DK0547165T3 - Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc - Google Patents
Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxycInfo
- Publication number
- DK0547165T3 DK0547165T3 DK91918278T DK91918278T DK0547165T3 DK 0547165 T3 DK0547165 T3 DK 0547165T3 DK 91918278 T DK91918278 T DK 91918278T DK 91918278 T DK91918278 T DK 91918278T DK 0547165 T3 DK0547165 T3 DK 0547165T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- compounds
- alkoxyc
- hydroxy
- water
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Auxiliary Devices For And Details Of Packaging Control (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fodder In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58964390A | 1990-09-28 | 1990-09-28 | |
PCT/US1991/006888 WO1992005785A1 (en) | 1990-09-28 | 1991-09-23 | Water soluble camptothecin analogues, processes and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0547165T3 true DK0547165T3 (da) | 2000-03-27 |
Family
ID=24358879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91918278T DK0547165T3 (da) | 1990-09-28 | 1991-09-23 | Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc |
Country Status (25)
Country | Link |
---|---|
US (1) | US5734056A (ja) |
EP (1) | EP0547165B1 (ja) |
JP (1) | JP2848958B2 (ja) |
CN (1) | CN1033509C (ja) |
AT (1) | ATE186461T1 (ja) |
AU (1) | AU664830B2 (ja) |
CA (1) | CA2090967C (ja) |
CZ (1) | CZ51593A3 (ja) |
DE (1) | DE69131775T2 (ja) |
DK (1) | DK0547165T3 (ja) |
ES (1) | ES2137932T3 (ja) |
FI (1) | FI931384A (ja) |
GR (1) | GR3031823T3 (ja) |
HK (1) | HK1012283A1 (ja) |
HU (1) | HUT70024A (ja) |
IE (1) | IE913402A1 (ja) |
IL (1) | IL99571A (ja) |
NO (1) | NO931153L (ja) |
NZ (1) | NZ239947A (ja) |
PT (1) | PT99109B (ja) |
SI (1) | SI9111599A (ja) |
SK (1) | SK283693B6 (ja) |
WO (1) | WO1992005785A1 (ja) |
YU (1) | YU159991A (ja) |
ZA (1) | ZA917748B (ja) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
US5527913A (en) * | 1993-02-25 | 1996-06-18 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5447936A (en) * | 1993-12-22 | 1995-09-05 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof |
GB9402934D0 (en) * | 1994-02-16 | 1994-04-06 | Erba Carlo Spa | Camptothecin derivatives and process for their preparation |
KR960029336A (ko) * | 1995-01-09 | 1996-08-17 | 김충환 | 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제 |
US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
JPH08333370A (ja) * | 1995-06-08 | 1996-12-17 | Kyorin Pharmaceut Co Ltd | 水に可溶な新規フルオロエチルカンプトテシン誘導体、及びその製造方法 |
WO1997019085A1 (en) * | 1995-11-22 | 1997-05-29 | Research Triangle Institute | Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties |
US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
US6407118B1 (en) | 1996-01-30 | 2002-06-18 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
US5731316A (en) * | 1996-01-30 | 1998-03-24 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
GB9601779D0 (en) * | 1996-01-30 | 1996-04-03 | Pharmacia Spa | 9, 10 Disubstituted camptothecin derivatives |
US6043367A (en) * | 1998-09-30 | 2000-03-28 | Roffler; Steve | Proactive antitumor compounds |
US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
US6352996B1 (en) | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
CA2385528C (en) | 1999-10-01 | 2013-12-10 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
WO2004055020A1 (en) * | 2002-12-16 | 2004-07-01 | Council Of Scientific And Industrial Research | Process for the direct preparation of 5-alkoxy and 5-acyloxy analogues of campthothecins or mappicene ketones |
CN100372854C (zh) * | 2003-03-31 | 2008-03-05 | 科学与工业研究委员会 | 从10-羟基-20-(s)-喜树碱制备托泊替康的方法 |
US7151179B2 (en) * | 2003-05-12 | 2006-12-19 | Scinopharm Taiwan, Ltd. | Process for the preparation of 7-alkyl-10-hydroxy-20(S)-camptothecin |
CZ299329B6 (cs) * | 2003-08-26 | 2008-06-18 | Pliva-Lachema A.S. | Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu |
CZ298934B6 (cs) * | 2003-08-26 | 2008-03-12 | Pliva- Lachema A.S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
TWI333492B (en) * | 2003-11-12 | 2010-11-21 | Smithkline Beecham Cork Ltd | Crystalline topotecan hydrochloride product and preparation thereof |
CZ299593B6 (cs) * | 2003-12-16 | 2008-09-10 | Pliva-Lachema A. S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
