DK0721461T3 - Syntese af 17-(3-pyridyl)-steroider - Google Patents

Syntese af 17-(3-pyridyl)-steroider

Info

Publication number
DK0721461T3
DK0721461T3 DK94927003T DK94927003T DK0721461T3 DK 0721461 T3 DK0721461 T3 DK 0721461T3 DK 94927003 T DK94927003 T DK 94927003T DK 94927003 T DK94927003 T DK 94927003T DK 0721461 T3 DK0721461 T3 DK 0721461T3
Authority
DK
Denmark
Prior art keywords
beta
steroid
hydroxy
group
pyridyl
Prior art date
Application number
DK94927003T
Other languages
Danish (da)
English (en)
Inventor
Ian Robert Hardcastle
Gerard Andrew Potter
Original Assignee
Btg Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939320132A external-priority patent/GB9320132D0/en
Priority claimed from GB9414192A external-priority patent/GB9414192D0/en
Application filed by Btg Int Ltd filed Critical Btg Int Ltd
Application granted granted Critical
Publication of DK0721461T3 publication Critical patent/DK0721461T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
DK94927003T 1993-09-30 1994-09-22 Syntese af 17-(3-pyridyl)-steroider DK0721461T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939320132A GB9320132D0 (en) 1993-09-30 1993-09-30 Synthesis of 17-(-3-pyridyl)steroids
GB9414192A GB9414192D0 (en) 1994-07-14 1994-07-14 Synthesis of 17-(3-pyridyl) steroids
PCT/GB1994/002054 WO1995009178A1 (en) 1993-09-30 1994-09-22 Synthesis of 17-(3-pyridyl) steroids

Publications (1)

Publication Number Publication Date
DK0721461T3 true DK0721461T3 (da) 1999-09-20

Family

ID=26303602

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94927003T DK0721461T3 (da) 1993-09-30 1994-09-22 Syntese af 17-(3-pyridyl)-steroider

Country Status (14)

Country Link
EP (1) EP0721461B1 (ja)
JP (1) JP3722835B2 (ja)
AT (1) ATE176481T1 (ja)
AU (1) AU676088B2 (ja)
CA (1) CA2170286C (ja)
DE (1) DE69416419T2 (ja)
DK (1) DK0721461T3 (ja)
ES (1) ES2127413T3 (ja)
GB (1) GB2282377B (ja)
GR (1) GR3029601T3 (ja)
HK (1) HK1002634A1 (ja)
NZ (1) NZ273367A (ja)
SG (1) SG49321A1 (ja)
WO (1) WO1995009178A1 (ja)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
JP5199667B2 (ja) 2004-08-24 2013-05-15 ビーティージー・インターナショナル・リミテッド 中間体としての１７−ｏ−ビニル−トリフレートの調製のための方法
GB0418900D0 (en) * 2004-08-24 2004-09-29 Btg Int Ltd Novel salt forms
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
JO2892B1 (en) 2009-06-26 2015-09-15 نوفارتيس ايه جي CYP inhibitors 17
US8946260B2 (en) 2010-09-16 2015-02-03 Novartis Ag 17α-hydroxylase/C17,20-lyase inhibitors
CN102558274B (zh) * 2010-12-08 2014-10-15 深圳万乐药业有限公司 一种适合工业化生产醋酸阿比特龙的合成方法
CN102558275A (zh) * 2010-12-20 2012-07-11 天津药物研究院 α型多晶型醋酸阿比特龙结晶、其制备方法、用途和药物组合物
US9029399B2 (en) 2011-04-28 2015-05-12 Novartis Ag 17α-hydroxylase/C17,20-lyase inhibitors
BR112014008671B1 (pt) * 2011-10-10 2022-07-12 Zach System Processos de preparação de abiraterona e de acetato de abiraterona, e, composto intermediário
CN103059090B (zh) * 2011-10-20 2016-06-22 连云港润众制药有限公司 醋酸阿比特龙草酸盐以及醋酸阿比特龙的纯化方法
CN102336801B (zh) * 2011-10-31 2013-05-15 南京卡文迪许生物工程技术有限公司 醋酸阿比特龙多晶型物和药用组合物
EP2607371A1 (en) 2011-12-23 2013-06-26 Crystal Pharma, S.A.U. Processes for the preparation of abiraterone and related compouds
CN105461777B (zh) * 2012-01-04 2017-07-18 连云港润众制药有限公司 一种醋酸阿比特龙的纯化方法
CN103254265B (zh) 2012-02-21 2016-07-13 上海希迈医药科技有限公司 醋酸阿比特龙三氟乙酸盐及其制备方法和应用
CN102627681B (zh) * 2012-03-23 2016-04-13 山东新时代药业有限公司 一种醋酸阿比特龙的制备方法
WO2013159225A1 (en) * 2012-04-23 2013-10-31 Alphora Research Inc. Process for preparation of 17-substituted steroids
CN102731605B (zh) * 2012-06-19 2016-04-13 鲁南制药集团股份有限公司 一种醋酸阿比特龙的纯化方法
WO2014009436A1 (en) 2012-07-11 2014-01-16 Sandoz Ag Nanosuspension of abiraterone acetate
WO2014009434A1 (en) 2012-07-11 2014-01-16 Sandoz Ag Self-microemulsifying drug delivery system of abiraterone or abiraterone acetate
WO2014009437A1 (en) 2012-07-11 2014-01-16 Sandoz Ag Oxidation stability of abiraterone acetate
CN102816199B (zh) * 2012-08-15 2015-04-08 武汉长联来福制药股份有限公司 醋酸阿比特龙二聚体化合物的制备及检测方法
CN102816200B (zh) * 2012-09-05 2015-04-15 中山大学 一种醋酸阿比特龙的制备方法
CN103665085B (zh) * 2012-09-24 2016-04-20 成都伊诺达博医药科技有限公司 一种改进的乙酸阿比特龙酯合成方法
CN102816201A (zh) * 2012-09-25 2012-12-12 成都伊诺达博医药科技有限公司 一种阿比特龙的纯化方法
WO2014058785A1 (en) 2012-10-10 2014-04-17 Novartis Ag Combination therapy
ITMI20121788A1 (it) * 2012-10-22 2014-04-23 Olon Spa Procedimento per la purificazione di abiraterone acetato
EP2917226A1 (en) 2012-11-09 2015-09-16 Synthon BV Process for making the 17-triflate intermediate of abiraterone-3-acetate
EP2917225A1 (en) 2012-11-09 2015-09-16 Synthon BV Process for making abiraterone-3-acetate
WO2014075978A1 (en) 2012-11-16 2014-05-22 Synthon B.V. Process for the production of abiraterone-3-acetate involving an enol trliflation reaction in the presence of an alkoxy-pyridine compound
CN103059091B (zh) * 2012-11-22 2017-04-19 常州靶点医药科技有限公司 一种避免重金属残留的醋酸阿比特龙的制备方法
WO2014083512A1 (en) * 2012-11-28 2014-06-05 Dr. Reddy's Laboratories Limited Process for preparation of abiraterone acetate
RS55673B1 (sr) 2013-04-19 2017-06-30 Zach System Postupak za dobijanje čvrstog oblika abirateron acetata
WO2014188445A1 (en) * 2013-04-26 2014-11-27 Srinivasan Thirumalai Rajan PROCESS FOR THE PREPARATION OF (3β)-17-(3-PYRIDINYL)ANDROSTA-5,16-DIEN-3-YL ACETATE AND POLYMORPH THEREOF
CN103387597B (zh) * 2013-08-21 2015-03-25 苏州明锐医药科技有限公司 阿比特龙醋酸酯的制备方法
CN104558090A (zh) * 2013-10-28 2015-04-29 重庆医药工业研究院有限责任公司 醋酸阿比特龙杂质及其测定方法
WO2015102022A2 (en) * 2013-12-31 2015-07-09 Laurus Labs Private Limited An improved process for the preparation of abiraterone acetate
WO2015114518A2 (en) 2014-01-28 2015-08-06 Olon S.P.A. Procedure for the preparation of abiraterone acetate and intermediates thereof
CN103965282B (zh) 2014-04-21 2016-01-20 武汉百科药物开发有限公司 一种醋酸阿比特龙的制备方法
WO2016001208A1 (en) 2014-06-30 2016-01-07 Galenicum Health S.L. Stable pharmaceutical compositions in the form of immediate release tablets
CZ2014475A3 (cs) 2014-07-09 2016-01-20 Zentiva, K.S. Způsob přípravy Abirateron acetátu o vysoké čistotě aplikovatelný v průmyslovém měřítku
CN105622703B (zh) * 2014-11-05 2019-09-27 兰州大学 一种制备醋酸阿比特龙的方法
MA45780A (fr) 2016-07-29 2019-06-05 Janssen Pharmaceutica Nv Méthodes de traitement du cancer de la prostate
CN107056871A (zh) * 2017-06-28 2017-08-18 李建恒 一种阿比特龙醋酸酯的合成方法
HU231297B1 (hu) 2018-07-31 2022-09-28 Richter Gedeon Nyrt Stabil gyógyszerkészítmények és eljárás az előállításukra
CN109134571B (zh) * 2018-09-13 2020-10-02 浙江工业大学 一种17-碘-雄甾-5,16-二烯-3β-醇的制备方法
EP3944860A1 (en) 2020-07-30 2022-02-02 Galenicum Health S.L.U. Abiraterone for use in a method of treating cancer
CN112125942B (zh) * 2020-09-28 2021-12-14 湖南新合新生物医药有限公司 醋酸阿比特龙及其中间体的合成方法
CN112940065A (zh) * 2021-02-03 2021-06-11 山东大学 三氟甲磺酸盐在制备醋酸阿比特龙中的应用及合成方法
CN114709557B (zh) * 2022-04-13 2023-10-27 南京工业大学 一种后修饰碳硼烷的共价有机框架材料的设计合成及其在锂硫电池隔膜中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ249911A (en) * 1992-03-31 1996-06-25 British Tech Group 17-(3-pyridyl) substituted steroids and use in pharmaceutical compositions

