DK0590006T3 - Syntetiske pulmonære surfaktantpeptider - Google Patents

Syntetiske pulmonære surfaktantpeptider

Info

Publication number
DK0590006T3
DK0590006T3 DK92912964T DK92912964T DK0590006T3 DK 0590006 T3 DK0590006 T3 DK 0590006T3 DK 92912964 T DK92912964 T DK 92912964T DK 92912964 T DK92912964 T DK 92912964T DK 0590006 T3 DK0590006 T3 DK 0590006T3
Authority
DK
Denmark
Prior art keywords
amino acid
synthetic pulmonary
pulmonary surfactant
acid residues
acid residue
Prior art date
Application number
DK92912964T
Other languages
Danish (da)
English (en)
Inventor
Charles G Cochrane
Susan D Revak
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of DK0590006T3 publication Critical patent/DK0590006T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
DK92912964T 1991-06-14 1992-06-01 Syntetiske pulmonære surfaktantpeptider DK0590006T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/715,397 US5260273A (en) 1988-01-06 1991-06-14 Pulmonary surfactant protein and related polypeptide
PCT/US1992/004537 WO1992022315A1 (en) 1991-06-14 1992-06-01 Synthetic pulmonary surfactant peptides

Publications (1)

Publication Number Publication Date
DK0590006T3 true DK0590006T3 (da) 2003-01-06

Family

ID=24873864

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92912964T DK0590006T3 (da) 1991-06-14 1992-06-01 Syntetiske pulmonære surfaktantpeptider

Country Status (11)

Country Link
US (3) US5260273A (de)
EP (1) EP0590006B1 (de)
JP (1) JP3459248B2 (de)
AT (1) ATE223436T1 (de)
AU (1) AU666857B2 (de)
CA (1) CA2111342A1 (de)
DE (1) DE69232760T2 (de)
DK (1) DK0590006T3 (de)
ES (1) ES2182821T3 (de)
IE (2) IE921897A1 (de)
WO (1) WO1992022315A1 (de)

Families Citing this family (59)

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US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US6013619A (en) * 1988-01-06 2000-01-11 The Scripps Research Institute Pulmonary surfactants and therapeutic uses, including pulmonary lavage
JPH07501519A (ja) * 1991-09-13 1995-02-16 マゲイニン　ファーマスーティカルズ，インコーポレーテッド 生物活性両親媒性ペプチド組成物およびその用途
ES2189825T3 (es) * 1993-12-08 2003-07-16 Mitsubishi Pharma Corp Nuevo peptido sintetico, tensioactivo pulmonar que lo contiene y remedio para el sindrome de malestar respiratorio.
US5750370A (en) * 1995-06-06 1998-05-12 Human Genome Sciences, Inc. Nucleic acid encoding human endothlein-bombesin receptor and method of producing the receptor
JP3856343B2 (ja) * 1995-11-20 2006-12-13 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 肺胞界面活性物質ペプチドの可溶化法
UA59358C2 (uk) 1996-01-24 2003-09-15 Бик Гулден Ломберг Хеміше Фабрік Гмбх Спосіб приготування порошкоподібного пульмонологічного порошкоподібного препарату та препарат, одержаний в такий спосіб
WO1997029738A1 (en) * 1996-02-16 1997-08-21 The Administrators Of The Tulane Educational Fund Methods and compositions for treating eustachian tube dysfunction by inhalation
US6120795A (en) * 1996-03-27 2000-09-19 Ortho Pharmaceutical Corp. Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation
WO1997035882A1 (en) * 1996-03-27 1997-10-02 Ortho Pharmaceutical Corporation Lyophilized pulmonary surfactant peptide compositions
US6013764A (en) 1996-07-17 2000-01-11 Ortho Pharmaceutical Corp. Liquid phase peptide synthesis of KL-4 pulmonary surfactant
GB9916316D0 (en) * 1999-07-12 1999-09-15 Quadrant Holdings Cambridge Dry powder compositions
US6676930B2 (en) 1999-11-28 2004-01-13 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
US6156294A (en) 1999-11-28 2000-12-05 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
ATE468131T1 (de) 2001-10-11 2010-06-15 Nycomed Gmbh Neue verwendung von lungensurfactant
US6998384B2 (en) 2001-12-12 2006-02-14 The Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
NZ536796A (en) * 2002-04-25 2007-03-30 Scripps Research Inst Treatment and prevention of pulmonary conditions comprising at least one lung surfactant polypeptide and at least one protease inhibitor, lipase inhibitor or an anti-oxidant
EP1481665A1 (de) * 2003-05-30 2004-12-01 CHIESI FARMACEUTICI S.p.A. Neue Lipidmischungen für synthetische Tenside
WO2005055994A1 (en) * 2003-12-04 2005-06-23 The Scripps Research Institute Treatment and preventions of asthma
AU2005247410A1 (en) * 2004-05-20 2005-12-08 Discovery Laboratories, Inc. Methods , systems and devices for noninvasive pulmonary delivery
EP1781323B1 (de) 2004-08-06 2010-02-17 Nycomed GmbH Zusammensetzung aus einem pulmonalen surfactant und einem von tnf stammenden peptid
US7582312B2 (en) 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
US8337815B2 (en) * 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
AU2006203978B2 (en) 2005-01-06 2011-11-03 Discovery Laboratories, Inc. Surfactant treatment regimen for treating or preventing bronchopulmonary dysplasia
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
HUE032584T2 (en) 2006-02-08 2017-09-28 Morphotek Inc Antigen GM-CSF peptides and GM-CSF antibodies
AU2007297691B2 (en) * 2006-09-19 2013-12-19 Discovery Laboratories, Inc. Pulmonary surfactant formulations and methods for promoting mucus clearance
US7951781B2 (en) 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides
EP1997502A1 (de) 2007-06-01 2008-12-03 CHIESI FARMACEUTICI S.p.A. Rekonstituierte Tenside mit verbesserten Eigenschaften
JP5554702B2 (ja) * 2007-06-05 2014-07-23 パカ パルモナリー ファーマシューティカルズ， インコーポレイテッド 薬剤を肺に送達するための方法および組成物
US8048043B2 (en) 2007-06-08 2011-11-01 Chiesi Farmaceutici S. P. A. Method of administration of a pulmonary surfactant
US9592361B2 (en) 2008-03-17 2017-03-14 Windtree Therapeutics, Inc. Ventilation circuit adaptor and proximal aerosol delivery system
ES2402241T3 (es) 2008-10-22 2013-04-30 Trudell Medical International Sistema de suministro de aerosol modular
CA2744940A1 (en) 2008-12-10 2010-06-17 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
CN102470150B (zh) 2009-09-08 2013-12-11 奇斯药制品公司 包含肺表面活性物质和抗氧化酶的治疗组合物
WO2011035140A1 (en) 2009-09-18 2011-03-24 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of contrast moieties to the lungs
GB201115910D0 (en) 2011-09-14 2011-10-26 Univ Manchester Peptides
WO2013067164A1 (en) 2011-11-04 2013-05-10 Discovery Laboratories, Inc. Ventilation circuit adaptor and proximal aerosol delivery system
MY164868A (en) * 2012-03-28 2018-01-30 Discovery Lab Inc Lyophilization of synthetic liposomal pulmonary surfactant
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation
WO2015061412A1 (en) * 2013-10-22 2015-04-30 The Scripps Research Institute Methods and compositions for promoting bronchioli dilatation
WO2016170087A1 (en) 2015-04-22 2016-10-27 Chiesi Farmaceutici S.P.A Method and system for effective breath-synchronized delivery of medicament to the lungs
EP3106090A1 (de) 2015-06-15 2016-12-21 CHIESI FARMACEUTICI S.p.A. System zur effektiven und atemsynchronisierten abgabe eines medikaments in die lungen
US11311691B2 (en) 2015-04-28 2022-04-26 Chiesi Farmaceutici S.P.A Device for facilitating the administration of a medicament to the lung by a catheter
US20180147262A1 (en) 2015-04-30 2018-05-31 University Of Bremen Novel skin medical and cosmetic care product
CN104817631B (zh) * 2015-05-26 2018-04-13 成都圣诺生物科技股份有限公司 一种合成西那普肽的方法
CA3028551A1 (en) 2016-07-28 2018-02-01 Chiesi Farmaceutici S.P.A. Method and system for delivery of an aerosolized medicament
RU2748417C2 (ru) 2016-08-24 2021-05-25 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Стабильная фармацевтическая композиция, включающая восстановленную композицию легочного сурфактанта
MA46605A (fr) 2016-10-26 2021-06-02 Chiesi Farm Spa Dispositif permettant de faciliter l'administration d'un médicament aux poumons par l'intermédiaire d'un cathéter
AU2017384467B2 (en) 2016-12-22 2023-10-19 Chiesi Farmaceutici S.P.A. A therapeutic combination comprising a pulmonary surfactant and a steroid for the treatment of evolving BPD
TW201927286A (zh) 2017-12-15 2019-07-16 義大利商凱西製藥公司 用於噴霧投藥之包含肺表面張力素的藥學調配物
WO2019115771A1 (en) 2017-12-15 2019-06-20 Pari Pharma Gmbh Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method
MX2020011127A (es) 2018-04-23 2021-01-15 Chiesi Farm Spa Combinacion terapeutica que comprende agente tensioactivo pulmonar y esteroide para la profilaxis de displasia broncopulmonar (bpd).
EP3666315A1 (de) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosolabgabevorrichtung und verfahren zum betrieb der aerosolabgabevorrichtung
EP3666316A1 (de) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosolabgabevorrichtung und verfahren zum betrieb der aerosolabgabevorrichtung
EP3843105A1 (de) 2019-12-23 2021-06-30 PARI Pharma GmbH Steuerungsvorrichtung für aerosolzerstäubersystem
EP4097128A1 (de) 2020-01-28 2022-12-07 Chiesi Farmaceutici S.p.A. Polypeptide mit verbesserten eigenschaften

