ES473087A1 - Procedimiento para la preparacion de eritrocitos intactos modificados. - Google Patents

Procedimiento para la preparacion de eritrocitos intactos modificados.

Info

Publication number
ES473087A1
ES473087A1 ES473087A ES473087A ES473087A1 ES 473087 A1 ES473087 A1 ES 473087A1 ES 473087 A ES473087 A ES 473087A ES 473087 A ES473087 A ES 473087A ES 473087 A1 ES473087 A1 ES 473087A1
Authority
ES
Spain
Prior art keywords
blood
preparation
erythrocytes
modified intact
intact erythrocytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES473087A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Studiengesellschaft Kohle gGmbH
Original Assignee
Studiengesellschaft Kohle gGmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19772740053 external-priority patent/DE2740053A1/de
Application filed by Studiengesellschaft Kohle gGmbH filed Critical Studiengesellschaft Kohle gGmbH
Priority claimed from DE19782820603 external-priority patent/DE2820603A1/de
Publication of ES473087A1 publication Critical patent/ES473087A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la preparación de eritrocitos intactos modificados, que garantizan una cesión mejorada de oxígeno de la sangre, y a los que son incorporados irreversiblemente efectores alostéricos con ayuda de vesículas de lípidos y estos efectores alostéricos son fijados a la hemoglobina en los eritrocitos, caracterizado porque se incorporan de modo irreversible vesículas de lípidos cargadas con efectores alostéricos en fluídos vehículos en el interior de los eritrocitos, y se fijan los efectores alostéricos a la hemoglobina en los eritrocitos.
ES473087A 1977-09-06 1978-05-09 Procedimiento para la preparacion de eritrocitos intactos modificados. Expired ES473087A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19772740053 DE2740053A1 (de) 1977-09-06 1977-09-06 Verwendung von allosterischen effektoren mit hilfe von lipidvesikeln ueber eine irreversible inkorporierung zwecks verbesserter o tief 2 -entladung des haemoglobins in erythrozyten
DE19782820603 DE2820603A1 (de) 1978-05-11 1978-05-11 Modifizierte intakte erythrozyten und sie enthaltendes blut bzw. blutkonserven

Publications (1)

Publication Number Publication Date
ES473087A1 true ES473087A1 (es) 1979-04-16

Family

ID=25772674

Family Applications (1)

Application Number Title Priority Date Filing Date
ES473087A Expired ES473087A1 (es) 1977-09-06 1978-05-09 Procedimiento para la preparacion de eritrocitos intactos modificados.

Country Status (12)

Country Link
EP (1) EP0001104B1 (es)
JP (1) JPS6022683B2 (es)
AT (1) AT364086B (es)
AU (1) AU524587B2 (es)
CA (1) CA1130724A (es)
DE (1) DE2860719D1 (es)
DK (1) DK393878A (es)
ES (1) ES473087A1 (es)
IE (1) IE47329B1 (es)
IN (1) IN149223B (es)
IT (1) IT1111675B (es)
YU (1) YU208078A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
FR2529463B1 (fr) * 1982-07-05 1986-01-10 Centre Nat Rech Scient Procede et dispositif pour l'encapsulation dans les erythrocytes d'au moins une substance a activite biologique, notamment des effecteurs allosteriques de l'hemoglobine et erythrocytes ainsi obtenus
NL8403425A (nl) * 1984-11-09 1986-06-02 Stichting Gastransport Stromavrije hemoglobine-oplossing, werkwijze voor de bereiding daarvan en toepassing daarvan.
JPS6461426A (en) * 1987-08-31 1989-03-08 Terumo Corp Artificial erythrocyte
JPH01305033A (ja) * 1988-06-01 1989-12-08 Sanwa Kagaku Kenkyusho Co Ltd 循環改善剤及び循環改善機能性食品並びにし好品
JPH01305032A (ja) * 1988-06-01 1989-12-08 Sanwa Kagaku Kenkyusho Co Ltd 機能後退性消耗疾患治療予防剤及び飲食、し好物
US4849416A (en) * 1988-07-25 1989-07-18 Rorer Pharmaceutical Corporation Treatment of conditions requiring enhanced oxygen availability to mammalian tissues
GB9225588D0 (en) 1992-12-08 1993-01-27 Univ Montfort Improving effectiveness of drugs
KR101376895B1 (ko) * 2004-05-03 2014-03-25 헤르메스 바이오사이언스, 인코포레이티드 약물 전달에 유용한 리포좀

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2249552A1 (de) * 1971-10-12 1973-05-30 Inchema S A Verfahren zur inkapsulation von insbesondere wasserloeslichen verbindungen

Also Published As

Publication number Publication date
IE781800L (en) 1979-03-06
EP0001104B1 (de) 1981-05-20
DE2860719D1 (en) 1981-08-27
EP0001104A2 (de) 1979-03-21
AT364086B (de) 1981-09-25
AU3955178A (en) 1980-03-13
DK393878A (da) 1979-03-07
ATA642478A (de) 1981-02-15
CA1130724A (en) 1982-08-31
IT1111675B (it) 1986-01-13
IN149223B (es) 1981-10-10
JPS6022683B2 (ja) 1985-06-03
IT7827388A0 (it) 1978-09-06
AU524587B2 (en) 1982-09-23
YU208078A (en) 1984-02-29
JPS5449314A (en) 1979-04-18
IE47329B1 (en) 1984-02-22
EP0001104A3 (en) 1979-04-04

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971201