DE3789041T2 - Reagenz für Beseitigung von Schutzgruppen in peptidischer Synthese. - Google Patents

Reagenz für Beseitigung von Schutzgruppen in peptidischer Synthese.

Info

Publication number
DE3789041T2
DE3789041T2 DE3789041T DE3789041T DE3789041T2 DE 3789041 T2 DE3789041 T2 DE 3789041T2 DE 3789041 T DE3789041 T DE 3789041T DE 3789041 T DE3789041 T DE 3789041T DE 3789041 T2 DE3789041 T2 DE 3789041T2
Authority
DE
Germany
Prior art keywords
deprotection
reagent
peptide synthesis
peptide
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3789041T
Other languages
English (en)
Other versions
DE3789041D1 (de
Inventor
Haruaki Yajima
Nobutaka Fujii
Gilberto M Guterres
Tatsuhiko Honguu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shin Etsu Chemical Co Ltd
Original Assignee
Shin Etsu Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shin Etsu Chemical Co Ltd filed Critical Shin Etsu Chemical Co Ltd
Application granted granted Critical
Publication of DE3789041D1 publication Critical patent/DE3789041D1/de
Publication of DE3789041T2 publication Critical patent/DE3789041T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/122—Hydrolysis with acids different from HF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE3789041T 1986-10-09 1987-10-08 Reagenz für Beseitigung von Schutzgruppen in peptidischer Synthese. Expired - Fee Related DE3789041T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61239059A JPS6393796A (ja) 1986-10-09 1986-10-09 ペプチド合成の脱保護基用薬剤

Publications (2)

Publication Number Publication Date
DE3789041D1 DE3789041D1 (de) 1994-03-24
DE3789041T2 true DE3789041T2 (de) 1994-06-16

Family

ID=17039254

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3789041T Expired - Fee Related DE3789041T2 (de) 1986-10-09 1987-10-08 Reagenz für Beseitigung von Schutzgruppen in peptidischer Synthese.

Country Status (4)

Country Link
US (1) US4950418A (de)
EP (1) EP0264063B1 (de)
JP (1) JPS6393796A (de)
DE (1) DE3789041T2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002138A1 (en) * 1988-08-18 1990-03-08 The Rockefeller University Deprotection of protected peptides
SE9401079L (sv) * 1994-03-30 1995-10-01 Anders Unden Nya derivat av asparaginsyra och glutaminsyra som är skyddade på sidokedjans karboxylsyragrupp form av estrar som försvårar aspartimidbildning vid fastfassyntes av peptider
JP4729752B2 (ja) * 2004-07-02 2011-07-20 国立大学法人大阪大学 アセタールの選択的脱保護法
US9969769B2 (en) 2014-12-19 2018-05-15 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
US10308677B2 (en) 2014-12-19 2019-06-04 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
WO2018225851A1 (ja) 2017-06-09 2018-12-13 中外製薬株式会社 Ｎ－置換アミノ酸を含むペプチドの合成方法
JPWO2020111238A1 (ja) * 2018-11-30 2021-10-21 中外製薬株式会社 ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3163800D1 (en) * 1980-02-12 1984-07-05 Takeda Chemical Industries Ltd Method for protecting guanidino group and restoring the same
JPS58134065A (ja) * 1982-02-03 1983-08-10 Kaken Pharmaceut Co Ltd ペプチドおよびそれを有効成分とするホルモン剤
FR2567524B1 (fr) * 1984-07-10 1987-11-27 Sanofi Sa Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires
US4689432A (en) * 1984-09-07 1987-08-25 The Regents Of The University Of California Chelators whose affinity for calcium is decreased by illumination
HUT39739A (en) * 1984-12-04 1986-10-29 Ciba Geigy Ag Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
JPS61204193A (ja) * 1985-03-05 1986-09-10 Takeda Chem Ind Ltd シトシンヌクレオシド類の製造法
US4731362A (en) * 1985-08-05 1988-03-15 Shionogi & Co., Ltd. Alkylcarbamoyloxymethylcephem compounds
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof
US4684722A (en) * 1986-01-06 1987-08-04 E. R. Squibb & Sons, Inc. Monosulfactams

Also Published As

Publication number Publication date
EP0264063A2 (de) 1988-04-20
EP0264063A3 (en) 1990-02-14
JPS6393796A (ja) 1988-04-25
EP0264063B1 (de) 1994-02-09
JPH0567158B2 (de) 1993-09-24
US4950418A (en) 1990-08-21
DE3789041D1 (de) 1994-03-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee