ES2189825T3 - Nuevo peptido sintetico, tensioactivo pulmonar que lo contiene y remedio para el sindrome de malestar respiratorio. - Google Patents

Nuevo peptido sintetico, tensioactivo pulmonar que lo contiene y remedio para el sindrome de malestar respiratorio.

Info

Publication number
ES2189825T3
ES2189825T3 ES95902920T ES95902920T ES2189825T3 ES 2189825 T3 ES2189825 T3 ES 2189825T3 ES 95902920 T ES95902920 T ES 95902920T ES 95902920 T ES95902920 T ES 95902920T ES 2189825 T3 ES2189825 T3 ES 2189825T3
Authority
ES
Spain
Prior art keywords
peptide
remedy
synthetic peptide
tensioactive
pulmonary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95902920T
Other languages
English (en)
Inventor
Tsunetomo Takei
Eiji Ohtsubo
Hirosi Ohkawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Pharma Corp
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Application granted granted Critical
Publication of ES2189825T3 publication Critical patent/ES2189825T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)

Abstract

UN PEPTIDO SINTETICO QUE CONTIENE LA SIGUIENTE SECUENCIA: XAA PRO - VAL - XBB - XCC - LYS - ARG - W, (EN DONDE XAA ESTA AUSENTE O REPRESENTA CYS O SER; XBB REPRESENTA HIS O ASN; XCC REPRESENTA LEU O LLE; Y W REPRESENTA UNA PORCION DE PEPTIDO HIDROFOBO); UN INTERMEDIO PARA PRODUCIR EL PEPTIDO; UN PROCESO PARA PRODUCIR EL PEPTIDO; UN SURFACTANTE PULMONAR QUE COMPRENDE EL PEPTIDO Y UNA MEZCLA DE LIPIDO; Y UN REMEDIO PARA EL SINDROME DE INSUFICIENCIA RESPIRATORIA QUE CONTIENE EL SURFACTANTE COMO EL INGREDIENTE ACTIVO. EL PEPTIDO ES FACIL DE AISLAR Y PURIFICAR Y ADECUADO PARA PRODUCCION EN GRAN CANTIDAD. COMO ES ALTAMENTE SOLUBLE EN METANOL Y SIMILARES, PUEDE SER RAPIDAMENTE MEZCLADO CON UNA MEZCLA DE LIPIDO Y ES ADECUADO PARA LA PREPARACION DE UN SURFACTANTE PULMONAR. COMO EL SURFACTANTE PULMONAR TIENE UNA BUENA SUSPENSION Y UNA POTENTE ACTIVIDAD SUPERFICIAL, ES UTIL COMO UN REMEDIO PARA EL SINDROME DE INSUFICIENCIA RESPIRATORIA.
ES95902920T 1993-12-08 1994-12-07 Nuevo peptido sintetico, tensioactivo pulmonar que lo contiene y remedio para el sindrome de malestar respiratorio. Expired - Lifetime ES2189825T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30765793 1993-12-08

Publications (1)

Publication Number Publication Date
ES2189825T3 true ES2189825T3 (es) 2003-07-16

Family

ID=17971685

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95902920T Expired - Lifetime ES2189825T3 (es) 1993-12-08 1994-12-07 Nuevo peptido sintetico, tensioactivo pulmonar que lo contiene y remedio para el sindrome de malestar respiratorio.

Country Status (22)

