DE68923401T2 - Peptide mit T-Zellen-Helfer-Wirksamkeit. - Google Patents

Peptide mit T-Zellen-Helfer-Wirksamkeit.

Info

Publication number
DE68923401T2
DE68923401T2 DE68923401T DE68923401T DE68923401T2 DE 68923401 T2 DE68923401 T2 DE 68923401T2 DE 68923401 T DE68923401 T DE 68923401T DE 68923401 T DE68923401 T DE 68923401T DE 68923401 T2 DE68923401 T2 DE 68923401T2
Authority
DE
Germany
Prior art keywords
peptides
effectiveness
cell helper
helper
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68923401T
Other languages
English (en)
Other versions
DE68923401D1 (de
Inventor
George Heavner
Gideon Goldstein
Tapan Audhya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunobiology Research Institute Inc
Original Assignee
Immunobiology Research Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunobiology Research Institute Inc filed Critical Immunobiology Research Institute Inc
Publication of DE68923401D1 publication Critical patent/DE68923401D1/de
Application granted granted Critical
Publication of DE68923401T2 publication Critical patent/DE68923401T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/66—Thymopoietins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE68923401T 1988-05-19 1989-05-17 Peptide mit T-Zellen-Helfer-Wirksamkeit. Expired - Fee Related DE68923401T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19613888A 1988-05-19 1988-05-19
US26869288A 1988-11-08 1988-11-08

Publications (2)

Publication Number Publication Date
DE68923401D1 DE68923401D1 (de) 1995-08-17
DE68923401T2 true DE68923401T2 (de) 1996-02-01

Family

ID=26891685

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68923401T Expired - Fee Related DE68923401T2 (de) 1988-05-19 1989-05-17 Peptide mit T-Zellen-Helfer-Wirksamkeit.

Country Status (21)

Country Link
US (1) US5298490A (de)
EP (3) EP0602004A1 (de)
JP (1) JPH03504013A (de)
KR (1) KR900701296A (de)
CN (2) CN1037711A (de)
AR (1) AR246352A1 (de)
AT (1) ATE124956T1 (de)
AU (1) AU625598B2 (de)
BR (1) BR8906988A (de)
DE (1) DE68923401T2 (de)
DK (1) DK14890D0 (de)
ES (1) ES2075050T3 (de)
FI (1) FI94350C (de)
GR (1) GR3017451T3 (de)
HU (1) HU205142B (de)
IE (1) IE62555B1 (de)
IL (1) IL90229A (de)
NZ (1) NZ229004A (de)
PT (1) PT90596B (de)
RU (1) RU2060998C1 (de)
WO (1) WO1989011289A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU201095B (en) * 1988-06-14 1990-09-28 Richter Gedeon Vegyeszet New peptides inhibiting the activity of the immune system and pharmaceutical compositions comprising same, as well as process for producing these peptides and compositions
BR8907105A (pt) * 1988-09-30 1991-02-05 Immunobiology Res Inst Inc Peptideos tendo atividade supressora de celula t
US5332726A (en) * 1989-09-29 1994-07-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic peptides and pseudopeptides
US5053392A (en) * 1989-12-01 1991-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
DD292382B5 (de) * 1990-03-06 1994-03-24 Berlin Chemie Ag Verfahren zur herstellung eines parenteral applizierbaren lagerbestaendigen immunstimulierenden praeparats
DE4011207A1 (de) * 1990-04-06 1991-10-10 Stiefel Thomas Humane splenopentinderivate und verfahren zu deren herstellung
EP0668770A1 (de) * 1991-04-24 1995-08-30 Warner-Lambert Company Alpha-substituierte polypeptide und therapeutischer aktivität
JPH06501961A (ja) * 1991-08-26 1994-03-03 日本たばこ産業株式会社 免疫調節活性を有するシユードペンタペプチド
US5554638A (en) * 1993-05-24 1996-09-10 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5612310A (en) * 1993-05-24 1997-03-18 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5639729A (en) * 1993-08-26 1997-06-17 Immunobiology Research Institute, Inc. Tripeptides useful in immune and CNS therapy
GB9425582D0 (en) * 1994-12-19 1995-02-15 Iaf Biochem Int Peptides having immunomodulatory activity
JPH11511137A (ja) * 1995-08-08 1999-09-28 ファイブロゲン，インコーポレーテッド コラーゲンの過剰生産に関係した疾患を治療するためのｃ−プロテイナーゼ阻害剤
US5843462A (en) 1995-11-30 1998-12-01 Regents Of The University Of Minnesota Diphtheria toxin epitopes
EP1037663A2 (de) 1997-12-16 2000-09-27 Regents Of The University Of Minnesota Verfahren zur behandlung unerwünschter immunantworten
US7144862B2 (en) * 2000-08-24 2006-12-05 The Regents Of The University Of California Orally administered peptides to ameliorate atherosclerosis
US7723303B2 (en) * 2000-08-24 2010-05-25 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
US7166578B2 (en) 2000-08-24 2007-01-23 The Regents Of The University Of California Orally administered peptides synergize statin activity
US7199102B2 (en) * 2000-08-24 2007-04-03 The Regents Of The University Of California Orally administered peptides synergize statin activity
US7148197B2 (en) * 2000-08-24 2006-12-12 The Regents Of The University Of California Orally administered small peptides synergize statin activity
US8568766B2 (en) * 2000-08-24 2013-10-29 Gattadahalli M. Anantharamaiah Peptides and peptide mimetics to treat pathologies associated with eye disease
AU2002249917A1 (en) * 2001-01-04 2002-08-12 Yale University Induction of immune responses to isoaspartyl-modified antigens
US20060205669A1 (en) * 2004-09-16 2006-09-14 The Regents Of The University Of California G-type peptides and other agents to ameliorate atherosclerosis and other pathologies
AU2005314043A1 (en) 2004-12-06 2006-06-15 The Regents Of The University Of California Methods for improving the structure and function of arterioles
AU2006242651B2 (en) * 2005-04-29 2013-05-16 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
US20080293639A1 (en) * 2005-04-29 2008-11-27 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
US8299214B2 (en) * 2006-03-13 2012-10-30 Keio University Influenza infection-inhibiting peptide, influenza virus infection inhibitor, liposome, and influenza preventive/therapeutic agent
RU2301074C1 (ru) * 2006-05-30 2007-06-20 Общество С Ограниченной Ответственностью "Сиа Пептайдс" Пептид, обладающий иммуногеропротекторным действием, фармацевтическая композиция на его основе и способ ее применения
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
PT2064228E (pt) 2006-11-10 2012-12-10 Cara Therapeutics Inc Amidas peptídicas sintéticas
US7713937B2 (en) 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US8906859B2 (en) 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US8236766B2 (en) 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US8557767B2 (en) 2007-08-28 2013-10-15 Uab Research Foundation Synthetic apolipoprotein E mimicking polypeptides and methods of use
AU2008296478B9 (en) * 2007-08-28 2015-03-19 The Uab Research Foundation Synthetic apolipoprotein E mimicking polypeptides and methods of use
US10653747B2 (en) 2014-07-31 2020-05-19 Uab Research Foundation ApoE mimetic peptides and higher potency to clear plasma cholesterol

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1237918A (de) * 1967-08-08 1971-07-07
US4190646A (en) * 1975-11-11 1980-02-26 Sloan-Kettering Institute For Cancer Research Polypeptide compositions and methods
US4190647A (en) * 1979-01-26 1980-02-26 Sloan-Kettering Institute For Cancer Research Polypeptides and methods
US4261886A (en) * 1980-03-13 1981-04-14 Ortho Pharmaceutical Corporation Peptides having thymopoietin-like activity
CA1157466A (en) * 1979-04-12 1983-11-22 Gideon Goldstein Peptides having thymopoietin-like activity
FR2460290A1 (fr) * 1979-06-29 1981-01-23 Rhone Poulenc Ind Nouveaux tetra- ou pentapeptides, leur preparation et les medicaments qui les contiennent
DE2938420A1 (de) * 1979-09-22 1981-04-09 Hoechst Ag, 6000 Frankfurt Neue peptide und verfahren zu ihrer herstellung
US4309340A (en) * 1980-03-31 1982-01-05 American Home Products Corporation Polypeptide compositions
US4298523A (en) * 1980-06-17 1981-11-03 Ortho Pharmaceutical Corporation Methods and compositions for preparation of H-ARG-X-Z-Y-TYR-R
US4361673A (en) 1980-09-19 1982-11-30 American Home Products Corporation Polypeptide compositions
HU185263B (en) * 1981-06-12 1984-12-28 Richter Gedeon Vegyeszet Process for producing peptides effective on the immuncontroll analogous with the tp5
DE3146598A1 (de) * 1981-11-25 1983-07-07 Hoechst Ag, 6230 Frankfurt "neue peptide und verfahren zu ihrer herstellung"
US4614517A (en) * 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
DE3401545A1 (de) * 1983-08-03 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue peptide mit immunstimulierender wirkung, verfahren zu deren herstellung und deren verwendung
US4505853A (en) * 1983-11-18 1985-03-19 Ortho Pharmaceutical Corporation Enzyme-resistant immunomodulatory peptides
DE3421614A1 (de) * 1984-06-09 1985-12-12 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von pentapeptiden mit wirkung auf das immunsystem und zwischenprodukte dieses verfahrens
US4547489A (en) * 1984-06-11 1985-10-15 Ortho Pharmaceutical Corporation Conformationally restricted thymopentin-like compounds
US4629723A (en) * 1984-06-27 1986-12-16 Ortho Pharmaceutical Corporation Potent thymopentin analogs
IT1216908B (it) * 1987-03-19 1990-03-14 Eniricerche Spa Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche.
US5097013A (en) * 1988-07-14 1992-03-17 Kao Corporation Novel peptides possessing a macrophage chemotactic activity

Also Published As

Publication number Publication date
RU2060998C1 (ru) 1996-05-27
EP0602003A1 (de) 1994-06-15
IE62555B1 (en) 1995-02-08
EP0342962A3 (en) 1990-12-27
PT90596A (pt) 1989-11-30
CN1104217A (zh) 1995-06-28
PT90596B (pt) 1994-09-30
US5298490A (en) 1994-03-29
CN1037711A (zh) 1989-12-06
WO1989011289A1 (en) 1989-11-30
ES2075050T3 (es) 1995-10-01
AU625598B2 (en) 1992-07-16
GR3017451T3 (en) 1995-12-31
HU205142B (en) 1992-03-30
IE891542L (en) 1989-11-19
AU3745589A (en) 1989-12-12
EP0342962A2 (de) 1989-11-23
FI94350B (fi) 1995-05-15
NZ229004A (en) 1993-09-27
EP0342962B1 (de) 1995-07-12
KR900701296A (ko) 1990-12-01
IL90229A0 (en) 1989-12-15
FI94350C (fi) 1995-08-25
ATE124956T1 (de) 1995-07-15
BR8906988A (pt) 1990-12-18
FI900267A0 (fi) 1990-01-17
EP0602004A1 (de) 1994-06-15
AR246352A1 (es) 1994-07-29
DK14890A (da) 1990-01-18
HU893392D0 (en) 1990-09-28
DK14890D0 (da) 1990-01-18
DE68923401D1 (de) 1995-08-17
IL90229A (en) 1995-12-08
JPH03504013A (ja) 1991-09-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee