DK0590006T3 - Syntetiske pulmonære surfaktantpeptider - Google Patents

Syntetiske pulmonære surfaktantpeptider

Info

Publication number
DK0590006T3
DK0590006T3 DK92912964T DK92912964T DK0590006T3 DK 0590006 T3 DK0590006 T3 DK 0590006T3 DK 92912964 T DK92912964 T DK 92912964T DK 92912964 T DK92912964 T DK 92912964T DK 0590006 T3 DK0590006 T3 DK 0590006T3
Authority
DK
Denmark
Prior art keywords
amino acid
synthetic pulmonary
pulmonary surfactant
acid residues
acid residue
Prior art date
Application number
DK92912964T
Other languages
English (en)
Inventor
Charles G Cochrane
Susan D Revak
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of DK0590006T3 publication Critical patent/DK0590006T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
DK92912964T 1991-06-14 1992-06-01 Syntetiske pulmonære surfaktantpeptider DK0590006T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/715,397 US5260273A (en) 1988-01-06 1991-06-14 Pulmonary surfactant protein and related polypeptide
PCT/US1992/004537 WO1992022315A1 (en) 1991-06-14 1992-06-01 Synthetic pulmonary surfactant peptides

Publications (1)

Publication Number Publication Date
DK0590006T3 true DK0590006T3 (da) 2003-01-06

Family

ID=24873864

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92912964T DK0590006T3 (da) 1991-06-14 1992-06-01 Syntetiske pulmonære surfaktantpeptider

Country Status (11)

