DK0552192T3 - Forbedret tangentialstrømningsfiltreringsfremgangsmåde og -apparat - Google Patents

Forbedret tangentialstrømningsfiltreringsfremgangsmåde og -apparat

Info

Publication number
DK0552192T3
DK0552192T3 DK91917291.6T DK91917291T DK0552192T3 DK 0552192 T3 DK0552192 T3 DK 0552192T3 DK 91917291 T DK91917291 T DK 91917291T DK 0552192 T3 DK0552192 T3 DK 0552192T3
Authority
DK
Denmark
Prior art keywords
flow filtration
tangential flow
filtration method
improved tangential
flux
Prior art date
Application number
DK91917291.6T
Other languages
English (en)
Inventor
Robert D Van Reis
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DK0552192T3 publication Critical patent/DK0552192T3/da

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/145Ultrafiltration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/145Ultrafiltration
    • B01D61/146Ultrafiltration comprising multiple ultrafiltration steps
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/147Microfiltration
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/34Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/58Reaction vessels connected in series or in parallel
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02Separating microorganisms from the culture medium; Concentration of biomass
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10Separation or concentration of fermentation products

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Water Supply & Treatment (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Cyclones (AREA)
  • Combined Means For Separation Of Solids (AREA)
DK91917291.6T 1990-09-17 1991-09-11 Forbedret tangentialstrømningsfiltreringsfremgangsmåde og -apparat DK0552192T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/583,886 US5256294A (en) 1990-09-17 1990-09-17 Tangential flow filtration process and apparatus

Publications (1)

Publication Number Publication Date
DK0552192T3 true DK0552192T3 (da) 1995-07-17

Family

ID=24334996

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91917291.6T DK0552192T3 (da) 1990-09-17 1991-09-11 Forbedret tangentialstrømningsfiltreringsfremgangsmåde og -apparat

Country Status (10)

Country Link
US (2) US5256294A (da)
EP (1) EP0552192B1 (da)
JP (2) JP3828143B2 (da)
AT (1) ATE119063T1 (da)
CA (1) CA2089663C (da)
DE (1) DE69107855T2 (da)
DK (1) DK0552192T3 (da)
ES (1) ES2072017T3 (da)
LV (1) LV11283B (da)
WO (1) WO1992004970A1 (da)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256294A (en) * 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
DE4139664A1 (de) * 1991-12-02 1993-06-03 Diagen Inst Molekularbio Vorrichtung und verfahren zur isolierung und reinigung von nukleinsaeuren
FR2693474B1 (fr) * 1992-07-09 1994-08-26 Daniel Garin Procédé et dispositif de séparation et de concentration de microorganismes contaminants.
US5705634A (en) * 1995-03-02 1998-01-06 Perimmune Holdings, Inc. High yield preparation of dimeric to decameric chitin oligomers
US6359114B1 (en) * 1995-06-07 2002-03-19 Aphton Corp. System for method for the modification and purification of proteins
US6165774A (en) * 1995-09-22 2000-12-26 Connaught Laboratories Limited Parainfluenza virus glycoproteins and vaccines
US6054051A (en) * 1996-01-17 2000-04-25 Genentech, Inc. Tangential-flow filtration system
US6268487B1 (en) * 1996-05-13 2001-07-31 Genzyme Transgenics Corporation Purification of biologically active peptides from milk
US7026468B2 (en) * 1996-07-19 2006-04-11 Valentis, Inc. Process and equipment for plasmid purification
US7807822B2 (en) * 1996-08-01 2010-10-05 Robert Bridenbaugh Methods for purifying nucleic acids
US6022333A (en) * 1997-05-01 2000-02-08 S.L.I.M. Tech, Ltd. Method and system for removing materials from lymphatic and other fluids
US5919376A (en) * 1997-06-10 1999-07-06 Cae Ransohoff Inc. Filtration apparatus and method
US6265542B1 (en) 1997-10-24 2001-07-24 Genentech, Inc. Purification of molecules
US6077940A (en) * 1997-12-24 2000-06-20 Genentech, Inc. Free solution ligand interaction molecular separation method
JP2001000842A (ja) * 1998-05-22 2001-01-09 Daicel Chem Ind Ltd 病原性原虫濃縮用モジュールおよび濃縮方法
JP2002517406A (ja) 1998-06-01 2002-06-18 ジェネンテック・インコーポレーテッド イオン交換クロマトグラフィーの使用による、凝集体からのタンパク質モノマーの分離
BR9905868A (pt) * 1998-11-06 2001-01-23 Bio Sidus S A Procedimento de cultivo massivo de células de mamìfero para a obtenção de eritropoetina humana, recombinante e a eritropoetina humana recombinante obtida com tal procedimento
US7316780B1 (en) * 1999-01-29 2008-01-08 Pall Corporation Range separation devices and processes
MXPA01013264A (es) * 1999-06-25 2002-06-04 American Cyanamid Co Extracion de proteinas de membrana integral.
JP2003505077A (ja) 1999-07-23 2003-02-12 ジェネンテック・インコーポレーテッド 平行流ろ過法を用いるrnase−及び有機溶媒−非含有プラスミドdnaの精製方法
US7108791B2 (en) * 1999-09-14 2006-09-19 Millipore Corporation High-resolution virus removal methodology and filtration capsule useful therefor
US6296770B1 (en) 1999-12-09 2001-10-02 Eastman Kodak Company Constant concentration at the UF membrane wall UF process control and apparatus
DE10000196B4 (de) 2000-01-05 2013-10-10 Sartorius Stedim Biotech Gmbh Verbesserte Crossflow-Filtrationseinheit
US6607669B2 (en) 2000-06-23 2003-08-19 Scilog, Inc. Method and apparatus for enhancing filtration yields in tangential flow filtration
GB0107634D0 (en) * 2001-03-27 2001-05-16 Fermentas Ab Nucleic acid purification
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
US20030171260A1 (en) * 2002-03-11 2003-09-11 Nelson Deanna Jean Compositions and methods utilizing hydroxamates to scavenge oxidant toxins
JP4319979B2 (ja) * 2002-04-26 2009-08-26 ジェネンテック・インコーポレーテッド タンパク質の非アフィニティ精製
US9283521B2 (en) 2002-06-14 2016-03-15 Parker-Hannifin Corporation Single-use manifold and sensors for automated, aseptic transfer of solutions in bioprocessing applications
US6712963B2 (en) 2002-06-14 2004-03-30 Scilog, Llc Single-use manifold for automated, aseptic transfer of solutions in bioprocessing applications
USRE49221E1 (en) 2002-06-14 2022-09-27 Parker Intangibles, Llc Single-use manifolds for automated, aseptic handling of solutions in bioprocessing applications
US7695627B2 (en) * 2002-06-19 2010-04-13 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for leukocyte enrichment
AU2003248780A1 (en) * 2002-07-10 2004-01-23 Pall Corporation Hollow fiber membrane systems
AU2003267175A1 (en) * 2002-09-13 2004-04-30 Valentis, Inc. Apparatus and method for preparative scale purification of nucleic acids
RU2005129745A (ru) * 2003-02-24 2006-03-20 Джитиси Байотерапьютикс, Инк. (Us) Способы и устройство проточной фильтрации вдоль потока
US7276163B2 (en) * 2003-10-01 2007-10-02 Ceramem Corporation Membrane devices with controlled transmembrane pressure and method of use
JP4655938B2 (ja) * 2004-01-21 2011-03-23 東レ株式会社 分画装置および分画方法
FR2866899B1 (fr) * 2004-02-27 2006-06-09 Gervais Danone Sa Procede de production d'un concentrat liquide de bacteries adaptees et viables a usage alimentaire
US20050197496A1 (en) * 2004-03-04 2005-09-08 Gtc Biotherapeutics, Inc. Methods of protein fractionation using high performance tangential flow filtration
CN1930281A (zh) 2004-03-05 2007-03-14 帝斯曼知识产权资产管理有限公司 用于通过连续灌注和交互切向流来培养细胞的方法
JP2007530279A (ja) * 2004-03-29 2007-11-01 ポール・コーポレーション プリーツを有するクロスフロー流体処理エレメント
WO2005113578A1 (en) * 2004-05-14 2005-12-01 New Jersey Institute Of Technology Highly selective membrane systems and methods for protein ultrafiltration
WO2005119126A1 (fr) * 2004-05-28 2005-12-15 Alstom Technology Ltd Dispositif a lit fluidise a agent comburant enrichi en oxygene
US20060043021A1 (en) * 2004-09-02 2006-03-02 Millipore Corporation Port adapter for tangential flow filtration
US20060051347A1 (en) 2004-09-09 2006-03-09 Winter Charles M Process for concentration of antibodies and therapeutic products thereof
ES2634323T3 (es) * 2004-09-30 2017-09-27 Bayer Healthcare Llc Dispositivos y procedimientos para la fabricación continua integrada de moléculas biológicas
AU2011203578B2 (en) * 2004-09-30 2012-10-11 Bayer Healthcare Llc Devices and methods for integrated continuous manufacturing of biological molecules
US20060130159A1 (en) * 2004-12-09 2006-06-15 Nick Masiello Method of purifying recombinant MSP 1-42 derived from Plasmodium falciparum
RS52470B (en) 2005-08-24 2013-02-28 Immunogen Inc. PROCEDURE FOR PREPARATION OF PURE CONJUGATED MEDICINES
CA2622294A1 (en) * 2005-09-28 2007-04-05 Pall Corporation Fluid treatment assemblies and elements and methods for making them
CN101379182A (zh) * 2005-12-14 2009-03-04 器官发生有限公司 皮肤护理组合物以及处理
US7510654B2 (en) 2005-12-29 2009-03-31 Spf Innovations, Llc Method and apparatus for the filtration of biological samples
US7531632B2 (en) * 2006-02-16 2009-05-12 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
BRPI0707027B1 (pt) 2006-02-24 2022-08-16 Toray Industries, Inc Método de fabricação de um produto químico e aparelho de fermentação contínua
EP2007506B1 (en) * 2006-03-31 2014-03-19 Danisco US Inc. Tangential flow filtration apparatuses, systems, and processes for the separation of compounds
US20070240578A1 (en) * 2006-04-12 2007-10-18 Dileo Anthony Filter with memory, communication and temperature sensor
US20110094310A1 (en) * 2006-04-12 2011-04-28 Millipore Corporation Filter with memory, communication and pressure sensor
US8007568B2 (en) * 2006-04-12 2011-08-30 Millipore Corporation Filter with memory, communication and pressure sensor
US20070243113A1 (en) 2006-04-12 2007-10-18 Dileo Anthony Filter with memory, communication and concentration sensor
US8119368B2 (en) 2006-07-14 2012-02-21 Dsm Ip Assets B.V. Process for the culturing of cells
US20090250653A1 (en) * 2006-08-07 2009-10-08 Kiely Donald E Hydroxycarboxylic Acids and Salts
CA2660389C (en) * 2006-08-07 2014-12-02 The University Of Montana Method for the preparation of organic acids via oxidization using nitric acid
CN101269298B (zh) * 2007-03-23 2011-06-01 中国科学院过程工程研究所 利用浓差极化浓缩生物大分子的膜过滤方法及其装置
RU2504549C2 (ru) * 2007-07-17 2014-01-20 Ф.Хоффманн-Ля Рош Аг Фильтрация в переменном тангенциальном потоке
CN101918114B (zh) * 2007-09-12 2014-12-31 丹尼斯科美国公司 具有内部污损控制的过滤
US8623943B2 (en) 2007-11-15 2014-01-07 The University Of Montana Hydroxypolyamide gel forming agents
US20100249384A1 (en) * 2007-11-29 2010-09-30 Stefan Hepbildikler Immunoglobulin aggregates
US8043512B2 (en) * 2008-04-11 2011-10-25 Pall Corporation Fluid treatment arrangements and methods
SG157290A1 (en) * 2008-05-09 2009-12-29 Millipore Corp Method for reducing performance variability of multi-layer filters
US7895084B2 (en) * 2008-05-15 2011-02-22 Doapp, Inc. Method and system for providing purchasing on a wireless device
US8216473B2 (en) * 2008-06-13 2012-07-10 Solution Dynamics, Llc Apparatus and methods for solution processing using reverse osmosis
US8048315B2 (en) * 2008-07-28 2011-11-01 Pall Corporation Fluid treatment arrangements and methods
US9320761B2 (en) * 2008-12-18 2016-04-26 Vivex Biomedical, Inc. Bone induction system and methods
CA2754393C (en) * 2009-03-24 2015-10-27 Wyeth Llc Membrane evaporation for generating highly concentrated protein therapeutics
CN102574912B (zh) * 2009-09-29 2014-12-24 弗·哈夫曼-拉罗切有限公司 缓冲溶质的过滤前调节
US8119005B1 (en) * 2009-11-12 2012-02-21 Gabriel George Pinter Method and apparatus for partial desalination of a concentrated salt solution
CN101745316B (zh) * 2010-01-22 2011-12-28 中国科学院过程工程研究所 一种重力场辅助浓缩生物大分子的新型超滤方法及装置
EP2525899A1 (en) * 2010-01-22 2012-11-28 Lonza Walkersville, Inc. High yield method and apparatus for volume reduction and washing of therapeutic cells using tangential flow filtration
CA2784777C (en) 2010-03-18 2018-11-27 Wolf-Dietrich Herberg System and method for filtering beverages
