WO1996038418A1
(en)
*
|
1995-06-02 |
1996-12-05 |
G.D. Searle & Co. |
Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
|
EP0833664A1
(de)
*
|
1995-06-12 |
1998-04-08 |
G.D. SEARLE & CO. |
Kombination aus einem cyclooxygenase-2 inhibitor und einem leukotrien b4 rezeptorantagonisten zur behandlung von entzündungen
|
US6136839A
(en)
*
|
1995-06-12 |
2000-10-24 |
G. D. Searle & Co. |
Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
|
WO1997029775A1
(en)
|
1996-02-13 |
1997-08-21 |
G.D. Searle & Co. |
Compositions comprising a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist
|
ES2169351T3
(es)
|
1996-02-13 |
2002-07-01 |
Searle & Co |
Combinaciones que tienen efectos inmunosupresores, que contienen inhibidores de ciclooxigenasa-2 y 5-lipoxigenasa.
|
WO1997029774A1
(en)
|
1996-02-13 |
1997-08-21 |
G.D. Searle & Co. |
Combinations, having immunosuppressive effects, containing a cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor
|
US5908858A
(en)
*
|
1996-04-05 |
1999-06-01 |
Sankyo Company, Limited |
1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses
|
HU225473B1
(en)
|
1996-04-12 |
2006-12-28 |
Searle & Co |
Heterocycle substituted n-acyl benzenesulfonamide derivatives, process for their preparation and their use as prodrug for the preparation of pharmaceutical compositions treating inflammation or inflammation-associated disorders
|
DK1479385T3
(da)
|
1996-10-15 |
2008-08-04 |
Searle Llc |
Anvendelse af cyclooxygenase-2 inhibitorer til behandling og forebyggelse af neoplasi
|
US5985930A
(en)
*
|
1996-11-21 |
1999-11-16 |
Pasinetti; Giulio M. |
Treatment of neurodegenerative conditions with nimesulide
|
ID18983A
(id)
*
|
1996-12-04 |
1998-05-28 |
Lilly Co Eli |
Pirazola sebagai inhibitor sekresi fosfolipase a2 non-pankreas pada manusia
|
AU725697B2
(en)
*
|
1997-04-03 |
2000-10-19 |
G.D. Searle & Co. |
Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of dementia
|
KR20010012808A
(ko)
*
|
1997-05-22 |
2001-02-26 |
윌리암스 로저 에이 |
p38 키나아제로서 4-아릴-3(5)-헤테로아릴 치환 피라졸
|
US6979686B1
(en)
|
2001-12-07 |
2005-12-27 |
Pharmacia Corporation |
Substituted pyrazoles as p38 kinase inhibitors
|
AU7726898A
(en)
|
1997-05-22 |
1998-12-11 |
G.D. Searle & Co. |
Pyrazole derivatives as p38 kinase inhibitors
|
US6514977B1
(en)
*
|
1997-05-22 |
2003-02-04 |
G.D. Searle & Company |
Substituted pyrazoles as p38 kinase inhibitors
|
GEP20033053B
(en)
*
|
1997-05-22 |
2003-08-25 |
Searle & Co |
Substituted Pyrazoles as P38 Kinase Inhibitors, Methods for their Production, Pharmaceutical Compositions Containing Them and Methods for Treatment
|
JP2002504909A
(ja)
|
1997-06-13 |
2002-02-12 |
スミスクライン・ビーチャム・コーポレイション |
新規な置換ピラゾールおよびピラゾリン化合物
|
US6525053B1
(en)
|
1997-08-22 |
2003-02-25 |
Abbott Laboratories |
Prostaglandin endoperoxide H synthase biosynthesis inhibitors
|
US6307047B1
(en)
*
|
1997-08-22 |
2001-10-23 |
Abbott Laboratories |
Prostaglandin endoperoxide H synthase biosynthesis inhibitors
|
AUPP042397A0
(en)
*
|
1997-11-18 |
1997-12-11 |
Fujisawa Pharmaceutical Co., Ltd. |
5-arylpyrazole compounds
|
US6025353A
(en)
*
|
1997-11-19 |
2000-02-15 |
G.D. Searle & Co. |
Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents
|
US6887893B1
(en)
*
|
1997-12-24 |
2005-05-03 |
Sankyo Company, Limited |
Methods and compositions for treatment and prevention of tumors, tumor-related disorders and cachexia
|
US6294558B1
(en)
*
|
1999-05-31 |
2001-09-25 |
Pfizer Inc. |
Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
|
US6727238B2
(en)
*
|
1998-06-11 |
2004-04-27 |
Pfizer Inc. |
Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
|
WO2000018741A2
(en)
*
|
1998-09-30 |
2000-04-06 |
Fujisawa Pharmaceutical Co., Ltd. |
Pyrazole compounds as cox-2 inhibitors
|
US6649645B1
(en)
*
|
1998-12-23 |
2003-11-18 |
Pharmacia Corporation |
Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
|
US6511997B1
(en)
|
1998-12-25 |
2003-01-28 |
Teikoku Hormone Mfg. Co., Ltd. |
Aminopyrazole derivatives
|
CN1281604C
(zh)
|
1999-06-03 |
2006-10-25 |
帝国脏器制药株式会社 |
取代吡唑化合物
|
PT1104758E
(pt)
*
|
1999-12-03 |
2003-12-31 |
Pfizer Prod Inc |
Derivados de acetileno como agentes anti-inflamatorios/analgesicos
|
BR0008060A
(pt)
*
|
1999-12-08 |
2002-02-05 |
Pharmacia Corp |
Composições inibidoras de ciclooxigenase-2 tendo rápido inìcio de eficácia terapêutica
|
AU5754701A
(en)
*
|
2000-07-13 |
2002-01-30 |
Pharmacia Corp |
Method of using cox-2 inhibitors in the treatment and prevention of ocular cox-2mediated disorders
|
PE20020146A1
(es)
*
|
2000-07-13 |
2002-03-31 |
Upjohn Co |
Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
|
CN100488500C
(zh)
|
2000-07-20 |
2009-05-20 |
劳拉斯有限公司 |
Cox-2抑制剂预防免疫缺陷的用途
|
PL365606A1
(en)
*
|
2000-09-06 |
2005-01-10 |
Ortho Mcneil Pharmaceutical, Inc. |
A method for treating allergies using substituted pyrazoles
|
US7115565B2
(en)
*
|
2001-01-18 |
2006-10-03 |
Pharmacia & Upjohn Company |
Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
|
EP1363669A2
(de)
*
|
2001-02-02 |
2003-11-26 |
Pharmacia Corporation |
Verfahren zur verwendung von einem cyclooxygenase-2 hemmer und sexsteroiden in einer kombinationstherapie zur behandlung und vorbeugung von dysmenorrhea
|
MY137736A
(en)
|
2001-04-03 |
2009-03-31 |
Pharmacia Corp |
Reconstitutable parenteral composition
|
US20030105144A1
(en)
|
2001-04-17 |
2003-06-05 |
Ping Gao |
Stabilized oral pharmaceutical composition
|
US6673818B2
(en)
|
2001-04-20 |
2004-01-06 |
Pharmacia Corporation |
Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
|
JP4310109B2
(ja)
|
2001-04-26 |
2009-08-05 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
ピラゾリル基を置換基として有する含窒素縮合環化合物およびその医薬組成物
|
US7076539B2
(en)
*
|
2001-07-30 |
2006-07-11 |
Hewlett-Packard Development Company, L.P. |
Network connectivity establishment at user log-in
|
UA80682C2
(en)
*
|
2001-08-06 |
2007-10-25 |
Pharmacia Corp |
Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
|
AR038957A1
(es)
|
2001-08-15 |
2005-02-02 |
Pharmacia Corp |
Terapia de combinacion para el tratamiento del cancer
|
CZ20022642A3
(cs)
*
|
2001-08-27 |
2003-09-17 |
Pfizer Products Inc. |
Způsob výroby dialkylpyridylboranů
|
US7057049B2
(en)
|
2001-09-25 |
2006-06-06 |
Pharmacia Corporation |
Process for making substituted pyrazoles
|
BR0212812A
(pt)
|
2001-09-25 |
2004-08-03 |
Pharmacia Corp |
Processos para a fabricação de pirazóis substituìdos e composição farmacêutica compreendendo os mesmos
|
DE60222804T2
(de)
*
|
