WO2000018741A3 - Pyrazole compounds as cox-2 inhibitors - Google Patents
Pyrazole compounds as cox-2 inhibitors Download PDFInfo
- Publication number
- WO2000018741A3 WO2000018741A3 PCT/JP1999/005289 JP9905289W WO0018741A3 WO 2000018741 A3 WO2000018741 A3 WO 2000018741A3 JP 9905289 W JP9905289 W JP 9905289W WO 0018741 A3 WO0018741 A3 WO 0018741A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optionally substituted
- hydroxy
- halogen
- hydrogen
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A compound of formula (I), wherein R1 is halo(lower)alkyl, halogen or cyano, R2 is aryl optionally substituted with substituent(s) selected from the group consisting of halogen, lower alkoxy, cyano, nitro, lower alkenyl, amino, acyl and hydroxyimino, R3 is hydrogen, hydroxy, acyloxy, lower alkoxy optionally substituted with lower alkoxy, amino optionally substituted with hydroxy or lower alkyl, lower alkylthio, or lower alkylsulfonyl, R4 is hydrogen or halogen, Q is pyrazolyl, A is lower alkylene optionally substituted with oxo or hydroxy, and n is 0, 1 or 2, provided that when R3 is hydrogen, R2 is aryl substituted with lower alkenyl or A is lower alkylene substituted with oxo, or its salt, processes for their preparation and pharmaceutical compositions.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPP6231A AUPP623198A0 (en) | 1998-09-30 | 1998-09-30 | Novel compounds |
AUPP6231 | 1998-09-30 | ||
AUPQ2243 | 1999-08-16 | ||
AUPQ2243A AUPQ224399A0 (en) | 1999-08-16 | 1999-08-16 | Novel compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000018741A2 WO2000018741A2 (en) | 2000-04-06 |
WO2000018741A3 true WO2000018741A3 (en) | 2000-06-08 |
Family
ID=25645886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1999/005289 WO2000018741A2 (en) | 1998-09-30 | 1999-09-27 | Pyrazole compounds as cox-2 inhibitors |
Country Status (1)
Country | Link |
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WO (1) | WO2000018741A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030100594A1 (en) * | 2001-08-10 | 2003-05-29 | Pharmacia Corporation | Carbonic anhydrase inhibitor |
JP2006502980A (en) * | 2002-06-25 | 2006-01-26 | ファルマシア・コーポレーション | Arylsulfonylhydroxamic acid and amide derivatives and their use as protease inhibitors |
WO2004002420A2 (en) * | 2002-06-28 | 2004-01-08 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use |
KR20050083761A (en) | 2002-12-02 | 2005-08-26 | 후지사와 야꾸힝 고교 가부시키가이샤 | Pyrazole derivatives useful as cox-i inhibitors |
EP3399976A4 (en) * | 2016-01-05 | 2019-11-27 | The Regents of the University of California | Benzothiazole amphiphiles |
CN107827820B (en) * | 2017-11-10 | 2020-01-07 | 山东大学 | Pyrazoline aminopeptidase N inhibitor and preparation method and application thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
WO1997013755A1 (en) * | 1995-10-09 | 1997-04-17 | Fujisawa Pharmaceutical Co., Ltd. | 1,3,5-trisubstituted pyrazoles for treament of inflammation |
-
1999
- 1999-09-27 WO PCT/JP1999/005289 patent/WO2000018741A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
WO1997013755A1 (en) * | 1995-10-09 | 1997-04-17 | Fujisawa Pharmaceutical Co., Ltd. | 1,3,5-trisubstituted pyrazoles for treament of inflammation |
Non-Patent Citations (2)
Title |
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TSUJI ET AL: "Studies on anti- inflammatory agents. IV. Synthesis and pharmacological properties of 1,5-diarylpyrazoles and related derivatives", CHEMICAL AND PHARMACEUTICAL BULLETIN,JP,PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, vol. 45, no. 6, June 1997 (1997-06-01), pages 987 - 995, XP002112608, ISSN: 0009-2363 * |
TSUJI ET AL: "Studies on anti- inflammatory agents. V. Synthesis and pharmacological properties of 3-(difluoromethyl)-1-(4-methoxyphenyl)- 5-[4-(methylsulfinyl)phenyl]pyrazole and related compounds", CHEMICAL AND PHARMACEUTICAL BULLETIN,JP,PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, vol. 45, no. 9, September 1997 (1997-09-01), pages 1475 - 1481, XP002112607, ISSN: 0009-2363 * |
Also Published As
Publication number | Publication date |
---|---|
WO2000018741A2 (en) | 2000-04-06 |
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