ES2114061T3 - Surfactantes peptidicos pulmonares y combinaciones terapeuticas. - Google Patents

Surfactantes peptidicos pulmonares y combinaciones terapeuticas.

Info

Publication number
ES2114061T3
ES2114061T3 ES93916906T ES93916906T ES2114061T3 ES 2114061 T3 ES2114061 T3 ES 2114061T3 ES 93916906 T ES93916906 T ES 93916906T ES 93916906 T ES93916906 T ES 93916906T ES 2114061 T3 ES2114061 T3 ES 2114061T3
Authority
ES
Spain
Prior art keywords
peptidic
lung
surfactants
therapeutic combinations
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93916906T
Other languages
English (en)
Inventor
Larry R Mclean
J Vincent Edwards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2114061T3 publication Critical patent/ES2114061T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

AGENTES ACTIVOS DE SUPERFICIE PULMONARES SINTETICOS QUE CONSISTEN EN UN COMPLEJO DE UN POLIPEPTIDO DE RESIDUOS DE AMINO ACIDO 3 - 4 QUE TIENEN ESTRUCTURA ALFA - HELICOIDAL Y UN GRUPO ACILO DE CADENA LARGA ENLAZADO COVALENTEMENTE. LOS PEPTIDOS SON UTILES CUANDO COMPRENDEN UNO O MAS LIPIDOS ASOCIADOS EN CONDICIONES RELACIONADAS CON AFECCIONES RESPIRATORIAS.
ES93916906T 1992-07-29 1993-07-01 Surfactantes peptidicos pulmonares y combinaciones terapeuticas. Expired - Lifetime ES2114061T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92227992A 1992-07-29 1992-07-29
US7780193A 1993-06-21 1993-06-21
PCT/US1993/006269 WO1994003485A1 (en) 1992-07-29 1993-07-01 Peptide lung surfactants and therapeutic combinations

Publications (1)

Publication Number Publication Date
ES2114061T3 true ES2114061T3 (es) 1998-05-16

Family

ID=26759683

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93916906T Expired - Lifetime ES2114061T3 (es) 1992-07-29 1993-07-01 Surfactantes peptidicos pulmonares y combinaciones terapeuticas.

Country Status (12)

Country Link
US (1) US5861481A (es)
EP (1) EP0656902B1 (es)
JP (1) JPH07509714A (es)
KR (1) KR100279540B1 (es)
AT (1) ATE161271T1 (es)
AU (1) AU671850B2 (es)
DE (1) DE69315849T2 (es)
ES (1) ES2114061T3 (es)
IL (1) IL106476A0 (es)
MX (1) MX9304540A (es)
NZ (1) NZ254503A (es)
WO (1) WO1994003485A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO161196A0 (en) * 1996-08-13 1996-09-05 Commonwealth Scientific And Industrial Research Organisation Novel compounds
US6660833B1 (en) 2000-02-29 2003-12-09 Harbor-Ucla Research And Education Institute Respiratory distress syndrome therapy with peptide analogs of human SP-B
WO2009148947A1 (en) * 2008-05-29 2009-12-10 Donald Owen Oligomeric biosurfactants in dermatocosmetic compositions
CN105288581A (zh) * 2006-06-01 2016-02-03 治疗剂肽有限公司 聚合生物表面活性剂
JP5554702B2 (ja) * 2007-06-05 2014-07-23 パカ パルモナリー ファーマシューティカルズ， インコーポレイテッド 薬剤を肺に送達するための方法および組成物
CA2744940A1 (en) 2008-12-10 2010-06-17 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
CN109689676B (zh) * 2016-09-15 2022-10-18 帝斯曼知识产权资产管理有限公司 新型化合物
CN111568853B (zh) * 2020-04-30 2023-07-28 杭州濡湜生物科技有限公司 一种新型肺部智能释药系统

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
AR245141A1 (es) * 1988-07-01 1993-12-30 Merrell Dow Pharma Procedimiento de sintesis secuencial o de bloques en fase solida para preparar polipeptidos de estructura helicoidal.
ZA926185B (en) * 1991-08-22 1993-03-01 Merrell Dow Pharma Novel orally-active elastase inhibitors.

Also Published As

Publication number Publication date
WO1994003485A1 (en) 1994-02-17
KR100279540B1 (ko) 2001-02-01
JPH07509714A (ja) 1995-10-26
EP0656902B1 (en) 1997-12-17
NZ254503A (en) 1996-08-27
KR950702574A (ko) 1995-07-29
IL106476A0 (en) 1993-11-15
DE69315849T2 (de) 1998-05-14
AU4660793A (en) 1994-03-03
US5861481A (en) 1999-01-19
MX9304540A (es) 1994-02-28
AU671850B2 (en) 1996-09-12
DE69315849D1 (de) 1998-01-29
EP0656902A1 (en) 1995-06-14
ATE161271T1 (de) 1998-01-15

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