NO314086B1 - Peptider og farmasöytiske sammensetninger inneholdende disse, nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slike DNA-sekvenser samt anvendelse av disse for fremstilling avfarmasöytiske preparater til - Google Patents
Peptider og farmasöytiske sammensetninger inneholdende disse, nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slike DNA-sekvenser samt anvendelse av disse for fremstilling avfarmasöytiske preparater til Download PDFInfo
- Publication number
- NO314086B1 NO314086B1 NO19982098A NO982098A NO314086B1 NO 314086 B1 NO314086 B1 NO 314086B1 NO 19982098 A NO19982098 A NO 19982098A NO 982098 A NO982098 A NO 982098A NO 314086 B1 NO314086 B1 NO 314086B1
- Authority
- NO
- Norway
- Prior art keywords
- peptides
- disease
- peptide
- mutated
- amino acids
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 134
- 102000004196 processed proteins & peptides Human genes 0.000 title claims description 82
- 239000013598 vector Substances 0.000 title claims description 21
- 150000007523 nucleic acids Chemical group 0.000 title claims description 19
- 108091028043 Nucleic acid sequence Proteins 0.000 title claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 15
- 239000013612 plasmid Substances 0.000 title claims description 15
- 241000700605 Viruses Species 0.000 title claims description 11
- 238000002360 preparation method Methods 0.000 title claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 claims description 56
- 208000024827 Alzheimer disease Diseases 0.000 claims description 51
- 102000004169 proteins and genes Human genes 0.000 claims description 45
- 230000037433 frameshift Effects 0.000 claims description 44
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- LQRJAEQXMSMEDP-XCHBZYMASA-N peptide a Chemical compound N([C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)NCCCC[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)C(\NC(=O)[C@@H](CCCCN)NC(=O)CNC(C)=O)=C/C=1C=CC=CC=1)C(N)=O)C(=O)C(\NC(=O)[C@@H](CCCCN)NC(=O)CNC(C)=O)=C\C1=CC=CC=C1 LQRJAEQXMSMEDP-XCHBZYMASA-N 0.000 claims 1
- 101000772905 Homo sapiens Polyubiquitin-B Proteins 0.000 description 38
- 102100030432 Polyubiquitin-B Human genes 0.000 description 33
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- 108010035452 HLA-A1 Antigen Proteins 0.000 description 2
- 102000013462 Interleukin-12 Human genes 0.000 description 2
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- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO19982098A NO314086B1 (no) | 1998-05-08 | 1998-05-08 | Peptider og farmasöytiske sammensetninger inneholdende disse, nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slike DNA-sekvenser samt anvendelse av disse for fremstilling avfarmasöytiske preparater til |
| CA002327523A CA2327523A1 (en) | 1998-05-08 | 1999-04-30 | Frameshift mutants of beta-amyloid precursor protein and ubiquitin-b and their use |
| US09/674,913 US6861057B2 (en) | 1998-05-08 | 1999-04-30 | Immunogenic β-amyloid peptide |
| CN99805976A CN1300294A (zh) | 1998-05-08 | 1999-04-30 | β－淀粉样前体蛋白和泛素－B的移码突变体和它们的用途 |
| AU54515/99A AU755736B2 (en) | 1998-05-08 | 1999-04-30 | Frameshift mutants of beta-amyloid precursor protein and ubiquitin-B and their use |
| PL99344186A PL344186A1 (en) | 1998-05-08 | 1999-04-30 | Frameshift mutants of beta-amyloid precursor protein and ubiquitin-b and their use |
| EP99940721A EP1075490A1 (en) | 1998-05-08 | 1999-04-30 | Frameshift mutants of beta-amyloid precursor protein and ubiquitin-b and their use |
| JP2000548366A JP2002514658A (ja) | 1998-05-08 | 1999-04-30 | β−アミロイド前駆体タンパク質およびユビキチンＢのフレームシフト変異体ならびにその使用 |
| HU0101734A HUP0101734A2 (hu) | 1998-05-08 | 1999-04-30 | Béta-amiloid prekurzor protein és ubiquitin-B kereteltolódásos mutánsok és alkalmazásuk |
| PCT/NO1999/000141 WO1999058564A1 (en) | 1998-05-08 | 1999-04-30 | Frameshift mutants of beta-amyloid precursor protein and ubiquitin-b and their use |
| ARP990102200A AR018603A1 (es) | 1998-05-08 | 1999-05-10 | Un peptido, util para el tratamiento y/o profilaxis de la enfermedad de alzheimer y el sindrome de down, las composiciones farmaceuticas y vacunas que locontienen, el uso de dicho peptido para la preparacion de las composiciones farmaceuticas, una secuencia de aislado de adn, un plasmido o vector vi |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO19982098A NO314086B1 (no) | 1998-05-08 | 1998-05-08 | Peptider og farmasöytiske sammensetninger inneholdende disse, nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slike DNA-sekvenser samt anvendelse av disse for fremstilling avfarmasöytiske preparater til |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO982098D0 NO982098D0 (no) | 1998-05-08 |
| NO982098L NO982098L (no) | 1999-11-09 |
| NO314086B1 true NO314086B1 (no) | 2003-01-27 |
Family
ID=19902022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19982098A NO314086B1 (no) | 1998-05-08 | 1998-05-08 | Peptider og farmasöytiske sammensetninger inneholdende disse, nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slike DNA-sekvenser samt anvendelse av disse for fremstilling avfarmasöytiske preparater til |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6861057B2 (hu) |
| EP (1) | EP1075490A1 (hu) |
| JP (1) | JP2002514658A (hu) |
| CN (1) | CN1300294A (hu) |
| AR (1) | AR018603A1 (hu) |
| AU (1) | AU755736B2 (hu) |
| CA (1) | CA2327523A1 (hu) |
| HU (1) | HUP0101734A2 (hu) |
| NO (1) | NO314086B1 (hu) |
| PL (1) | PL344186A1 (hu) |
| WO (1) | WO1999058564A1 (hu) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0866805A1 (en) | 1995-12-12 | 1998-09-30 | Karolinska Innovations AB | PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b) |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US6905686B1 (en) | 1997-12-02 | 2005-06-14 | Neuralab Limited | Active immunization for treatment of alzheimer's disease |
| NO315238B1 (no) | 1998-05-08 | 2003-08-04 | Gemvax As | Peptider som stammer fra leserammeforskyvingsmutasjoner i TBF<beta>II- eller BAX-genet, og farmasöytiske sammensetninger inneholdende disse,nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slikenukleinsy |
| US20030147882A1 (en) | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
| US7060670B1 (en) | 1999-05-05 | 2006-06-13 | Neurochem (International) Limited | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
| US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
| UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
| CN1433321A (zh) * | 1999-11-29 | 2003-07-30 | 尼奥切姆公司 | 预防和治疗Alzheimer症和其他与淀粉样蛋白有关的疾病的疫苗 |
| CN100569797C (zh) * | 2000-04-11 | 2009-12-16 | 首都医科大学宣武医院 | 一种十一肽及其用途 |
| US7034000B2 (en) | 2000-10-27 | 2006-04-25 | The Brigham And Women's Hospital, Inc. | Peptides derived from the human amyloid precursor protein |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| US7491702B2 (en) | 2001-04-18 | 2009-02-17 | The Open University | Polypeptides related to amyloid precursor protein, pharmaceutical compositions thereof, and methods of treatment using the same |
| EP2228388A1 (en) * | 2001-04-18 | 2010-09-15 | The Open University | Protected Arg-Glu-Arg polypeptides and uses thereof |
| US7622446B2 (en) | 2001-04-18 | 2009-11-24 | The Open University | Polypeptides, derivatives and uses thereof |
| MY144532A (en) | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| EP1581174B1 (en) * | 2002-12-16 | 2018-04-25 | GlobeImmune, Inc. | Yeast-based vaccines as immunotherapy |
| US8343502B2 (en) * | 2002-12-16 | 2013-01-01 | Globeimmune, Inc. | Yeast-based vaccines as immunotherapy |
| US7439042B2 (en) * | 2002-12-16 | 2008-10-21 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5753624A (en) * | 1990-04-27 | 1998-05-19 | Milkhaus Laboratory, Inc. | Materials and methods for treatment of plaquing disease |
| US5780587A (en) * | 1990-08-24 | 1998-07-14 | President And Fellows Of Harvard College | Compounds and methods for inhibiting β-protein filament formation and neurotoxicity |
| GB9103974D0 (en) | 1991-02-26 | 1991-04-10 | Norsk Hydro As | Therapeutically useful peptides or peptide fragments |
| GB9410922D0 (en) * | 1994-06-01 | 1994-07-20 | Townsend Alain R M | Vaccines |
| AU7142796A (en) * | 1995-10-02 | 1997-04-28 | Erasmus University Rotterdam | Diagnosis method and reagents |
| EP0971952A2 (en) * | 1997-04-10 | 2000-01-19 | Royal Netherlands Academy of Arts and Sciences | Diagnosis method and reagents |
| NO315238B1 (no) | 1998-05-08 | 2003-08-04 | Gemvax As | Peptider som stammer fra leserammeforskyvingsmutasjoner i TBF<beta>II- eller BAX-genet, og farmasöytiske sammensetninger inneholdende disse,nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slikenukleinsy |
| WO2001040804A2 (en) * | 1999-12-03 | 2001-06-07 | Koninklijke Nederlandse Akademie Van Wetenschappen | Clearance of aberrant protein in correlation with disease |
| JP4804690B2 (ja) * | 1999-12-08 | 2011-11-02 | インテレクト・ニューロサイエンシズ・インコーポレーテッド | 免疫原としてのキメラペプチド、それに対する抗体、およびキメラペプチドまたは抗体を用いた免疫法 |
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1998
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- 1999-04-30 CA CA002327523A patent/CA2327523A1/en not_active Abandoned
- 1999-04-30 EP EP99940721A patent/EP1075490A1/en not_active Withdrawn
- 1999-04-30 WO PCT/NO1999/000141 patent/WO1999058564A1/en not_active Application Discontinuation
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| HUP0101734A2 (hu) | 2001-09-28 |
| AU755736B2 (en) | 2002-12-19 |
| AU5451599A (en) | 1999-11-29 |
| WO1999058564A1 (en) | 1999-11-18 |
| NO982098L (no) | 1999-11-09 |
| PL344186A1 (en) | 2001-10-08 |
| CN1300294A (zh) | 2001-06-20 |
| NO982098D0 (no) | 1998-05-08 |
| JP2002514658A (ja) | 2002-05-21 |
| EP1075490A1 (en) | 2001-02-14 |
| US20030171266A1 (en) | 2003-09-11 |
| AR018603A1 (es) | 2001-11-28 |
| US6861057B2 (en) | 2005-03-01 |
| CA2327523A1 (en) | 1999-11-18 |
| WO1999058564B1 (en) | 2000-01-27 |
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