ES2182821T3 - Peptidos tensioactivos pulmonares sinteticos. - Google Patents
Peptidos tensioactivos pulmonares sinteticos.Info
- Publication number
- ES2182821T3 ES2182821T3 ES92912964T ES92912964T ES2182821T3 ES 2182821 T3 ES2182821 T3 ES 2182821T3 ES 92912964 T ES92912964 T ES 92912964T ES 92912964 T ES92912964 T ES 92912964T ES 2182821 T3 ES2182821 T3 ES 2182821T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- synthetic pulmonary
- peptides
- tensioactive
- acid residues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
LA INVENCION CONTEMPLA SURFACTANTES PULMONARES SINTETICOS. EN UNA CONFORMACION, UN SURFACTANTE PULMONAR SINTETICO DE LA INVENCION COMPRENDE UN FOSFOLIPIDO FARMACOLOGICAMENTE ACEPTABLE MEZCLADO CON UN POLIPEPTIDO QUE COMPRENDE AL MENOS 10 RESIDUOS DE AMINOACIDOS Y NO MAS DE 60 RESIDUOS DE AMINOACIDO, EN DONDE EL POLIPEPTIDO INCLUYE UNA SECUENCIA QUE TIENE REGIONES DE RESIDUOS DE AMINOACIDO ALTERNATIVAMENTE HIDROFOBICOS E HIDROFILICOS REPRESENTADOS POR LA FORMULA (ZAUB)CZ. EN VARIAS CONFORMACIONES ALTERNATIVAS, Z ES UN RESIDUO HIDROFILICO DE AMINOACIDO INDEPENDIENTEMENTE SELECCIONADO ENTRE EL GRUPO QUE CONSTA DE R Y K; U ES RESIDUO HIDROFOBIDO DE AMINOACIDO INDEPENDIENTEMENTE SELECCIONADO ENTRE EL GRUPO QUE CONSTA DE V, I, L, C, Y Y F, CON L Y C SIENDO PARTICULARMENTE ADECUADAS; A TIENE UN VALOR MEDIO DE ENTRE 1 Y 5; B TIENE UN VALOR MEDIO DE ENTRE 3 Y 20; C VALE ENTRE 1 Y 10; Y D VALE ENTRE 0 Y 3, CON UN VALOR DE 0, 1 O 2 PARTICULARMENTE ADECUADO. EN OTRAS VARIACIONES, UN POLIPEPTIDO DE LA INVENCION, CUANDO SE MEZCLA CON UN FOSFOLIPIDO FARMACOLOGICAMENTE ACEPTABLE, FORMA UN SURFACTANTE PULMONAR SINTETICO QUE TIENE UNA ACTIVIDAD SURFACTANTE MAYOR QUE LA ACTIVIDAD SURFACTANTE DEL FOSFOLIPIDO SOLO. TAMBIEN SE PRESENTAN METODOS PARA SINTETIZAR Y UTILIZAR LOS POLIPEPTIDOS Y LOS SURFACTANTES SINTETICOS DE LA INVENCION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/715,397 US5260273A (en) | 1988-01-06 | 1991-06-14 | Pulmonary surfactant protein and related polypeptide |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2182821T3 true ES2182821T3 (es) | 2003-03-16 |
Family
ID=24873864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92912964T Expired - Lifetime ES2182821T3 (es) | 1991-06-14 | 1992-06-01 | Peptidos tensioactivos pulmonares sinteticos. |
Country Status (11)
Country | Link |
---|---|
US (3) | US5260273A (es) |
EP (1) | EP0590006B1 (es) |
JP (1) | JP3459248B2 (es) |
AT (1) | ATE223436T1 (es) |
AU (1) | AU666857B2 (es) |
CA (1) | CA2111342A1 (es) |
DE (1) | DE69232760T2 (es) |
DK (1) | DK0590006T3 (es) |
ES (1) | ES2182821T3 (es) |
IE (2) | IE921897A1 (es) |
WO (1) | WO1992022315A1 (es) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260273A (en) * | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
US6613734B2 (en) * | 1988-01-06 | 2003-09-02 | The Scripps Research Institute | Peptides-containing liposomal surfactants |
US6013619A (en) * | 1988-01-06 | 2000-01-11 | The Scripps Research Institute | Pulmonary surfactants and therapeutic uses, including pulmonary lavage |
CA2118939A1 (en) * | 1991-09-13 | 1993-04-01 | W. Lee Maloy | Biologically active amphiphilic peptide compositions and uses thereof |
EP0733645B1 (en) * | 1993-12-08 | 2003-03-19 | Mitsubishi Pharma Corporation | Novel synthetic peptide, lung surfactant containing the same, and remedy for respiratory distress syndrome |
