HUP0101734A2 - Frameshift mutants of betha-amyloid precursor protein and ubiquitin-b and their use - Google Patents
Frameshift mutants of betha-amyloid precursor protein and ubiquitin-b and their useInfo
- Publication number
- HUP0101734A2 HUP0101734A2 HU0101734A HUP0101734A HUP0101734A2 HU P0101734 A2 HUP0101734 A2 HU P0101734A2 HU 0101734 A HU0101734 A HU 0101734A HU P0101734 A HUP0101734 A HU P0101734A HU P0101734 A2 HUP0101734 A2 HU P0101734A2
- Authority
- HU
- Hungary
- Prior art keywords
- disease
- alzheimer
- betha
- ubiquitin
- precursor protein
- Prior art date
Links
- 230000037433 frameshift Effects 0.000 title abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 230000005867 T cell response Effects 0.000 abstract 1
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 231100000221 frame shift mutation induction Toxicity 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A találmány tárgya Alzheimer-kór vagy Down-kór kezelésére alkalmaspeptid, amely Alzheimer-kórral vagy Down-kórral összefüggőkereteltolódásos mutáció eredményeként keletkezett mutáns <APP vagyUbi-B protein fragmense, és vagy teljes hosszúságú vagyantigénbemutató sejt által végzett feldolgozását követően elnyertalakjában T-sejtes válaszreakció kiváltására képes, továbbá akereteltolódásos mutáns peptidet kódoló DNS-szekvencia és az azttartalmazó vektor. A találmány tárgyát képezik továbbá a peptideket vagy a DNS-szekvenciákat tartalmazó gyógyászati készítmények és vakcinák. Atalálmány tárgya továbbá eljárás Alzheimer-kórban szenvedő vagy arrahajlamos, vagy Down-kórban szenvedő páciens kezelésére. ÓThe subject of the invention is a peptide suitable for the treatment of Alzheimer's disease or Down's disease, which is a fragment of a mutant <APP or Ubi-B protein produced as a result of a frameshift mutation associated with Alzheimer's disease or Down's disease, and either full-length or in its form obtained after processing by an antigen-presenting cell to trigger a T-cell response able, and the DNA sequence encoding the mutant peptide and the vector containing it. The invention also relates to pharmaceutical preparations and vaccines containing peptides or DNA sequences. The subject of the invention is also a method for the treatment of a patient suffering from Alzheimer's disease or prone to it, or suffering from Down's disease. HE
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO19982098A NO314086B1 (en) | 1998-05-08 | 1998-05-08 | Peptides and pharmaceutical compositions containing them, nucleic acid sequences encoding such peptides, plasmids and virus vectors encompassing such DNA sequences and their use for the preparation of pharmaceutical preparations for |
PCT/NO1999/000141 WO1999058564A1 (en) | 1998-05-08 | 1999-04-30 | Frameshift mutants of beta-amyloid precursor protein and ubiquitin-b and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0101734A2 true HUP0101734A2 (en) | 2001-09-28 |
Family
ID=19902022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0101734A HUP0101734A2 (en) | 1998-05-08 | 1999-04-30 | Frameshift mutants of betha-amyloid precursor protein and ubiquitin-b and their use |
Country Status (11)
Country | Link |
---|---|
US (1) | US6861057B2 (en) |
EP (1) | EP1075490A1 (en) |
JP (1) | JP2002514658A (en) |
CN (1) | CN1300294A (en) |
AR (1) | AR018603A1 (en) |
AU (1) | AU755736B2 (en) |
CA (1) | CA2327523A1 (en) |
HU (1) | HUP0101734A2 (en) |
NO (1) | NO314086B1 (en) |
PL (1) | PL344186A1 (en) |
WO (1) | WO1999058564A1 (en) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0866805A1 (en) | 1995-12-12 | 1998-09-30 | Karolinska Innovations AB | PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b) |