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US4643988A (en) * 1984-05-15 1987-02-17 Research Corporation Amphipathic peptides
US4562003A (en) * 1984-10-26 1985-12-31 California Biotechnology, Inc. Monoclonal antibodies against alveolar surfactant protein
US4933280A (en) * 1984-12-11 1990-06-12 California Biotechnology Inc. Recombinant DNA sequence encoding Alveolar Surfactant Protein
US4659805A (en) * 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
EP0290516A4 (de) * 1986-10-24 1989-11-14 Jeffrey A Whitsett Proteine, die mit oberflächenwirksamen hydrophoben lungenwirkstoffen verbunden sind.
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
AR245141A1 (es) * 1988-07-01 1993-12-30 Merrell Dow Pharma Procedimiento de sintesis secuencial o de bloques en fase solida para preparar polipeptidos de estructura helicoidal.

Also Published As

Publication number Publication date
CA2111342A1 (en) 1992-12-23
IE20040101A1 (en) 2004-04-07
DE69232760D1 (de) 2002-10-10
US5260273A (en) 1993-11-09
US5407914A (en) 1995-04-18
ES2182821T3 (es) 2003-03-16
JP3459248B2 (ja) 2003-10-20
IE921897A1 (en) 1992-12-16
EP0590006A4 (en) 1994-07-13
EP0590006A1 (de) 1994-04-06
EP0590006B1 (de) 2002-09-04
DE69232760T2 (de) 2003-02-06
WO1992022315A1 (en) 1992-12-23
ATE223436T1 (de) 2002-09-15
AU2177792A (en) 1993-01-12
JPH06508619A (ja) 1994-09-29
US5789381A (en) 1998-08-04
AU666857B2 (en) 1996-02-29

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