FI112492B - DNA-sekvens som kodar för växttoxin gelonin - Google Patents

DNA-sekvens som kodar för växttoxin gelonin Download PDF

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Publication number
FI112492B
FI112492B FI930626A FI930626A FI112492B FI 112492 B FI112492 B FI 112492B FI 930626 A FI930626 A FI 930626A FI 930626 A FI930626 A FI 930626A FI 112492 B FI112492 B FI 112492B
Authority
FI
Finland
Prior art keywords
gelonin
eller
protein
sequence
dna sequence
Prior art date
Application number
FI930626A
Other languages
English (en)
Finnish (fi)
Other versions
FI930626A (fi
FI930626A0 (fi
Inventor
Bharat Aggarwal
Michael Rosenblum
William J Kohr
Original Assignee
Res Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Dev Foundation filed Critical Res Dev Foundation
Publication of FI930626A publication Critical patent/FI930626A/fi
Publication of FI930626A0 publication Critical patent/FI930626A0/fi
Application granted granted Critical
Publication of FI112492B publication Critical patent/FI112492B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
FI930626A 1990-08-14 1993-02-12 DNA-sekvens som kodar för växttoxin gelonin FI112492B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56722090A 1990-08-14 1990-08-14
US56722090 1990-08-14
PCT/US1991/005766 WO1992003144A1 (en) 1990-08-14 1991-08-14 Protein structure of the plant toxin gelonin
US9105766 1991-08-14

Publications (3)

Publication Number Publication Date
FI930626A FI930626A (fi) 1993-02-12
FI930626A0 FI930626A0 (fi) 1993-02-12
FI112492B true FI112492B (sv) 2003-12-15

Family

ID=24266242

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930626A FI112492B (sv) 1990-08-14 1993-02-12 DNA-sekvens som kodar för växttoxin gelonin

Country Status (22)

Country Link
US (2) US5631348A (sv)
EP (1) EP0546087B1 (sv)
JP (1) JPH06502847A (sv)
KR (1) KR100220502B1 (sv)
CN (1) CN1055123C (sv)
AT (1) ATE150791T1 (sv)
CA (1) CA2088068C (sv)
DE (1) DE69125381T2 (sv)
DK (1) DK0546087T3 (sv)
ES (1) ES2100960T3 (sv)
FI (1) FI112492B (sv)
GR (1) GR3023593T3 (sv)
HK (1) HK1006727A1 (sv)
IE (1) IE912716A1 (sv)
IL (1) IL99079A (sv)
NO (1) NO309656B1 (sv)
NZ (1) NZ239249A (sv)
PT (1) PT98669B (sv)
RU (1) RU2104285C1 (sv)
SA (1) SA92130322B1 (sv)
WO (1) WO1992003144A1 (sv)
ZA (1) ZA916171B (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE62496B1 (en) * 1990-04-19 1995-02-08 Res Dev Foundation Antibody conjugates for treatment of neoplastic disease
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin
EP0602144B1 (en) * 1991-09-06 1998-11-04 Research Development Foundation Dna sequences encoding gelonin polypeptide
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US5621083A (en) * 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US6599505B1 (en) * 1992-04-10 2003-07-29 Research Development Foundation Immunotoxins directed against CD33 related surface antigens
US5684129A (en) * 1992-07-07 1997-11-04 Fish; Eleanor N. Interferon receptor binding peptides
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
US7101977B2 (en) * 2001-07-17 2006-09-05 Research Development Foundation Therapeutic agents comprising pro-apoptotic proteins
CA2488858A1 (en) * 2002-06-12 2003-12-24 Research Development Foundation Immunotoxin as a therapeutic agent and uses thereof
WO2006083961A2 (en) * 2005-02-01 2006-08-10 Research Development Foundation Blys fusion proteins for targeting blys receptor and methods for treatment of b-cell proliferative disorders
WO2014127211A1 (en) 2013-02-15 2014-08-21 Research Development Foundation Deimmunized gelonin molecules and therapies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446240A (en) * 1981-01-30 1984-05-01 Nerenberg Samuel T Pancreas specific protein systems
US4921802A (en) * 1983-05-05 1990-05-01 Pioneer Hi-Bred International, Inc. Plant virus cDNA
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin
US4810648A (en) * 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
JPH02502287A (ja) 1987-11-24 1990-07-26 ジェネティックス・インスティテュート・インコーポレイテッド 改良されたリシン分子およびリシン毒素コンジュゲート
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein
IE62463B1 (en) * 1988-07-07 1995-02-08 Res Dev Foundation Immunoconjugates for cancer diagnosis and therapy
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin

Also Published As

Publication number Publication date
RU2104285C1 (ru) 1998-02-10
NZ239249A (en) 1992-10-28
ES2100960T3 (es) 1997-07-01
CA2088068A1 (en) 1992-02-15
EP0546087A1 (en) 1993-06-16
NO930428L (no) 1993-03-29
IE912716A1 (en) 1992-02-26
KR100220502B1 (ko) 1999-10-01
EP0546087B1 (en) 1997-03-26
DK0546087T3 (da) 1997-09-22
GR3023593T3 (en) 1997-08-29
DE69125381D1 (de) 1997-04-30
HK1006727A1 (en) 1999-03-12
AU8624091A (en) 1992-03-17
EP0546087A4 (sv) 1994-01-05
CN1055123C (zh) 2000-08-02
CA2088068C (en) 1999-06-15
FI930626A (fi) 1993-02-12
JPH06502847A (ja) 1994-03-31
IL99079A0 (en) 1992-07-15
ZA916171B (en) 1992-04-29
NO930428D0 (no) 1993-02-08
AU653365B2 (en) 1994-09-29
USRE37462E1 (en) 2001-12-04
NO309656B1 (no) 2001-03-05
ATE150791T1 (de) 1997-04-15
PT98669B (pt) 1999-01-29
WO1992003144A1 (en) 1992-03-05
US5631348A (en) 1997-05-20
KR930701487A (ko) 1993-06-11
DE69125381T2 (de) 1997-07-03
CN1058990A (zh) 1992-02-26
FI930626A0 (fi) 1993-02-12
SA92130322B1 (ar) 2004-05-25
IL99079A (en) 1998-09-24
PT98669A (pt) 1992-07-31

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