FI112492B - Kasvitoksiini geloniinia koodaava DNA-sekvenssi - Google Patents

Kasvitoksiini geloniinia koodaava DNA-sekvenssi Download PDF

Info

Publication number
FI112492B
FI112492B FI930626A FI930626A FI112492B FI 112492 B FI112492 B FI 112492B FI 930626 A FI930626 A FI 930626A FI 930626 A FI930626 A FI 930626A FI 112492 B FI112492 B FI 112492B
Authority
FI
Finland
Prior art keywords
gelonin
eller
protein
sequence
dna sequence
Prior art date
Application number
FI930626A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI930626A (fi
FI930626A0 (fi
Inventor
Bharat Aggarwal
Michael Rosenblum
William J Kohr
Original Assignee
Res Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Dev Foundation filed Critical Res Dev Foundation
Publication of FI930626A publication Critical patent/FI930626A/fi
Publication of FI930626A0 publication Critical patent/FI930626A0/fi
Application granted granted Critical
Publication of FI112492B publication Critical patent/FI112492B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/55Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
FI930626A 1990-08-14 1993-02-12 Kasvitoksiini geloniinia koodaava DNA-sekvenssi FI112492B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56722090A 1990-08-14 1990-08-14
US56722090 1990-08-14
PCT/US1991/005766 WO1992003144A1 (en) 1990-08-14 1991-08-14 Protein structure of the plant toxin gelonin
US9105766 1991-08-14

Publications (3)

Publication Number Publication Date
FI930626A FI930626A (fi) 1993-02-12
FI930626A0 FI930626A0 (fi) 1993-02-12
FI112492B true FI112492B (fi) 2003-12-15

Family

ID=24266242

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930626A FI112492B (fi) 1990-08-14 1993-02-12 Kasvitoksiini geloniinia koodaava DNA-sekvenssi

Country Status (22)

Country Link
US (2) US5631348A (ru)
EP (1) EP0546087B1 (ru)
JP (1) JPH06502847A (ru)
KR (1) KR100220502B1 (ru)
CN (1) CN1055123C (ru)
AT (1) ATE150791T1 (ru)
CA (1) CA2088068C (ru)
DE (1) DE69125381T2 (ru)
DK (1) DK0546087T3 (ru)
ES (1) ES2100960T3 (ru)
FI (1) FI112492B (ru)
GR (1) GR3023593T3 (ru)
HK (1) HK1006727A1 (ru)
IE (1) IE912716A1 (ru)
IL (1) IL99079A (ru)
NO (1) NO309656B1 (ru)
NZ (1) NZ239249A (ru)
PT (1) PT98669B (ru)
RU (1) RU2104285C1 (ru)
SA (1) SA92130322B1 (ru)
WO (1) WO1992003144A1 (ru)
ZA (1) ZA916171B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE62496B1 (en) * 1990-04-19 1995-02-08 Res Dev Foundation Antibody conjugates for treatment of neoplastic disease
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin
RU2142015C1 (ru) * 1991-09-06 1999-11-27 Рисерч Дивелопмент Фаундейшн Фрагмент днк, кодирующий белок гелонина, и способ его получения, вектор, обеспечивающий экспрессию белка гелонина, рекомбинантный штамм e.coli - продуцент белка гелонина
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US5621083A (en) * 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US6599505B1 (en) * 1992-04-10 2003-07-29 Research Development Foundation Immunotoxins directed against CD33 related surface antigens
US5684129A (en) * 1992-07-07 1997-11-04 Fish; Eleanor N. Interferon receptor binding peptides
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
US7101977B2 (en) * 2001-07-17 2006-09-05 Research Development Foundation Therapeutic agents comprising pro-apoptotic proteins
WO2003105761A2 (en) * 2002-06-12 2003-12-24 Research Development Foundation Immunotoxin as a therapeutic agent and uses thereof
WO2006083961A2 (en) * 2005-02-01 2006-08-10 Research Development Foundation Blys fusion proteins for targeting blys receptor and methods for treatment of b-cell proliferative disorders
US9388397B2 (en) * 2013-02-15 2016-07-12 Research Development Foundation Deimmunized gelonin molecules and therapies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446240A (en) * 1981-01-30 1984-05-01 Nerenberg Samuel T Pancreas specific protein systems
US4921802A (en) * 1983-05-05 1990-05-01 Pioneer Hi-Bred International, Inc. Plant virus cDNA
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin
US4810648A (en) * 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
EP0341304A4 (en) 1987-11-24 1991-01-30 Genetics Institute, Inc. Improved ricin molecules and ricin toxin conjugates
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein
IE62463B1 (en) * 1988-07-07 1995-02-08 Res Dev Foundation Immunoconjugates for cancer diagnosis and therapy
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin

Also Published As

Publication number Publication date
US5631348A (en) 1997-05-20
EP0546087A4 (ru) 1994-01-05
IL99079A0 (en) 1992-07-15
NO930428D0 (no) 1993-02-08
NO309656B1 (no) 2001-03-05
DE69125381D1 (de) 1997-04-30
KR930701487A (ko) 1993-06-11
NO930428L (no) 1993-03-29
RU2104285C1 (ru) 1998-02-10
EP0546087A1 (en) 1993-06-16
WO1992003144A1 (en) 1992-03-05
CN1055123C (zh) 2000-08-02
CA2088068C (en) 1999-06-15
NZ239249A (en) 1992-10-28
IE912716A1 (en) 1992-02-26
ES2100960T3 (es) 1997-07-01
CN1058990A (zh) 1992-02-26
GR3023593T3 (en) 1997-08-29
USRE37462E1 (en) 2001-12-04
ATE150791T1 (de) 1997-04-15
EP0546087B1 (en) 1997-03-26
HK1006727A1 (en) 1999-03-12
DK0546087T3 (da) 1997-09-22
IL99079A (en) 1998-09-24
FI930626A (fi) 1993-02-12
AU8624091A (en) 1992-03-17
ZA916171B (en) 1992-04-29
KR100220502B1 (ko) 1999-10-01
AU653365B2 (en) 1994-09-29
SA92130322B1 (ar) 2004-05-25
FI930626A0 (fi) 1993-02-12
JPH06502847A (ja) 1994-03-31
PT98669A (pt) 1992-07-31
PT98669B (pt) 1999-01-29
CA2088068A1 (en) 1992-02-15
DE69125381T2 (de) 1997-07-03

Similar Documents

Publication Publication Date Title
Simonds et al. Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells.
FI112492B (fi) Kasvitoksiini geloniinia koodaava DNA-sekvenssi
CN103987728B (zh) 抗癌融合蛋白
JPH07506842A (ja) 二本鎖を有する非毒性リボソーム不活性化蛋白(rip),その製法および適用
CN108456254B (zh) 一种tcs-穿膜肽-肿瘤蛋白酶底物肽融合蛋白、其制备方法和用途
HU225738B1 (en) Recombinant mistletoe lectin
JP2829405B2 (ja) 機能性ポリペプチド
Schoentgen et al. Complete amino acid sequence of ostrich (Struthio camelus) egg‐white lysozyme, a goose‐type lysozyme
CN111363048B (zh) 一种具有穿膜活性的可溶性重组苦荞金属硫蛋白FtMT及其制备方法
Kanaya et al. Comparison of the primary structures of ribonuclease U2 isoforms
CA2010256C (en) Protein anti-cancer agent
Pescatori et al. The cloning of a cDNA encoding a protein (latrodectin) which co‐purifies with the α‐latrotoxin from the black widow spider Latrodectus tredecimguttatus (Theridiidae)
Park et al. Isolation and characterization of β-galactoside specific lectin from Korean mistletoe (Viscum album var. coloratum) with lactose-BSA-Sepharose 4B and changes of lectin conformation
JPH02152990A (ja) 細胞接着活性ポリペプチド
AU653365C (en) Protein structure of the plant toxin gelonin
JPH10505835A (ja) 特定の細胞型への化学試薬の細胞内送達
JP3104178B2 (ja) 機能性ポリペプチド
KR101254004B1 (ko) 세포 투과성 설피레독신 융합 단백질을 포함하는 염증 예방 및 치료용 조성물
EP0609242B1 (de) Neues thrombininhibitorisches protein aus zecken
CN109942715A (zh) 一种靶向治疗肿瘤的重组融合蛋白及其制备方法和应用
EP2768520A1 (en) Chemically and thermodynamically stable insulin analogues and improved methods for their production
WO2012091590A1 (en) A recombinant cytotoxin as well as a method of producing it
US5827731A (en) Thrombin-inhibitory protein from ticks
JPH03218400A (ja) 甘味誘導物質
JPH0335793A (ja) 修正されたpe↓4↓0の産生