AR246352A1 - Procedimiento para preparar un peptido y un reactivo de diagnostico para uso in vitro que lo contiene. - Google Patents

Procedimiento para preparar un peptido y un reactivo de diagnostico para uso in vitro que lo contiene.

Info

Publication number
AR246352A1
AR246352A1 AR89313972A AR31397289A AR246352A1 AR 246352 A1 AR246352 A1 AR 246352A1 AR 89313972 A AR89313972 A AR 89313972A AR 31397289 A AR31397289 A AR 31397289A AR 246352 A1 AR246352 A1 AR 246352A1
Authority
AR
Argentina
Prior art keywords
lys
asp
ala
ile
asn
Prior art date
Application number
AR89313972A
Other languages
English (en)
Original Assignee
Inmunobiology Res Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inmunobiology Res Inst Inc filed Critical Inmunobiology Res Inst Inc
Application granted granted Critical
Publication of AR246352A1 publication Critical patent/AR246352A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/66—Thymopoietins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR UN PEPTIDO QUE COMPRENDE LA MISMA SECUENCIA DE AMINOACIDOS, DE LA FORMULA: R-ARG-X-W-Y-Z-R1, DONDE R ES H; ACETILO; FORMILO, O DES-AMINO, X ES PRO, DESHIRO-PRO, HIDROXI-PRO, D-LYS, AIB O LYS, W ESTA AUSENTE O ALA, Y ES UNA FORMA D O L DE UN AMINOACIDO SELECCIONADO ENTRE ALA, ASP, GLU, GLN, ASN, BETA-ASP, VAL, LEU, ILE O LYS, Z ES GLY O UNA FORMA D O L DE UN AMINOACIDO SELECCIONADO ENTRE VAL, ALA, LEU, ILE, TYR, HIS O TRP, R1 ES OH O NRQ2R3, DONDE R2 Y R3 SON H O UN ALQUILO O ALQUENILO, O DONDE R2 Y RQ3 EN CONJUNTO COMPRENDEN UN GRUPO METILENO CICLICO DE 3 A 7 ATOMOS DE CARBONO, A CONDICION DE QUE CUANDO X ES LYS, Y Z ES VAL, Y ES DISTINTO QUE ASP, ASN, ALA O GLU, Y CUANDO X ES LYS, Y ES DISTINTO QUE ASP; CUANDO W ESTA AUSENTE, Y ES DISTINTO QUE D-LYS O L-LYS, Z ES DISTINTO QUE LA FORMA D O L DE TYR, HIS O TRP, Y R2 ES DISTINTO QUE DES- AMINO; Y CUANDO W ES ALA, Y ES DISTINTO QUE LA FORMA D O L DE ASN O BETA- ASP, Y Z ES DISTINTO QUE GLY, D-ILE O L-ILE; QUE COMPRENDE LA REALIZACION DE UNA SINTESIS EN FASE SOLIDA QUE EMPLEA UN INTERMEDIARIO PEPTIDO-RESINA QUE COMPRENDE LOS RESTOS DE AMINOACIDOS DE LA SECUENCIA IDENTIFICADA PRECEDENTEMENTE ASOCIADA CON GRUPOS PROTECTORES DE AMINO, DE HIDROXILO, DE INDOL, DE IMIDAZOL Y UNA RESINA QUE ES UN POLIMERO EN FASE SOLIDA AL CUAL SE PUEDE ENLAZAR FIRMEMENTE LA ARGININA MEDIANTE UN ENLACE COVALENTE.
AR89313972A 1988-05-19 1989-05-19 Procedimiento para preparar un peptido y un reactivo de diagnostico para uso in vitro que lo contiene. AR246352A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19613888A 1988-05-19 1988-05-19
US26869288A 1988-11-08 1988-11-08

Publications (1)

Publication Number Publication Date
AR246352A1 true AR246352A1 (es) 1994-07-29

Family

ID=26891685

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89313972A AR246352A1 (es) 1988-05-19 1989-05-19 Procedimiento para preparar un peptido y un reactivo de diagnostico para uso in vitro que lo contiene.

Country Status (21)

Country Link
US (1) US5298490A (es)
EP (3) EP0342962B1 (es)
JP (1) JPH03504013A (es)
KR (1) KR900701296A (es)
CN (2) CN1037711A (es)
AR (1) AR246352A1 (es)
AT (1) ATE124956T1 (es)
AU (1) AU625598B2 (es)
BR (1) BR8906988A (es)
DE (1) DE68923401T2 (es)
DK (1) DK14890D0 (es)
ES (1) ES2075050T3 (es)
FI (1) FI94350C (es)
GR (1) GR3017451T3 (es)
HU (1) HU205142B (es)
IE (1) IE62555B1 (es)
IL (1) IL90229A (es)
NZ (1) NZ229004A (es)
PT (1) PT90596B (es)
RU (1) RU2060998C1 (es)
WO (1) WO1989011289A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU201095B (en) * 1988-06-14 1990-09-28 Richter Gedeon Vegyeszet New peptides inhibiting the activity of the immune system and pharmaceutical compositions comprising same, as well as process for producing these peptides and compositions
KR900701298A (ko) * 1988-09-30 1990-12-01 원본미기재 T-세포 억제작용을 보유한 펩티드
US5332726A (en) * 1989-09-29 1994-07-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic peptides and pseudopeptides
US5053392A (en) * 1989-12-01 1991-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
DD292382B5 (de) * 1990-03-06 1994-03-24 Berlin Chemie Ag Verfahren zur herstellung eines parenteral applizierbaren lagerbestaendigen immunstimulierenden praeparats
DE4011207A1 (de) * 1990-04-06 1991-10-10 Stiefel Thomas Humane splenopentinderivate und verfahren zu deren herstellung
CA2106764A1 (en) * 1991-04-24 1992-10-25 David C. Horwell Ó-substituted polypeptides having therapeutic activity
WO1993004080A1 (en) * 1991-08-26 1993-03-04 Japan Tobacco Inc. Pseudopentapeptides with immunomodulating activity
US5612310A (en) * 1993-05-24 1997-03-18 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5554638A (en) * 1993-05-24 1996-09-10 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5639729A (en) * 1993-08-26 1997-06-17 Immunobiology Research Institute, Inc. Tripeptides useful in immune and CNS therapy
GB9425582D0 (en) * 1994-12-19 1995-02-15 Iaf Biochem Int Peptides having immunomodulatory activity
MX9801093A (es) * 1995-08-08 1998-04-30 Fibrogen Inc Inhibidores de la proteinasa c para el tratamiento de enfermedades relacionadas con la sobreproduccion de colagena.
US5843462A (en) 1995-11-30 1998-12-01 Regents Of The University Of Minnesota Diphtheria toxin epitopes
CA2315537A1 (en) 1997-12-16 1999-06-24 Regents Of The University Of Minnesota Methods to treat undesirable immune responses
US8568766B2 (en) * 2000-08-24 2013-10-29 Gattadahalli M. Anantharamaiah Peptides and peptide mimetics to treat pathologies associated with eye disease
US7144862B2 (en) * 2000-08-24 2006-12-05 The Regents Of The University Of California Orally administered peptides to ameliorate atherosclerosis
US7199102B2 (en) * 2000-08-24 2007-04-03 The Regents Of The University Of California Orally administered peptides synergize statin activity
US7166578B2 (en) 2000-08-24 2007-01-23 The Regents Of The University Of California Orally administered peptides synergize statin activity
US7723303B2 (en) * 2000-08-24 2010-05-25 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
US7148197B2 (en) * 2000-08-24 2006-12-12 The Regents Of The University Of California Orally administered small peptides synergize statin activity
WO2002060390A2 (en) * 2001-01-04 2002-08-08 Yale University Induction of immune responses to isoaspartyl-modified antigens
CN101065137A (zh) * 2004-09-16 2007-10-31 加利福尼亚大学董事会 用于改善动脉粥样硬化和其它病变的g型多肽和其它剂
RU2414236C2 (ru) 2004-12-06 2011-03-20 Зе Риджентс Оф Зи Юнивесити Оф Кэлифонье Способ улучшения структуры и/или функций артериол
MX2007013430A (es) * 2005-04-29 2008-03-19 Univ California Peptidos y peptidos mimeticos para tratar patologias caracterizadas por una respuesta inflamatoria.
US20080293639A1 (en) * 2005-04-29 2008-11-27 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
JP5093100B2 (ja) * 2006-03-13 2012-12-05 学校法人慶應義塾 インフルエンザ感染阻害ペプチド、インフルエンザウイルス感染阻害剤、リポソーム、インフルエンザ予防・治療剤
RU2301074C1 (ru) * 2006-05-30 2007-06-20 Общество С Ограниченной Ответственностью "Сиа Пептайдс" Пептид, обладающий иммуногеропротекторным действием, фармацевтическая композиция на его основе и способ ее применения
CN101627049B (zh) 2006-11-10 2012-09-05 卡拉治疗学股份有限公司 合成酞酰胺
US8906859B2 (en) 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US8236766B2 (en) 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US7713937B2 (en) 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
JP2010538005A (ja) * 2007-08-28 2010-12-09 ユーエービー リサーチ ファウンデーション 合成アポリポ蛋白質ｅ模倣ポリペプチドおよび使用方法
US8557767B2 (en) 2007-08-28 2013-10-15 Uab Research Foundation Synthetic apolipoprotein E mimicking polypeptides and methods of use
BR112017001860A2 (pt) 2014-07-31 2018-02-27 Uab Research Foundation peptídeo sintético, composição farmacêutica, métodos, regime de dosagem, e, anticorpo monoclonal

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1237918A (es) * 1967-08-08 1971-07-07
US4190646A (en) * 1975-11-11 1980-02-26 Sloan-Kettering Institute For Cancer Research Polypeptide compositions and methods
US4190647A (en) * 1979-01-26 1980-02-26 Sloan-Kettering Institute For Cancer Research Polypeptides and methods
US4261886A (en) * 1980-03-13 1981-04-14 Ortho Pharmaceutical Corporation Peptides having thymopoietin-like activity
CA1157466A (en) * 1979-04-12 1983-11-22 Gideon Goldstein Peptides having thymopoietin-like activity
FR2460290A1 (fr) * 1979-06-29 1981-01-23 Rhone Poulenc Ind Nouveaux tetra- ou pentapeptides, leur preparation et les medicaments qui les contiennent
DE2938420A1 (de) * 1979-09-22 1981-04-09 Hoechst Ag, 6000 Frankfurt Neue peptide und verfahren zu ihrer herstellung
US4309340A (en) * 1980-03-31 1982-01-05 American Home Products Corporation Polypeptide compositions
US4298523A (en) * 1980-06-17 1981-11-03 Ortho Pharmaceutical Corporation Methods and compositions for preparation of H-ARG-X-Z-Y-TYR-R
US4361673A (en) 1980-09-19 1982-11-30 American Home Products Corporation Polypeptide compositions
HU185263B (en) * 1981-06-12 1984-12-28 Richter Gedeon Vegyeszet Process for producing peptides effective on the immuncontroll analogous with the tp5
DE3146598A1 (de) * 1981-11-25 1983-07-07 Hoechst Ag, 6230 Frankfurt "neue peptide und verfahren zu ihrer herstellung"
US4614517A (en) * 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
DE3401545A1 (de) * 1983-08-03 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue peptide mit immunstimulierender wirkung, verfahren zu deren herstellung und deren verwendung
US4505853A (en) * 1983-11-18 1985-03-19 Ortho Pharmaceutical Corporation Enzyme-resistant immunomodulatory peptides
DE3421614A1 (de) * 1984-06-09 1985-12-12 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von pentapeptiden mit wirkung auf das immunsystem und zwischenprodukte dieses verfahrens
US4547489A (en) * 1984-06-11 1985-10-15 Ortho Pharmaceutical Corporation Conformationally restricted thymopentin-like compounds
US4629723A (en) * 1984-06-27 1986-12-16 Ortho Pharmaceutical Corporation Potent thymopentin analogs
IT1216908B (it) * 1987-03-19 1990-03-14 Eniricerche Spa Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche.
US5097013A (en) * 1988-07-14 1992-03-17 Kao Corporation Novel peptides possessing a macrophage chemotactic activity

Also Published As

Publication number Publication date
CN1104217A (zh) 1995-06-28
DE68923401D1 (de) 1995-08-17
US5298490A (en) 1994-03-29
KR900701296A (ko) 1990-12-01
ATE124956T1 (de) 1995-07-15
AU3745589A (en) 1989-12-12
EP0342962A3 (en) 1990-12-27
IL90229A0 (en) 1989-12-15
AU625598B2 (en) 1992-07-16
JPH03504013A (ja) 1991-09-05
CN1037711A (zh) 1989-12-06
DK14890A (da) 1990-01-18
IL90229A (en) 1995-12-08
HU893392D0 (en) 1990-09-28
DE68923401T2 (de) 1996-02-01
FI94350B (fi) 1995-05-15
GR3017451T3 (en) 1995-12-31
FI94350C (fi) 1995-08-25
RU2060998C1 (ru) 1996-05-27
EP0342962B1 (en) 1995-07-12
DK14890D0 (da) 1990-01-18
FI900267A0 (fi) 1990-01-17
EP0342962A2 (en) 1989-11-23
PT90596B (pt) 1994-09-30
NZ229004A (en) 1993-09-27
HU205142B (en) 1992-03-30
WO1989011289A1 (en) 1989-11-30
EP0602003A1 (en) 1994-06-15
ES2075050T3 (es) 1995-10-01
IE891542L (en) 1989-11-19
BR8906988A (pt) 1990-12-18
EP0602004A1 (en) 1994-06-15
IE62555B1 (en) 1995-02-08
PT90596A (pt) 1989-11-30

Similar Documents

Publication Publication Date Title
AR246352A1 (es) Procedimiento para preparar un peptido y un reactivo de diagnostico para uso in vitro que lo contiene.
Rudinger The design of peptide hormone analogs
US4457864A (en) Synthetic analogues of α-melanotropin
Huang et al. Isolation and structure of pro-methionine-enkephalin: Potential enkephalin precursor from porcine hypothalamus
PT883687E (pt) Receptores de quimiocinas c-c, ckr-5, cc, os seus derivados e as suas utilizacoes
SE8007763L (sv) Sett att framstella en polypeptid
TW343198B (en) Cyclopeptides useful as adhesion inhibitors, process for the preparation thereof, and pharmaceutical composition containing them
AR008680A1 (es) Substitutos de plaquetas y metodos de conjugacion apropiados para su preparacion
US4253997A (en) Anti-ovulatory decapeptides
KR860000314A (ko) 펩타이드의 제조방법
TR199802534T2 (xx) Leptin (OB Protein) fragmanlar�
US4396606A (en) Novel polypeptide analgesics
EP0055113B1 (en) Deca- undeca- dodeca- and tridecapeptides with thymic activity, method for their preparation and compositions containing them
Lemaire et al. Synthesis and biological activity of. beta.-endorphin and analogs. Additional evidence for multiple opiate receptors
US3855199A (en) P-glu-d-phe-t rp-ser-tyr-d-ala-leu-arg-pro-gly-nh2-and intermediates
GB1570210A (en) Peptides
US3928307A (en) P-Glu-D-Phe-Trp-Ser-Tyr-D-Phee-Leu-Arg-Pro-Gly-NH2 and intermediates
ES8701785A1 (es) Un procedimiento para preparar un peptido ciclico basico conactividad antagonista de v1-vasopresina y oxitocina
GB1530560A (en) Cyclic hexapeptides
Janković et al. In vivo modulation of the immune system by enkephalins
IE893110L (en) Peptides having t cell suppressor activity
KR850002834A (ko) 염기성 헵타 펩타이드 바조프레신 길항근의 제조방법
DK527187A (da) Gonadoliberin-analoge, fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
US3890437A (en) Method of inhibiting fertility in mammals using D{13 Phe{hu 2{b {13 D{13 Ala{hu 6{b {13 LRF
US3886137A (en) P-Glu-D-Phe-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-Gly-NH{HD 2 {B and intermediates