina alakjában. A peptidet kódolópolinukleotid szekvencia, a peptid kifejezésére transzformáltgazdaszervezet, valamint a gyengített mikroorganizmus, amely anukleotid szekvenciák valamelyikének kifejeződését károsító mutációnment át, ugyancsak a találmány tárgyát képezi. Ó
Applications Claiming Priority (26)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9930474.3A GB9930474D0 (en) | 1999-12-23 | 1999-12-23 | Virulence gene and protein, and their use |
GBGB9930469.3A GB9930469D0 (en) | 1999-12-23 | 1999-12-23 | Virulence gene and protein,and their use |
GBGB9930462.8A GB9930462D0 (en) | 1999-12-23 | 1999-12-23 | Virulence gene and protein and their use |
GBGB9930467.7A GB9930467D0 (en) | 1999-12-23 | 1999-12-23 | Virulence gene and protein,and their use |
GBGB9930472.7A GB9930472D0 (en) | 1999-12-23 | 1999-12-23 | Virulence gene and protein,and their use |
GBGB9930476.8A GB9930476D0 (en) | 1999-12-23 | 1999-12-23 | Virulence gene and protein,and their use |
GBGB9930475.0A GB9930475D0 (en) | 1999-12-23 | 1999-12-23 | Virulence gene and protein,and their use |
GBGB9930473.5A GB9930473D0 (en) | 1999-12-23 | 1999-12-23 | Virulence gene and protein, and their use |
GBGB9930471.9A GB9930471D0 (en) | 1999-12-23 | 1999-12-23 | Virulence gene and protein,and their use |
GBGB9930463.6A GB9930463D0 (en) | 1999-12-23 | 1999-12-23 | Virulence gene and protein and their use |
GBGB9930466.9A GB9930466D0 (en) | 1999-12-23 | 1999-12-23 | Virulence gene and protein,and their use |
GBGB9930464.4A GB9930464D0 (en) | 1999-12-23 | 1999-12-23 | Virullence gene and protein and their use |
GB0003727A GB0003727D0 (en) | 2000-02-17 | 2000-02-17 | Virulence gene and protein and their use |
GB0003725A GB0003725D0 (en) | 2000-02-17 | 2000-02-17 | Virulence gene and protein and their use |
GB0003726A GB0003726D0 (en) | 2000-02-17 | 2000-02-17 | Virulence gene and protein and their use |
GB0003735A GB0003735D0 (en) | 2000-02-17 | 2000-02-17 | Virulence gene and protein, and their use |
GB0003733A GB0003733D0 (en) | 2000-02-17 | 2000-02-17 | Virulence gene and protein, and their use |
GB0003736A GB0003736D0 (en) | 2000-02-17 | 2000-02-17 | Virulence gene and protein, an their use |
GB0003730A GB0003730D0 (en) | 2000-02-17 | 2000-02-17 | Virulence gene and protein, and their use |
GB0003728A GB0003728D0 (en) | 2000-02-17 | 2000-02-17 | Virulence gene and protein, and their use |
GB0003731A GB0003731D0 (en) | 2000-02-17 | 2000-02-17 | Virulence gene and protein, and their use |
GB0003729A GB0003729D0 (en) | 2000-02-17 | 2000-02-17 | Virulene gene and protein, and their use |
GB0003732A GB0003732D0 (en) | 2000-02-17 | 2000-02-17 | Virulence gene and protein, and their use |
GB0010585A GB0010585D0 (en) | 2000-05-02 | 2000-05-02 | Virulence gene and protein, and their use |
GB0010587A GB0010587D0 (en) | 2000-05-02 | 2000-05-02 | Virulence gene and protein, and their use |
PCT/GB2000/004997 WO2001048208A2 (en) | 1999-12-23 | 2000-12-22 | Streptococcus pyogenes virulence genes and proteins and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0203880A2 true HUP0203880A2 (hu) | 2003-03-28 |
Family
ID=27586758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0203880A HUP0203880A2 (hu) | 1999-12-23 | 2000-12-22 | Virulencia gének, proteinek és alkalmazásuk |
Country Status (12)
Country | Link |
---|---|
US (2) | US6951732B2 (hu) |
EP (2) | EP1905834A3 (hu) |
JP (1) | JP2003520034A (hu) |
KR (1) | KR20020073150A (hu) |
AT (1) | ATE384797T1 (hu) |
AU (1) | AU775385B2 (hu) |
CA (1) | CA2397710A1 (hu) |
HK (1) | HK1048134B (hu) |
HU (1) | HUP0203880A2 (hu) |
NO (1) | NO20023006D0 (hu) |
NZ (1) | NZ519669A (hu) |
WO (1) | WO2001048208A2 (hu) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1160469C (zh) * | 1994-12-09 | 2004-08-04 | 帝国大学改革有限公司 | 基因的鉴定 |
WO2000014240A2 (en) * | 1998-09-04 | 2000-03-16 | Creatogen Aktiengesellschaft | Attenuated salmonella sp12 mutants as antigen carriers |
GB9910812D0 (en) * | 1999-05-10 | 1999-07-07 | Microscience Ltd | Vaccine composition |
WO2006048757A2 (en) * | 2004-11-05 | 2006-05-11 | Pharmacia & Upjohn Company Llc | Anti-bacterial vaccine compositions |
WO2006048753A2 (en) * | 2004-11-05 | 2006-05-11 | Pharmacia & Upjohn Company Llc | Anti-bacterial vaccine compositions |
GB2428006A (en) * | 2005-07-07 | 2007-01-17 | Jevgenis Morov | AMI-3 vaccine comprising group A Streptococcus pyogenes bacteria |
WO2009158240A1 (en) | 2008-06-16 | 2009-12-30 | Emergent Product Development Uk Limited | Salmonella vectored vaccines against chlamydia and methods of use |
EP2135877A1 (en) | 2008-06-19 | 2009-12-23 | Helmholtz-Zentrum für Infektionsforschung GmbH | Marker of steptococcus anginosus/Streptococcus constellatus (Moac) and uses thereof |
JP5931724B2 (ja) | 2009-06-29 | 2016-06-08 | ジェノセア バイオサイエンシーズ, インコーポレイテッド | StreptococcusPneumoniaeに対するワクチンおよび組成物 |
EP2665490B1 (en) | 2011-01-20 | 2020-03-04 | Genocea Biosciences, Inc. | Vaccines and compositions against streptococcus pneumoniae |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9503495L (sv) * | 1995-10-09 | 1997-04-10 | Actinova Ltd | Nytt protein |
US6737248B2 (en) | 1996-01-05 | 2004-05-18 | Human Genome Sciences, Inc. | Staphylococcus aureus polynucleotides and sequences |
US6346392B1 (en) * | 1996-11-27 | 2002-02-12 | Smithkline Beecham Corporation | Polynucleotides encoding a novel glutamine transport ATP-binding protein |
DE69737125T3 (de) * | 1996-10-31 | 2015-02-26 | Human Genome Sciences, Inc. | Streptococcus pneumoniae-Antigene und Impfstoffe |
MXPA03003690A (es) * | 2000-10-27 | 2004-05-05 | Chiron Spa | Acidos nucleicos y proteinas de los grupos a y b de estreptococos. |
-
2000
- 2000-12-22 CA CA002397710A patent/CA2397710A1/en not_active Abandoned
- 2000-12-22 AT AT00987575T patent/ATE384797T1/de not_active IP Right Cessation
- 2000-12-22 EP EP07119228A patent/EP1905834A3/en not_active Withdrawn
- 2000-12-22 JP JP2001548721A patent/JP2003520034A/ja active Pending
- 2000-12-22 KR KR1020027008093A patent/KR20020073150A/ko not_active Application Discontinuation
- 2000-12-22 NZ NZ519669A patent/NZ519669A/en unknown
- 2000-12-22 US US10/169,048 patent/US6951732B2/en not_active Expired - Fee Related
- 2000-12-22 WO PCT/GB2000/004997 patent/WO2001048208A2/en active IP Right Grant
- 2000-12-22 AU AU23823/01A patent/AU775385B2/en not_active Ceased
- 2000-12-22 EP EP00987575A patent/EP1240332B1/en not_active Expired - Lifetime
- 2000-12-22 HU HU0203880A patent/HUP0203880A2/hu unknown
-
2002
- 2002-06-21 NO NO22000GBW00/A patent/NO20023006D0/no not_active Application Discontinuation
- 2002-11-21 HK HK02108435.4A patent/HK1048134B/zh not_active IP Right Cessation
-
2005
- 2005-06-03 US US11/144,352 patent/US20050232942A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1905834A2 (en) | 2008-04-02 |
ATE384797T1 (de) | 2008-02-15 |
US20030072769A1 (en) | 2003-04-17 |
WO2001048208A3 (en) | 2001-12-20 |
AU775385B2 (en) | 2004-07-29 |
EP1905834A3 (en) | 2008-07-23 |
HK1048134B (zh) | 2008-09-05 |
AU2382301A (en) | 2001-07-09 |
EP1240332B1 (en) | 2008-01-23 |
KR20020073150A (ko) | 2002-09-19 |
US6951732B2 (en) | 2005-10-04 |
HK1048134A1 (en) | 2003-03-21 |
US20050232942A1 (en) | 2005-10-20 |
NZ519669A (en) | 2004-03-26 |
EP1240332A2 (en) | 2002-09-18 |
JP2003520034A (ja) | 2003-07-02 |
NO20023006L (no) | 2002-06-21 |
WO2001048208A2 (en) | 2001-07-05 |
NO20023006D0 (no) | 2002-06-21 |
CA2397710A1 (en) | 2001-07-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |