DK0729353T4 - Fremstilling af bionedbrydelige mikropartikler som indeholder et biologisk aktivt middel - Google Patents

Fremstilling af bionedbrydelige mikropartikler som indeholder et biologisk aktivt middel

Info

Publication number
DK0729353T4
DK0729353T4 DK95901961.3T DK95901961T DK0729353T4 DK 0729353 T4 DK0729353 T4 DK 0729353T4 DK 95901961 T DK95901961 T DK 95901961T DK 0729353 T4 DK0729353 T4 DK 0729353T4
Authority
DK
Denmark
Prior art keywords
active agent
biologically active
preparation
microparticles containing
biodegradable microparticles
Prior art date
Application number
DK95901961.3T
Other languages
English (en)
Other versions
DK0729353T3 (da
Inventor
Azar M Hazrati
Paul F Herbert
Original Assignee
Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27387578&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0729353(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alkermes Inc filed Critical Alkermes Inc
Application granted granted Critical
Publication of DK0729353T3 publication Critical patent/DK0729353T3/da
Publication of DK0729353T4 publication Critical patent/DK0729353T4/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/895—Manufacture, treatment, or detection of nanostructure having step or means utilizing chemical property
    • Y10S977/896—Chemical synthesis, e.g. chemical bonding or breaking
    • Y10S977/898—Enzymatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/90—Manufacture, treatment, or detection of nanostructure having step or means utilizing mechanical or thermal property, e.g. pressure, heat

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Colloid Chemistry (AREA)
DK95901961.3T 1993-11-19 1994-11-18 Fremstilling af bionedbrydelige mikropartikler som indeholder et biologisk aktivt middel DK0729353T4 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15440993A 1993-11-19 1993-11-19
US29878794A 1994-08-31 1994-08-31
US33880594A 1994-11-10 1994-11-10
PCT/US1994/013453 WO1995013799A1 (en) 1993-11-19 1994-11-18 Preparation of biodegradable microparticles containing a biologically active agent

Publications (2)

Publication Number Publication Date
DK0729353T3 DK0729353T3 (da) 2002-05-27
DK0729353T4 true DK0729353T4 (da) 2012-10-01

Family

ID=27387578

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95901961.3T DK0729353T4 (da) 1993-11-19 1994-11-18 Fremstilling af bionedbrydelige mikropartikler som indeholder et biologisk aktivt middel

Country Status (11)

Country Link
US (1) US5654008A (da)
EP (5) EP1649850A1 (da)
JP (3) JPH09505308A (da)
AT (1) ATE212830T1 (da)
AU (2) AU684324B2 (da)
CA (2) CA2176716C (da)
DE (1) DE69429820T3 (da)
DK (1) DK0729353T4 (da)
ES (1) ES2172574T5 (da)
PT (1) PT729353E (da)
WO (1) WO1995013799A1 (da)

Families Citing this family (196)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
CN1074923C (zh) * 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
EP1649850A1 (en) * 1993-11-19 2006-04-26 Alkermes Controlled Therapeutics Inc. II Preparation of biodegradable microparticles containing a biologically active agent
US5879712A (en) * 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
DE69632569T2 (de) 1995-06-09 2005-08-18 Euroceltique S.A. Formulierungen und verfahren für eine verlängerte lokalanästhesie
WO1997002019A1 (en) * 1995-06-30 1997-01-23 Baylor University Polyester/carboxylic acid composite materials
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
EP0862419B2 (en) 1995-11-09 2010-11-17 Microbiological Research Authority Microencapsulated dna for vaccination and gene therapy
DE19545257A1 (de) * 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
GB2310801A (en) * 1996-03-04 1997-09-10 Merck & Co Inc Process for removing an organic solvent from lactide-glycoside copolymer microspheres
US5792477A (en) * 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
MY118174A (en) * 1996-05-07 2004-09-30 Alkermes Inc Process for the preparation of microparticles
TW487572B (en) * 1996-05-20 2002-05-21 Janssen Pharmaceutica Nv Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
AU733867B2 (en) * 1996-06-24 2001-05-31 Euro-Celtique S.A. Methods for providing safe local anesthesia
JP2001500254A (ja) * 1996-08-23 2001-01-09 アボツト・ラボラトリーズ 物質を粒子に付着させる手順
US6046187A (en) 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
US20020182258A1 (en) * 1997-01-22 2002-12-05 Zycos Inc., A Delaware Corporation Microparticles for delivery of nucleic acid
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
PT996426E (pt) 1997-06-05 2007-06-18 Bertex Pharma Gmbh Sistema multifásico
CA2271750C (en) 1997-07-02 2004-04-27 Euro-Celtique, S.A. Prolonged anesthesia in joints and body spaces
ES2248914T3 (es) 1997-08-29 2006-03-16 Corixa Corporation Agentes bioactivos encapsulados de liberacion rapida que permiten inducir o potenciar una respuesta inmunitaria y metodos para utilizar los mismos.
UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
US6451335B1 (en) 1998-07-02 2002-09-17 Euro-Celtique S.A. Formulations and methods for providing prolonged local anesthesia
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
US6194006B1 (en) * 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
US6498153B1 (en) * 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
EP1044683A1 (en) * 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. One-step dispersion method for the microencapsulation of water soluble substances
US6291013B1 (en) * 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
DE19925184A1 (de) * 1999-05-26 2000-11-30 Schering Ag Kontinuierliches Verfahren zur Herstellung von morphologisch einheitlichen Mikro- und Nanopartikeln mittels Mikromischer sowie nach diesem Verfahren hergestellte Partikel
GB9914412D0 (en) * 1999-06-22 1999-08-18 Worrall Eric E Method for the preservation of viruses,bacteria and biomolecules
FR2797784B1 (fr) * 1999-08-27 2001-11-30 Mainelab Procede d'encapsulation de matieres actives par coacervation de polymeres en solvant organique non-chlore
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
US6331317B1 (en) 1999-11-12 2001-12-18 Alkermes Controlled Therapeutics Ii Inc. Apparatus and method for preparing microparticles
US6705757B2 (en) 1999-11-12 2004-03-16 Alkermes Controlled Therapeutics, Inc. Ii Method and apparatus for preparing microparticles using in-line solvent extraction
US6495166B1 (en) * 1999-11-12 2002-12-17 Alkermes Controlled Therapeutics Inc. Apparatus and method for preparing microparticles using in-line solvent extraction
PT1248596E (pt) 2000-01-11 2007-06-21 Bertex Pharma Gmbh Kit para implantações contendo uma fase de veículo e um solvente
DK1255547T3 (da) 2000-02-08 2008-12-01 Euro Celtique Sa Kontrolleret-frigivelsessammensætninger indeholdende opioid-agonist og antagonist
GB0008411D0 (en) * 2000-04-05 2000-05-24 Vectura Ltd Pharmaceutical preparations and their manufacture
AR023940A1 (es) 2000-05-03 2002-09-04 Eriochem Sa Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua
US6264987B1 (en) * 2000-05-19 2001-07-24 Alkermes Controlled Therapeutics Inc. Ii Method for preparing microparticles having a selected polymer molecular weight
IL153058A0 (en) * 2000-05-24 2003-06-24 Jordan Loyal Holtzman Agents and methods for increasing brain chaperonin levels
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
US6467949B1 (en) * 2000-08-02 2002-10-22 Chemineer, Inc. Static mixer element and method for mixing two fluids
US6362308B1 (en) 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
KR100867392B1 (ko) * 2000-08-15 2008-11-06 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 마이크로입자
DE10044545A1 (de) * 2000-09-05 2002-04-04 Roland Bodmeier Retardpartikeldispersion
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
US6482440B2 (en) 2000-09-21 2002-11-19 Phase 2 Discovery, Inc. Long acting antidepressant microparticles
US6471995B1 (en) 2000-09-27 2002-10-29 Alkermes Controlled Therapeutics, Inc. Ii Apparatus and method for preparing microparticles using liquid-liquid extraction
US7666445B2 (en) * 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
ES2326209T3 (es) 2000-10-27 2009-10-05 Baxter Healthcare S.A. Produccion de microesferas.
US20020114843A1 (en) 2000-12-27 2002-08-22 Ramstack J. Michael Preparation of microparticles having improved flowability
WO2002058670A1 (en) * 2001-01-25 2002-08-01 Euroceltique S.A. Local anesthetic, and method of use
CA2438208A1 (en) * 2001-02-07 2002-08-15 Durect Corporation Devices and methods for management of bone density
US6730772B2 (en) 2001-06-22 2004-05-04 Venkatram P. Shastri Degradable polymers from derivatized ring-opened epoxides
ES2307779T3 (es) * 2001-08-16 2008-12-01 Baxter International Inc. Formulaciones de microparticulas a base de propelentes.
US20080026068A1 (en) * 2001-08-16 2008-01-31 Baxter Healthcare S.A. Pulmonary delivery of spherical insulin microparticles
EP1446100B1 (en) * 2001-11-14 2011-05-04 Durect Corporation Injectable depot compositions and uses thereof
NZ533436A (en) * 2001-11-14 2007-10-26 Alza Corp Catheter injectable depot compositons and uses thereof
AU2003221497A1 (en) * 2002-03-13 2003-09-22 Novartis Ag Pharmaceutical microparticles
PT2561860T (pt) * 2002-05-31 2018-05-08 Titan Pharmaceuticals Inc Dispositivo polimérico implantável para a libertação prolongada de buprenorfina
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
US7838034B2 (en) * 2002-07-30 2010-11-23 Grunenthal Gmbh Intravenous pharmaceutical form of administration
KR20050038008A (ko) * 2002-07-31 2005-04-25 알자 코포레이션 주사용 저장형 조성물 및 이의 용도
EP1556018A1 (en) * 2002-09-30 2005-07-27 Acusphere, Inc. Sustained release porous microparticles for inhalation
US7544657B2 (en) * 2002-10-02 2009-06-09 Zealand Pharma A/S Stabilized Exendin-4 compounds
US20040071848A1 (en) * 2002-10-15 2004-04-15 Cargill Inc. Process for producing cocoa butter and cocoa powder by liquefied gas extraction
US20040071847A1 (en) * 2002-10-15 2004-04-15 Cargill, Inc. Producing cocoa powders with different cocoa butter contents by liquefied gas extraction on substantially the same production line
US6800663B2 (en) * 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
AU2003295409B2 (en) 2002-11-06 2010-02-11 Durect Corporation Controlled release depot formulations
ES2359977T3 (es) 2003-03-31 2011-05-30 Titan Pharmaceuticals, Inc. Dispositivo polimérico implantable para liberación sostenida de agonista de dopamina.
JP2007515392A (ja) 2003-04-10 2007-06-14 ピーアール ファーマシューティカルズ，インコーポレイテッド エマルジョンベースの微粒子の製造のための方法
US20070207211A1 (en) * 2003-04-10 2007-09-06 Pr Pharmaceuticals, Inc. Emulsion-based microparticles and methods for the production thereof
CN100571682C (zh) 2003-06-03 2009-12-23 参天制药株式会社 微粒的制造方法
WO2004108084A2 (en) * 2003-06-04 2004-12-16 Alkermes Controlled Therapeutics, Ii Polymorphic forms of naltrexone
JP5165239B2 (ja) * 2003-07-15 2013-03-21 ピーアール ファーマシューティカルズ， インコーポレイテッド 制御放出処方物の調製のための方法
US20070092452A1 (en) * 2003-07-18 2007-04-26 Julia Rashba-Step Methods for fabrication, uses, compositions of inhalable spherical particles
CN1826170B (zh) * 2003-07-18 2010-12-08 巴克斯特国际公司 通过受控相分离制备的小球形颗粒的制造方法、其用途和成分
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
JP2007508240A (ja) * 2003-07-22 2007-04-05 バクスター・インターナショナル・インコーポレイテッド 低分子量有機分子の小球状粒子ならびにその調製方法および使用方法
ES2741576T3 (es) 2003-07-23 2020-02-11 Evonik Corp Composiciones de liberación controlada
US6987111B2 (en) 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
US20050031713A1 (en) * 2003-08-06 2005-02-10 Elliot Ehrich Methods for administering active agents to CYP3A4 sensitive patients
JP2007533634A (ja) * 2003-09-30 2007-11-22 アキュスフィア， インコーポレイテッド 注射、経口、または局所用の徐放性医薬製剤
US7309500B2 (en) * 2003-12-04 2007-12-18 The Board Of Trustees Of The University Of Illinois Microparticles
US8329203B2 (en) * 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
WO2005070332A1 (en) * 2004-01-12 2005-08-04 The Trustees Of The University Of Pennsylvania Long-term delivery formulations and methods of use thereof
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US20050245461A1 (en) * 2004-03-19 2005-11-03 Elliot Ehrich Methods for treating alcoholism
US20050245541A1 (en) * 2004-03-19 2005-11-03 Elliot Ehrich Methods for treating alcoholism
ES2375802T3 (es) 2004-04-15 2012-03-06 Alkermes Pharma Ireland Limited Dispositivo de liberación sostenida a base de pol�?mero.
US7919499B2 (en) * 2004-04-22 2011-04-05 Alkermes, Inc. Naltrexone long acting formulations and methods of use
WO2005107714A2 (en) * 2004-05-05 2005-11-17 Alkermes Controlled Therapeutics, Inc. Method of forming microparticles that include a bisphosphonate and a polymer
US8728525B2 (en) 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
EP1758558B1 (en) * 2004-05-12 2013-10-16 Baxter International Inc. Oligonucleotide-containing microspheres, their use for the manufacture of a medicament for treating diabetes type 1
AU2005244840C1 (en) 2004-05-12 2012-05-10 Baxter Healthcare S.A. Microspheres comprising protein and showing injectability at high concentrations of said agent
DE602005009954D1 (de) * 2004-05-12 2008-11-06 Baxter Int Nukleinsäure-mikrokügelchen, ihre herstellung und abgabe
US20060253100A1 (en) 2004-10-22 2006-11-09 Medtronic, Inc. Systems and Methods to Treat Pain Locally
US7748343B2 (en) 2004-11-22 2010-07-06 The Board Of Trustees Of The University Of Illinois Electrohydrodynamic spraying system
US20080213593A1 (en) * 2005-01-21 2008-09-04 President And Fellows Of Harvard College Systems And Methods For Forming Fluidic Droplets Encapsulated In Particles Such As Colloidal Particles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
EP1885335A1 (en) * 2005-04-27 2008-02-13 BAXTER INTERNATIONAL INC. (a Delaware corporation) Surface-modified microparticles and methods of forming and using the same
US20090317376A1 (en) 2005-06-06 2009-12-24 Georgetown University Medical School Compositions And Methods For Lipo Modeling
GB0516549D0 (en) * 2005-08-12 2005-09-21 Sulaiman Brian Milling system
HUE045165T2 (hu) 2005-08-19 2019-12-30 Amylin Pharmaceuticals Llc Exendin diabetes kezelésére és testtömeg csökkentésére
US8852638B2 (en) * 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
US7669732B2 (en) * 2005-10-25 2010-03-02 Imi Cornelius Inc. Cup lid dispenser
PL116330U1 (en) 2005-10-31 2007-04-02 Alza Corp Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation
US20070099947A1 (en) * 2005-11-03 2007-05-03 Alkermes, Inc. Methods and compositions for the treatment of brain reward system disorders by combination therapy
JP2009519972A (ja) * 2005-12-15 2009-05-21 アキュスフィア， インコーポレイテッド 粒子ベースの経肺投与または経鼻投与用製薬の製造方法
EP1978933A2 (en) * 2005-12-15 2008-10-15 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for oral administration
US8182134B2 (en) * 2005-12-16 2012-05-22 PRC De Soto International, Inc. Mixing system for thermoset compositions including static and rotary mixers
US7600911B2 (en) * 2006-01-13 2009-10-13 Bechtold Gerald L Water-mixing device, sand trap and method of using same
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
EP2046435A4 (en) * 2006-07-13 2012-06-27 Medtronic Inc METHOD AND FORMULATIONS FOR OPTIMAL LOCAL ADMINISTRATION OF CELL THERAPY BY MEANS OF MINIMALLY INVASIVE PROCEDURES
MX2009001226A (es) 2006-08-04 2009-03-20 Baxter Int Composicion basada en microesferas para prevenir y/o revertir la diabetes autoinmune de nuevo inicio.
DK2049081T3 (da) 2006-08-09 2013-02-25 Intarcia Therapeutics Inc Osmotiske leveringssystemer og stempelarrangementer
MX2009003661A (es) * 2006-10-06 2009-04-22 Baxter Int Microcapsulas que contienen microparticulas modificadas en la superficie y metodos para formar y utilizar las mismas.
US20080098900A1 (en) * 2006-11-01 2008-05-01 Babatunde Aremu Beverage manufacture using a static mixer
CA2680365A1 (en) * 2007-03-22 2008-10-02 Alkermes, Inc. Coacervation process
ES2402172T3 (es) 2007-04-23 2013-04-29 Intarcia Therapeutics, Inc Formulación en suspensión de péptidos insulinotrópicos y usos de los mismos
CN100548278C (zh) * 2007-05-17 2009-10-14 中国人民解放军军事医学科学院生物工程研究所 一种提高纳曲酮微球包封率的制备方法
EP2167039B1 (en) 2007-05-18 2016-09-28 Durect Corporation Improved depot formulations
CA2687979C (en) 2007-05-25 2017-07-04 Tolmar Therapeutics, Inc. Sustained delivery formulations of risperidone compounds
WO2008157540A1 (en) * 2007-06-20 2008-12-24 Alkermes, Inc. Quench liquids and washing systems for production of microparticles
UA96342C2 (en) * 2007-06-25 2011-10-25 Оцука Фармасьютикал Ко., Лтд. Microspheres having core/shell structure
FR2918296B1 (fr) * 2007-07-05 2009-09-18 Oreal Capsules de type noyau/ecorce et procede de preparation
NZ583632A (en) 2007-11-16 2012-05-25 Univ Rockefeller Antibodies specific for the protofibril form of beta-amyloid protein
US20110081422A1 (en) * 2007-11-19 2011-04-07 Capsulated Systems Inc. Prolonged release of local anesthetics using microparticles and surgery applications
WO2009085952A1 (en) * 2007-12-20 2009-07-09 Brookwood Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
EP2240155B1 (en) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
EP2259677A4 (en) * 2008-02-29 2011-11-02 Alseres Pharmaceuticals Inc SYSTEMIC PURINARY ADMINISTRATION FOR MODULATING THE AXONAL GROWTH OF THE CENTRAL NERVOUS SYSTEM
US9216152B2 (en) * 2008-06-27 2015-12-22 Tepha, Inc. Injectable delivery of microparticles and compositions therefore
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
US20100047292A1 (en) * 2008-08-20 2010-02-25 Baxter International Inc. Methods of processing microparticles and compositions produced thereby
US8323685B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US8367427B2 (en) * 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US20100087337A1 (en) 2008-09-10 2010-04-08 Bind Biosciences, Inc. High Throughput Fabrication of Nanoparticles
CA2736780C (en) * 2008-09-11 2017-01-17 Surmodics Pharmaceuticals, Inc. Solvent extraction microencapsulation with tunable extraction rates
KR101820024B1 (ko) 2008-10-17 2018-01-18 사노피-아벤티스 도이칠란트 게엠베하 인슐린과 ｇｌｐ－1 효능제의 병용물
WO2010057215A1 (en) * 2008-11-17 2010-05-20 Wayne State University Engineering porous particles of water soluble therapeutics for pressurized metered-dose inhaler formulations
JP2012515790A (ja) * 2009-01-23 2012-07-12 サーモディクス ファーマシューティカルズ， インコーポレイテッド 微粒子製造のための連続二重エマルジョン工程
US20100196436A1 (en) * 2009-01-30 2010-08-05 Gooberman Lance L Implants containing disulfiram and an anti-inflammatory agent
US8791093B2 (en) * 2009-05-29 2014-07-29 Lance L. Gooberman Pharmaceutical delivery systems for treatment of substance abuse and other addictions
CN107638562B (zh) 2009-09-28 2022-12-02 精达制药公司 基本稳态药物递送的快速建立和/或终止
HUE037735T2 (hu) 2009-11-13 2018-09-28 Sanofi Aventis Deutschland DesPro36exendin-4(1-39)-Lys6-NH2-t és metionint tartalmazó gyógyszerkészítmény
ES2534191T3 (es) 2009-11-13 2015-04-20 Sanofi-Aventis Deutschland Gmbh Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
AU2011223807B2 (en) * 2010-03-02 2016-05-12 Fervent Pharmaceuticals, Llc Methods and compositions for treating or preventing symptoms of hormonal variations
US8461102B2 (en) 2010-03-02 2013-06-11 George E. Royster, JR. Methods and compositions for treating and preventing symptoms of hormonal variations
US8207290B2 (en) 2010-03-26 2012-06-26 Cerulean Pharma Inc. Methods and systems for generating nanoparticles
UA111162C2 (uk) 2010-08-04 2016-04-11 Флекшен Терап'Ютікс, Інк. Ін'єкційна композиція ацетоніду триамцинолону для лікування болю
US8778960B2 (en) 2010-08-23 2014-07-15 Alkermes Pharma Ireland Limited Methods for treating antipsychotic-induced weight gain
KR20130100290A (ko) 2010-08-30 2013-09-10 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 협착성 병변을 위한 전단 제어 방출 및 혈전 용해 치료법
BR112013004756B1 (pt) 2010-08-30 2020-04-28 Sanofi Aventis Deutschland uso de ave0010 para a fabricação de um medicamento para o tratamento da diabetes melito tipo 2
US8546521B2 (en) 2011-01-28 2013-10-01 Cerulean Pharma Inc. Method for fabricating nanoparticles
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
ES2642312T3 (es) 2011-08-04 2017-11-16 Flexion Therapeutics, Inc. Corticosteroides para el tratamiento del dolor de articulaciones
RU2650616C2 (ru) 2011-08-29 2018-04-16 Санофи-Авентис Дойчланд Гмбх Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
US10357496B2 (en) 2011-11-05 2019-07-23 South Alabama Medical Science Foundation Methods, formulations, and kits for rapidly repleting folate levels in women
US20150224176A1 (en) 2012-08-14 2015-08-13 Wockhardt Limited Pharmaceutical microparticulate compositions of polypeptides
EP2931300A1 (en) 2012-08-14 2015-10-21 Wockhardt Limited Pharmaceutical microparticulate compositions of polypeptides
US20150328377A1 (en) * 2012-12-31 2015-11-19 Bacterin International, Inc. Composition of d-alpha hydroxy acids and antimicrobials
TWI641381B (zh) 2013-02-04 2018-11-21 法商賽諾菲公司 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
US9737605B2 (en) 2013-03-11 2017-08-22 Durect Corporation Injectable controlled release composition comprising high viscosity liquid carrier
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
US9895424B2 (en) 2014-01-09 2018-02-20 Sanofi Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
US9839692B2 (en) 2014-01-09 2017-12-12 Sanofi Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
SG11201604706TA (en) 2014-01-09 2016-07-28 Sanofi Sa Stabilized pharmaceutical formulations of insulin aspart
WO2015150942A2 (en) 2014-03-29 2015-10-08 The WOCKHARDT LIMITED Improved process for preparing microparticles
US9439864B2 (en) 2014-07-07 2016-09-13 Antriabio, Inc. Solvent extraction from biodegradable microparticles
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
JP6970615B2 (ja) 2014-12-12 2021-11-24 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インスリングラルギン／リキシセナチド固定比処方
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
WO2017043494A1 (ja) * 2015-09-07 2017-03-16 ニプロ株式会社 リスペリドンを含有するマイクロカプセル、その製造方法および放出制御方法
JP2017071740A (ja) * 2015-10-09 2017-04-13 信越化学工業株式会社 球状ポリオルガノシルセスキオキサン粒子の製造方法
CA3013904C (en) 2016-02-10 2023-12-12 Rutgers, The State University Of New Jersey Novel anti-lam and anti-pim6/lam monoclonal antibodies for diagnosis and treatment of mycobacterium tuberculosis infections
WO2017160818A1 (en) 2016-03-14 2017-09-21 Flexion Therapeutics, Inc. Triamcinolone acetonide formulations for joint pain in diabetics
BR112018073511A2 (pt) 2016-05-16 2019-03-26 Intarcia Therapeutics, Inc. polipeptídeos seletivos do receptor de glucagon e métodos de uso dos mesmos
WO2017199123A1 (en) 2016-05-17 2017-11-23 Ecole Polytechnique Federale De Lausanne (Epfl) Device and methods for shell phase removal of core-shell capsules
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
WO2018044970A1 (en) 2016-08-31 2018-03-08 University Of Rochester Human monoclonal antibodies to human endogenous retrovirus k envelope (herv-k) and uses thereof
MX2019008006A (es) 2017-01-03 2019-08-29 Intarcia Therapeutics Inc Metodos que comprenden la administracion continua de un agonista del receptor de glp-1 y la co-administracion de un farmaco.
KR102142026B1 (ko) * 2017-05-31 2020-08-06 주식회사 대웅제약 방출제어가 용이한 서방성 약물 미립자의 제조방법
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
KR102259589B1 (ko) * 2020-11-30 2021-06-02 (주)인벤티지랩 미소구체 제조 시스템 및 미소구체 제조 방법

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL280825A (da) 1962-07-11
US3197180A (en) * 1963-10-11 1965-07-27 Chemineer Mixing device
US3415493A (en) * 1967-08-21 1968-12-10 Chemineer Mixing device
BE744162A (fr) 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd Procede d'encapsulage
DE2010115A1 (de) 1970-03-04 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Mikrogranulaten
GB1351811A (en) * 1971-05-07 1974-05-01 Kenics Corp Mixing device
JPS523342B2 (da) 1972-01-26 1977-01-27
GB1413186A (en) 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
US3923288A (en) * 1973-12-27 1975-12-02 Komax Systems Inc Material mixing apparatus
US4034965A (en) * 1973-12-27 1977-07-12 Komax Systems, Inc. Material distributing and mixing apparatus
JPS51111866A (en) * 1975-03-28 1976-10-02 Dainippon Toryo Kk Apparatus for making ballllike synthetic resin particles
US4111402A (en) * 1976-10-05 1978-09-05 Chemineer, Inc. Motionless mixer
JPS54127064A (en) * 1978-03-06 1979-10-02 Komax Systems Inc Charging instrument of stationary mixer
DE2822096A1 (de) * 1978-05-20 1979-11-22 Bayer Ag Gebohrte mischelemente fuer statische und dynamische mischer
US4208136A (en) * 1978-12-01 1980-06-17 Komax Systems, Inc. Static mixing apparatus
US4622244A (en) * 1979-09-04 1986-11-11 The Washington University Process for preparation of microcapsules
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
DE3274720D1 (en) * 1981-07-28 1987-01-29 Statiflo Inc Static mixers
GB2120113B (en) * 1982-05-13 1985-10-09 Komax Systems Inc Mixing in flow
US4808007A (en) * 1982-05-13 1989-02-28 Komax Systems, Inc. Dual viscosity mixer
US4530840A (en) * 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US4511258A (en) 1983-03-25 1985-04-16 Koflo Corporation Static material mixing apparatus
US4574110A (en) * 1983-07-28 1986-03-04 Mitsui Toatsu Chemicals, Incorporated Process for producing microcapsules and microcapsule slurry
DE3421865A1 (de) * 1984-06-13 1985-12-19 Bayer Ag, 5090 Leverkusen Kontinuierliche herstellung von mikrokapseldispersionen
US4612364A (en) * 1984-10-05 1986-09-16 Takeda Chemical Industries Method for producing formed product of high molecular compounds
DE3678308D1 (de) * 1985-02-07 1991-05-02 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
US4614440A (en) * 1985-03-21 1986-09-30 Komax Systems, Inc. Stacked motionless mixer
US4616937A (en) * 1985-04-16 1986-10-14 Komax Systems, Inc. Intermittent mixing apparatus
US4643584A (en) * 1985-09-11 1987-02-17 Koch Engineering Company, Inc. Motionless mixer
US4936901A (en) * 1986-07-09 1990-06-26 Monsanto Company Formulations of water-dispersible granules and process for preparation thereof
US4765204A (en) * 1986-09-03 1988-08-23 Koch Engineering Company, Inc. Method of manufacturing a motionless mixer
US4731205A (en) * 1986-09-08 1988-03-15 Koch Engineering Company, Inc. Random packing for fluid contact devices and method of preparing said packing
JPH0725689B2 (ja) * 1986-10-07 1995-03-22 中外製薬株式会社 顆粒球コロニ−刺激因子を含有する徐放性製剤
US4753535A (en) * 1987-03-16 1988-06-28 Komax Systems, Inc. Motionless mixer
US4793713A (en) * 1987-04-06 1988-12-27 Komax Systems, Inc. Rotary mixer
US4861627A (en) * 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
US4978483A (en) * 1987-09-28 1990-12-18 Redding Bruce K Apparatus and method for making microcapsules
WO1989003678A1 (en) * 1987-10-30 1989-05-05 Stolle Research & Development Corporation Low residual solvent microspheres and microencapsulation process
US4936689A (en) * 1988-07-11 1990-06-26 Koflo Corporation Static material mixing apparatus
IL92344A0 (en) * 1989-01-04 1990-07-26 Gist Brocades Nv Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules
JP2502146B2 (ja) * 1989-04-12 1996-05-29 日本製紙株式会社 微小カプセルの製造方法
JP2582186B2 (ja) 1989-05-04 1997-02-19 サウザン リサーチ インスティチュート カプセル封じ法及びその製品
EP0499619B1 (en) * 1989-11-06 1996-02-07 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
CA2071867A1 (en) * 1989-11-06 1991-05-07 Edith Mathiowitz Method for producing protein microspheres
MX9201782A (es) * 1991-04-19 1992-10-01 Sandoz Ag Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene.
JP2684473B2 (ja) * 1991-09-02 1997-12-03 富士写真フイルム株式会社 マイクロカプセルの連続的製造方法
ATE188375T1 (de) * 1992-11-17 2000-01-15 Yoshitomi Pharmaceutical Ein antipsychotikum enthaltende mikrokugel zur verzögerten freisetzung und verfahren für ihre herstellung
FR2703263B1 (fr) * 1993-03-31 1995-05-19 Rhone Poulenc Nutrition Animal Procédé de préparation de sphérules de principes actifs.
ES2182850T3 (es) * 1993-10-22 2003-03-16 Genentech Inc Procedimientos y composiciones para la microencapsulacion de adyuvantes.
CN1074923C (zh) * 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
EP1649850A1 (en) * 1993-11-19 2006-04-26 Alkermes Controlled Therapeutics Inc. II Preparation of biodegradable microparticles containing a biologically active agent

