HUP0101734A2 - Béta-amiloid prekurzor protein és ubiquitin-B kereteltolódásos mutánsok és alkalmazásuk - Google Patents

Béta-amiloid prekurzor protein és ubiquitin-B kereteltolódásos mutánsok és alkalmazásuk

Info

Publication number
HUP0101734A2
HUP0101734A2 HU0101734A HUP0101734A HUP0101734A2 HU P0101734 A2 HUP0101734 A2 HU P0101734A2 HU 0101734 A HU0101734 A HU 0101734A HU P0101734 A HUP0101734 A HU P0101734A HU P0101734 A2 HUP0101734 A2 HU P0101734A2
Authority
HU
Hungary
Prior art keywords
disease
alzheimer
betha
ubiquitin
precursor protein
Prior art date
Application number
HU0101734A
Other languages
English (en)
Inventor
Jon Amund Eriksen
Gustav Gaudernack
Mona Moller
Original Assignee
Norsk Hydro Asa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro Asa filed Critical Norsk Hydro Asa
Publication of HUP0101734A2 publication Critical patent/HUP0101734A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A találmány tárgya Alzheimer-kór vagy Down-kór kezelésére alkalmaspeptid, amely Alzheimer-kórral vagy Down-kórral összefüggőkereteltolódásos mutáció eredményeként keletkezett mutáns <APP vagyUbi-B protein fragmense, és vagy teljes hosszúságú vagyantigénbemutató sejt által végzett feldolgozását követően elnyertalakjában T-sejtes válaszreakció kiváltására képes, továbbá akereteltolódásos mutáns peptidet kódoló DNS-szekvencia és az azttartalmazó vektor. A találmány tárgyát képezik továbbá a peptideket vagy a DNS-szekvenciákat tartalmazó gyógyászati készítmények és vakcinák. Atalálmány tárgya továbbá eljárás Alzheimer-kórban szenvedő vagy arrahajlamos, vagy Down-kórban szenvedő páciens kezelésére. Ó
HU0101734A 1998-05-08 1999-04-30 Béta-amiloid prekurzor protein és ubiquitin-B kereteltolódásos mutánsok és alkalmazásuk HUP0101734A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO19982098A NO314086B1 (no) 1998-05-08 1998-05-08 Peptider og farmasöytiske sammensetninger inneholdende disse, nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slike DNA-sekvenser samt anvendelse av disse for fremstilling avfarmasöytiske preparater til
PCT/NO1999/000141 WO1999058564A1 (en) 1998-05-08 1999-04-30 Frameshift mutants of beta-amyloid precursor protein and ubiquitin-b and their use

Publications (1)

Publication Number Publication Date
HUP0101734A2 true HUP0101734A2 (hu) 2001-09-28

Family

ID=19902022

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101734A HUP0101734A2 (hu) 1998-05-08 1999-04-30 Béta-amiloid prekurzor protein és ubiquitin-B kereteltolódásos mutánsok és alkalmazásuk

Country Status (11)

Country Link
US (1) US6861057B2 (hu)
EP (1) EP1075490A1 (hu)
JP (1) JP2002514658A (hu)
CN (1) CN1300294A (hu)
AR (1) AR018603A1 (hu)
AU (1) AU755736B2 (hu)
CA (1) CA2327523A1 (hu)
HU (1) HUP0101734A2 (hu)
NO (1) NO314086B1 (hu)
PL (1) PL344186A1 (hu)
WO (1) WO1999058564A1 (hu)

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US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US6787523B1 (en) 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
US6905686B1 (en) 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
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US20030147882A1 (en) 1998-05-21 2003-08-07 Alan Solomon Methods for amyloid removal using anti-amyloid antibodies
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US6787637B1 (en) 1999-05-28 2004-09-07 Neuralab Limited N-Terminal amyloid-β antibodies
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US7034000B2 (en) 2000-10-27 2006-04-25 The Brigham And Women's Hospital, Inc. Peptides derived from the human amyloid precursor protein
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
EP2228387A2 (en) * 2001-04-18 2010-09-15 The Open University Polypeptides derived from amyloid precursor peptide (app) and their uses
US7622446B2 (en) 2001-04-18 2009-11-24 The Open University Polypeptides, derivatives and uses thereof
US7491702B2 (en) 2001-04-18 2009-02-17 The Open University Polypeptides related to amyloid precursor protein, pharmaceutical compositions thereof, and methods of treatment using the same
MY144532A (en) * 2001-08-20 2011-09-30 Lundbeck & Co As H Novel method for down-regulation of amyloid
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
KR101455222B1 (ko) * 2002-12-16 2014-10-31 글로브이뮨 면역 요법으로서의 효모계 백신
US8343502B2 (en) * 2002-12-16 2013-01-01 Globeimmune, Inc. Yeast-based vaccines as immunotherapy
US7439042B2 (en) * 2002-12-16 2008-10-21 Globeimmune, Inc. Yeast-based therapeutic for chronic hepatitis C infection
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
TWI374893B (en) 2003-05-30 2012-10-21 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
US20080107601A1 (en) * 2004-10-13 2008-05-08 Ablynx N.V. Nanobodies Tm Against Amyloid-Beta and Polypeptides Comprising the Same for the Treatment of Degenerative Neural Diseases Such as Alzheimer's Disease
EP1809773B1 (en) * 2004-10-18 2014-07-16 Globeimmune, Inc. Yeast-based therapeutic for chronic hepatitis c infection
CA2590337C (en) 2004-12-15 2017-07-11 Neuralab Limited Humanized amyloid beta antibodies for use in improving cognition
JP5486808B2 (ja) 2005-11-30 2014-05-07 アッヴィ・インコーポレイテッド アミロイドベータタンパク質に対するモノクローナル抗体及びその使用
PL1954718T3 (pl) 2005-11-30 2015-04-30 Abbvie Inc Przeciwciała skierowane przeciwko A globulomerowi, ich reszty wiążące antygeny, odpowiednie hybrydomy, kwasy nukleinowe, wektory, komórki gospodarze, sposoby wytwarzania tych przeciwciał, kompozycje zawierające te przeciwciała, zastosowania tych przeciwciał i sposoby stosowania tych przeciwciał
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Also Published As

Publication number Publication date
AR018603A1 (es) 2001-11-28
WO1999058564B1 (en) 2000-01-27
WO1999058564A1 (en) 1999-11-18
CA2327523A1 (en) 1999-11-18
PL344186A1 (en) 2001-10-08
NO982098D0 (no) 1998-05-08
NO314086B1 (no) 2003-01-27
EP1075490A1 (en) 2001-02-14
CN1300294A (zh) 2001-06-20
US6861057B2 (en) 2005-03-01
US20030171266A1 (en) 2003-09-11
AU755736B2 (en) 2002-12-19
JP2002514658A (ja) 2002-05-21
NO982098L (no) 1999-11-09
AU5451599A (en) 1999-11-29

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