US8480978B2 (en) * 2010-08-12 2013-07-09 University Of Southern California Microfluidic fluid separator and related methods
JP5968898B2 (ja) 2010-11-11 2016-08-10 リバートツプ・リニユーワブルズ 腐食抑制組成物
EP3578522A1 (en) * 2010-12-06 2019-12-11 Pall Corporation Continuous processing methods for biological products
CN103649290B (zh) 2011-04-21 2015-08-05 里弗领袖可再生能源公司 钙螯合组合物
US9266066B2 (en) * 2011-12-13 2016-02-23 Pall Corporation Membrane with localized asymmetries
AU2012274016B2 (en) * 2011-12-13 2014-09-04 Cytiva Us Llc Membrane with localized asymmetries
GB2501611B (en) * 2012-02-21 2015-03-04 Cytonics Corp Alpha-2-macroglobulin compositions and therapeutic uses
CN104884933B (zh) * 2012-10-18 2019-03-01 伊诺瓦普瑞普有限公司 液体向液体的生物粒子分级和浓缩
ES2706190T3 (es) 2012-10-30 2019-03-27 Hoffmann La Roche Purificación de polipéptidos utilizando ultrafiltración de flujo tangencial de dos fases
EP2730330A1 (en) 2012-11-09 2014-05-14 Tine SA Membrane filtration assembly and method of controlling trans-membrane pressure
EP2925826A1 (en) 2012-11-28 2015-10-07 Rivertop Renewables Corrosion inhibiting, freezing point lowering compositions
US9346736B2 (en) 2013-03-13 2016-05-24 Rivertop Renewables, Inc. Oxidation process
US9670124B2 (en) 2013-03-13 2017-06-06 Rivertop Renewables, Inc. Nitric acid oxidation process
US9187398B2 (en) 2013-03-13 2015-11-17 Rivertop Renewables, Inc. Nitric acid oxidation processes
US9957499B2 (en) 2013-03-14 2018-05-01 Translate Bio, Inc. Methods for purification of messenger RNA
PT2970948T (pt) 2013-03-15 2019-03-20 Glaxosmithkline Biologicals Sa Métodos de purificação de arn
EP2971165A4 (en) * 2013-03-15 2016-11-23 Moderna Therapeutics Inc DISSOLUTION OF DNA FRAGMENTS IN MRNA MANUFACTURING METHODS
PL3016729T3 (pl) 2013-07-05 2020-09-07 Laboratoire Français Du Fractionnement Et Des Biotechnologies Société Anonyme Matryca do chromatografii powinowactwa
SG11201607382TA (en) * 2014-03-07 2016-10-28 Agency Science Tech & Res Apparatus and methods for fractionation of biological products
WO2015153370A2 (en) 2014-03-29 2015-10-08 Labib Mohamed E Blood processing cartridges and systems, and methods for extracorporeal blood therapies
WO2015164511A1 (en) * 2014-04-23 2015-10-29 Oleg Shinkazh High efficiency continuous countercurrent tangential chromatography
ES2750661T3 (es) * 2014-04-25 2020-03-26 Translate Bio Inc Métodos para la purificación de ARN mensajero
EP4218991A1 (en) * 2014-05-13 2023-08-02 Amgen Inc. Process control systems and methods for use with filters and filtration processes
DE102015108501A1 (de) * 2015-05-29 2016-12-01 Sartorius Stedim Biotech Gmbh Verfahren und Filtrationsvorrichtung zur Herstellung einer konzentrierten Produktlösung
US10426884B2 (en) 2015-06-26 2019-10-01 Novaflux Inc. Cartridges and systems for outside-in flow in membrane-based therapies
EP3328522A4 (en) 2015-07-29 2019-04-24 Gradiant Corporation OSMOTIC DESALINATION METHODS AND ASSOCIATED SYSTEMS
EP3337597B1 (en) 2015-08-20 2022-11-30 Cytiva Sweden AB Improved method for enhancing filtration yields in tangential flow filtration system
WO2017053805A1 (en) 2015-09-24 2017-03-30 Labib Mohamed E Cartridges for hollow fibre membrane-based therapies
US11359058B2 (en) 2015-11-18 2022-06-14 Arytha Biosciences, Llc Processes and systems for preparing cellular or viral membranes and nanoparticles
US10596298B2 (en) 2016-04-22 2020-03-24 Vivex Biologics Group, Inc. Malleable demineralized bone composition and method of manufacture
US11253629B2 (en) 2016-04-22 2022-02-22 Vivex Biologics Group, Inc. Bone gel sheet composition and method of manufacture
US11253630B2 (en) 2016-04-22 2022-02-22 Vivex Biologics Group, Inc. Malleable demineralized bone composition and method of manufacture
US10463767B2 (en) 2016-04-22 2019-11-05 Vivex Biologics Group, Inc. Moldable bone composition
US9788950B1 (en) 2016-04-22 2017-10-17 Vivex Biomedical, Inc. Cohesive bone composition
CN110241012B (zh) * 2018-03-09 2022-11-01 嘉和生物药业有限公司 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用
AU2019325567A1 (en) 2018-08-22 2021-03-04 Gradiant Corporation Liquid solution concentration system comprising isolated subsystem and related methods
US11174500B2 (en) 2018-08-24 2021-11-16 Translate Bio, Inc. Methods for purification of messenger RNA
CN213222222U (zh) * 2019-01-25 2021-05-18 贝克顿·迪金森公司 从生物样品中选择性提取组分的仪器、系统和试剂盒
ES1256540Y (es) * 2020-07-30 2021-02-10 Euromed S A Composicion alimenticia en polvo que comprende eriocitrina
CA3197204A1 (en) 2020-11-17 2022-05-27 Richard STOVER Osmotic methods and systems involving energy recovery
EP4243966A1 (en) 2020-11-23 2023-09-20 Abec, Inc. Filtration systems,components and methods
US20240043826A1 (en) 2022-07-29 2024-02-08 Sanofi Methods for ethanol-free mrna purification

