EP0828718A1
(en)
*
|
1995-06-02 |
1998-03-18 |
G.D. SEARLE & CO. |
Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
|
DE69635048T2
(de)
*
|
1995-06-12 |
2006-02-16 |
G.D. Searle & Co. |
Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor
|
CA2224563A1
(en)
*
|
1995-06-12 |
1996-12-27 |
G.D. Searle & Co. |
Combination of a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist for the treatment of inflammations
|
ATE296114T1
(de)
*
|
1996-02-13 |
2005-06-15 |
Searle & Co |
Zubereitungen, enthaltend einen cyclooxygenase-2- inhibitor und einen leukotrien-b4-rezeptor- antagonisten
|
ES2183140T3
(es)
|
1996-02-13 |
2003-03-16 |
Searle & Co |
Combinaciones, que tienen efectos inmunosupresores, que contienen un inhibidor de ciclooxigenasa-2 y un inhibidor de leucotrieno a4 hidrolasa.
|
DK0888127T3
(da)
|
1996-02-13 |
2002-04-08 |
Searle & Co |
Kombinationer med immunoundertrykkende virkninger indeholdende cyclooxygenase-2-inhibitorer og 5-lipooxygenaseinhibitortorer
|
US5908858A
(en)
*
|
1996-04-05 |
1999-06-01 |
Sankyo Company, Limited |
1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses
|
DE69739003D1
(de)
|
1996-04-12 |
2008-10-30 |
Searle Llc |
Substituierte Benzensulfonamid-Derivate als Wirkstoff-Vorläufer von COX-2 Inhibitoren
|
PT1479385E
(pt)
|
1996-10-15 |
2008-09-02 |
Searle Llc |
Utilização de inibidores de ciclo-oxigenase 2 no tratamento e na prevenção de neoplasias
|
US5985930A
(en)
|
1996-11-21 |
1999-11-16 |
Pasinetti; Giulio M. |
Treatment of neurodegenerative conditions with nimesulide
|
ID18983A
(id)
*
|
1996-12-04 |
1998-05-28 |
Lilly Co Eli |
Pirazola sebagai inhibitor sekresi fosfolipase a2 non-pankreas pada manusia
|
ES2185154T3
(es)
*
|
1997-04-03 |
2003-04-16 |
Searle & Co |
Metodo de uso de inhibidores de la ciclooxigenasa-2 en el tratamiento y prevencion de la demencia.
|
WO1998052941A1
(en)
*
|
1997-05-22 |
1998-11-26 |
G.D. Searle And Co. |
PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS
|
WO1998052937A2
(en)
*
|
1997-05-22 |
1998-11-26 |
G.D. Searle And Co. |
4-aryl-3(5)-heteroaryl substituted pyrazoles as p38 kinase
|
US6514977B1
(en)
|
1997-05-22 |
2003-02-04 |
G.D. Searle & Company |
Substituted pyrazoles as p38 kinase inhibitors
|
EA003925B1
(ru)
*
|
1997-05-22 |
2003-10-30 |
Дж.Д.Сирл Энд Ко |
ЗАМЕЩЕННЫЕ ПИРАЗОЛЫ, КАК ИНГИБИТОРЫ p 38 КИНАЗЫ
|
US6979686B1
(en)
|
2001-12-07 |
2005-12-27 |
Pharmacia Corporation |
Substituted pyrazoles as p38 kinase inhibitors
|
JP2002504909A
(ja)
*
|
1997-06-13 |
2002-02-12 |
スミスクライン・ビーチャム・コーポレイション |
新規な置換ピラゾールおよびピラゾリン化合物
|
US6307047B1
(en)
*
|
1997-08-22 |
2001-10-23 |
Abbott Laboratories |
Prostaglandin endoperoxide H synthase biosynthesis inhibitors
|
US6525053B1
(en)
|
1997-08-22 |
2003-02-25 |
Abbott Laboratories |
Prostaglandin endoperoxide H synthase biosynthesis inhibitors
|
AUPP042397A0
(en)
*
|
1997-11-18 |
1997-12-11 |
Fujisawa Pharmaceutical Co., Ltd. |
5-arylpyrazole compounds
|
US6025353A
(en)
*
|
1997-11-19 |
2000-02-15 |
G.D. Searle & Co. |
Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents
|
NZ333399A
(en)
|
1997-12-24 |
2000-05-26 |
Sankyo Co |
Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis
|
US6727238B2
(en)
*
|
1998-06-11 |
2004-04-27 |
