DE69313647D1 - Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien - Google Patents

Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien

Info

Publication number
DE69313647D1
DE69313647D1 DE69313647T DE69313647T DE69313647D1 DE 69313647 D1 DE69313647 D1 DE 69313647D1 DE 69313647 T DE69313647 T DE 69313647T DE 69313647 T DE69313647 T DE 69313647T DE 69313647 D1 DE69313647 D1 DE 69313647D1
Authority
DE
Germany
Prior art keywords
tied
covalent
antioxidants
synthetic peptides
lung surfactants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69313647T
Other languages
English (en)
Other versions
DE69313647T2 (de
Inventor
Larry Mclean
J Edwards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69313647D1 publication Critical patent/DE69313647D1/de
Application granted granted Critical
Publication of DE69313647T2 publication Critical patent/DE69313647T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69313647T 1992-07-31 1993-06-30 Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien Expired - Fee Related DE69313647T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92309292A 1992-07-31 1992-07-31
US7780293A 1993-06-21 1993-06-21
PCT/US1993/006249 WO1994003484A1 (en) 1992-07-31 1993-06-30 Synthetic peptide lung surfactants having covalently bonded antioxidants

Publications (2)

Publication Number Publication Date
DE69313647D1 true DE69313647D1 (de) 1997-10-09
DE69313647T2 DE69313647T2 (de) 1998-03-12

Family

ID=26759685

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69313647T Expired - Fee Related DE69313647T2 (de) 1992-07-31 1993-06-30 Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien

Country Status (13)

Country Link
US (2) US5623052A (de)
EP (1) EP0652894B1 (de)
JP (1) JPH07509713A (de)
KR (1) KR100279059B1 (de)
AT (1) ATE157671T1 (de)
AU (1) AU664112B2 (de)
CA (1) CA2137348C (de)
DE (1) DE69313647T2 (de)
ES (1) ES2107048T3 (de)
IL (1) IL106503A0 (de)
MX (1) MX9304621A (de)
NZ (1) NZ254496A (de)
WO (1) WO1994003484A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69313647T2 (de) * 1992-07-31 1998-03-12 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien
EP1098902A4 (de) 1998-07-23 2002-07-24 Yeda Res & Dev Behandlung von autoimmunkrankheiten mittels copolymer 1 und ähnlichen copolymeren und peptiden
ES2527760T3 (es) * 1998-07-23 2015-01-29 Yeda Research And Development Co., Ltd. Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos
US6800287B2 (en) 1998-09-25 2004-10-05 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
ZA200206457B (en) 2000-02-18 2003-08-13 Yeda Res & Dev Oral, nasal and pulmonary dosage formulations of copolymer 1.
US20020077278A1 (en) 2000-06-05 2002-06-20 Yong V. Wee Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
WO2002076503A1 (en) * 2000-06-20 2002-10-03 Mayo Foundation For Medical Education And Research Treatment of central nervous system diseases by antibodies against glatiramer acetate
EP1307212B1 (de) 2000-07-31 2007-03-28 World Resources Corporation Antioxidantien aus pflanzenmaterial
US6465432B1 (en) 2000-08-28 2002-10-15 Kraft Food Holdings, Inc. Isolated antioxidant peptides form casein and methods for preparing, isolating, and identifying antioxidant peptides
NZ533327A (en) 2001-12-04 2006-11-30 Teva Pharma Processes for the measurement of the potency of glatiramer acetate
CN1838964A (zh) * 2002-04-25 2006-09-27 斯克里普斯研究学院 肺病的治疗与预防
WO2006044738A2 (en) * 2004-10-18 2006-04-27 Maroon Biotech Corporation Methods and compositions for treatment of free radical injury

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
AR245141A1 (es) * 1988-07-01 1993-12-30 Merrell Dow Pharma Procedimiento de sintesis secuencial o de bloques en fase solida para preparar polipeptidos de estructura helicoidal.
FR2676056B1 (fr) * 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
AU655831B2 (en) * 1991-08-22 1995-01-12 Merrell Pharmaceuticals Inc. Novel orally-active elastase inhibitors
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
DE69313647T2 (de) * 1992-07-31 1998-03-12 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien

Also Published As

Publication number Publication date
IL106503A0 (en) 1993-11-15
DE69313647T2 (de) 1998-03-12
US5623052A (en) 1997-04-22
CA2137348C (en) 2000-11-28
ATE157671T1 (de) 1997-09-15
KR950702573A (ko) 1995-07-29
US5886156A (en) 1999-03-23
NZ254496A (en) 1996-08-27
EP0652894B1 (de) 1997-09-03
CA2137348A1 (en) 1994-02-17
EP0652894A1 (de) 1995-05-17
MX9304621A (es) 1994-02-28
ES2107048T3 (es) 1997-11-16
WO1994003484A1 (en) 1994-02-17
KR100279059B1 (ko) 2001-01-15
JPH07509713A (ja) 1995-10-26
AU4659693A (en) 1994-03-03
AU664112B2 (en) 1995-11-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee