EP0828718A1
(de)
*
|
1995-06-02 |
1998-03-18 |
G.D. SEARLE & CO. |
Heterocyclo-substituierte hydroxaminsäurederivate als cyclooxygenase-2 und 5-lipoxygenase inhibitoren
|
US6136839A
(en)
*
|
1995-06-12 |
2000-10-24 |
G. D. Searle & Co. |
Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
|
WO1996041645A1
(en)
*
|
1995-06-12 |
1996-12-27 |
G.D. Searle & Co. |
Combination of a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist for the treatment of inflammations
|
PT880362E
(pt)
*
|
1996-02-13 |
2005-10-31 |
Searle & Co |
Composicoes compreendendo um inibidor do cicloxigenase tipo 2 e um antagonista do receptor do leucotrieno b4
|
DE69709069T2
(de)
|
1996-02-13 |
2002-07-04 |
Searle & Co |
Zusammensetzungen mit immunosuppressiven wirkungen, welche 5-lipoxygenase-inhibitoren und cyclooxygenase-2-inhibitoren enthalten
|
DK0880363T3
(da)
*
|
1996-02-13 |
2003-01-20 |
Searle & Co |
Kombinationer der omfatter en cyclooxygenase-2 hæmmer samt en leukotrien A4 hydrolasehæmmer, som har immunsuppressive virkninger
|
US5908858A
(en)
*
|
1996-04-05 |
1999-06-01 |
Sankyo Company, Limited |
1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses
|
EP0892791B1
(de)
|
1996-04-12 |
2003-03-05 |
G.D. Searle & Co. |
N-[[4-(5-METHYL-3-PHENYLISOXAZOL-4-YL]PHENYL]SULPHONYLPROPYLAMID und sein NATRIUMSALZ ALS PRO-PHARMAKON VON COX-2 INHIBITOREN
|
TWI235060B
(en)
|
1996-10-15 |
2005-07-01 |
Searle & Co |
Pharmaceutical compositions comprising substituted pyrazolyl benzenesulfonamide derivatives for use in treating or preventing an epithelial cell-derived neoplasia
|
US5985930A
(en)
*
|
1996-11-21 |
1999-11-16 |
Pasinetti; Giulio M. |
Treatment of neurodegenerative conditions with nimesulide
|
ID18983A
(id)
*
|
1996-12-04 |
1998-05-28 |
Lilly Co Eli |
Pirazola sebagai inhibitor sekresi fosfolipase a2 non-pankreas pada manusia
|
EP0971714B1
(de)
*
|
1997-04-03 |
2002-10-09 |
G.D. Searle & Co. |
Verfahren zur verwendung von cyclooxygenase-2 hemmern zur behandlung und vorbeugung der demenz
|
US6514977B1
(en)
*
|
1997-05-22 |
2003-02-04 |
G.D. Searle & Company |
Substituted pyrazoles as p38 kinase inhibitors
|
US6979686B1
(en)
|
2001-12-07 |
2005-12-27 |
Pharmacia Corporation |
Substituted pyrazoles as p38 kinase inhibitors
|
CA2291115A1
(en)
*
|
1997-05-22 |
1998-11-26 |
G.D. Searle & Co. |
Substituted pyrazoles as p38 kinase inhibitors
|
US5932576A
(en)
*
|
1997-05-22 |
1999-08-03 |
G. D. Searle & Company |
3(5)-heteroaryl substituted pyrazoles as p38 kinase inhibitors
|
US6087381A
(en)
*
|
1997-05-22 |
2000-07-11 |
G. D. Searle & Company |
Pyrazole derivatives as p38 kinase inhibitors
|
AU7966198A
(en)
|
1997-06-13 |
1998-12-30 |
Smithkline Beecham Corporation |
Novel pyrazole and pyrazoline substituted compounds
|
US6525053B1
(en)
|
1997-08-22 |
2003-02-25 |
Abbott Laboratories |
Prostaglandin endoperoxide H synthase biosynthesis inhibitors
|
US6307047B1
(en)
*
|
1997-08-22 |
2001-10-23 |
Abbott Laboratories |
Prostaglandin endoperoxide H synthase biosynthesis inhibitors
|
AUPP042397A0
(en)
*
|
1997-11-18 |
1997-12-11 |
Fujisawa Pharmaceutical Co., Ltd. |
5-arylpyrazole compounds
|
US6025353A
(en)
*
|
1997-11-19 |
2000-02-15 |
G.D. Searle & Co. |
Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents
