MX341531B - Derivados de triazol como estimuladores de la guanilato ciclasa soluble gcs. - Google Patents

Derivados de triazol como estimuladores de la guanilato ciclasa soluble gcs.

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Publication number
MX341531B
MX341531B MX2013005124A MX2013005124A MX341531B MX 341531 B MX341531 B MX 341531B MX 2013005124 A MX2013005124 A MX 2013005124A MX 2013005124 A MX2013005124 A MX 2013005124A MX 341531 B MX341531 B MX 341531B
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MX
Mexico
Prior art keywords
sgc stimulators
stimulators
compounds
useful
formula
Prior art date
Application number
MX2013005124A
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English (en)
Other versions
MX2013005124A (es
Inventor
Wai-Ho Lee Thomas
Kim Charles
Moore Joel
Rohde Jason
Nakai Takashi
Robert Perl Nicholas
Original Assignee
Ironwood Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Ironwood Pharmaceuticals Inc filed Critical Ironwood Pharmaceuticals Inc
Publication of MX2013005124A publication Critical patent/MX2013005124A/es
Publication of MX341531B publication Critical patent/MX341531B/es

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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Se describen compuestos de la Fórmula (lA) y la Fórmula (IB). Éstos son útiles como estimuladores de la GCs, particularmente estimuladores NO independientes, hemo-dependientes. Estos compuestos pueden ser útiles para tratar, prevenir o manejar diversos trastornos que se describen en la presente. (SGC o sGC = GCs, Guanilato cilasa soluble).
MX2013005124A 2010-11-09 2011-11-02 Derivados de triazol como estimuladores de la guanilato ciclasa soluble gcs. MX341531B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41173010P 2010-11-09 2010-11-09
US201161546707P 2011-10-13 2011-10-13
PCT/US2011/058902 WO2012064559A1 (en) 2010-11-09 2011-11-02 Sgc stimulators

Publications (2)

Publication Number Publication Date
MX2013005124A MX2013005124A (es) 2013-10-30
MX341531B true MX341531B (es) 2016-08-22

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MX2013005124A MX341531B (es) 2010-11-09 2011-11-02 Derivados de triazol como estimuladores de la guanilato ciclasa soluble gcs.

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US (3) US9061030B2 (es)
EP (1) EP2637659B1 (es)
JP (1) JP5878546B2 (es)
CN (2) CN107266433A (es)
AU (2) AU2011326241B2 (es)
CA (1) CA2817319A1 (es)
ES (1) ES2572803T3 (es)
HK (1) HK1189358A1 (es)
MX (1) MX341531B (es)
NZ (1) NZ609955A (es)
RU (2) RU2016101964A (es)
WO (1) WO2012064559A1 (es)

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CN107266433A (zh) 2010-11-09 2017-10-20 铁木医药有限公司 sGC刺激剂
JP6010545B2 (ja) 2010-12-23 2016-10-19 トゥエルヴ， インコーポレイテッド 僧帽弁の修復および置換のためのシステム
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