Country Link
US (3) US5260273A (da)
EP (1) EP0590006B1 (da)
JP (1) JP3459248B2 (da)
AT (1) ATE223436T1 (da)
AU (1) AU666857B2 (da)
CA (1) CA2111342A1 (da)
DE (1) DE69232760T2 (da)
DK (1) DK0590006T3 (da)
ES (1) ES2182821T3 (da)
IE (2) IE20040101A1 (da)
WO (1) WO1992022315A1 (da)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US6613734B2 (en) * 1988-01-06 2003-09-02 The Scripps Research Institute Peptides-containing liposomal surfactants
US6013619A (en) * 1988-01-06 2000-01-11 The Scripps Research Institute Pulmonary surfactants and therapeutic uses, including pulmonary lavage
WO1993005802A1 (en) * 1991-09-13 1993-04-01 Magainin Pharmaceuticals Inc. Biologically active amphiphilic peptide compositions and uses therefor
CN1057099C (zh) * 1993-12-08 2000-10-04 三菱东京制药株式会社 新的合成肽，其中间体及其生产方法
US5750370A (en) * 1995-06-06 1998-05-12 Human Genome Sciences, Inc. Nucleic acid encoding human endothlein-bombesin receptor and method of producing the receptor
JP3856343B2 (ja) * 1995-11-20 2006-12-13 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 肺胞界面活性物質ペプチドの可溶化法
DK0877602T3 (da) 1996-01-24 2002-05-06 Byk Gulden Lomberg Chem Fab Fremgangsmåde til fremstilling af pulverformede lungesurfactant-præparater
WO1997029738A1 (en) * 1996-02-16 1997-08-21 The Administrators Of The Tulane Educational Fund Methods and compositions for treating eustachian tube dysfunction by inhalation
US6120795A (en) * 1996-03-27 2000-09-19 Ortho Pharmaceutical Corp. Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation
WO1997035882A1 (en) * 1996-03-27 1997-10-02 Ortho Pharmaceutical Corporation Lyophilized pulmonary surfactant peptide compositions
US6013764A (en) * 1996-07-17 2000-01-11 Ortho Pharmaceutical Corp. Liquid phase peptide synthesis of KL-4 pulmonary surfactant
GB9916316D0 (en) * 1999-07-12 1999-09-15 Quadrant Holdings Cambridge Dry powder compositions
US6156294A (en) 1999-11-28 2000-12-05 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
US6676930B2 (en) 1999-11-28 2004-01-13 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
ES2346048T3 (es) 2001-10-11 2010-10-08 Nycomed Gmbh Nueva utilizacion de un agente tensioactivo pulmonar.
US6998384B2 (en) 2001-12-12 2006-02-14 The Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
IL164795A0 (en) * 2002-04-25 2005-12-18 Scripps Research Inst Treatment and prevention of pulmonary conditions
EP1481665A1 (en) * 2003-05-30 2004-12-01 CHIESI FARMACEUTICI S.p.A. Novel lipid mixtures for synthetic surfactants
EP1694314A4 (en) * 2003-12-04 2009-07-01 Scripps Research Inst TREATMENT AND PREVENTION OF ASTHMA
US20060078506A1 (en) * 2004-05-20 2006-04-13 Ralph Niven Methods, systems and devices for noninvasive pulmonary delivery
WO2006013183A1 (en) 2004-08-06 2006-02-09 Altana Pharma Ag Composition comprising a pulmonary surfactant and a tnf-derived peptide
US7582312B2 (en) 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
US8337815B2 (en) * 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
CA2593758A1 (en) 2005-01-06 2006-07-13 Discovery Laboratories, Inc. Surfactant treatment regimen for treating or preventing bronchopulmonary dysplasia
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
PL1981909T3 (pl) 2006-02-08 2017-08-31 Morphotek, Inc. Antygenowe peptydy GM-CSF oraz przeciwciała wobec GM-CSF
MX2009003002A (es) * 2006-09-19 2009-06-01 Discovery Lab Inc Formulaciones de tensioactivos pulmonares y metodos para promover la aclaracion del moco.
US7951781B2 (en) 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides
EP1997502A1 (en) 2007-06-01 2008-12-03 CHIESI FARMACEUTICI S.p.A. Reconstituted surfactants having improved properties
US20100284969A1 (en) * 2007-06-05 2010-11-11 Frank Guarnieri Methods and Compositions for Delivery of Medicaments to the Lungs
US8048043B2 (en) 2007-06-08 2011-11-01 Chiesi Farmaceutici S. P. A. Method of administration of a pulmonary surfactant
EP2265309B1 (en) 2008-03-17 2015-12-16 Discovery Laboratories, Inc. Ventilation circuit adaptor and proximal aerosol delivery system
CA2683353C (en) 2008-10-22 2015-12-15 Trudell Medical International Modular aerosol delivery system
US9289388B2 (en) 2008-12-10 2016-03-22 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
EP2475373B1 (en) 2009-09-08 2013-11-13 Chiesi Farmaceutici S.p.A. A therapeutic combination comprising a pulmonary surfactant and antioxidant enzymes
WO2011035140A1 (en) 2009-09-18 2011-03-24 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of contrast moieties to the lungs
GB201115910D0 (en) 2011-09-14 2011-10-26 Univ Manchester Peptides
WO2013067164A1 (en) 2011-11-04 2013-05-10 Discovery Laboratories, Inc. Ventilation circuit adaptor and proximal aerosol delivery system
DK2723323T3 (da) * 2012-03-28 2016-01-11 Discovery Lab Inc Frysetørring af syntetisk liposomal pulmonært overfladeaktivt stof
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation
WO2015061412A1 (en) * 2013-10-22 2015-04-30 The Scripps Research Institute Methods and compositions for promoting bronchioli dilatation
CN107666933A (zh) 2015-04-22 2018-02-06 奇斯药制品公司 用于药物有效地呼吸同步递送到肺部的方法和系统
EP3106090A1 (en) 2015-06-15 2016-12-21 CHIESI FARMACEUTICI S.p.A. System for effective breath-synchronized delivery of medicament to the lungs
WO2016173634A1 (en) 2015-04-28 2016-11-03 Chiesi Farmaceutici S.P.A Device for facilitating the administration of a medicament to the lung by a catheter
WO2016174269A1 (en) 2015-04-30 2016-11-03 University Of Bremen A novel skin medical and cosmetic care product
CN104817631B (zh) * 2015-05-26 2018-04-13 成都圣诺生物科技股份有限公司 一种合成西那普肽的方法
US11207475B2 (en) 2016-07-28 2021-12-28 Chiesi Farmaceutici S.P.A Method and system for delivery of an aerosolized medicament
CA3029456A1 (en) 2016-08-24 2018-03-01 Chiesi Farmaceutici S.P.A. Stable pharmaceutical formulation comprising a reconstituted pulmonary surfactant composition
MX2019004394A (es) 2016-10-26 2019-07-15 Chiesi Farm Spa Dispositivo para facilitar la administracion de un medicamento al pulmon por un cateter.
CN110099695B (zh) 2016-12-22 2022-01-25 奇斯药制品公司 用于治疗进展性bpd的包含肺表面活性物质和类固醇的治疗组合
WO2019115771A1 (en) 2017-12-15 2019-06-20 Pari Pharma Gmbh Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method
TW201927286A (zh) 2017-12-15 2019-07-16 義大利商凱西製藥公司 用於噴霧投藥之包含肺表面張力素的藥學調配物
MX2020011127A (es) 2018-04-23 2021-01-15 Chiesi Farm Spa Combinacion terapeutica que comprende agente tensioactivo pulmonar y esteroide para la profilaxis de displasia broncopulmonar (bpd).
EP3666315A1 (en) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosol delivery device and method of operating the aerosol delivery device
EP3666316A1 (en) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosol delivery device and method of operating the aerosol delivery device
EP3843105A1 (en) 2019-12-23 2021-06-30 PARI Pharma GmbH Control device for aerosol nebulizer system
EP4097128A1 (en) 2020-01-28 2022-12-07 Chiesi Farmaceutici S.p.A. Polypeptides having improved properties
EP4411745A1 (en) 2023-02-01 2024-08-07 Pari Medical Holding GmbH Medical evaluation method, aerosol nebulizer and medical evaluation system

