DE69313647T2 - Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien - Google Patents

Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien

Info

Publication number
DE69313647T2
DE69313647T2 DE69313647T DE69313647T DE69313647T2 DE 69313647 T2 DE69313647 T2 DE 69313647T2 DE 69313647 T DE69313647 T DE 69313647T DE 69313647 T DE69313647 T DE 69313647T DE 69313647 T2 DE69313647 T2 DE 69313647T2
Authority
DE
Germany
Prior art keywords
tied
covalent
antioxidants
synthetic peptides
lung surfactants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69313647T
Other languages
English (en)
Other versions
DE69313647D1 (de
Inventor
Larry Mclean
J Edwards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69313647D1 publication Critical patent/DE69313647D1/de
Application granted granted Critical
Publication of DE69313647T2 publication Critical patent/DE69313647T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69313647T 1992-07-31 1993-06-30 Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien Expired - Fee Related DE69313647T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92309292A 1992-07-31 1992-07-31
US7780293A 1993-06-21 1993-06-21
PCT/US1993/006249 WO1994003484A1 (en) 1992-07-31 1993-06-30 Synthetic peptide lung surfactants having covalently bonded antioxidants

Publications (2)

Publication Number Publication Date
DE69313647D1 DE69313647D1 (de) 1997-10-09
DE69313647T2 true DE69313647T2 (de) 1998-03-12

Family

ID=26759685

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69313647T Expired - Fee Related DE69313647T2 (de) 1992-07-31 1993-06-30 Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien

Country Status (13)

Country Link
US (2) US5623052A (de)
EP (1) EP0652894B1 (de)
JP (1) JPH07509713A (de)
KR (1) KR100279059B1 (de)
AT (1) ATE157671T1 (de)
AU (1) AU664112B2 (de)
CA (1) CA2137348C (de)
DE (1) DE69313647T2 (de)
ES (1) ES2107048T3 (de)
IL (1) IL106503A0 (de)
MX (1) MX9304621A (de)
NZ (1) NZ254496A (de)
WO (1) WO1994003484A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ254496A (en) * 1992-07-31 1996-08-27 Merrell Dow Pharma Polypeptides (3-4 amino acids) with antioxidant moieties covalently attached and their use as pulmonary surfactants
CA2337688C (en) 1998-07-23 2016-04-05 Yeda Research And Development Co., Ltd. Treatment of autoimmune conditions with copolymer 1 and related copolymers
ES2527760T3 (es) 1998-07-23 2015-01-29 Yeda Research And Development Co., Ltd. Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos
US6800287B2 (en) 1998-09-25 2004-10-05 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
ZA200206457B (en) 2000-02-18 2003-08-13 Yeda Res & Dev Oral, nasal and pulmonary dosage formulations of copolymer 1.
US20020077278A1 (en) 2000-06-05 2002-06-20 Yong V. Wee Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
WO2002076503A1 (en) * 2000-06-20 2002-10-03 Mayo Foundation For Medical Education And Research Treatment of central nervous system diseases by antibodies against glatiramer acetate
ATE358138T1 (de) * 2000-07-31 2007-04-15 World Resources Corp Antioxidantien aus pflanzenmaterial
US6465432B1 (en) 2000-08-28 2002-10-15 Kraft Food Holdings, Inc. Isolated antioxidant peptides form casein and methods for preparing, isolating, and identifying antioxidant peptides
WO2003048735A2 (en) 2001-12-04 2003-06-12 Teva Pharmaceutical Industries, Ltd. Processes for the measurement of the potency of glatiramer acetate
JP4651946B2 (ja) * 2002-04-25 2011-03-16 ザ スクリプス リサーチ インスティテュート 肺病態の治療および予防
EP1809272A4 (de) * 2004-10-18 2008-01-02 Maroon Biotech Corp Verfahren und zusammensetzungen zur behandlung von schäden durch freie radikale

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
NZ229737A (en) * 1988-07-01 1991-05-28 Merrell Dow Pharma Polypeptides and derivatives of them with lung surfactant properties and their preparation
FR2676056B1 (fr) * 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ZA926185B (en) * 1991-08-22 1993-03-01 Merrell Dow Pharma Novel orally-active elastase inhibitors.
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
NZ254496A (en) * 1992-07-31 1996-08-27 Merrell Dow Pharma Polypeptides (3-4 amino acids) with antioxidant moieties covalently attached and their use as pulmonary surfactants

Also Published As

Publication number Publication date
JPH07509713A (ja) 1995-10-26
NZ254496A (en) 1996-08-27
US5886156A (en) 1999-03-23
CA2137348A1 (en) 1994-02-17
ES2107048T3 (es) 1997-11-16
AU664112B2 (en) 1995-11-02
WO1994003484A1 (en) 1994-02-17
MX9304621A (es) 1994-02-28
CA2137348C (en) 2000-11-28
DE69313647D1 (de) 1997-10-09
EP0652894B1 (de) 1997-09-03
AU4659693A (en) 1994-03-03
EP0652894A1 (de) 1995-05-17
ATE157671T1 (de) 1997-09-15
US5623052A (en) 1997-04-22
KR100279059B1 (ko) 2001-01-15
IL106503A0 (en) 1993-11-15
KR950702573A (ko) 1995-07-29

Similar Documents

Publication Publication Date Title
DK0590006T3 (da) Syntetiske pulmonære surfaktantpeptider
FI832095A0 (fi) Dynorfinamidanaloger
GR3029279T3 (en) Synthetic lung surfactant having antioxidant properties.
DE69313647T2 (de) Synthetische peptide als lungensurfactants mit kovalent gebundenen antioxidantien
DE69838143D1 (de) Antimikrobielle peptide
CA2113995A1 (en) Use of gentisic acid or gentisyl alcohol for stabilising radiolabeled peptides and proteins
DK0728148T3 (da) Forbedrede immunogene sammensætninger mod humant gastrin 17
ATE81345T1 (de) Synthetische atriale peptide.
EP0082568A3 (en) Retro-inverso analogues of c-terminal penta and hexapeptides of substance p.
WO1993019178A3 (en) Peptides useful for inducing tolerance
ES2114061T3 (es) Surfactantes peptidicos pulmonares y combinaciones terapeuticas.
EP0490383A3 (en) Peptides of the hiv-gag protein, their preparation and use
MY107451A (en) Cloning and expression of a rhoptry associated protein of p.falciparum
CA2137349A1 (en) Peptide lung surfactants and therapeutic combinations

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee