AR008680A1 - Substitutos de plaquetas y metodos de conjugacion apropiados para su preparacion - Google Patents
Substitutos de plaquetas y metodos de conjugacion apropiados para su preparacionInfo
- Publication number
- AR008680A1 AR008680A1 ARP970104847A ARP970104847A AR008680A1 AR 008680 A1 AR008680 A1 AR 008680A1 AR P970104847 A ARP970104847 A AR P970104847A AR P970104847 A ARP970104847 A AR P970104847A AR 008680 A1 AR008680 A1 AR 008680A1
- Authority
- AR
- Argentina
- Prior art keywords
- substitutes
- platelets
- preparation
- fibrinogen
- methods suitable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
Los sustitutos de plaquetas, que comprenden fibrinogeno, o productos análogos que son utiles en terapia, comprenden en portador insoluble al cualestá adherido una proteína activa esencialmente no degradada que incluye la secuencia RGD. Dichos conjugados pueden prepararse mediante un procedimiento deconjugacion que comprende 0,01 a 2,5% en peso de fibrinogeno activo y no más de 50% de fibrinogeno inactivo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9621886.2A GB9621886D0 (en) | 1996-10-21 | 1996-10-21 | Microparticles and their therapeutic use |
GBGB9702652.0A GB9702652D0 (en) | 1997-02-10 | 1997-02-10 | Conjugates and their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
AR008680A1 true AR008680A1 (es) | 2000-02-09 |
Family
ID=26310263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970104847A AR008680A1 (es) | 1996-10-21 | 1997-10-20 | Substitutos de plaquetas y metodos de conjugacion apropiados para su preparacion |
Country Status (10)
Country | Link |
---|---|
US (1) | US5977313A (es) |
EP (1) | EP1028752B1 (es) |
JP (1) | JP2001504813A (es) |
AR (1) | AR008680A1 (es) |
AT (1) | ATE284714T1 (es) |
AU (1) | AU718956B2 (es) |
CA (1) | CA2269335C (es) |
DE (1) | DE69731985T2 (es) |
ES (1) | ES2232862T3 (es) |
WO (1) | WO1998017319A2 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6391343B1 (en) | 1991-01-15 | 2002-05-21 | Hemosphere, Inc. | Fibrinogen-coated particles for therapeutic use |
AU741528B2 (en) | 1997-06-05 | 2001-12-06 | Hemosphere, Inc. | Fibrinogen-coated microspheres |
GB9724143D0 (en) | 1997-11-14 | 1998-01-14 | Andaris Ltd | Pharmaceutical conjugate |
US20030021777A1 (en) * | 1998-02-20 | 2003-01-30 | Roy Harris | Product comprising bound fibrinogen and thrombin for use in wound therapy or surgical repair |
GB9825105D0 (en) * | 1998-11-16 | 1999-01-13 | Andaris Ltd | Pharamaceutical conjugates |
GB9827813D0 (en) * | 1998-12-17 | 1999-02-10 | Andaris Ltd | Pharmaceutical conjugates |
DE19926475A1 (de) * | 1999-06-10 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Träger-Pharmaka-Konjugate |
US20040126900A1 (en) * | 2001-04-13 | 2004-07-01 | Barry Stephen E | High affinity peptide- containing nanoparticles |
DE10135356C1 (de) * | 2001-07-20 | 2003-04-17 | Schering Ag | Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen |
US7906102B2 (en) | 2001-10-03 | 2011-03-15 | Vanderbilt University | Ligands to radiation-induced molecules |
US7306925B2 (en) * | 2001-11-09 | 2007-12-11 | Vanderbilt University | Phage antibodies to radiation-inducible neoantigens |
WO2003028640A2 (en) * | 2001-10-03 | 2003-04-10 | Vanderbilt University | In vivo panning for ligands to radiation-induced molecules |
GB0323378D0 (en) * | 2003-10-07 | 2003-11-05 | Univ Leicester | Therapeutic agent |
GB0516091D0 (en) * | 2005-08-04 | 2005-09-14 | Haemostatix Ltd | Therapeutic agent |
US20080015145A1 (en) * | 2006-07-11 | 2008-01-17 | Maria Gyongyossy-Issa | Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions |
GB0623607D0 (en) | 2006-11-27 | 2007-01-03 | Haemostatix Ltd | Tissue adhesive |
US20110077202A1 (en) | 2008-05-16 | 2011-03-31 | Bayer Healthcare Llc | Targeted Coagulation Factors and Method of Using the Same |
US9119897B2 (en) | 2009-05-28 | 2015-09-01 | Profibrix B.V. | Dry powder fibrin sealant |
GB201101740D0 (en) | 2011-02-01 | 2011-03-16 | Haemostatix Ltd | Therapeutic agents with improved fibrinogen binding |
WO2013019730A1 (en) | 2011-07-29 | 2013-02-07 | The Washington University | Antibodies to tip-1 and grp78 |
GB201201751D0 (en) | 2012-02-01 | 2012-03-14 | Haemostatix Ltd | Haemostatic wound dressing |
US8999376B2 (en) | 2012-02-03 | 2015-04-07 | Xcede Technologies, Inc. | Tissue patch |
GB201204868D0 (en) | 2012-03-20 | 2012-05-02 | San Raffaele Centro Fond | Peptides |
EP3172222A4 (en) | 2014-07-24 | 2018-03-21 | Washington University | Compositions targeting radiation-induced molecules and methods of use thereof |
US9540548B1 (en) | 2015-08-07 | 2017-01-10 | Xcede Technologies, Inc. | Adhesive compositions and related methods |
US10588998B2 (en) | 2015-08-07 | 2020-03-17 | Xcede Technologies, Inc. | Adhesive compositions and related methods |
US9833538B2 (en) | 2015-08-07 | 2017-12-05 | Xcede Technologies, Inc. | Adhesive compositions and related methods |
CN107686508B (zh) * | 2016-08-05 | 2021-02-12 | 首都医科大学 | 阿霉素-rgds,其合成,活性和应用 |
CN107686507B (zh) * | 2016-08-05 | 2021-02-12 | 首都医科大学 | Rgds-阿霉素,其合成,活性和应用 |
EP3634459A4 (en) | 2017-02-10 | 2021-01-06 | Washington University | ANTIBODIES DIRECTED AGAINST TIP1 AND THEIR PROCEDURES FOR USE |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8334499D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Derivatives |
GB8400653D0 (en) * | 1984-01-11 | 1984-02-15 | Beecham Group Plc | Conjugates |
US4666884A (en) * | 1984-04-10 | 1987-05-19 | New England Deaconess Hospital | Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls |
US4661471A (en) * | 1984-04-10 | 1987-04-28 | New England Deaconess Hospital | Method of inhibiting and inducing human platelet aggregation |
US5069936A (en) * | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
AU3149289A (en) * | 1988-03-18 | 1989-09-21 | Rockefeller University, The | Method and agent for inhibiting the binding of human polymorphonuclear leukocytes to endothelium and compositions therefor |
DE68924783T2 (de) * | 1988-09-30 | 1996-03-28 | Neorx Corp | Wässrige additivsysteme, verfahren und polymerteilchen. |
DE69118861T2 (de) * | 1991-01-10 | 1996-09-05 | Basf Corp | Verfahren zur Vernetzen von Gelatine und Aufnahme eines Materials |
US5616311A (en) * | 1991-01-15 | 1997-04-01 | Hemosphere, Inc. | Non-crosslinked protein particles for therapeutic and diagnostic use |
DE69124357T2 (de) * | 1991-01-15 | 1997-07-10 | Hemosphere Inc | Protein Nanomatrizen und Verfahren zur Herstellung |
US5725804A (en) * | 1991-01-15 | 1998-03-10 | Hemosphere, Inc. | Non-crosslinked protein particles for therapeutic and diagnostic use |
WO1992013495A1 (en) * | 1991-02-07 | 1992-08-20 | Fibratek, Inc. | Fibrinogen based adhesive |
WO1992013547A1 (en) * | 1991-02-07 | 1992-08-20 | Alexander Mellon Eaton | Drug delivery composition and method of using the same |
GB9107628D0 (en) * | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
WO1994013692A1 (en) * | 1992-12-10 | 1994-06-23 | Regents Of The University Of Minnesota | Polypeptides useful for treating inflammatory disorders |
GB9423419D0 (en) * | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
ES2191721T3 (es) * | 1994-12-16 | 2003-09-16 | Elan Drug Delivery Ltd | Microparticulas reticuladas y su utilizacion como vehiculos terapeuticos. |
EP0727225A3 (en) * | 1995-02-14 | 1997-01-15 | Sonus Pharma Inc | Compositions and methods for directed ultrasonic imaging |
AU6100296A (en) * | 1995-06-06 | 1996-12-24 | Hemosphere, Inc. | Protein particles for therapeutic and diagnostic use |
-
1997
- 1997-10-17 DE DE69731985T patent/DE69731985T2/de not_active Expired - Lifetime
- 1997-10-17 JP JP51910098A patent/JP2001504813A/ja active Pending
- 1997-10-17 CA CA2269335A patent/CA2269335C/en not_active Expired - Fee Related
- 1997-10-17 EP EP97909451A patent/EP1028752B1/en not_active Expired - Lifetime
- 1997-10-17 AT AT97909451T patent/ATE284714T1/de active
- 1997-10-17 US US08/953,514 patent/US5977313A/en not_active Expired - Lifetime
- 1997-10-17 WO PCT/GB1997/002877 patent/WO1998017319A2/en active IP Right Grant
- 1997-10-17 ES ES97909451T patent/ES2232862T3/es not_active Expired - Lifetime
- 1997-10-17 AU AU47135/97A patent/AU718956B2/en not_active Ceased
- 1997-10-20 AR ARP970104847A patent/AR008680A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
ES2232862T3 (es) | 2005-06-01 |
JP2001504813A (ja) | 2001-04-10 |
EP1028752A2 (en) | 2000-08-23 |
DE69731985T2 (de) | 2005-12-29 |
EP1028752B1 (en) | 2004-12-15 |
CA2269335C (en) | 2010-05-25 |
AU4713597A (en) | 1998-05-15 |
ATE284714T1 (de) | 2005-01-15 |
WO1998017319A2 (en) | 1998-04-30 |
CA2269335A1 (en) | 1998-04-30 |
US5977313A (en) | 1999-11-02 |
AU718956B2 (en) | 2000-05-04 |
WO1998017319A3 (en) | 1998-06-11 |
DE69731985D1 (de) | 2005-01-20 |
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