2001-12-21 |
2008-07-03 |
Vernalis (Cambridge) Ltd., Abington |
3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung
|
JP4723242B2
(ja)
*
|
2002-06-12 |
2011-07-13 |
ケモセントリックス インコーポレーティッド |
炎症および免疫障害治療用ccr1アンタゴニストとして使用するための1−アリール−4−置換ピペラジン誘導体
|
US7589199B2
(en)
|
2002-06-12 |
2009-09-15 |
Chemocentryx, Inc. |
Substituted piperazines
|
US20050256130A1
(en)
*
|
2002-06-12 |
2005-11-17 |
Chemocentryx, Inc. |
Substituted piperazines
|
US7842693B2
(en)
*
|
2002-06-12 |
2010-11-30 |
Chemocentryx, Inc. |
Substituted piperazines
|
KR100478467B1
(ko)
*
|
2002-06-24 |
2005-03-23 |
씨제이 주식회사 |
피라졸-3-온 유도체, 그 제조방법 및 약제학적 조성물
|
WO2004002420A2
(en)
*
|
2002-06-28 |
2004-01-08 |
Nitromed, Inc. |
Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
|
WO2004009560A1
(en)
*
|
2002-07-22 |
2004-01-29 |
Orchid Chemicals & Pharmaceuticals Ltd |
Novel bio-active molecules
|
WO2004054560A1
(en)
|
2002-12-13 |
2004-07-01 |
Warner-Lambert Company Llc |
Alpha-2-delta ligand to treat lower urinary tract symptoms
|
GB0229618D0
(en)
*
|
2002-12-19 |
2003-01-22 |
Cancer Rec Tech Ltd |
Pyrazole compounds
|
CL2004000234A1
(es)
*
|
2003-02-12 |
2005-04-15 |
Biogen Idec Inc |
Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid
|
ES2312968T3
(es)
*
|
2003-02-27 |
2009-03-01 |
Smithkline Beecham Corporation |
Compuestos novedosos.
|
TW201018661A
(en)
*
|
2003-03-14 |
2010-05-16 |
Ono Pharmaceutical Co |
Heterocyclic rinf having nitrogen atom derivatives and medicament containing the derivatives as active ingredient
|
PL1622630T3
(pl)
*
|
2003-05-07 |
2013-01-31 |
Osteologix As |
Połączenia strontu w profilaktyce/leczeniu schorzeń tkanki chrzęstnej i/lub kostnej
|
PL1534305T3
(pl)
*
|
2003-05-07 |
2007-03-30 |
Osteologix As |
Leczenie zaburzeń chrząstek i kości solami strontu rozpuszczalnymi w wodzie
|
JP2007529993A
(ja)
*
|
2003-07-02 |
2007-11-01 |
シンジェンタ パーティシペーションズ アーゲー |
グルカナーゼ、それらをコードする核酸並びにそれらを製造及び使用する方法
|
WO2005037797A1
(en)
*
|
2003-10-21 |
2005-04-28 |
Pharmacia Corporation |
Substituted pyrazole urea compounds for the treatment of inflammation
|
WO2005044227A1
(en)
*
|
2003-11-05 |
2005-05-19 |
Glenmark Pharmaceuticals Limited |
Topical pharmaceutical compositions
|
US20050100594A1
(en)
*
|
2003-11-12 |
2005-05-12 |
Nilendu Sen |
Pharmaceutical formulation containing muscle relaxant and COX-II inhibitor
|
US7449462B2
(en)
|
2004-01-22 |
2008-11-11 |
Pfizer, Inc. |
Triazole derivatives which inhibit vasopressin antagonistic activity
|
CA2558211C
(en)
*
|
2004-03-03 |
2013-09-03 |
Chemocentryx, Inc. |
Bicyclic and bridged nitrogen heterocycles
|
US7435831B2
(en)
*
|
2004-03-03 |
2008-10-14 |
Chemocentryx, Inc. |
Bicyclic and bridged nitrogen heterocycles
|
NZ553696A
(en)
|
2004-09-13 |
2010-02-26 |
Ono Pharmaceutical Co |
Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient
|
CA2582885A1
(en)
*
|
2004-10-13 |
2006-04-27 |
Ptc Therapeutics, Inc. |
Compounds for nonsense suppression, use of these compounds for the manufacture of a medicament for treating somatic mutation-related diseases
|
TW200639163A
(en)
*
|
2005-02-04 |
2006-11-16 |
Genentech Inc |
RAF inhibitor compounds and methods
|
NL2000351C2
(nl)
|
2005-12-22 |
2007-09-11 |
Pfizer Prod Inc |
Estrogeen-modulatoren.
