EP0290516A4 - Proteine, die mit oberflächenwirksamen hydrophoben lungenwirkstoffen verbunden sind. - Google Patents
Proteine, die mit oberflächenwirksamen hydrophoben lungenwirkstoffen verbunden sind.Info
- Publication number
- EP0290516A4 EP0290516A4 EP19870907365 EP87907365A EP0290516A4 EP 0290516 A4 EP0290516 A4 EP 0290516A4 EP 19870907365 EP19870907365 EP 19870907365 EP 87907365 A EP87907365 A EP 87907365A EP 0290516 A4 EP0290516 A4 EP 0290516A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- pulmonary
- associated proteins
- hydrophobic surfactant
- hydrophobic
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Developmental Biology & Embryology (AREA)
- Toxicology (AREA)
- Physiology (AREA)
- Marine Sciences & Fisheries (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
WOPCT/US86/02258 | 1986-10-24 | ||
PCT/US1986/002258 WO1987006943A1 (en) | 1986-05-06 | 1986-10-24 | Pulmonary hydrophobic surfactant-associated protein of 6,000 daltons molecular weight and multimers thereof |
US93920686A | 1986-12-08 | 1986-12-08 | |
US939206 | 1986-12-08 | ||
US6071987A | 1987-06-10 | 1987-06-10 | |
US60719 | 1987-06-10 | ||
US10168087A | 1987-10-01 | 1987-10-01 | |
US101680 | 1987-10-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0290516A1 EP0290516A1 (de) | 1988-11-17 |
EP0290516A4 true EP0290516A4 (de) | 1989-11-14 |
Family
ID=27490143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19870907365 Withdrawn EP0290516A4 (de) | 1986-10-24 | 1987-10-02 | Proteine, die mit oberflächenwirksamen hydrophoben lungenwirkstoffen verbunden sind. |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP0290516A4 (de) |
WO (1) | WO1988003170A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989000167A1 (en) * | 1987-07-01 | 1989-01-12 | Kabigen Ab | Proteins and protein compositions and their use |
AU625394B2 (en) * | 1987-11-04 | 1992-07-09 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Alveolar surfactant proteins |
US6613734B2 (en) | 1988-01-06 | 2003-09-02 | The Scripps Research Institute | Peptides-containing liposomal surfactants |
US5260273A (en) * | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
US5164369A (en) * | 1988-01-06 | 1992-11-17 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
US5124255A (en) * | 1988-03-11 | 1992-06-23 | Abbott Laboratories | CKS method of protein synthesis |
AU650038B2 (en) * | 1988-03-11 | 1994-06-09 | Abbott Laboratories | CKS method of protein synthesis |
AU4216689A (en) * | 1988-08-11 | 1990-03-05 | California Biotechnology, Inc. | Method for stabilizing heterologous protein expression and vectors for use therein |
SE8803713D0 (sv) * | 1988-10-18 | 1988-10-18 | Kabigen Ab | Biologically active lipoprotein and its use |
US5238920A (en) * | 1989-08-22 | 1993-08-24 | Abbott Laboratories | Pulmonary surfactant protein fragments |
EP0458167B1 (de) * | 1990-05-21 | 1997-04-23 | Abbott Laboratories | Fettsäure-Oberflächenaktives-Lungenprotein Konjate |
US5272252A (en) * | 1991-11-04 | 1993-12-21 | Merrell Dow Pharmaceuticals Inc. | Synthetic lung surfactant having antioxidant properties |
ES2192190T3 (es) * | 1992-04-10 | 2003-10-01 | Abbott Lab | Fragmentos proteicos tensioactivos pulmonares. |
RO118298B1 (ro) * | 1993-12-08 | 2003-04-30 | Tokyo Tanabe Co | Peptida sintetica, procedeu pentru prepararea acesteia, surfactantul pulmonar si agentul terapeutic continand aceasta peptida |
US6372720B1 (en) * | 1998-02-05 | 2002-04-16 | Kenneth J. Longmuir | Liposome fusion and delivery vehicle |
DE50214446D1 (de) | 2001-10-11 | 2010-07-01 | Nycomed Gmbh | Neue verwendung von lungensurfactant |
DE602005019416D1 (de) | 2004-08-06 | 2010-04-01 | Nycomed Gmbh | Zusammensetzung aus einem pulmonalen surfactant und einem von tnf stammenden peptid |
US7951781B2 (en) | 2006-11-02 | 2011-05-31 | University Of Iowa Research Foundation | Methods and compositions related to PLUNC surfactant polypeptides |
CN102271666A (zh) | 2008-12-10 | 2011-12-07 | Paka肺部医药公司 | 用于向肺脏递送药物的方法和组合物 |
EP2391379B1 (de) | 2009-01-30 | 2017-08-02 | Alphabeta AB | Verbindungen und verfahren zur behandlung von morbus alzheimer |
US8785391B2 (en) | 2010-06-24 | 2014-07-22 | Alphabeta Ab | Compound and method for treatment of alzheimer's disease and familial dementia |
EP2689252A1 (de) * | 2011-03-25 | 2014-01-29 | Roche Diagnostics GmbH | Messung von c-terminiertem prosp-b |
WO2012138284A1 (en) | 2011-04-05 | 2012-10-11 | Alphabeta Ab | Amyloidosis target useful in methods of treatment and for screening of compounds |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986003408A1 (en) * | 1984-12-11 | 1986-06-19 | California Biotechnology Inc. | Recombinant alveolar surfactant protein |
WO1987002037A1 (en) * | 1985-09-26 | 1987-04-09 | Genetics Institute, Inc. | Pulmonary surfactant proteins |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4016258A (en) * | 1975-08-05 | 1977-04-05 | Said Sami I | Vasoactive intestinal peptide from fowl |
-
1987
- 1987-10-02 WO PCT/US1987/002536 patent/WO1988003170A1/en not_active Application Discontinuation
- 1987-10-02 EP EP19870907365 patent/EP0290516A4/de not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986003408A1 (en) * | 1984-12-11 | 1986-06-19 | California Biotechnology Inc. | Recombinant alveolar surfactant protein |
WO1987002037A1 (en) * | 1985-09-26 | 1987-04-09 | Genetics Institute, Inc. | Pulmonary surfactant proteins |
Non-Patent Citations (3)
Title |
---|
PEDIATRIC RESEARCH, vol. 20, no. 8, August 1986, pages 744-749, International Pediatric Research Foundation, Inc., US; J.A. WHITSETT et al.: "Immunologic identification of a pulmonary surfactant-associated protein of molecular weight = 6000 daltons" * |
See also references of WO8803170A1 * |
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 262, no. 20, 15th July 1987, pages 9808-9811, The American Society of Biological Chemists, Inc., US; K.A. JACOBS et al.: "Isolation of a cDNA clone encoding a high molecular weight precursor to a 6-kDa pulmonary surfactant-associated protein" * |
Also Published As
Publication number | Publication date |
---|---|
WO1988003170A1 (en) | 1988-05-05 |
EP0290516A1 (de) | 1988-11-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
17P | Request for examination filed |
Effective date: 19881026 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19891114 |
|
17Q | First examination report despatched |
Effective date: 19920508 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19941008 |