DK0527801T3 - Thiophensulfonamider, der er anvendelige som carboanhydraseinhibitorer - Google Patents
Thiophensulfonamider, der er anvendelige som carboanhydraseinhibitorerInfo
- Publication number
- DK0527801T3 DK0527801T3 DK91908317T DK91908317T DK0527801T3 DK 0527801 T3 DK0527801 T3 DK 0527801T3 DK 91908317 T DK91908317 T DK 91908317T DK 91908317 T DK91908317 T DK 91908317T DK 0527801 T3 DK0527801 T3 DK 0527801T3
- Authority
- DK
- Denmark
- Prior art keywords
- sulfonamides useful
- thiophene sulfonamides
- carbohydrate inhibitors
- carbohydrate
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Lubricants (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50673090A | 1990-04-09 | 1990-04-09 | |
US07/618,765 US5153192A (en) | 1990-04-09 | 1990-11-27 | Thiophene sulfonamides useful as carbonic anhydrase inhibitors |
PCT/US1991/002262 WO1991015486A1 (en) | 1990-04-09 | 1991-04-03 | Thiophene sulfonamides useful as carbonic anydrase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0527801T3 true DK0527801T3 (da) | 2002-11-25 |
Family
ID=27055558
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91908317T DK0527801T3 (da) | 1990-04-09 | 1991-04-03 | Thiophensulfonamider, der er anvendelige som carboanhydraseinhibitorer |
Country Status (20)
Country | Link |
---|---|
US (2) | US5153192A (ko) |
EP (1) | EP0527801B1 (ko) |
JP (1) | JP2562394B2 (ko) |
KR (1) | KR100196414B1 (ko) |
AT (1) | ATE221527T1 (ko) |
AU (1) | AU655924B2 (ko) |
BR (1) | BR9106330A (ko) |
CA (1) | CA2080223C (ko) |
DE (3) | DE122009000026I1 (ko) |
DK (1) | DK0527801T3 (ko) |
ES (1) | ES2180530T3 (ko) |
FI (2) | FI924553A0 (ko) |
HK (1) | HK1014186A1 (ko) |
IL (1) | IL97800A (ko) |
LU (2) | LU90935I2 (ko) |
NL (2) | NL300098I2 (ko) |
NO (1) | NO923948L (ko) |
NZ (1) | NZ237754A (ko) |
WO (1) | WO1991015486A1 (ko) |
ZA (1) | ZA912580B (ko) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5585377A (en) * | 1990-04-09 | 1996-12-17 | Alcon Laboratories, Inc. | Sulfonamides useful as carbonic anhydrase inhibitors |
FR2662439B1 (fr) * | 1990-05-23 | 1993-11-19 | Rhone Poulenc Chimie | Reactif et procede de perfluoroalkylation de substrats nucleophiles par les perfluoroalcanesulfinates de sodium en milieu oxydant. |
SG84487A1 (en) | 1991-04-17 | 2001-11-20 | Merck & Co Inc | Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist |
CA2129037C (en) * | 1992-02-21 | 1998-03-24 | Thomas Robert Dean | Topical antiglaucoma compositions comprising carbonic anhydrase inhibitors and beta-blockers |
US5932572A (en) * | 1992-02-21 | 1999-08-03 | Alcon Laboratories, Inc. | Topical anti-glaucoma compositions |
US5308842A (en) * | 1992-09-09 | 1994-05-03 | Merck & Co., Inc. | Tricyclic derivatives of the thienodiazocine and thienothiadiazocine classes of compounds |
US5276025A (en) * | 1992-09-09 | 1994-01-04 | Merck & Co., Inc. | Heterobicyclic sulfonamides |
AU3722793A (en) * | 1992-09-17 | 1994-04-12 | Alcon Laboratories, Inc. | Topical carbonic anhydrase inhibitor composition |
US5344929A (en) * | 1993-02-18 | 1994-09-06 | Alcon Laboratories, Inc. | Preparation of carbonic anhydrase inhibitors |
AU1684895A (en) * | 1994-01-21 | 1995-08-08 | Alcon Laboratories, Inc. | Thienothiazine sulfonamide derivatives process and intermediates for their preparation and their use as carbonic anhydrase inhibitors |
US5538966A (en) * | 1994-01-21 | 1996-07-23 | Alcon Laboratories, Inc. | Carbonic anhydrase inhibitors |
US5646142A (en) * | 1994-07-08 | 1997-07-08 | Alcon Laboratories, Inc. | Thiophene sulfonamides useful as carbonic anhydrase inhibitors |
US6316443B1 (en) | 1994-08-04 | 2001-11-13 | Merck & Co., Inc. | Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist |
US5464831A (en) * | 1994-09-09 | 1995-11-07 | Alcon Laboratories, Inc. | Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors |
US5510347A (en) * | 1994-09-09 | 1996-04-23 | Alcon Laboratories, Inc. | Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors |
US5470973A (en) * | 1994-10-03 | 1995-11-28 | Alcon Laboratories, Inc. | Synthesis of sulfonamide intermediates |
US5620970A (en) * | 1995-06-05 | 1997-04-15 | Alcon Laboratories, Inc. | Topical ophthalmic carbonic anhydrase inhibitor formulations |
US6172054B1 (en) | 1995-06-15 | 2001-01-09 | Alcon Laboratories, Inc. | Combination therapy for lowering and controlling intraocular pressure |