|
US7863446B2
(en)
*
|
2006-01-19 |
2011-01-04 |
Orchid Research Laboratories Limited |
Heterocycles
|
PL1973884T3
(pl)
*
|
2006-01-19 |
2017-05-31 |
Orchid Pharma Limited |
Nowe związki heterocykliczne
|
EA200870344A1
(ru)
*
|
2006-03-10 |
2009-04-28 |
Оно Фармасьютикал Ко., Лтд. |
Азотсодержащее гетероциклическое производное и фармацевтическое средство, включающее такое производное в качестве активного ингредиента
|
US20080161324A1
(en)
*
|
2006-09-14 |
2008-07-03 |
Johansen Lisa M |
Compositions and methods for treatment of viral diseases
|
US20080153888A1
(en)
|
2006-12-22 |
2008-06-26 |
Recordati Ireland Limited |
Alpha-2-delta ligand/nsaid therapeutic treatment of lower urinary tract disorders
|
JP2010516679A
(ja)
*
|
2007-01-19 |
2010-05-20 |
マリンクロット インコーポレイテッド |
診断用および治療用シクロオキシゲナーゼ−2結合リガンド
|
JP2010522763A
(ja)
|
2007-03-26 |
2010-07-08 |
ユニヴァーシティー オブ サザン カリフォルニア |
Erストレスを刺激することによりアポトーシスを誘導するための方法および化合物
|
CA2692977A1
(en)
|
2007-07-12 |
2009-01-15 |
Tragara Pharmaceuticals, Inc. |
Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders
|
CN101965338B
(zh)
*
|
2008-02-01 |
2014-09-17 |
幽兰化学医药有限公司 |
杂环
|
JP2011521969A
(ja)
*
|
2008-05-30 |
2011-07-28 |
スムマ ヘルス システムズ エルエルシー |
眼疾患を治療するためのTGF−β受容体阻害剤又はアクチビン様キナーゼ(ALK)5阻害剤、A−83−01及びSB−431542の使用方法及び創傷治療条件
|
CN102695511A
(zh)
*
|
2009-04-17 |
2012-09-26 |
舒玛健康系统有限责任公司 |
抑制眼部瘢痕形成的转化生长因子-β受体抑制剂的用途
|
WO2011038261A1
(en)
*
|
2009-09-24 |
2011-03-31 |
Selexagen Therapeutics, Inc. |
Heterocyclic kinase inhibitors
|
EP2308866A1
(de)
*
|
2009-10-09 |
2011-04-13 |
Bayer CropScience AG |
Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
|
EA026692B1
(ru)
|
2010-06-30 |
2017-05-31 |
Айронвуд Фармасьютикелз, Инк. |
Стимуляторы sgc
|
MX341531B
(es)
|
2010-11-09 |
2016-08-22 |
Ironwood Pharmaceuticals Inc |
Derivados de triazol como estimuladores de la guanilato ciclasa soluble gcs.
|
WO2013101830A1
(en)
|
2011-12-27 |
2013-07-04 |
Ironwood Pharmaceuticals, Inc. |
2 - benzyl, 3 - (pyrimidin- 2 -yl) substituted pyrazoles useful as sgc stimulators
|
US10500178B2
(en)
|
2015-03-13 |
2019-12-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
LTB4 inhibition to prevent and treat human lymphedema
|
US10669528B2
(en)
|
2015-06-25 |
2020-06-02 |
Children's Medical Center Corporation |
Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
|
DK3429603T3
(da)
|
2016-03-15 |
2022-03-14 |
Childrens Medical Center |
Fremgangsmåder og sammensætninger vedrørende ekspansion af hæmatopoietiske stamceller
|
CN110963957B
(zh)
*
|
2018-09-28 |
2021-10-22 |
深圳恩多凯医药科技有限公司 |
N-芳香酰胺类化合物及其制备方法和用途
|
CN113004179B
(zh)
*
|
2019-12-20 |
2022-06-24 |
江苏中旗科技股份有限公司 |
一种异噁唑草酮关键中间体的制备方法
|
CA3209491A1
(en)
|
2021-03-15 |
2022-09-22 |
Saul Yedgar |
Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease
|
PL442982A1
(pl)
*
|
2022-11-29 |
2024-06-03 |
Uniwersytet Medyczny W Lublinie |
N-podstawione pochodne 1-(1-fenylo-3-arylo)-1H-pirazol-4-ylo)metanaminy, sposób ich wytwarzania i ich zastosowanie
|