Also Published As

Publication number Publication date
GB2282377B (en) 1997-09-03
HK1002634A1 (en) 1998-09-04
NZ273367A (en) 1997-07-27
WO1995009178A1 (en) 1995-04-06
GB2282377A (en) 1995-04-05
JPH09502994A (ja) 1997-03-25
CA2170286C (en) 2005-04-05
DE69416419T2 (de) 1999-06-10
ES2127413T3 (es) 1999-04-16
GR3029601T3 (en) 1999-06-30
AU676088B2 (en) 1997-02-27
ATE176481T1 (de) 1999-02-15
JP3722835B2 (ja) 2005-11-30
EP0721461A1 (en) 1996-07-17
CA2170286A1 (en) 1995-04-06
AU7661894A (en) 1995-04-18
EP0721461B1 (en) 1999-02-03
DE69416419D1 (de) 1999-03-18
GB9419139D0 (en) 1994-11-09
SG49321A1 (en) 1998-05-18

Similar Documents

Publication Publication Date Title
DK0721461T3 (da) Syntese af 17-(3-pyridyl)-steroider
MacKay et al. REACTIONS OF ATOMIC CARBON WITH SIMPLE HYDROCARBONS: EVIDENCE FOR CH BOND INSERTION1
NO146865B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 16-dehydro-androstanderivater
Caballero et al. Cleavage of acetals promoted by copper (II) sulphate adsorbed on silica gel
GB2000137A (en) 7,8-Dihydro-14-hydroxy-normorphine
Collins et al. An efficient route to steroidal 6α-and 6β-Malonates and acetates by alkylation of π-Allylpalladium complexes
Grishko et al. Chemical conversions of betulone produced by biotransformation
Nahar et al. Synthesis of ester-linked lithocholic acid dimers
US2806043A (en) 16-alpha oxy-delta1, 4-pregnadienes
Ekhato et al. Norethindrone acetate (NA) and ethinyl estradiol (EE) related oxidative transformation products in stability samples of formulated drug product: synthesis of authentic references
KADOTA et al. Studies on the Constituents of Orchidaceous Plants. VII. The C-24 Stereochemistry of Cyclohomonervilol and 24-Isopropenylcholesterol, Non-conventional Side Chain Triterpene and Sterol, from Nervilia purpurea SCHLECHTER
Masamune et al. The Synthesis of an Etiojervane Analog of Progesterone
US3004045A (en) delta5(10)-3,6-diketo androstenes
Oommen Synthesis of Methyl 2-oxo-2, 3, 4, 4a, 9, 10-hexahydrophenanthrene-4a-carboxylates
US3845040A (en) Protection of steroid carbonyl group by enolisation
Sharif et al. An Aromatization Reaction of a Cross-conjugated Dienone System with Zinc. V. Aromatization of Santonin with Zinc1
US3257427A (en) 3-desoxy-delta-estratrienes and processes for the preparation thereof
US2859223A (en) delta4, 7-3, 20-diketo-17-hydroxy-11, 21-bis-oxygenated pregnadienes and processes of preparing the same
US2844601A (en) 3-oxygenated bisnor-17(20)-cholen-22-ols
US3372174A (en) Process for converting 17alpha-hydroperoxy-20-keto-pregnanes into the corresponding 17-keto-androstanes
GB893450A (en) New í~-steroids
Galbraith et al. Moulting hormones. LIII. The synthesis and biological activity of some ecdysone analogues
US4165326A (en) Steroids and their preparation
US2949478A (en) Process of cleaving 9, 11 oxido steroids with alcohols and organic acids
Ottow et al. Highly diastereoselective synthesis of 11β, 17β‐diaryl‐18a‐homo‐19‐nor steroids