Pfizer Inc. |
Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
|
US6294558B1
(en)
*
|
1999-05-31 |
2001-09-25 |
Pfizer Inc. |
Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
|
WO2000018741A2
(en)
*
|
1998-09-30 |
2000-04-06 |
Fujisawa Pharmaceutical Co., Ltd. |
Pyrazole compounds as cox-2 inhibitors
|
US6649645B1
(en)
|
1998-12-23 |
2003-11-18 |
Pharmacia Corporation |
Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
|
DE69926542T2
(de)
*
|
1998-12-25 |
2006-04-27 |
Teikoku Hormone Mfg. Co., Ltd. |
Aminopyrazolderivate
|
AU766079B2
(en)
*
|
1999-06-03 |
2003-10-09 |
Teikoku Hormone Mfg. Co., Ltd. |
Substituted pyrazole compounds
|
DK1104758T3
(da)
*
|
1999-12-03 |
2003-10-20 |
Pfizer Prod Inc |
Acetylenderivativer som anti-inflammatoriske/analgesiske lægemidler
|
ES2236007T3
(es)
*
|
1999-12-08 |
2005-07-16 |
Pharmacia Corporation |
Composiciones de inhibidor de ciclooxigenasa-2 ue tiene un efecto terapeutico rapido.
|
AU5754701A
(en)
*
|
2000-07-13 |
2002-01-30 |
Pharmacia Corp |
Method of using cox-2 inhibitors in the treatment and prevention of ocular cox-2mediated disorders
|
PE20020146A1
(es)
*
|
2000-07-13 |
2002-03-31 |
Upjohn Co |
Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
|
HUP0302068A3
(en)
|
2000-07-20 |
2005-05-30 |
Lauras As |
Use of cox-2 inhibitors for treating or preventing immunodeficiency and pharmaceutical compositions containing them
|
CA2421493A1
(en)
*
|
2000-09-06 |
2002-03-14 |
Ortho-Mcneil Pharmaceutical, Inc. |
A method for treating allergies using substituted pyrazoles
|
US7115565B2
(en)
*
|
2001-01-18 |
2006-10-03 |
Pharmacia & Upjohn Company |
Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
|
EP1363669A2
(en)
*
|
2001-02-02 |
2003-11-26 |
Pharmacia Corporation |
Method of using a cyclooxygenase-2 inhibitor and sex steroids as a combination therapy for the treatment and prevention of dismenorrhea
|
US7695736B2
(en)
|
2001-04-03 |
2010-04-13 |
Pfizer Inc. |
Reconstitutable parenteral composition
|
US20030105144A1
(en)
|
2001-04-17 |
2003-06-05 |
Ping Gao |
Stabilized oral pharmaceutical composition
|
US6673818B2
(en)
|
2001-04-20 |
2004-01-06 |
Pharmacia Corporation |
Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
|
DE60227794D1
(de)
|
2001-04-26 |
2008-09-04 |
Eisai R&D Man Co Ltd |
Stickstoffhaltige verbindung mit kondensiertem ring und pyrazolylgruppe als substituent und medizinische zusammensetzung davon
|
US7076539B2
(en)
*
|
2001-07-30 |
2006-07-11 |
Hewlett-Packard Development Company, L.P. |
Network connectivity establishment at user log-in
|
UA80682C2
(en)
*
|
2001-08-06 |
2007-10-25 |
Pharmacia Corp |
Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
|
AR038957A1
(es)
|
2001-08-15 |
2005-02-02 |
Pharmacia Corp |
Terapia de combinacion para el tratamiento del cancer
|
CZ20022642A3
(cs)
*
|
2001-08-27 |
2003-09-17 |
Pfizer Products Inc. |
Způsob výroby dialkylpyridylboranů
|
IL161009A0
(en)
|
2001-09-25 |
2004-08-31 |
Pharmacia Corp |
Process for making substituted pyrazoles
|
US7057049B2
(en)
|
2001-09-25 |
2006-06-06 |
Pharmacia Corporation |
Process for making substituted pyrazoles
|
AU2002356301A1
(en)
|
2001-12-21 |
2003-07-15 |
Cancer Research Technology Ltd. |
3,4-diarylpyrazoles and their use in the therapy of cancer
|
US7842693B2
(en)
*
|
2002-06-12 |
2010-11-30 |
Chemocentryx, Inc. |
Substituted piperazines
|
US20050256130A1
(en)
*
|
2002-06-12 |
2005-11-17 |
Chemocentryx, Inc. |
Substituted piperazines
|
US7589199B2
(en)
*
|
2002-06-12 |
2009-09-15 |
Chemocentryx, Inc. |
Substituted piperazines
|
AU2003236500B9
(en)
*
|
2002-06-12 |
2009-07-02 |
Chemocentryx, Inc. |
1-aryl-4-substituted piperazine derivatives for use as CCR1 antagonists for the treatment of inflammation and immune disorders
|
KR100478467B1
(ko)
*
|
2002-06-24 |
2005-03-23 |
씨제이 주식회사 |
피라졸-3-온 유도체, 그 제조방법 및 약제학적 조성물
|
EP1539679A4
(en)
*
|
2002-06-28 |
2007-07-04 |
Nitromed Inc |
OXIM- AND / OR HYDRAZO-CONTAINING, NITROSED AND / OR NITROSYLATED CYCLOOXIGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND USE METHODS
|
EP1542978B1
(en)
*
|
2002-07-22 |
2011-04-13 |
Orchid Research Laboratories Limited |
Novel bio-active molecules
|
ES2341240T3
(es)
|
2002-12-13 |
2010-06-17 |
Warner-Lambert Company Llc |
Ligando alfa-2-delta para tratar los sintomas del tracto urinario inferior.
|
GB0229618D0
(en)
*
|
2002-12-19 |
2003-01-22 |
Cancer Rec Tech Ltd |
Pyrazole compounds
|
CL2004000234A1
(es)
*
|
2003-02-12 |
2005-04-15 |
Biogen Idec Inc |
Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid
|
JP2006519234A
(ja)
*
|
2003-02-27 |
2006-08-24 |
スミスクライン ビーチャム コーポレーション |
新規化合物
|
BRPI0408332A
(pt)
*
|
2003-03-14 |
2006-03-21 |
Ono Pharmaceutical Co |
derivados heterocìclicos contendo nitrogênio e medicamentos contendo os mesmos como ingrediente ativo
|
SI1622630T1
(sl)
*
|
2003-05-07 |
2012-12-31 |
Osteologix A/S |
Stroncijeva kombinacije za profilakso/zdravljenje patologij hrustanca in/ali kosti
|
JP4354984B2
(ja)
*
|
2003-05-07 |
2009-10-28 |
オステオロジックス エイ/エス |
水溶性ストロンチウム塩を用いる軟骨/骨症状の治療
|
US7960148B2
(en)
*
|
2003-07-02 |
2011-06-14 |
Verenium Corporation |
Glucanases, nucleic acids encoding them and methods for making and using them
|
WO2005037797A1
(en)
*
|
2003-10-21 |
2005-04-28 |
Pharmacia Corporation |
Substituted pyrazole urea compounds for the treatment of inflammation
|
WO2005044227A1
(en)
*
|
2003-11-05 |
2005-05-19 |
Glenmark Pharmaceuticals Limited |
Topical pharmaceutical compositions
|
US20050100594A1
(en)
*
|
2003-11-12 |
2005-05-12 |
Nilendu Sen |
Pharmaceutical formulation containing muscle relaxant and COX-II inhibitor
|
EP1708718A1
(en)
|
2004-01-22 |
2006-10-11 |
Pfizer Limited |
Triazole derivatives which inhibit vasopressin antagonistic activity
|
JP4845873B2
(ja)
*
|
2004-03-03 |
2011-12-28 |
ケモセントリックス インコーポレーティッド |
二環式および架橋した窒素複素環
|
US7435831B2
(en)
*
|
2004-03-03 |
2008-10-14 |
Chemocentryx, Inc. |
Bicyclic and bridged nitrogen heterocycles
|
CN101775013A
(zh)
*
|
2004-09-13 |
2010-07-14 |
小野药品工业株式会社 |
含氮杂环衍生物及含有其作为活性成分的药物
|
EP1812071A2
(en)
|
2004-10-13 |
2007-08-01 |
PTC Therapeutics, Inc. |
Compounds for nonsense suppression, use of these compounds for the manufacture of a medicament for treating somatic mutation-related diseases
|
TW200639163A
(en)
*
|
2005-02-04 |
2006-11-16 |
Genentech Inc |
RAF inhibitor compounds and methods
|
NL2000351C2
(nl)
|
2005-12-22 |
2007-09-11 |
Pfizer Prod Inc |
Estrogeen-modulatoren.