US20050267141A1 (en) | 2004-05-28 | 2005-12-01 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives |
US20050272757A1 (en) * | 2004-06-04 | 2005-12-08 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives and novel intermediate and compounds thereof |
EP1791846A1 (en) * | 2004-08-09 | 2007-06-06 | Shilpa Medicare Limited | An improved process for the preparation of irinotecan hydrochloride trihydrate |
KR100848919B1 (ko) * | 2004-11-05 | 2008-07-29 | 주식회사 삼양사 | 10-히드록시캄토테신 화합물의 극성 비수성 용매에 대한용해도를 증가시키기 위한 약제학적 제형 |
US20060135546A1 (en) * | 2004-12-16 | 2006-06-22 | Jagadevappa Basavaraja | Methods for the purification of 20(S)- camptothecin |
NZ587586A (en) * | 2005-07-18 | 2012-04-27 | Bipar Sciences Inc | Treatment of cancer |
WO2007042799A1 (en) * | 2005-10-10 | 2007-04-19 | Cipla Limited | Novel crystalline forms |
US7547785B2 (en) | 2005-12-26 | 2009-06-16 | Dr. Reddy's Laboratories Limited | Process for preparing topotecan |
US20070259031A1 (en) * | 2006-04-26 | 2007-11-08 | The Regents Of The University Of California | Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics |
AR060635A1 (es) | 2006-04-27 | 2008-07-02 | Banyu Pharma Co Ltd | Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer |
CA2655257A1 (en) * | 2006-06-12 | 2008-12-04 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
US20100279327A1 (en) * | 2006-06-12 | 2010-11-04 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
US20080039485A1 (en) * | 2006-08-08 | 2008-02-14 | Targetgen Biotechnology Co., Ltd. | Low-dose-long-term pharmaceutical composition comprising camptothecin derivatives for the treatment of cancers |
JP2008081492A (ja) | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | オーロラa選択的阻害作用を有する新規アミノピリジン誘導体 |
US8143447B2 (en) * | 2006-09-05 | 2012-03-27 | Bipar Sciences, Inc. | Treatment of cancer |
CN101534836B (zh) * | 2006-09-05 | 2011-09-28 | 彼帕科学公司 | Parp抑制剂在制备治疗肥胖症的药物中的用途 |
US7977336B2 (en) | 2006-12-28 | 2011-07-12 | Banyu Pharmaceutical Co. Ltd | Aminopyrimidine derivatives as PLK1 inhibitors |
US7977483B2 (en) | 2007-04-11 | 2011-07-12 | Scinopharm Taiwan, Ltd. | Process for making topotecan |
JP2011500684A (ja) * | 2007-10-19 | 2011-01-06 | バイパー サイエンシズ,インコーポレイティド | ベンゾピロン系parp阻害剤を用いる癌の処置方法および組成物 |
AU2008315048A1 (en) | 2007-10-23 | 2009-04-30 | Msd K.K. | Pyridone-substituted-dihydropyrazolopyrimidinone derivative |
WO2009064444A2 (en) * | 2007-11-12 | 2009-05-22 | Bipar Sciences, Inc. | Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents |
NZ586125A (en) * | 2007-11-12 | 2012-12-21 | Bipar Sciences Inc | Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents |
ITMI20072268A1 (it) | 2007-12-04 | 2009-06-05 | Antibioticos Spa | Polimorfi cristallini di topotecan cloridrato con elevato grado di purezza e metodi per la loro preparazione |
CN101888777A (zh) * | 2007-12-07 | 2010-11-17 | 彼帕科学公司 | 用拓扑异构酶抑制剂和parp抑制剂的组合治疗癌症 |
CN101450949B (zh) * | 2007-12-07 | 2011-10-05 | 上海龙翔生物医药开发有限公司 | 一种10-羟基喜树碱的化学半合成工艺 |
AU2009252303B2 (en) | 2008-05-29 | 2013-04-04 | Microbiopharm Japan Co., Ltd. | Production method for camptothecin derivative |
EP2401281A4 (en) | 2009-02-25 | 2012-08-15 | Msd Kk | PYRIMIDINPYRIMIDOINDAZOLDERIVAT |
US8481503B2 (en) | 2009-03-06 | 2013-07-09 | Merck Sharp & Dohme Corp. | Combination cancer therapy with an AKT inhibitor and other anticancer agents |
EP2654754B1 (en) | 2010-12-17 | 2016-12-21 | Novartis AG | Combination for treating osteosarcoma, rhabdomyosarcoma and neuroblastoma |
JP2014504638A (ja) | 2011-02-01 | 2014-02-24 | グラクソスミスクライン インテレクチュアル プロパティ リミテッド | 組合せ |
CN103145720B (zh) * | 2013-02-20 | 2015-09-30 | 上海北卡医药技术有限公司 | 一种10-羟基喜树碱的一水合物的制备方法 |
EP2881396A1 (en) * | 2013-12-03 | 2015-06-10 | Synbias Pharma AG | Method for the synthesis of irinotecan |
WO2023220641A2 (en) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Methods and uses related to t cell therapy and production of same |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4473692A (en) * | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
JPS595188A (ja) * | 1982-06-30 | 1984-01-12 | Yakult Honsha Co Ltd | 10−ヒドロキシカンプトテシンの製造法 |
JPS5946284A (ja) * | 1982-09-10 | 1984-03-15 | Yakult Honsha Co Ltd | 11−ニトロカンプトテシン誘導体およびその製造法 |
US4894456A (en) * | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
GB9008605D0 (en) * | 1990-04-17 | 1990-06-13 | Smith Kline French Lab | Process |
HU213136B (en) * | 1990-08-14 | 1997-02-28 | Kyorin Seiyaku Kk | Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them |
US5352789A (en) * | 1993-02-25 | 1994-10-04 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
-
1991
- 1991-09-23 AT AT91918278T patent/ATE186461T1/de not_active IP Right Cessation
- 1991-09-23 HU HU9300878A patent/HUT70024A/hu unknown
- 1991-09-23 SK SK259-93A patent/SK283693B6/sk not_active IP Right Cessation
- 1991-09-23 JP JP3516992A patent/JP2848958B2/ja not_active Expired - Lifetime
- 1991-09-23 DK DK91918278T patent/DK0547165T3/da active
- 1991-09-23 WO PCT/US1991/006888 patent/WO1992005785A1/en active IP Right Grant
- 1991-09-23 CZ CS93515A patent/CZ51593A3/cs unknown
- 1991-09-23 AU AU87399/91A patent/AU664830B2/en not_active Expired
- 1991-09-23 DE DE69131775T patent/DE69131775T2/de not_active Expired - Lifetime
- 1991-09-23 ES ES91918278T patent/ES2137932T3/es not_active Expired - Lifetime
- 1991-09-23 CA CA002090967A patent/CA2090967C/en not_active Expired - Lifetime
- 1991-09-23 EP EP91918278A patent/EP0547165B1/en not_active Expired - Lifetime
- 1991-09-26 NZ NZ23994791A patent/NZ239947A/en not_active IP Right Cessation
- 1991-09-26 IL IL9957191A patent/IL99571A/xx not_active IP Right Cessation
- 1991-09-27 ZA ZA917748A patent/ZA917748B/xx unknown
- 1991-09-27 PT PT99109A patent/PT99109B/pt not_active IP Right Cessation
- 1991-09-27 IE IE340291A patent/IE913402A1/en not_active IP Right Cessation
- 1991-09-28 CN CN91110656A patent/CN1033509C/zh not_active Expired - Lifetime
- 1991-09-30 SI SI9111599A patent/SI9111599A/sl unknown
- 1991-09-30 YU YU159991A patent/YU159991A/sh unknown
-
1993
- 1993-03-26 FI FI931384A patent/FI931384A/fi not_active Application Discontinuation
- 1993-03-26 NO NO93931153A patent/NO931153L/no unknown
-
1995
- 1995-05-25 US US08/451,079 patent/US5734056A/en not_active Expired - Lifetime
-
1998
- 1998-12-16 HK HK98113607A patent/HK1012283A1/xx not_active IP Right Cessation
-
1999
- 1999-11-11 GR GR990402820T patent/GR3031823T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0547165T3 (da) | Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc | |
JPS5412381A (en) | N-alkylpiperidine derivative | |
DK161744C (da) | Fremgangsmaade til fremstilling af fritstroemmende ethylcellulosemikrokapsler | |
ES550106A0 (es) | Un procedimiento para preparar heteroarilpiperazinas biciclicas. | |
DK155944C (da) | Analogifremgangsmaade til fremstilling af 7-omega-substitueretethylen(cis)-thio-acetamido)-3-cephem-4-carboxylsyrederivater. | |
JPS52286A (en) | Method of preparing 1-(3-phenylpropyl)-4-acylpiperazine derivatives | |
JPS5235227A (en) | Preparation of filters for adhesives | |
JPS547427A (en) | Novel disazo compounds and their preparation | |
JPS51128483A (en) | Process for cultivating algae using fermentation waste gas | |
DK132283D0 (da) | Fremgangsmade til fremstilling af indolizino(8,7-b)indolderivater | |
JPS51139688A (en) | Process for preparing new alkaloid tm-64 substance by fermentation | |
JPS5251394A (en) | Preparation of 6-n-substituted-aminopurines | |
JPS53101373A (en) | Imidazole-4(5)-carboxylic acid anilide derivatives | |
ES516584A0 (es) | Mejoras introducidas en un procedimiento para la preparacion de hidroximidatos y tiolhidroximidatos heterobiciclicos y derivados ester carbamato de lso mismos. | |
JPS51131697A (en) | Bill discriminator | |
JPS5411296A (en) | Preparation of uricase by fermentation | |
JPS5231093A (en) | Preparation of 3- methylenecephalosporanic acid derivatives | |
JPS51128988A (en) | Process for preparing quinazolone compounds | |
JPS5269491A (en) | Preparation of high polymeric selenium compounds | |
JPS5217465A (en) | Preparation of 4-iodo-5-bromoindole-3- phosphates | |
JPS543059A (en) | Preparation of tryptophane | |
JPS5248697A (en) | Preparation of novel homo-proaporphine compounds | |
JPS5248632A (en) | Process for preparation of novel l-leucyl-p-alakyaminoanilide homologu es | |
JPS51123890A (en) | Process for preparing optically active 1-cyclopentene-3, 5-diol and or its derivatives | |
JPS52122388A (en) | Preparation of 7-amino-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid derivatives |