US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US6905686B1 (en) | 1997-12-02 | 2005-06-14 | Neuralab Limited | Active immunization for treatment of alzheimer's disease |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
NO315238B1 (en) | 1998-05-08 | 2003-08-04 | Gemvax As | Peptides derived from reading frame shift mutations in the TBF <beta> II or BAX gene, and pharmaceutical compositions containing them, nucleic acid sequences encoding such peptides, plasmids, and virus vector-encompassing such nucleic acid |
US20030147882A1 (en) | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
US7060670B1 (en) | 1999-05-05 | 2006-06-13 | Neurochem (International) Limited | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
CA2388559A1 (en) * | 1999-11-29 | 2001-06-07 | Neurochem Inc. | Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases |
CN100447153C (en) * | 2000-04-11 | 2008-12-31 | 首都医科大学宣武医院 | Novel 11 peptide, preparation method and application thereof |
US7034000B2 (en) * | 2000-10-27 | 2006-04-25 | The Brigham And Women's Hospital, Inc. | Peptides derived from the human amyloid precursor protein |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
US7622446B2 (en) | 2001-04-18 | 2009-11-24 | The Open University | Polypeptides, derivatives and uses thereof |
US7491702B2 (en) | 2001-04-18 | 2009-02-17 | The Open University | Polypeptides related to amyloid precursor protein, pharmaceutical compositions thereof, and methods of treatment using the same |
EP2316849A2 (en) * | 2001-04-18 | 2011-05-04 | The Open University | Polypeptides comprising RER, derivatives and uses thereof |
MY144532A (en) | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
US7439042B2 (en) * | 2002-12-16 | 2008-10-21 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
US8343502B2 (en) * | 2002-12-16 | 2013-01-01 | Globeimmune, Inc. | Yeast-based vaccines as immunotherapy |
KR101241272B1 (en) * | 2002-12-16 | 2013-03-15 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | Yeast-based vaccines as immunotherapy |
DE10303974A1 (en) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid β (1-42) oligomers, process for their preparation and their use |
PE20050627A1 (en) | 2003-05-30 | 2005-08-10 | Wyeth Corp | HUMANIZED ANTIBODIES THAT RECOGNIZE THE BETA AMYLOID PEPTIDE |
EP1814917A2 (en) * | 2004-10-13 | 2007-08-08 | Ablynx N.V. | Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenerative neural diseases such as alzheimer's disease |
AU2005295317B2 (en) * | 2004-10-18 | 2011-10-13 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
JP2008523815A (en) | 2004-12-15 | 2008-07-10 | エラン ファーマ インターナショナル リミテッド | Humanized amyloid beta antibody for use in improving cognition |
CA2631195C (en) | 2005-11-30 | 2016-04-05 | Abbott Laboratories | Monoclonal antibodies against amyloid beta protein and uses thereof |
CN101432302A (en) | 2005-11-30 | 2009-05-13 | 艾博特公司 | Anti-a globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibod |
US9732131B2 (en) | 2006-02-27 | 2017-08-15 | Calviri, Inc. | Identification and use of novopeptides for the treatment of cancer |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
EP2124952A2 (en) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
EP2182983B1 (en) | 2007-07-27 | 2014-05-21 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases with humanised anti-abeta antibodies |
JO3076B1 (en) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | Immunotherapy regimes dependent on apoe status |
AT506820B1 (en) * | 2008-06-12 | 2011-07-15 | Affiris Forschungs Und Entwicklungs Gmbh | VZZINE AGAINST ALZHEIMER DISEASE |
JP2012503011A (en) | 2008-09-19 | 2012-02-02 | グローブイミューン,インコーポレイテッド | Immunotherapy of chronic hepatitis C virus infection |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