|
US7863446B2
(en)
*
|
2006-01-19 |
2011-01-04 |
Orchid Research Laboratories Limited |
Heterocycles
|
ES2600804T3
(es)
*
|
2006-01-19 |
2017-02-10 |
Orchid Pharma Limited |
Nuevos heterociclos
|
WO2007105637A1
(ja)
*
|
2006-03-10 |
2007-09-20 |
Ono Pharmaceutical Co., Ltd. |
含窒素複素環誘導体およびそれらを有効成分とする薬剤
|
US20080161324A1
(en)
*
|
2006-09-14 |
2008-07-03 |
Johansen Lisa M |
Compositions and methods for treatment of viral diseases
|
CN101600458A
(zh)
|
2006-12-22 |
2009-12-09 |
瑞蔻达蒂爱尔兰有限公司 |
采用α2δ配体和NSAID的下泌尿道疾病的联合治疗
|
JP2010516679A
(ja)
*
|
2007-01-19 |
2010-05-20 |
マリンクロット インコーポレイテッド |
診断用および治療用シクロオキシゲナーゼ−2結合リガンド
|
US7981917B2
(en)
|
2007-03-26 |
2011-07-19 |
University Of Southern California |
Methods and compositions for including apoptosis by stimulating ER stress
|
EP2170062A4
(en)
|
2007-07-12 |
2010-12-29 |
Tragara Pharmaceuticals Inc |
METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER DISORDERS, TUMORS AND TUMOR-DISORDED DISEASES
|
JP5704924B2
(ja)
|
2008-02-01 |
2015-04-22 |
オーキッド リサーチ ラボラトリーズ リミティド |
新規複素環化合物
|
JP2011521969A
(ja)
*
|
2008-05-30 |
2011-07-28 |
スムマ ヘルス システムズ エルエルシー |
眼疾患を治療するためのTGF−β受容体阻害剤又はアクチビン様キナーゼ(ALK)5阻害剤、A−83−01及びSB−431542の使用方法及び創傷治療条件
|
WO2010121162A1
(en)
*
|
2009-04-17 |
2010-10-21 |
Summa Health Systems Llc |
Use of transforming growth factor-b receptor inhibitors to suppress ocular scarring
|
WO2011038261A1
(en)
*
|
2009-09-24 |
2011-03-31 |
Selexagen Therapeutics, Inc. |
Heterocyclic kinase inhibitors
|
EP2308866A1
(de)
*
|
2009-10-09 |
2011-04-13 |
Bayer CropScience AG |
Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
|
WO2012003405A1
(en)
|
2010-06-30 |
2012-01-05 |
Ironwood Pharmaceuticals, Inc. |
Sgc stimulators
|
NZ609955A
(en)
|
2010-11-09 |
2015-05-29 |
Ironwood Pharmaceuticals Inc |
Sgc stimulators
|
EP2797915B1
(en)
|
2011-12-27 |
2016-07-13 |
Ironwood Pharmaceuticals, Inc. |
2-benzyl-3-(oxazole/thiazole)-5-(pyrimidin-2-yl)-1(H)-pyrazole derivatives as stimulators of the soluble guanylate cyclase (sGC) for the treatment of e.g. hypertension or heart failure
|
US10500178B2
(en)
|
2015-03-13 |
2019-12-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
LTB4 inhibition to prevent and treat human lymphedema
|
WO2016210292A1
(en)
|
2015-06-25 |
2016-12-29 |
Children's Medical Center Corporation |
Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
|
US20190119642A1
(en)
|
2016-03-15 |
2019-04-25 |
Children's Medical Center Corporation |
Methods and compositions relating to hematopoietic stem cell expansion
|
CN110963957B
(zh)
|
2018-09-28 |
2021-10-22 |
深圳恩多凯医药科技有限公司 |
N-芳香酰胺类化合物及其制备方法和用途
|
CN113004179B
(zh)
*
|
2019-12-20 |
2022-06-24 |
江苏中旗科技股份有限公司 |
一种异噁唑草酮关键中间体的制备方法
|
WO2022195579A1
(en)
|
2021-03-15 |
2022-09-22 |
Saul Yedgar |
Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases
|