Also Published As

Publication number Publication date
AU3683197A (en) 1997-11-20
DE69429820D1 (de) 2002-03-21
CA2474701A1 (en) 1995-05-26
ES2172574T5 (es) 2012-11-29
PT729353E (pt) 2002-07-31
EP0729353A4 (en) 1998-01-21
EP0729353B1 (en) 2002-02-06
AU1101095A (en) 1995-06-06
EP0729353B2 (en) 2012-09-12
EP0729353A1 (en) 1996-09-04
AU684324B2 (en) 1997-12-11
JP2010202657A (ja) 2010-09-16
AU697887B2 (en) 1998-10-22
ATE212830T1 (de) 2002-02-15
EP2283821A1 (en) 2011-02-16
CA2176716A1 (en) 1995-05-26
EP1649850A1 (en) 2006-04-26
WO1995013799A1 (en) 1995-05-26
US5654008A (en) 1997-08-05
ES2172574T3 (es) 2002-10-01
JP2012211199A (ja) 2012-11-01
EP0998917A1 (en) 2000-05-10
CA2176716C (en) 2009-04-07
EP2275089A1 (en) 2011-01-19
CA2474701C (en) 2009-01-27
EP2275089A9 (en) 2011-04-06
JPH09505308A (ja) 1997-05-27
DE69429820T3 (de) 2013-02-28
DE69429820T2 (de) 2002-11-14
DK0729353T3 (da) 2002-05-27

Similar Documents

Publication Publication Date Title
DK0729353T3 (da) Fremstilling af bionedbrydelige mikropartikler, som indeholder et biologisk aktivt middel
TR199800729T2 (xx) Eritmeli ekstr�zyonla haz�rlanan siklodekstrin kat� kar���mlar�.
ES2141183T3 (es) Utilizacion de disolventes de hidrocarburos halogenados.
RU93043995A (ru) Способ получения каталитической системы сополимеризации олефинов, способ сополимеризации, сополимер
BR9910067A (pt) Sistema de telecomunicações, e, processo para operar um sistema de telecomunicações
KR930016091A (ko) 거의 수불용성인 약제의 고체 분산액을 제조하는 방법
FR2692168B1 (fr) Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères.
DE60238500D1 (de) Zweiphasenzusammensetzung aus superabsorbierendem und hydrophobem polymer
RU93005176A (ru) Жидкая антибактериальная композиция
BR8707631A (pt) Materiais e dispositivos cirurgicos
DE59108530D1 (de) Antimikrobielle Mittel sowie substituierte 2-Cyclohexan-1-yl-amin-Derivate und deren Herstellung
DE860442T1 (de) Oligosaccharidoxazolines, Konjugate von Oligosacchariden und Verfahren zu ihrer Herstellung
NO913513L (no) Fast katalysatorbestanddel for (ko)polymerisering av etylen. r
DE69513930D1 (de) Darstellung von Poly(phenylen-vinylen)-Derivaten über lösliche Vorläuferpolymere
FR2692147B1 (fr) Microsphères en polymère biorésorbable exemptes de tensioactif, leur préparation et leur application comme médicament.
EP0823458A4 (en) POLYMERIC MATERIAL, MEDICAL MATERIAL, AND LIQUID POLYMER COMPOSITION
DE69008566D1 (de) Pyridazin-Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen.
DK0904063T3 (da) Fremgangsmåde til fremstilling af mikropartikler
DE69307391D1 (de) Polyhalogenierte Phenylindane, Verfahren zu ihrer Herstellung und diese enthaltenden feuerhemmenden Polymerzusammensetzungen
ES2059862T3 (es) Combinaciones de aglutinantes y un procedimiento para su obtencion y su empleo.
DE59600039D1 (de) Verfahren zur Herstellung von hochaktiven, stabilen Metallocen-Katalysatorsystemen und gemäss diesem Verfahren hergestellte Formulierungen
Cisco Customizing Protocol Monitor
BR9502704A (pt) Tablete cápsula ou granulo para administração oral contendo desogestrel e processo para incorporação de um desogestrel e opcionalmente um estrogenio em um solido
DE69100297D1 (de) Katalytische Zusammensetzungen und Polymerisationsverfahren, Hexakiphosphin- und Hexahalid-Verbindungen.
DE69111339D1 (de) System zum Mischen und Aktivieren von Polymeren.