GB0821616D0 (en) | 2008-11-26 | 2008-12-31 | Lytix Biopharma As | Compounds |
US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
MX358739B (en) | 2010-08-14 | 2018-09-03 | Abbvie Inc Star | Amyloid-beta binding proteins. |
WO2015017280A1 (en) | 2013-07-28 | 2015-02-05 | Qantu Therapeutics, Inc. | Vaccine formulations that induce a th2 immune response |
WO2018213766A1 (en) * | 2017-05-19 | 2018-11-22 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for improving cognition |
EP3630130B1 (en) | 2017-06-02 | 2022-08-31 | Arizona Board of Regents on behalf of Arizona State University | A method to create personalized cancer vaccines |
US12025615B2 (en) | 2017-09-15 | 2024-07-02 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods of classifying response to immunotherapy for cancer |
EP4038222A4 (en) | 2019-10-02 | 2023-10-18 | Arizona Board of Regents on behalf of Arizona State University | Methods and compositions for identifying neoantigens for use in treating and preventing cancer |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5753624A (en) * | 1990-04-27 | 1998-05-19 | Milkhaus Laboratory, Inc. | Materials and methods for treatment of plaquing disease |
US5780587A (en) * | 1990-08-24 | 1998-07-14 | President And Fellows Of Harvard College | Compounds and methods for inhibiting β-protein filament formation and neurotoxicity |
GB9103974D0 (en) | 1991-02-26 | 1991-04-10 | Norsk Hydro As | Therapeutically useful peptides or peptide fragments |
GB9410922D0 (en) | 1994-06-01 | 1994-07-20 | Townsend Alain R M | Vaccines |
US5958684A (en) * | 1995-10-02 | 1999-09-28 | Van Leeuwen; Frederik Willem | Diagnosis of neurodegenerative disease |
JP2001522241A (en) | 1997-04-10 | 2001-11-13 | ロイヤル ネザーランズ アカデミー オブ アーツ アンド サイエンシズ | Diagnostic methods and reagents |
NO315238B1 (en) | 1998-05-08 | 2003-08-04 | Gemvax As | Peptides derived from reading frame shift mutations in the TBF <beta> II or BAX gene, and pharmaceutical compositions containing them, nucleic acid sequences encoding such peptides, plasmids, and virus vector-encompassing such nucleic acid |
AU2715601A (en) * | 1999-12-03 | 2001-06-12 | Koninklijke Nederlandse Akademie Van Wetenschappen | Clearance of aberrant protein in correlation with disease |
EP1237930B1 (en) * | 1999-12-08 | 2006-11-08 | Intellect Neurosciences, Inc. | Chimeric amyloid beta peptides |
-
1998
- 1998-05-08 NO NO19982098A patent/NO314086B1/en unknown
-
1999
- 1999-04-30 HU HU0101734A patent/HUP0101734A2/en unknown
- 1999-04-30 AU AU54515/99A patent/AU755736B2/en not_active Ceased
- 1999-04-30 EP EP99940721A patent/EP1075490A1/en not_active Withdrawn
- 1999-04-30 CN CN99805976A patent/CN1300294A/en active Pending
- 1999-04-30 CA CA002327523A patent/CA2327523A1/en not_active Abandoned
- 1999-04-30 US US09/674,913 patent/US6861057B2/en not_active Expired - Fee Related
- 1999-04-30 JP JP2000548366A patent/JP2002514658A/en not_active Withdrawn
- 1999-04-30 WO PCT/NO1999/000141 patent/WO1999058564A1/en not_active Application Discontinuation
- 1999-04-30 PL PL99344186A patent/PL344186A1/en not_active Application Discontinuation
- 1999-05-10 AR ARP990102200A patent/AR018603A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU755736B2 (en) | 2002-12-19 |
JP2002514658A (en) | 2002-05-21 |
AU5451599A (en) | 1999-11-29 |
CN1300294A (en) | 2001-06-20 |
NO982098D0 (en) | 1998-05-08 |
US20030171266A1 (en) | 2003-09-11 |
WO1999058564A1 (en) | 1999-11-18 |
EP1075490A1 (en) | 2001-02-14 |
NO982098L (en) | 1999-11-09 |
AR018603A1 (en) | 2001-11-28 |
US6861057B2 (en) | 2005-03-01 |
WO1999058564B1 (en) | 2000-01-27 |
PL344186A1 (en) | 2001-10-08 |
NO314086B1 (en) | 2003-01-27 |
CA2327523A1 (en) | 1999-11-18 |
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