MX9304540A - Tensioactivos pulmonares peptidicos y combinaciones terapeuticas. - Google Patents

Tensioactivos pulmonares peptidicos y combinaciones terapeuticas.

Info

Publication number
MX9304540A
MX9304540A MX9304540A MX9304540A MX9304540A MX 9304540 A MX9304540 A MX 9304540A MX 9304540 A MX9304540 A MX 9304540A MX 9304540 A MX9304540 A MX 9304540A MX 9304540 A MX9304540 A MX 9304540A
Authority
MX
Mexico
Prior art keywords
peptidic
therapeutic combinations
lung surfactants
peptides
polypeptide
Prior art date
Application number
MX9304540A
Other languages
English (en)
Inventor
Larry R Mclean
J Vincent Edwards
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of MX9304540A publication Critical patent/MX9304540A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se proporciona un tensioactivo pulmonar sintético que consiste de un complejo de un polipéptido de 3-4 residuos aminoácidos que tienen una estructura alfa-helicoidal y un grupo asilo de cadena larga unido covalentemente. Los péptidos son útiles cuando consisten en uno o más lípidos asociados en combinación en condiciones asociadas con el malestar respiratorio.
MX9304540A 1992-07-29 1993-07-28 Tensioactivos pulmonares peptidicos y combinaciones terapeuticas. MX9304540A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92227992A 1992-07-29 1992-07-29
US7780193A 1993-06-21 1993-06-21

Publications (1)

Publication Number Publication Date
MX9304540A true MX9304540A (es) 1994-02-28

Family

ID=26759683

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9304540A MX9304540A (es) 1992-07-29 1993-07-28 Tensioactivos pulmonares peptidicos y combinaciones terapeuticas.

Country Status (12)

Country Link
US (1) US5861481A (es)
EP (1) EP0656902B1 (es)
JP (1) JPH07509714A (es)
KR (1) KR100279540B1 (es)
AT (1) ATE161271T1 (es)
AU (1) AU671850B2 (es)
DE (1) DE69315849T2 (es)
ES (1) ES2114061T3 (es)
IL (1) IL106476A0 (es)
MX (1) MX9304540A (es)
NZ (1) NZ254503A (es)
WO (1) WO1994003485A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO161196A0 (en) * 1996-08-13 1996-09-05 Commonwealth Scientific And Industrial Research Organisation Novel compounds
US6660833B1 (en) * 2000-02-29 2003-12-09 Harbor-Ucla Research And Education Institute Respiratory distress syndrome therapy with peptide analogs of human SP-B
CA2654008C (en) * 2006-06-01 2015-11-24 Therapeutic Peptides, Inc. Polymeric biosurfactants
US20100284969A1 (en) * 2007-06-05 2010-11-11 Frank Guarnieri Methods and Compositions for Delivery of Medicaments to the Lungs
EP2331048B1 (en) * 2008-05-29 2019-07-10 Donald Owen Oligomeric biosurfactants
US9289388B2 (en) 2008-12-10 2016-03-22 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
US10836791B2 (en) * 2016-09-15 2020-11-17 Dsm Ip Assets B.V. Compounds
CN111568853B (zh) * 2020-04-30 2023-07-28 杭州濡湜生物科技有限公司 一种新型肺部智能释药系统

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
AR245141A1 (es) * 1988-07-01 1993-12-30 Merrell Dow Pharma Procedimiento de sintesis secuencial o de bloques en fase solida para preparar polipeptidos de estructura helicoidal.
AU655831B2 (en) * 1991-08-22 1995-01-12 Merrell Pharmaceuticals Inc. Novel orally-active elastase inhibitors

Also Published As

Publication number Publication date
WO1994003485A1 (en) 1994-02-17
AU4660793A (en) 1994-03-03
JPH07509714A (ja) 1995-10-26
ATE161271T1 (de) 1998-01-15
NZ254503A (en) 1996-08-27
DE69315849T2 (de) 1998-05-14
EP0656902B1 (en) 1997-12-17
US5861481A (en) 1999-01-19
IL106476A0 (en) 1993-11-15
AU671850B2 (en) 1996-09-12
KR100279540B1 (ko) 2001-02-01
DE69315849D1 (de) 1998-01-29
EP0656902A1 (en) 1995-06-14
ES2114061T3 (es) 1998-05-16
KR950702574A (ko) 1995-07-29

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