DE69232760D1 - Synthetische pulmonäre oberflächenaktive peptide - Google Patents

Synthetische pulmonäre oberflächenaktive peptide

Info

Publication number
DE69232760D1
DE69232760D1 DE69232760T DE69232760T DE69232760D1 DE 69232760 D1 DE69232760 D1 DE 69232760D1 DE 69232760 T DE69232760 T DE 69232760T DE 69232760 T DE69232760 T DE 69232760T DE 69232760 D1 DE69232760 D1 DE 69232760D1
Authority
DE
Germany
Prior art keywords
amino acid
synthetic pulmonary
surface active
active peptides
pulmonary surface
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69232760T
Other languages
English (en)
Other versions
DE69232760T2 (de
Inventor
G Cochrane
D Revak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Application granted granted Critical
Publication of DE69232760D1 publication Critical patent/DE69232760D1/de
Publication of DE69232760T2 publication Critical patent/DE69232760T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
DE69232760T 1991-06-14 1992-06-01 Synthetische pulmonäre oberflächenaktive peptide Expired - Lifetime DE69232760T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/715,397 US5260273A (en) 1988-01-06 1991-06-14 Pulmonary surfactant protein and related polypeptide
PCT/US1992/004537 WO1992022315A1 (en) 1991-06-14 1992-06-01 Synthetic pulmonary surfactant peptides

Publications (2)

Publication Number Publication Date
DE69232760D1 true DE69232760D1 (de) 2002-10-10
DE69232760T2 DE69232760T2 (de) 2003-02-06

Family

ID=24873864

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69232760T Expired - Lifetime DE69232760T2 (de) 1991-06-14 1992-06-01 Synthetische pulmonäre oberflächenaktive peptide

Country Status (11)

Country Link
US (3) US5260273A (de)
EP (1) EP0590006B1 (de)
JP (1) JP3459248B2 (de)
AT (1) ATE223436T1 (de)
AU (1) AU666857B2 (de)
CA (1) CA2111342A1 (de)
DE (1) DE69232760T2 (de)
DK (1) DK0590006T3 (de)
ES (1) ES2182821T3 (de)
IE (2) IE20040101A1 (de)
WO (1) WO1992022315A1 (de)

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KR100449789B1 (ko) 1996-01-24 2005-02-03 알타나 파마 아게 분말형폐계면활성제제의제조방법
WO1997029738A1 (en) * 1996-02-16 1997-08-21 The Administrators Of The Tulane Educational Fund Methods and compositions for treating eustachian tube dysfunction by inhalation
WO1997035882A1 (en) * 1996-03-27 1997-10-02 Ortho Pharmaceutical Corporation Lyophilized pulmonary surfactant peptide compositions
AU2066897A (en) * 1996-03-27 1997-10-17 Ortho Pharmaceutical Corporation Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation
US6013764A (en) * 1996-07-17 2000-01-11 Ortho Pharmaceutical Corp. Liquid phase peptide synthesis of KL-4 pulmonary surfactant
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US6156294A (en) 1999-11-28 2000-12-05 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
US6676930B2 (en) 1999-11-28 2004-01-13 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
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US6998384B2 (en) 2001-12-12 2006-02-14 The Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
WO2003090682A2 (en) * 2002-04-25 2003-11-06 The Scripps Research Institute Treatment and prevention of pulmonary conditions
EP1481665A1 (de) * 2003-05-30 2004-12-01 CHIESI FARMACEUTICI S.p.A. Neue Lipidmischungen für synthetische Tenside
JP2007513180A (ja) * 2003-12-04 2007-05-24 ザ スクリプス リサーチ インスティテュート 喘息の処置および予防
CA2567334A1 (en) * 2004-05-20 2005-12-08 Discovery Laboratories, Inc. Methods , systems and devices for noninvasive pulmonary delivery
AU2005268755B2 (en) 2004-08-06 2011-04-07 Takeda Gmbh Composition comprising a pulmonary surfactant and a TNF-derived peptide
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
US7582312B2 (en) 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US8337815B2 (en) * 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
JP2008526868A (ja) 2005-01-06 2008-07-24 ディスカバリー ラボラトリーズ，インコーポレイテッド 表面活性剤処置療法
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
CN101501070B (zh) 2006-02-08 2013-12-25 诺福泰克公司 抗原性gm-csf肽和针对gm-csf的抗体
RU2455021C2 (ru) * 2006-09-19 2012-07-10 Дискавери Лабораториз, Инк. Композиции легочных сурфактантов и способы их применения, содействующие очищению от слизи
US7951781B2 (en) 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides
EP1997502A1 (de) 2007-06-01 2008-12-03 CHIESI FARMACEUTICI S.p.A. Rekonstituierte Tenside mit verbesserten Eigenschaften
CN101754747A (zh) * 2007-06-05 2010-06-23 Paka肺部医药公司 用于向肺脏递送药物的方法以及组合物
US8048043B2 (en) 2007-06-08 2011-11-01 Chiesi Farmaceutici S. P. A. Method of administration of a pulmonary surfactant
JP5507539B2 (ja) 2008-03-17 2014-05-28 ディスカバリー ラボラトリーズ、インク． 換気回路アダプターおよび近位エアロゾル送達システム
ES2402241T3 (es) 2008-10-22 2013-04-30 Trudell Medical International Sistema de suministro de aerosol modular
WO2010068754A2 (en) 2008-12-10 2010-06-17 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
KR101767693B1 (ko) 2009-09-08 2017-08-23 키에시 파르마슈티시 엣스. 피. 에이. 폐 계면 활성제와 항산화 효소를 포함하는 치료용 혼합물
WO2011035140A1 (en) 2009-09-18 2011-03-24 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of contrast moieties to the lungs
GB201115910D0 (en) 2011-09-14 2011-10-26 Univ Manchester Peptides
WO2013067164A1 (en) 2011-11-04 2013-05-10 Discovery Laboratories, Inc. Ventilation circuit adaptor and proximal aerosol delivery system
HUE026363T2 (en) 2012-03-28 2016-06-28 Discovery Lab Inc Lyophilization of pulmonary synthetic liposomal surfactant
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation
WO2015061412A1 (en) * 2013-10-22 2015-04-30 The Scripps Research Institute Methods and compositions for promoting bronchioli dilatation
EP3106090A1 (de) 2015-06-15 2016-12-21 CHIESI FARMACEUTICI S.p.A. System zur effektiven und atemsynchronisierten abgabe eines medikaments in die lungen
WO2016170087A1 (en) 2015-04-22 2016-10-27 Chiesi Farmaceutici S.P.A Method and system for effective breath-synchronized delivery of medicament to the lungs
WO2016173634A1 (en) 2015-04-28 2016-11-03 Chiesi Farmaceutici S.P.A Device for facilitating the administration of a medicament to the lung by a catheter
CN107979996A (zh) 2015-04-30 2018-05-01 不莱梅大学 新的皮肤医疗和美容护理产品
CN104817631B (zh) * 2015-05-26 2018-04-13 成都圣诺生物科技股份有限公司 一种合成西那普肽的方法
MX2019000651A (es) 2016-07-28 2019-04-01 Chiesi Farm Spa Metodo y sistema para suministro de medicamento en aerosol.
WO2018036819A1 (en) 2016-08-24 2018-03-01 Chiesi Farmaceutici S.P.A. Stable pharmaceutical formulation comprising a reconstituted pulmonary surfactant composition
JP2019531821A (ja) 2016-10-26 2019-11-07 キエージィ ファーマチェウティチ エス．ペー．アー． カテーテルによる肺に対する薬剤の投与を容易にする装置
RU2757902C2 (ru) 2016-12-22 2021-10-22 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Терапевтическая комбинация для лечения развивающейся bpd, содержащая легочный сурфактант и стероид
WO2019115771A1 (en) 2017-12-15 2019-06-20 Pari Pharma Gmbh Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method
TW201927286A (zh) 2017-12-15 2019-07-16 義大利商凱西製藥公司 用於噴霧投藥之包含肺表面張力素的藥學調配物
US20190321452A1 (en) 2018-04-23 2019-10-24 Chiesi Farmaceutici S.P.A. Therapeutic combination comprising a pulmonary surfactant and a steroid for the prophylaxis of bpd
EP3666316A1 (de) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosolabgabevorrichtung und verfahren zum betrieb der aerosolabgabevorrichtung
EP3666315A1 (de) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosolabgabevorrichtung und verfahren zum betrieb der aerosolabgabevorrichtung
EP3843105A1 (de) 2019-12-23 2021-06-30 PARI Pharma GmbH Steuerungsvorrichtung für aerosolzerstäubersystem
EP4097128A1 (de) 2020-01-28 2022-12-07 Chiesi Farmaceutici S.p.A. Polypeptide mit verbesserten eigenschaften

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US4643988A (en) * 1984-05-15 1987-02-17 Research Corporation Amphipathic peptides
US4562003A (en) * 1984-10-26 1985-12-31 California Biotechnology, Inc. Monoclonal antibodies against alveolar surfactant protein
US4659805A (en) * 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
US4933280A (en) * 1984-12-11 1990-06-12 California Biotechnology Inc. Recombinant DNA sequence encoding Alveolar Surfactant Protein
EP0290516A4 (de) * 1986-10-24 1989-11-14 Jeffrey A Whitsett Proteine, die mit oberflächenwirksamen hydrophoben lungenwirkstoffen verbunden sind.
US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
AR245141A1 (es) * 1988-07-01 1993-12-30 Merrell Dow Pharma Procedimiento de sintesis secuencial o de bloques en fase solida para preparar polipeptidos de estructura helicoidal.

Also Published As

Publication number Publication date
US5789381A (en) 1998-08-04
AU2177792A (en) 1993-01-12
DE69232760T2 (de) 2003-02-06
CA2111342A1 (en) 1992-12-23
EP0590006B1 (de) 2002-09-04
EP0590006A4 (en) 1994-07-13
JPH06508619A (ja) 1994-09-29
AU666857B2 (en) 1996-02-29
IE921897A1 (en) 1992-12-16
US5407914A (en) 1995-04-18
ATE223436T1 (de) 2002-09-15
ES2182821T3 (es) 2003-03-16
WO1992022315A1 (en) 1992-12-23
US5260273A (en) 1993-11-09
EP0590006A1 (de) 1994-04-06
IE20040101A1 (en) 2004-04-07
DK0590006T3 (da) 2003-01-06
JP3459248B2 (ja) 2003-10-20

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