ES2075050T3 - Peptidos que tienen actividad cooperadora de celulas t. - Google Patents

Peptidos que tienen actividad cooperadora de celulas t.

Info

Publication number
ES2075050T3
ES2075050T3 ES89304998T ES89304998T ES2075050T3 ES 2075050 T3 ES2075050 T3 ES 2075050T3 ES 89304998 T ES89304998 T ES 89304998T ES 89304998 T ES89304998 T ES 89304998T ES 2075050 T3 ES2075050 T3 ES 2075050T3
Authority
ES
Spain
Prior art keywords
peptides
activity
cooperator
cell
tisplenine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89304998T
Other languages
English (en)
Inventor
George Heavner
Gideon Goldstein
Tapan Audhya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunobiology Research Institute Inc
Original Assignee
Immunobiology Research Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunobiology Research Institute Inc filed Critical Immunobiology Research Institute Inc
Application granted granted Critical
Publication of ES2075050T3 publication Critical patent/ES2075050T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/66—Thymopoietins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE DESCRIBEN TETRAPEPTIDOS Y PENTAPEPTIDOS QUE TIENEN LA ACTIVIDAD BIOLOGICA DE LA MOLECULA HUMANA TISPLENINA. TAMBIIEN SE PRESENTAN COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS PEPTIDOS Y METODOS PARA SU USO.
ES89304998T 1988-05-19 1989-05-17 Peptidos que tienen actividad cooperadora de celulas t. Expired - Lifetime ES2075050T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19613888A 1988-05-19 1988-05-19
US26869288A 1988-11-08 1988-11-08

Publications (1)

Publication Number Publication Date
ES2075050T3 true ES2075050T3 (es) 1995-10-01

Family

ID=26891685

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89304998T Expired - Lifetime ES2075050T3 (es) 1988-05-19 1989-05-17 Peptidos que tienen actividad cooperadora de celulas t.

Country Status (21)

Country Link
US (1) US5298490A (es)
EP (3) EP0342962B1 (es)
JP (1) JPH03504013A (es)
KR (1) KR900701296A (es)
CN (2) CN1037711A (es)
AR (1) AR246352A1 (es)
AT (1) ATE124956T1 (es)
AU (1) AU625598B2 (es)
BR (1) BR8906988A (es)
DE (1) DE68923401T2 (es)
DK (1) DK14890D0 (es)
ES (1) ES2075050T3 (es)
FI (1) FI94350C (es)
GR (1) GR3017451T3 (es)
HU (1) HU205142B (es)
IE (1) IE62555B1 (es)
IL (1) IL90229A (es)
NZ (1) NZ229004A (es)
PT (1) PT90596B (es)
RU (1) RU2060998C1 (es)
WO (1) WO1989011289A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU201095B (en) * 1988-06-14 1990-09-28 Richter Gedeon Vegyeszet New peptides inhibiting the activity of the immune system and pharmaceutical compositions comprising same, as well as process for producing these peptides and compositions
JPH03502930A (ja) * 1988-09-30 1991-07-04 イミユノバイオロジー・リサーチ・インスチチユート・インコーポレーテツド Ｔ細胞のサプレツサー活性を有するペプチド
US5332726A (en) * 1989-09-29 1994-07-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic peptides and pseudopeptides
US5053392A (en) * 1989-12-01 1991-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
DD292382B5 (de) * 1990-03-06 1994-03-24 Berlin Chemie Ag Verfahren zur herstellung eines parenteral applizierbaren lagerbestaendigen immunstimulierenden praeparats
DE4011207A1 (de) * 1990-04-06 1991-10-10 Stiefel Thomas Humane splenopentinderivate und verfahren zu deren herstellung
EP0668770A1 (en) * 1991-04-24 1995-08-30 Warner-Lambert Company $g(a)-SUBSTITUTED POLYPEPTIDES HAVING THERAPEUTIC ACTIVITY
JPH06501961A (ja) * 1991-08-26 1994-03-03 日本たばこ産業株式会社 免疫調節活性を有するシユードペンタペプチド
US5612310A (en) * 1993-05-24 1997-03-18 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5554638A (en) * 1993-05-24 1996-09-10 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5639729A (en) * 1993-08-26 1997-06-17 Immunobiology Research Institute, Inc. Tripeptides useful in immune and CNS therapy
GB9425582D0 (en) * 1994-12-19 1995-02-15 Iaf Biochem Int Peptides having immunomodulatory activity
EP0845987A4 (en) * 1995-08-08 2000-05-24 Fibrogen Inc C-PROTEINASE INHIBITORS FOR THE TREATMENT OF CONDITIONS RELATED TO COLLAGEN OVERPRODUCTION
US5843462A (en) 1995-11-30 1998-12-01 Regents Of The University Of Minnesota Diphtheria toxin epitopes
WO1999030736A2 (en) 1997-12-16 1999-06-24 Regents Of The University Of Minnesota Methods to treat undesirable immune responses
US7199102B2 (en) 2000-08-24 2007-04-03 The Regents Of The University Of California Orally administered peptides synergize statin activity
US7166578B2 (en) 2000-08-24 2007-01-23 The Regents Of The University Of California Orally administered peptides synergize statin activity
US8568766B2 (en) * 2000-08-24 2013-10-29 Gattadahalli M. Anantharamaiah Peptides and peptide mimetics to treat pathologies associated with eye disease
US7723303B2 (en) * 2000-08-24 2010-05-25 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
US7148197B2 (en) * 2000-08-24 2006-12-12 The Regents Of The University Of California Orally administered small peptides synergize statin activity
US7144862B2 (en) * 2000-08-24 2006-12-05 The Regents Of The University Of California Orally administered peptides to ameliorate atherosclerosis
WO2002060390A2 (en) * 2001-01-04 2002-08-08 Yale University Induction of immune responses to isoaspartyl-modified antigens
CN101065137A (zh) * 2004-09-16 2007-10-31 加利福尼亚大学董事会 用于改善动脉粥样硬化和其它病变的g型多肽和其它剂
US7579319B2 (en) 2004-12-06 2009-08-25 The Regents Of The University Of California Methods for improving the structure and function of arterioles
EP2269623A1 (en) * 2005-04-29 2011-01-05 The Regents of The University of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
US20080293639A1 (en) * 2005-04-29 2008-11-27 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
CA2649261A1 (en) * 2006-03-13 2007-09-20 Keio University Influenza infection-inhibiting peptide, influenza virus-infection inhibitor, liposome and influenza preventive/therapeutic agent
RU2301074C1 (ru) * 2006-05-30 2007-06-20 Общество С Ограниченной Ответственностью "Сиа Пептайдс" Пептид, обладающий иммуногеропротекторным действием, фармацевтическая композиция на его основе и способ ее применения
US8236766B2 (en) 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US8906859B2 (en) 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
NZ577107A (en) 2006-11-10 2012-01-12 Cara Therapeutics Inc Synthetic peptide amide ligands of the kappa opiod receptor
US7713937B2 (en) 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
AU2008296478B9 (en) * 2007-08-28 2015-03-19 The Uab Research Foundation Synthetic apolipoprotein E mimicking polypeptides and methods of use
EP2195340A4 (en) 2007-08-28 2011-05-11 Uab Research Foundation SYNTHETIC APOLIPOPROTEIN E-IMITATING POLYPEPTIDES AND METHOD OF USE
US10653747B2 (en) 2014-07-31 2020-05-19 Uab Research Foundation ApoE mimetic peptides and higher potency to clear plasma cholesterol

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1237918A (es) * 1967-08-08 1971-07-07
US4190646A (en) * 1975-11-11 1980-02-26 Sloan-Kettering Institute For Cancer Research Polypeptide compositions and methods
US4190647A (en) * 1979-01-26 1980-02-26 Sloan-Kettering Institute For Cancer Research Polypeptides and methods
US4261886A (en) * 1980-03-13 1981-04-14 Ortho Pharmaceutical Corporation Peptides having thymopoietin-like activity
CA1157466A (en) * 1979-04-12 1983-11-22 Gideon Goldstein Peptides having thymopoietin-like activity
FR2460290A1 (fr) * 1979-06-29 1981-01-23 Rhone Poulenc Ind Nouveaux tetra- ou pentapeptides, leur preparation et les medicaments qui les contiennent
DE2938420A1 (de) * 1979-09-22 1981-04-09 Hoechst Ag, 6000 Frankfurt Neue peptide und verfahren zu ihrer herstellung
US4309340A (en) * 1980-03-31 1982-01-05 American Home Products Corporation Polypeptide compositions
US4298523A (en) * 1980-06-17 1981-11-03 Ortho Pharmaceutical Corporation Methods and compositions for preparation of H-ARG-X-Z-Y-TYR-R
US4361673A (en) 1980-09-19 1982-11-30 American Home Products Corporation Polypeptide compositions
HU185263B (en) * 1981-06-12 1984-12-28 Richter Gedeon Vegyeszet Process for producing peptides effective on the immuncontroll analogous with the tp5
DE3146598A1 (de) * 1981-11-25 1983-07-07 Hoechst Ag, 6230 Frankfurt "neue peptide und verfahren zu ihrer herstellung"
US4614517A (en) * 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
DE3401545A1 (de) * 1983-08-03 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue peptide mit immunstimulierender wirkung, verfahren zu deren herstellung und deren verwendung
US4505853A (en) * 1983-11-18 1985-03-19 Ortho Pharmaceutical Corporation Enzyme-resistant immunomodulatory peptides
DE3421614A1 (de) * 1984-06-09 1985-12-12 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von pentapeptiden mit wirkung auf das immunsystem und zwischenprodukte dieses verfahrens
US4547489A (en) * 1984-06-11 1985-10-15 Ortho Pharmaceutical Corporation Conformationally restricted thymopentin-like compounds
US4629723A (en) * 1984-06-27 1986-12-16 Ortho Pharmaceutical Corporation Potent thymopentin analogs
IT1216908B (it) * 1987-03-19 1990-03-14 Eniricerche Spa Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche.
US5097013A (en) * 1988-07-14 1992-03-17 Kao Corporation Novel peptides possessing a macrophage chemotactic activity

Also Published As

Publication number Publication date
AU625598B2 (en) 1992-07-16
CN1104217A (zh) 1995-06-28
AR246352A1 (es) 1994-07-29
IE891542L (en) 1989-11-19
HU893392D0 (en) 1990-09-28
DE68923401T2 (de) 1996-02-01
EP0342962B1 (en) 1995-07-12
EP0602004A1 (en) 1994-06-15
PT90596A (pt) 1989-11-30
FI94350B (fi) 1995-05-15
EP0602003A1 (en) 1994-06-15
DK14890A (da) 1990-01-18
GR3017451T3 (en) 1995-12-31
CN1037711A (zh) 1989-12-06
US5298490A (en) 1994-03-29
IL90229A0 (en) 1989-12-15
IE62555B1 (en) 1995-02-08
HU205142B (en) 1992-03-30
ATE124956T1 (de) 1995-07-15
DK14890D0 (da) 1990-01-18
PT90596B (pt) 1994-09-30
DE68923401D1 (de) 1995-08-17
FI94350C (fi) 1995-08-25
IL90229A (en) 1995-12-08
BR8906988A (pt) 1990-12-18
EP0342962A3 (en) 1990-12-27
FI900267A0 (fi) 1990-01-17
WO1989011289A1 (en) 1989-11-30
RU2060998C1 (ru) 1996-05-27
JPH03504013A (ja) 1991-09-05
NZ229004A (en) 1993-09-27
AU3745589A (en) 1989-12-12
EP0342962A2 (en) 1989-11-23
KR900701296A (ko) 1990-12-01

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