|
NZ333399A
(en)
*
|
1997-12-24 |
2000-05-26 |
Sankyo Co |
Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis
|
US6294558B1
(en)
|
1999-05-31 |
2001-09-25 |
Pfizer Inc. |
Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
|
US6727238B2
(en)
*
|
1998-06-11 |
2004-04-27 |
Pfizer Inc. |
Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
|
WO2000018741A2
(en)
*
|
1998-09-30 |
2000-04-06 |
Fujisawa Pharmaceutical Co., Ltd. |
Pyrazole compounds as cox-2 inhibitors
|
US6649645B1
(en)
|
1998-12-23 |
2003-11-18 |
Pharmacia Corporation |
Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
|
WO2000039116A1
(fr)
|
1998-12-25 |
2000-07-06 |
Teikoku Hormone Mfg. Co., Ltd. |
Derives d'aminopyrazole
|
CN1281604C
(zh)
|
1999-06-03 |
2006-10-25 |
帝国脏器制药株式会社 |
取代吡唑化合物
|
DK1104758T3
(da)
*
|
1999-12-03 |
2003-10-20 |
Pfizer Prod Inc |
Acetylenderivativer som anti-inflammatoriske/analgesiske lægemidler
|
KR100793668B1
(ko)
*
|
1999-12-08 |
2008-01-10 |
파마시아 코포레이션 |
강화된 생체이용률을 지닌 고체상 형태의 셀레콕시브
|
WO2002005848A2
(en)
*
|
2000-07-13 |
2002-01-24 |
Pharmacia Corporation |
Use of cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders
|
PE20020146A1
(es)
*
|
2000-07-13 |
2002-03-31 |
Upjohn Co |
Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
|
PT1303265E
(pt)
|
2000-07-20 |
2007-10-09 |
Lauras As |
''utilização de inibidores da cox-2 como imuno-estimulantes, no tratamento do vih ou da sida''
|
WO2002020011A2
(en)
*
|
2000-09-06 |
2002-03-14 |
Ortho Mcneil Pharmaceutical, Inc. |
A method for treating allergies using substituted pyrazoles
|
US7115565B2
(en)
*
|
2001-01-18 |
2006-10-03 |
Pharmacia & Upjohn Company |
Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
|
CA2435350A1
(en)
*
|
2001-02-02 |
2002-08-15 |
Pharmacia Corporation |
Method of using a cyclooxygenase-2 inhibitor and sex steroids as a combination therapy for the treatment and prevention of dismenorrhea
|
US7695736B2
(en)
|
2001-04-03 |
2010-04-13 |
Pfizer Inc. |
Reconstitutable parenteral composition
|
US20030105144A1
(en)
|
2001-04-17 |
2003-06-05 |
Ping Gao |
Stabilized oral pharmaceutical composition
|
US6673818B2
(en)
|
2001-04-20 |
2004-01-06 |
Pharmacia Corporation |
Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
|
ATE402164T1
(de)
|
2001-04-26 |
2008-08-15 |
Eisai R&D Man Co Ltd |
Stickstoffhaltige verbindung mit kondensiertem ring und pyrazolylgruppe als substituent und medizinische zusammensetzung davon
|
US7076539B2
(en)
*
|
2001-07-30 |
2006-07-11 |
Hewlett-Packard Development Company, L.P. |
Network connectivity establishment at user log-in
|
UA80682C2
(en)
*
|
2001-08-06 |
2007-10-25 |
Pharmacia Corp |
Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
|
AR038957A1
(es)
|
2001-08-15 |
2005-02-02 |
Pharmacia Corp |
Terapia de combinacion para el tratamiento del cancer
|
CZ20022642A3
(cs)
*
|
2001-08-27 |
2003-09-17 |
Pfizer Products Inc. |
Způsob výroby dialkylpyridylboranů
|
US7057049B2
(en)
|
2001-09-25 |
2006-06-06 |
Pharmacia Corporation |
Process for making substituted pyrazoles
|
BR0212812A
(pt)
|
2001-09-25 |
2004-08-03 |
Pharmacia Corp |
Processos para a fabricação de pirazóis substituìdos e composição farmacêutica compreendendo os mesmos
|
DE60222804T2
(de)
*
|
2001-12-21 |
2008-07-03 |
Vernalis (Cambridge) Ltd., Abington |
3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung
|
CN1867336B
(zh)
|
2002-06-12 |
2010-05-12 |
凯莫森特里克斯股份有限公司 |
1-芳基-4-取代的哌嗪衍生物及其制药用途
|
US20050256130A1
(en)
*
|
2002-06-12 |
2005-11-17 |
Chemocentryx, Inc. |
Substituted piperazines
|
US7589199B2
(en)
|
2002-06-12 |
2009-09-15 |
Chemocentryx, Inc. |
Substituted piperazines
|
US7842693B2
(en)
*
|
2002-06-12 |
2010-11-30 |
Chemocentryx, Inc. |
Substituted piperazines
|
KR100478467B1
(ko)
*
|
2002-06-24 |
2005-03-23 |
씨제이 주식회사 |
피라졸-3-온 유도체, 그 제조방법 및 약제학적 조성물
|
EP1539679A4
(de)
*
|
2002-06-28 |
2007-07-04 |
Nitromed Inc |
Oxim- und/oder hydrazonhaltige, nitrosierte und/oder nitrosylierte cyclooxigenase-2-selektive inhibitoren, zusammensetzungen und anwendungsverfahren
|
AU2003249484A1
(en)
*
|
2002-07-22 |
2004-02-09 |
Orchid Chemicals And Pharmaceuticals Ltd |
Novel bio-active molecules
|
CA2509605C
(en)
|
2002-12-13 |
2010-10-05 |
Warner-Lambert Company Llc |
Alpha-2-delta ligand to treat lower urinary tract symptoms
|
GB0229618D0
(en)
*
|
2002-12-19 |
2003-01-22 |
Cancer Rec Tech Ltd |
Pyrazole compounds
|
CL2004000234A1
(es)
*
|
2003-02-12 |
2005-04-15 |
Biogen Idec Inc |
Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid
|
DE602004016964D1
(de)
*
|
2003-02-27 |
2008-11-20 |
Smithkline Beecham Corp |
Neue verbindungen
|
CA2517888C
(en)
*
|
2003-03-14 |
2012-05-01 |
Ono Pharmaceutical Co., Ltd. |
Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
|
EP2266584B1
(de)
*
|
2003-05-07 |
2012-09-05 |
Osteologix A/S |
Strontium-Vitamin D-Zusammensetzung zur Prophylaxe/Behandlung von Knorpel- und Knochenzuständen
|
EP1534305B9
(de)
|
2003-05-07 |
2007-03-07 |
Osteologix A/S |
Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
|
EP2404929B1
(de)
*
|
2003-07-02 |
2014-06-18 |
BP Corporation North America Inc. |
Glucanasen, Nukleinsäuren, die diese codieren, und Verfahren zu deren Herstellung und Verwendung
|
WO2005037797A1
(en)
*
|
2003-10-21 |
2005-04-28 |
Pharmacia Corporation |
Substituted pyrazole urea compounds for the treatment of inflammation
|
WO2005044227A1
(en)
*
|
2003-11-05 |
2005-05-19 |
Glenmark Pharmaceuticals Limited |
Topical pharmaceutical compositions
|
US20050100594A1
(en)
*
|
2003-11-12 |
2005-05-12 |
Nilendu Sen |
Pharmaceutical formulation containing muscle relaxant and COX-II inhibitor
|
EP1708718A1
(de)
|
2004-01-22 |
2006-10-11 |
Pfizer Limited |
Triazol-derivate zur hemmung der vasopressing-antagonistischen aktivität
|
AU2005219438B2
(en)
*
|
2004-03-03 |
2011-02-17 |
Chemocentryx, Inc. |
Bicyclic and bridged nitrogen heterocycles
|
US7435831B2
(en)
*
|
2004-03-03 |
2008-10-14 |
Chemocentryx, Inc. |
Bicyclic and bridged nitrogen heterocycles
|
TWI400232B
(zh)
*
|
2004-09-13 |
2013-07-01 |
Ono Pharmaceutical Co |
含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑
|
EP2363129A1
(de)
|
2004-10-13 |
2011-09-07 |
PTC Therapeutics, Inc. |
Verbindungen zur Nonsense-Unterdrückung und Verfahren zu deren Verwendung
|
TW200639163A
(en)
*
|
2005-02-04 |
2006-11-16 |
Genentech Inc |
RAF inhibitor compounds and methods
|
NL2000351C2
(nl)
|
2005-12-22 |
2007-09-11 |
Pfizer Prod Inc |
Estrogeen-modulatoren.
|
US7863446B2
(en)
*
|
2006-01-19 |
2011-01-04 |
Orchid Research Laboratories Limited |
Heterocycles
|
WO2007083182A2
(en)
|
2006-01-19 |
2007-07-26 |
Orchid Research Laboratories Limited |
Novel heterocycles
|
CA2644368A1
(en)
*
|
2006-03-10 |
2007-09-20 |
Ono Pharmaceutical Co., Ltd. |
Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
|
WO2008033466A2
(en)
*
|
2006-09-14 |
2008-03-20 |
Combinatorx (Singapore) Pre. Ltd. |
Compositions and methods for treatment of viral diseases
|
EA017171B1
(ru)
|
2006-12-22 |
2012-10-30 |
Рекордати Айерленд Лимитед |
КОМБИНИРОВАННАЯ ТЕРАПИЯ ЗАБОЛЕВАНИЙ НИЖНИХ МОЧЕВЫВОДЯЩИХ ПУТЕЙ С ИСПОЛЬЗОВАНИЕМ ЛИГАНДОВ αδ И НЕСТЕРОИДНЫХ ПРОТИВОВОСПАЛИТЕЛЬНЫХ ПРЕПАРАТОВ (НПВП)
|
CA2676413A1
(en)
*
|
2007-01-19 |
2008-07-31 |
Mallinckrodt Inc. |
Diagnostic and therapeutic cyclooxygenase-2 binding ligands
|
EP2952186A1
(de)
|
2007-03-26 |
2015-12-09 |
University Of Southern California |
Zusammensetzungen zur Induzierung von Apoptose mittels Stimulierung von ER-Stress
|
BRPI0814542A2
(pt)
|
2007-07-12 |
2014-09-30 |
Tragara Pharmaceuticals Inc |
Métodos e composições para o tratamento de câncer, tumores e desordens relacionadas a tumores
|
BRPI0912029A2
(pt)
*
|
2008-02-01 |
2020-06-30 |
Orchid Research Laboratories Limited |
novos heterociclos
|
WO2009146408A1
(en)
*
|
2008-05-30 |
2009-12-03 |
Summa Health Systems Llc |
Methods for using tgf-b receptor inhibitors or activin-like kinase (alk) 5 inhibitors a-83-01 and sb-431542 to treat eye disease and wound healing conditions
|
EP2419105A4
(de)
*
|
2009-04-17 |
2012-09-12 |
Summa Health Systems Llc |
Transformation von wachstumsfaktor-b-rezeptorhemmern zur unterdrückung von okularer narbenbildung
|
WO2011038261A1
(en)
*
|
2009-09-24 |
2011-03-31 |
Selexagen Therapeutics, Inc. |
Heterocyclic kinase inhibitors
|
EP2308866A1
(de)
*
|
2009-10-09 |
2011-04-13 |
Bayer CropScience AG |
Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
|
DK2588465T3
(en)
|
2010-06-30 |
2017-05-01 |
Ironwood Pharmaceuticals Inc |
SGC stimulators
|
US9061030B2
(en)
|
2010-11-09 |
2015-06-23 |
Ironwood Pharmaceuticals, Inc. |
sGC stimulators
|
EP3112363A1
(de)
|
2011-12-27 |
2017-01-04 |
Ironwood Pharmaceuticals, Inc. |
2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1h-pyrazol-3-yl]-pyrimidinderivate und verwandte verbindungen als stimulatoren der löslichen guanylatcyclase (lgc) zur behandlung von pulmonarer hypertonie
|
WO2016149126A1
(en)
|
2015-03-13 |
2016-09-22 |
The Board Of Trustees Of The Leland Stanford Junior University |
Ltb4 inhibition to prevent and treat human lymphedema
|
WO2016210292A1
(en)
|
2015-06-25 |
2016-12-29 |
Children's Medical Center Corporation |
Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
|
AU2017235461B2
(en)
|
2016-03-15 |
2023-02-23 |
Children's Medical Center Corporation |
Methods and compositions relating to hematopoietic stem cell expansion
|
CN110963957B
(zh)
*
|
2018-09-28 |
2021-10-22 |
深圳恩多凯医药科技有限公司 |
N-芳香酰胺类化合物及其制备方法和用途
|
CN113004179B
(zh)
*
|
2019-12-20 |
2022-06-24 |
江苏中旗科技股份有限公司 |
一种异噁唑草酮关键中间体的制备方法
|
CA3209491A1
(en)
|
2021-03-15 |
2022-09-22 |
Saul Yedgar |
Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease
|