Country Link
US (1) US5827825A (es)
EP (1) EP0733645B1 (es)
JP (1) JP3644035B2 (es)
KR (1) KR100342806B1 (es)
CN (1) CN1057099C (es)
AT (1) ATE234865T1 (es)
AU (1) AU682738B2 (es)
BG (1) BG62777B1 (es)
CA (1) CA2178345A1 (es)
CZ (1) CZ162396A3 (es)
DE (1) DE69432313T2 (es)
DK (1) DK0733645T3 (es)
ES (1) ES2189825T3 (es)
FI (1) FI962355A (es)
HU (1) HU215933B (es)
NO (1) NO962403D0 (es)
NZ (1) NZ277095A (es)
PL (1) PL180020B1 (es)
PT (1) PT733645E (es)
RO (1) RO118298B1 (es)
SK (1) SK71496A3 (es)
WO (1) WO1995015980A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996017872A1 (fr) * 1994-12-07 1996-06-13 Tokyo Tanabe Company Limited Intermediaire pour la production d'un peptide surfactant
WO1997035882A1 (en) * 1996-03-27 1997-10-02 Ortho Pharmaceutical Corporation Lyophilized pulmonary surfactant peptide compositions
JPH11217397A (ja) * 1997-11-27 1999-08-10 Saburo Aimoto ペプチドチオールエステルの製造方法
IT1308180B1 (it) 1999-02-12 2001-12-07 Chiesi Farma Spa Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante
BR9906091A (pt) * 1999-12-22 2002-06-04 Conselho Nacional Cnpq Usos de resina de troca aniÈnica (epm-7) como suporte sólido para a sìntese peptìdica e para cromatografia de afinidade
US6998384B2 (en) 2001-12-12 2006-02-14 The Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
ES2295961T3 (es) * 2003-12-31 2008-04-16 F. Hoffmann-La Roche Ag Proceso para la sintesis peptidica utilizacndo una cantidad reducida de agente de desproteccion.
AU2005247319B2 (en) * 2004-04-28 2011-12-01 Molecules For Health, Inc. Methods for treating or preventing restenosis and other vascular proliferative disorders
US7638493B2 (en) * 2004-04-29 2009-12-29 Sannamu Lee Artificial pulmonary surfactant compositions and use of the same
KR100635541B1 (ko) * 2004-10-12 2006-10-18 경북대학교 산학협력단 신규한 염증성 질환의 예방 또는 치료용 약학적 조성물
US7582312B2 (en) * 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
CA2593758A1 (en) 2005-01-06 2006-07-13 Discovery Laboratories, Inc. Surfactant treatment regimen for treating or preventing bronchopulmonary dysplasia
WO2007084136A2 (en) * 2006-01-23 2007-07-26 Ony, Inc. Treatment of acute respiratory distress syndrome
MX2009003002A (es) * 2006-09-19 2009-06-01 Discovery Lab Inc Formulaciones de tensioactivos pulmonares y metodos para promover la aclaracion del moco.
EP2022798A1 (en) * 2007-08-09 2009-02-11 CHIESI FARMACEUTICI S.p.A. Synthetic pulmonary surfactant peptides
KR101614344B1 (ko) 2008-04-02 2016-04-21 토쿠시마 대학 합성 펩티드를 함유하는 항원약물 비이클과 이것을 사용하는 점막 백신
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003170A1 (en) * 1986-10-24 1988-05-05 Whitsett Jeffrey A Pulmonary hydrophobic surfactant-associated proteins
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質
ATE163013T1 (de) * 1987-11-04 1998-02-15 Byk Gulden Lomberg Chem Fab Alveolare oberflächenaktive proteine
US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
SE8803713D0 (sv) * 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
JPH05294996A (ja) * 1992-04-17 1993-11-09 Tokyo Tanabe Co Ltd 合成ペプチド、それを含有する肺サーファクタント及び呼吸窮迫症候群治療剤

Also Published As

Publication number Publication date
HU9601563D0 (en) 1996-08-28
HUT74880A (en) 1997-02-28
FI962355A0 (fi) 1996-06-06
DE69432313T2 (de) 2003-10-16
KR100342806B1 (ko) 2002-11-29
DE69432313D1 (de) 2003-04-24
FI962355A (fi) 1996-06-06
HU215933B (hu) 1999-03-29
JP3644035B2 (ja) 2005-04-27
CN1057099C (zh) 2000-10-04
PT733645E (pt) 2003-07-31
DK0733645T3 (da) 2003-07-14
AU682738B2 (en) 1997-10-16
NO962403L (no) 1996-06-07
EP0733645A1 (en) 1996-09-25
US5827825A (en) 1998-10-27
RO118298B1 (ro) 2003-04-30
NO962403D0 (no) 1996-06-07
CZ162396A3 (en) 1996-10-16
SK71496A3 (en) 1996-11-06
AU1199295A (en) 1995-06-27
NZ277095A (en) 1997-09-22
WO1995015980A1 (fr) 1995-06-15
KR960706507A (ko) 1996-12-09
ATE234865T1 (de) 2003-04-15
EP0733645A4 (en) 1998-12-09
CA2178345A1 (en) 1995-06-15
PL314872A1 (en) 1996-09-30
BG62777B1 (bg) 2000-07-31
BG100554A (bg) 1996-12-31
PL180020B1 (en) 2000-12-29
CN1136813A (zh) 1996-11-27
EP0733645B1 (en) 2003-03-19

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