RU93005126A - Гелонин, днк - Google Patents

Гелонин, днк

Info

Publication number
RU93005126A
RU93005126A RU93005126/04A RU93005126A RU93005126A RU 93005126 A RU93005126 A RU 93005126A RU 93005126/04 A RU93005126/04 A RU 93005126/04A RU 93005126 A RU93005126 A RU 93005126A RU 93005126 A RU93005126 A RU 93005126A
Authority
RU
Russia
Prior art keywords
gelonin
dna
cell
receptors
polypeptide
Prior art date
Application number
RU93005126/04A
Other languages
English (en)
Other versions
RU2104285C1 (ru
Inventor
Розенблюм Маукл
Аггарвал Бхарат
Дж.Кор Уилльям
Original Assignee
Рисерч Дивелопмент Фаундейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рисерч Дивелопмент Фаундейшн filed Critical Рисерч Дивелопмент Фаундейшн
Priority claimed from PCT/US1991/005766 external-priority patent/WO1992003144A1/en
Publication of RU93005126A publication Critical patent/RU93005126A/ru
Application granted granted Critical
Publication of RU2104285C1 publication Critical patent/RU2104285C1/ru

Links

Claims (1)

  1. Кодирующая ДНК и аминокислотная последовательность гелонина или полипептида, которые ингибируют синтез белка в клетке, но не могут связываться с рецепторами на поверхности клетки.
RU93005126A 1990-08-14 1991-08-14 Пептид-гелонин RU2104285C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56722090A 1990-08-14 1990-08-14
US567220 1990-08-14
PCT/US1991/005766 WO1992003144A1 (en) 1990-08-14 1991-08-14 Protein structure of the plant toxin gelonin

Publications (2)

Publication Number Publication Date
RU93005126A true RU93005126A (ru) 1995-02-20
RU2104285C1 RU2104285C1 (ru) 1998-02-10

Family

ID=24266242

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93005126A RU2104285C1 (ru) 1990-08-14 1991-08-14 Пептид-гелонин

Country Status (22)

Country Link
US (2) US5631348A (ru)
EP (1) EP0546087B1 (ru)
JP (1) JPH06502847A (ru)
KR (1) KR100220502B1 (ru)
CN (1) CN1055123C (ru)
AT (1) ATE150791T1 (ru)
CA (1) CA2088068C (ru)
DE (1) DE69125381T2 (ru)
DK (1) DK0546087T3 (ru)
ES (1) ES2100960T3 (ru)
FI (1) FI112492B (ru)
GR (1) GR3023593T3 (ru)
HK (1) HK1006727A1 (ru)
IE (1) IE912716A1 (ru)
IL (1) IL99079A (ru)
NO (1) NO309656B1 (ru)
NZ (1) NZ239249A (ru)
PT (1) PT98669B (ru)
RU (1) RU2104285C1 (ru)
SA (1) SA92130322B1 (ru)
WO (1) WO1992003144A1 (ru)
ZA (1) ZA916171B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ237688A (en) * 1990-04-19 1993-01-27 Res Dev Foundation Antibody-cytotoxic immunoconjugate-containing compositions and cancer treatment
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin
RU2142015C1 (ru) * 1991-09-06 1999-11-27 Рисерч Дивелопмент Фаундейшн Фрагмент днк, кодирующий белок гелонина, и способ его получения, вектор, обеспечивающий экспрессию белка гелонина, рекомбинантный штамм e.coli - продуцент белка гелонина
US5621083A (en) * 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US6599505B1 (en) * 1992-04-10 2003-07-29 Research Development Foundation Immunotoxins directed against CD33 related surface antigens
AU4554493A (en) * 1992-07-07 1994-01-31 Eleanor N. Fish Interferon receptor binding peptides
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
JP2004535202A (ja) * 2001-07-17 2004-11-25 リサーチ　ディベロップメント　ファンデーション アポトーシス促進性蛋白質を含む治療剤
WO2003105761A2 (en) * 2002-06-12 2003-12-24 Research Development Foundation Immunotoxin as a therapeutic agent and uses thereof
CA2595904A1 (en) * 2005-02-01 2006-08-10 Research Development Foundation Blys fusion proteins for targeting blys receptor and methods for treatment of b-cell proliferative disorders
WO2014127211A1 (en) 2013-02-15 2014-08-21 Research Development Foundation Deimmunized gelonin molecules and therapies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446240A (en) * 1981-01-30 1984-05-01 Nerenberg Samuel T Pancreas specific protein systems
US4921802A (en) * 1983-05-05 1990-05-01 Pioneer Hi-Bred International, Inc. Plant virus cDNA
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin
US4810648A (en) * 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
WO1989004839A1 (en) 1987-11-24 1989-06-01 Genetics Institute, Inc. Improved ricin molecules and ricin toxin conjugates
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein
IE62463B1 (en) * 1988-07-07 1995-02-08 Res Dev Foundation Immunoconjugates for cancer diagnosis and therapy
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin

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