US5750370A (en) * | 1995-06-06 | 1998-05-12 | Human Genome Sciences, Inc. | Nucleic acid encoding human endothlein-bombesin receptor and method of producing the receptor |
DK0886652T3 (da) * | 1995-11-20 | 2002-08-12 | Ortho Mcneil Pharm Inc | Fremgangsmåde til solubilisering af pulmonale overfladeaktive peptider |
ATE212220T1 (de) | 1996-01-24 | 2002-02-15 | Byk Gulden Lomberg Chem Fab | Verfahren zur herstellung von pulverförmigen lungensurfactant-zubereitungen |
WO1997029738A1 (en) * | 1996-02-16 | 1997-08-21 | The Administrators Of The Tulane Educational Fund | Methods and compositions for treating eustachian tube dysfunction by inhalation |
WO1997035559A2 (en) * | 1996-03-27 | 1997-10-02 | Ortho Pharmaceutical Corporation | Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation |
AU2322097A (en) * | 1996-03-27 | 1997-10-17 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
US6013764A (en) * | 1996-07-17 | 2000-01-11 | Ortho Pharmaceutical Corp. | Liquid phase peptide synthesis of KL-4 pulmonary surfactant |
GB9916316D0 (en) * | 1999-07-12 | 1999-09-15 | Quadrant Holdings Cambridge | Dry powder compositions |
US6676930B2 (en) | 1999-11-28 | 2004-01-13 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
US6156294A (en) | 1999-11-28 | 2000-12-05 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
ES2346048T3 (es) | 2001-10-11 | 2010-10-08 | Nycomed Gmbh | Nueva utilizacion de un agente tensioactivo pulmonar. |
WO2003053455A1 (en) | 2001-12-12 | 2003-07-03 | Penn State Research Foundation | Surfactant prevention of lung complications from cancer chemotherapy |
JP4651946B2 (ja) * | 2002-04-25 | 2011-03-16 | ザ スクリプス リサーチ インスティテュート | 肺病態の治療および予防 |
EP1481665A1 (en) * | 2003-05-30 | 2004-12-01 | CHIESI FARMACEUTICI S.p.A. | Novel lipid mixtures for synthetic surfactants |
WO2005055994A1 (en) * | 2003-12-04 | 2005-06-23 | The Scripps Research Institute | Treatment and preventions of asthma |
WO2005115520A1 (en) * | 2004-05-20 | 2005-12-08 | Discovery Laboratories, Inc. | Methods , systems and devices for noninvasive pulmonary delivery |
US8236750B2 (en) | 2004-08-06 | 2012-08-07 | Nycomed Gmbh | Composition comprising a pulmonary surfactant and a TNF-derived peptide |
US7582312B2 (en) * | 2004-11-15 | 2009-09-01 | Discovery Laboratories, Inc. | Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof |
US7464012B2 (en) * | 2004-12-10 | 2008-12-09 | L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude | Simplified process simulator |
US8337815B2 (en) * | 2004-12-23 | 2012-12-25 | Discovery Laboratories, Inc. | Pulmonary surfactant formulations |
PL1841458T3 (pl) | 2005-01-06 | 2012-05-31 | Discovery Lab Inc | Schemat stosowania środka powierzchniowo czynnego do leczenia lub zapobiegania dysplazji oskrzelowo-płucnej |
US8028697B2 (en) | 2005-04-28 | 2011-10-04 | Trudell Medical International | Ventilator circuit and method for the use thereof |
HUE032584T2 (en) | 2006-02-08 | 2017-09-28 | Morphotek Inc | Antigen GM-CSF peptides and GM-CSF antibodies |
AU2007297691B2 (en) * | 2006-09-19 | 2013-12-19 | Discovery Laboratories, Inc. | Pulmonary surfactant formulations and methods for promoting mucus clearance |
US7951781B2 (en) | 2006-11-02 | 2011-05-31 | University Of Iowa Research Foundation | Methods and compositions related to PLUNC surfactant polypeptides |
EP1997502A1 (en) | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Reconstituted surfactants having improved properties |
ES2562806T3 (es) * | 2007-06-05 | 2016-03-08 | Paka Pulmonary Pharmaceuticals, Inc. | Composiciones para administrar medicamentos en los pulmones, y usos de las mismas |
US8048043B2 (en) | 2007-06-08 | 2011-11-01 | Chiesi Farmaceutici S. P. A. | Method of administration of a pulmonary surfactant |
DK2265309T3 (en) | 2008-03-17 | 2016-03-29 | Discovery Lab Inc | FAN EXCEEDED RACE ADAPTER AND proximal AEROSOLFORSYNINGSSYSTEM |
US8596265B2 (en) | 2008-10-22 | 2013-12-03 | Trudell Medical International | Modular aerosol delivery system |
AU2009324637B2 (en) | 2008-12-10 | 2016-09-08 | Paka Pulmonary Pharmaceuticals, Inc. | Methods and compositions for delivery of medicaments to the lungs |
BR112012004651B1 (pt) | 2009-09-08 | 2022-02-08 | Chiesi Farmaceutici S.P.A. | Surfactante pulmonar exógeno, uso de uma combinação terapêutica, medicamento e kit |
WO2011035140A1 (en) | 2009-09-18 | 2011-03-24 | Paka Pulmonary Pharmaceuticals, Inc. | Methods and compositions for delivery of contrast moieties to the lungs |
GB201115910D0 (en) | 2011-09-14 | 2011-10-26 | Univ Manchester | Peptides |
WO2013067164A1 (en) | 2011-11-04 | 2013-05-10 | Discovery Laboratories, Inc. | Ventilation circuit adaptor and proximal aerosol delivery system |
RS54513B1 (en) * | 2012-03-28 | 2016-06-30 | Discovery Laboratories, Inc. | LYOPHILIZATION OF SYNTHETIC LIPOSOMAL LUNG SURFACTANT |
WO2013188016A2 (en) | 2012-05-04 | 2013-12-19 | Discovery Laboratories, Inc. | Surfactant therapy for exposure to ionizing radiation |
WO2015061412A1 (en) * | 2013-10-22 | 2015-04-30 | The Scripps Research Institute | Methods and compositions for promoting bronchioli dilatation |
EP3285645B1 (en) | 2015-04-22 | 2020-08-12 | Chiesi Farmaceutici S.p.A. | System for effective breath-synchronized delivery of medicament to the lungs |
EP3106090A1 (en) | 2015-06-15 | 2016-12-21 | CHIESI FARMACEUTICI S.p.A. | System for effective breath-synchronized delivery of medicament to the lungs |
US11311691B2 (en) | 2015-04-28 | 2022-04-26 | Chiesi Farmaceutici S.P.A | Device for facilitating the administration of a medicament to the lung by a catheter |
EP3288579A1 (en) | 2015-04-30 | 2018-03-07 | University of Bremen | A novel skin medical and cosmetic care product |
CN104817631B (zh) * | 2015-05-26 | 2018-04-13 | 成都圣诺生物科技股份有限公司 | 一种合成西那普肽的方法 |
CN109496159A (zh) | 2016-07-28 | 2019-03-19 | 奇斯药制品公司 | 用于递送雾化药剂的方法和系统 |
EP3503905A1 (en) | 2016-08-24 | 2019-07-03 | Chiesi Farmaceutici S.p.A. | Stable pharmaceutical formulation comprising a reconstituted pulmonary surfactant composition |
CA3038183A1 (en) | 2016-10-26 | 2018-05-03 | Chiesi Farmaceutici S.P.A. | Device for facilitating the administration of a medicament to the lung by a catheter |
CN110099695B (zh) | 2016-12-22 | 2022-01-25 | 奇斯药制品公司 | 用于治疗进展性bpd的包含肺表面活性物质和类固醇的治疗组合 |
WO2019115771A1 (en) | 2017-12-15 | 2019-06-20 | Pari Pharma Gmbh | Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method |
TW201927286A (zh) | 2017-12-15 | 2019-07-16 | 義大利商凱西製藥公司 | 用於噴霧投藥之包含肺表面張力素的藥學調配物 |
MX2020011127A (es) | 2018-04-23 | 2021-01-15 | Chiesi Farm Spa | Combinacion terapeutica que comprende agente tensioactivo pulmonar y esteroide para la profilaxis de displasia broncopulmonar (bpd). |