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643988A (en) * 1984-05-15 1987-02-17 Research Corporation Amphipathic peptides
US4562003A (en) * 1984-10-26 1985-12-31 California Biotechnology, Inc. Monoclonal antibodies against alveolar surfactant protein
US4933280A (en) * 1984-12-11 1990-06-12 California Biotechnology Inc. Recombinant DNA sequence encoding Alveolar Surfactant Protein
US4659805A (en) * 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
WO1988003170A1 (en) * 1986-10-24 1988-05-05 Whitsett Jeffrey A Pulmonary hydrophobic surfactant-associated proteins
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
AR245141A1 (es) * 1988-07-01 1993-12-30 Merrell Dow Pharma Procedimiento de sintesis secuencial o de bloques en fase solida para preparar polipeptidos de estructura helicoidal.

Also Published As

Publication number Publication date
WO1992022315A1 (en) 1992-12-23
US5407914A (en) 1995-04-18
EP0590006A1 (en) 1994-04-06
US5789381A (en) 1998-08-04
ATE223436T1 (de) 2002-09-15
JP3459248B2 (ja) 2003-10-20
US5260273A (en) 1993-11-09
CA2111342A1 (en) 1992-12-23
IE921897A1 (en) 1992-12-16
ES2182821T3 (es) 2003-03-16
AU666857B2 (en) 1996-02-29
DE69232760D1 (de) 2002-10-10
IE20040101A1 (en) 2004-04-07
JPH06508619A (ja) 1994-09-29
EP0590006B1 (en) 2002-09-04
DE69232760T2 (de) 2003-02-06
AU2177792A (en) 1993-01-12
EP0590006A4 (en) 1994-07-13

Similar Documents

Publication Publication Date Title
DK0590006T3 (da) Syntetiske pulmonære surfaktantpeptider
EP0350506A4 (en) Pulmonary surfactant protein and related polypeptide
DE69838143D1 (de) Antimikrobielle peptide
ATE327254T1 (de) Interferon-beta fusionsproteine und deren verwendungen
DE69638025D1 (de) Parathyroidhormon Analoge
NZ503850A (en) April - a novel protein with growth effects
CA2085750A1 (en) Osteoinductive pharmaceutical formulations
WO1996028470A3 (en) Peptide analogues of human myelin basic protein useful in treating multiple sclerosis
WO1993019178A3 (en) Peptides useful for inducing tolerance
GB9606040D0 (en) Active peptide
DE3261304D1 (en) Retro-inverso analogues of c-terminal penta and hexapeptides of substance p.
EP1006126A3 (en) Osteogenic peptides
CA2020663A1 (en) Substitution analogues of magainin peptides
DE69313647D1 (de) Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien
CA2201944A1 (en) Analogs of keratinocyte growth factor having enhanced temperature stability
ES2114061T3 (es) Surfactantes peptidicos pulmonares y combinaciones terapeuticas.
EP0490383A3 (en) Peptides of the hiv-gag protein, their preparation and use
DE69408299D1 (de) Phospholipase c inhibitierendes peptid
DE69030293D1 (de) Neue Peptide, deren Intermediate, Verfahren zu deren Herstellung, antiallergische Agenzien, Vasodilatoren und Immunoregulatoren
CA2088478A1 (en) Cloning and expression of a rhoptry associated protein of p. falciparum
ITMI931627A0 (it) Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione
RU97117935A (ru) Свойства пептидов, стимулирующих рост