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3744642A (en) * 1970-12-30 1973-07-10 Westinghouse Electric Corp Interface condensation desalination membranes
SE396017B (sv) * 1974-12-23 1977-09-05 Alfa Laval Ab Filtreringsforfarande, serskilt for ultrafiltrering
FR2380052A1 (fr) * 1977-02-11 1978-09-08 Akzo Nv Membrane de dialyse pour l'hemodialyse
US4191182A (en) * 1977-09-23 1980-03-04 Hemotherapy Inc. Method and apparatus for continuous plasmaphersis
JPS5681521A (en) * 1979-12-10 1981-07-03 Toyo Soda Mfg Co Ltd Separation of blood serum and protein
US4350156A (en) * 1980-05-29 1982-09-21 Japan Foundation For Artificial Organs Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid
US4746436A (en) * 1981-06-25 1988-05-24 Baxter Travenol Laboratories, Inc. Membrane plasmapheresis apparatus and process which utilize a flexible wall to variably restrict the flow of plasma filtrate and thereby stabilize transmembrane pressure
NO158658C (no) * 1981-07-01 1988-10-19 Pfizer Fremgangsmaate for konsentrering av vandige pseudoplastiske loesninger.
US4420398A (en) * 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
US4435289A (en) * 1981-12-23 1984-03-06 Romicon, Inc. Series ultrafiltration with pressurized permeate
EP0112510A1 (fr) * 1982-11-30 1984-07-04 "Continental Belro" Procédé et dispositif pour régler la concentration de matières déterminées dans un liquide
JPH0669530B2 (ja) * 1983-03-10 1994-09-07 シー.ピー.シー.エンジニアリング コーポレイション クロスフロ−濾過システムの流束率を向上せしめる方法並びに装置
JPS6135803A (ja) * 1984-07-26 1986-02-20 Shin Etsu Chem Co Ltd 複合中空糸
US4879040A (en) * 1984-11-15 1989-11-07 Baxter International Inc. Adaptive filter concentrate flow control system and method
US4874516A (en) * 1984-12-29 1989-10-17 Ngk Insulators, Ltd. A ceramic filter for semi-ultrafiltration
JPS61283305A (ja) * 1985-06-05 1986-12-13 Ube Ind Ltd 多孔質中空糸膜
WO1987000213A1 (en) * 1985-06-27 1987-01-15 Mitsubishi Rayon Co., Ltd. Composite hollow yarn and a process for producing the same
JPS621404A (ja) * 1985-06-27 1987-01-07 Mitsubishi Rayon Co Ltd 多層複合中空繊維状膜及びその製造法
GB8600582D0 (en) * 1986-01-10 1986-02-19 Ca Minister Nat Defence Purifying biological materials
US4789482A (en) * 1986-02-10 1988-12-06 Millipore Corporation Method for separating liquid compositions on the basis of molecular weight
US4828705A (en) * 1986-10-31 1989-05-09 Kingston Technologies, Inc. Pressure-dependent anisotropic-transport membrane system
US4789489A (en) * 1988-02-26 1988-12-06 Buckman Laboratories International, Inc. Method for the control of mollusks
GB8812217D0 (en) * 1988-05-24 1988-06-29 Alcan Int Ltd Composite membranes
EP0344011A1 (en) * 1988-05-27 1989-11-29 Ngk Insulators, Ltd. Inorganic porous membrane
US5256294A (en) * 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus

Also Published As

Publication number Publication date
ATE119063T1 (de) 1995-03-15
JPH06500730A (ja) 1994-01-27
WO1992004970A1 (en) 1992-04-02
CA2089663A1 (en) 1992-03-18
ES2072017T3 (es) 1995-07-01
LV11283A (lv) 1996-06-20
US5256294A (en) 1993-10-26
DE69107855T2 (de) 1995-09-07
EP0552192B1 (en) 1995-03-01
DE69107855D1 (de) 1995-04-06
EP0552192A1 (en) 1993-07-28
JP2003334425A (ja) 2003-11-25
CA2089663C (en) 2002-05-28
JP3828143B2 (ja) 2006-10-04
US5490937A (en) 1996-02-13
LV11283B (en) 1996-12-20

Similar Documents

Publication Publication Date Title
DK0552192T3 (da) Forbedret tangentialstrømningsfiltreringsfremgangsmåde og -apparat
DE3852037T2 (de) Verfahren zur trennung von teilchen nach grösse.
ATE171641T1 (de) Verfahren und apparat zur wassergewinnung aus einem vorfluter
EP0536297A4 (en) Process and apparatus for removal of dna and viruses
JPS53108882A (en) Back washing method for hollow filament membrane
DE3884352T2 (de) Pervaporationsverfahren zur Trennung von Alkoholen von Äthern.
NZ332916A (en) Purification of biologically active peptides from milk
DK0553319T3 (da) Fremgangsmåde til adskillelse af en plastblanding bestående af mindst tre komponenter under anvendelse af elektrostatiske teknikker
DE69106815T2 (de) Verfahren zur Herstellung von veränderten Kohlenstoffmolekularsieben zur Gastrennung.
ATE18776T1 (de) Verfahren und vorrichtung zur zuechtung von mikroorganismen.
AU4685889A (en) Process for separating organometallic compounds and/or metal carbonyls from their solutions in organic media
DK0418517T3 (da) Skillemembran og skillefremgangsmåde
DE59107901D1 (de) Verfahren zur herstellung gereinigter glycolipide durch membrantrennverfahren
JPS56110625A (en) Separating method of blood plasma and apparatus for the same
DE68905403D1 (de) Verfahren zur erniedrigung des truebungspunktes von materialien unter anwendung eines ultrafiltrations-separationsprozesses.
ATE90662T1 (de) Verfahren zur trennung eines gemisches aus 1methoxypropanol-2 und wasser in seine bestandteile.
ATE32436T1 (de) Verfahren zur fraktionierten auftrennung von proteingemischen mittels membranen.
DE3780364T4 (de) Verfahren zur Abscheidung von Kohlendioxyd.
ATE48014T1 (de) Vorrichtung zur abtrennung von produkten aus einem produkt-substrat-gemisch.
DE3882154D1 (de) Verfahren zur herstellung des pres 1/s2/s-hepatitis-b-antigens aus hefe.
JPS5411322A (en) Hollow cellulose fibers and their production
DE3784179T2 (de) Verfahren zur sauerstofftrennung von luft.
ATE25586T1 (de) Vorrichtung zur behandlung von blut und verfahren zur bluttrennung zur plasmagewinnung.
ATA54782A (de) Verfahren zur herstellung eines adsorbens aus verfahren zur herstellung eines adsorbens aus mordenit enthaltendem rhiolittuff zur trennung mordenit enthaltendem rhiolittuff zur trennung von sauerstoff und stickstoff enthaltenden von sauerstoff und stickstoff enthaltenden gasgemischen gasgemischen
JPS5227072A (en) Process for washing of membrane separating apparatus