EP3666315A1 (en) | 2018-12-14 | 2020-06-17 | PARI Pharma GmbH | Aerosol delivery device and method of operating the aerosol delivery device |
EP3666316A1 (en) | 2018-12-14 | 2020-06-17 | PARI Pharma GmbH | Aerosol delivery device and method of operating the aerosol delivery device |
EP3843105A1 (en) | 2019-12-23 | 2021-06-30 | PARI Pharma GmbH | Control device for aerosol nebulizer system |
EP4097128A1 (en) | 2020-01-28 | 2022-12-07 | Chiesi Farmaceutici S.p.A. | Polypeptides having improved properties |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4643988A (en) * | 1984-05-15 | 1987-02-17 | Research Corporation | Amphipathic peptides |
US4562003A (en) * | 1984-10-26 | 1985-12-31 | California Biotechnology, Inc. | Monoclonal antibodies against alveolar surfactant protein |
US4659805A (en) * | 1984-12-11 | 1987-04-21 | California Biotechnology, Inc. | Recombinant alveolar surfactant protein |
US4933280A (en) * | 1984-12-11 | 1990-06-12 | California Biotechnology Inc. | Recombinant DNA sequence encoding Alveolar Surfactant Protein |
EP0290516A4 (en) * | 1986-10-24 | 1989-11-14 | Jeffrey A Whitsett | PROTEINS RELATED TO SURFACE-EFFECTIVE HYDROPHOBIC LUNG ACTIVE SUBSTANCES. |
US5164369A (en) * | 1988-01-06 | 1992-11-17 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
US5260273A (en) * | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
US4861756A (en) * | 1988-03-08 | 1989-08-29 | Merrell Dow Pharmaceuticals Inc. | Synthetic pulmonary surfactant |
NZ229737A (en) * | 1988-07-01 | 1991-05-28 | Merrell Dow Pharma | Polypeptides and derivatives of them with lung surfactant properties and their preparation |
-
1991
- 1991-06-14 US US07/715,397 patent/US5260273A/en not_active Expired - Lifetime
-
1992
- 1992-06-01 EP EP92912964A patent/EP0590006B1/en not_active Expired - Lifetime
- 1992-06-01 AT AT92912964T patent/ATE223436T1/de active
- 1992-06-01 DK DK92912964T patent/DK0590006T3/da active
- 1992-06-01 JP JP50088893A patent/JP3459248B2/ja not_active Expired - Lifetime
- 1992-06-01 ES ES92912964T patent/ES2182821T3/es not_active Expired - Lifetime
- 1992-06-01 DE DE69232760T patent/DE69232760T2/de not_active Expired - Lifetime
- 1992-06-01 AU AU21777/92A patent/AU666857B2/en not_active Expired
- 1992-06-01 WO PCT/US1992/004537 patent/WO1992022315A1/en active IP Right Grant
- 1992-06-01 CA CA002111342A patent/CA2111342A1/en not_active Abandoned
- 1992-07-01 IE IE189792A patent/IE921897A1/en not_active IP Right Cessation
- 1992-07-01 IE IE20040101A patent/IE20040101A1/en not_active Application Discontinuation
-
1993
- 1993-05-12 US US08/060,833 patent/US5407914A/en not_active Expired - Lifetime
-
1995
- 1995-04-11 US US08/419,824 patent/US5789381A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU2177792A (en) | 1993-01-12 |
JP3459248B2 (ja) | 2003-10-20 |
EP0590006A4 (en) | 1994-07-13 |
US5789381A (en) | 1998-08-04 |
AU666857B2 (en) | 1996-02-29 |
WO1992022315A1 (en) | 1992-12-23 |
EP0590006A1 (en) | 1994-04-06 |
CA2111342A1 (en) | 1992-12-23 |
DK0590006T3 (da) | 2003-01-06 |
IE20040101A1 (en) | 2004-04-07 |
IE921897A1 (en) | 1992-12-16 |
DE69232760T2 (de) | 2003-02-06 |
US5260273A (en) | 1993-11-09 |
EP0590006B1 (en) | 2002-09-04 |
ATE223436T1 (de) | 2002-09-15 |
US5407914A (en) | 1995-04-18 |
DE69232760D1 (de) | 2002-10-10 |
JPH06508619A (ja) | 1994-09-29 |
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