WO1997002825A1 (en) * | 1995-07-12 | 1997-01-30 | Alcon Laboratories, Inc. | Thiophene sulfonamides useful as carbonic anhydrase inhibitors |
US6441047B2 (en) | 1995-11-17 | 2002-08-27 | Alcon Manufacturing Ltd.. | Combination therapy for treating glaucoma |
CA2237898A1 (en) * | 1995-11-17 | 1997-05-29 | Louis Desantis Jr. | Combination therapy for treating glaucoma |
SK284371B6 (sk) * | 1996-02-26 | 2005-02-04 | Advanced Research And Technology Institute | Použitie oftalmologickej kompozície obsahujúcej účinné množstvo lokálneho inhibítora anhydrázy kyseliny uhličitej na prípravu liečiva |
US5900427A (en) * | 1996-05-03 | 1999-05-04 | Wisconsin Alumni Research Foundation | N-heteroarenesulfonyl-protected amino acid reagents for peptide synthesis |
AUPO227896A0 (en) | 1996-09-13 | 1996-10-03 | Fujisawa Pharmaceutical Co., Ltd. | Novel compounds and their preparation |
CA2310230C (en) | 1997-12-23 | 2008-05-06 | Alcon Laboratories, Inc. | The use of brinzolamide to prevent visual field loss |
US6156785A (en) * | 1998-01-23 | 2000-12-05 | Merck Sharp & Dohme B.V. | Method for increasing oxygen tension in the optic nerve and retina |
AU741525B2 (en) * | 1998-03-06 | 2001-12-06 | Board Of Regents, The University Of Texas System | Composition and method for treating macular disorders |
US5948801A (en) * | 1998-03-09 | 1999-09-07 | Alcon Laboratories, Inc. | Treatment of retinal edema with brinzolamide |
US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
DE60135972D1 (de) * | 2000-01-18 | 2008-11-13 | Merck & Co Inc | Orhthalmologische zusammenstellungen zur behandlung von ocularer hypertension |
US6548535B2 (en) | 2000-01-18 | 2003-04-15 | Merck & Co., Inc. | Method for treating ocular hypertension |
WO2001074827A1 (en) * | 2000-03-31 | 2001-10-11 | Purdue Research Foundation | Phosphoramidate prodrugs |
EP1341541A4 (en) * | 2000-11-16 | 2004-11-17 | Alcon Mfg Ltd | COMBINATION THERAPY FOR LOWERING AND CONTROLLING THE EYE PRESSURE |
US20040067992A1 (en) * | 2001-08-10 | 2004-04-08 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a carbonic anhydrase inhibitor for the treatment of neoplasia |
US20040254230A1 (en) * | 2001-12-03 | 2004-12-16 | Ogidigben Miller J. | Method for treating ocular hypertension |
US20050124595A1 (en) * | 2002-03-15 | 2005-06-09 | Goetz Michael A. | Compositions and methods for treating glaucoma and ocular hypertension |
US20060258726A1 (en) * | 2002-06-06 | 2006-11-16 | Xavier Billot | 1,5-Disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases |
WO2003105847A1 (en) * | 2002-06-14 | 2003-12-24 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
JP2005533055A (ja) * | 2002-06-17 | 2005-11-04 | メルク エンド カムパニー インコーポレーテッド | 新規マキシkチャンネルブロッカー、その使用方法および製造方法 |
US20050239787A1 (en) * | 2002-06-17 | 2005-10-27 | Goetz Michael A | Novel maxi-k channel blockers, methods of use and process for making the same |
EP1515722A4 (en) * | 2002-06-17 | 2006-06-21 | Merck & Co Inc | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION |
WO2004019938A1 (en) * | 2002-08-28 | 2004-03-11 | Merck Frosst Canada & Co. | Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma |
CA2502914A1 (en) * | 2002-10-25 | 2004-05-06 | Merck Frosst Canada & Co. | 2-pyrrolidones as ep4 receptor agonists |
KR100503618B1 (ko) * | 2002-11-07 | 2005-07-26 | 안헌상 | 케이크용 장식용품 |
US20040216749A1 (en) * | 2003-01-23 | 2004-11-04 | Hosheng Tu | Vasomodulation during glaucoma surgery |
CN1791402A (zh) * | 2003-03-27 | 2006-06-21 | 麦克公司 | 治疗眼高压的眼科组合物 |
US6949518B1 (en) | 2003-06-25 | 2005-09-27 | Pao-Hsien Chu | Methods for treating macular degeneration with topiramate |
US20050119262A1 (en) * | 2003-08-21 | 2005-06-02 | Pharmacia Corporation | Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent |
KR100537781B1 (ko) * | 2004-06-02 | 2005-12-20 | 안헌상 | 케이크 장식용품의 제조방법 및 그 물품 |
KR101333990B1 (ko) | 2005-07-12 | 2013-11-27 | 코와 가부시키가이샤 | 녹내장을 예방 또는 치료하는 약제 |
JP4831668B2 (ja) * | 2006-02-16 | 2011-12-07 | 独立行政法人産業技術総合研究所 | 新規なチアジノインドール化合物およびその製造方法 |
LT5504B (lt) | 2006-08-02 | 2008-06-25 | Biotechnologijos Institutas | Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti |
PT2106260T (pt) | 2007-01-25 | 2018-03-05 | Naia Metabolic Inc | Sensibilizadores de insulina e métodos de tratamento |
WO2008120099A1 (en) * | 2007-03-30 | 2008-10-09 | Pfizer Inc. | Thieno [3, 2-e] [1, 2] thiazine derivative as inhibitor of carbonic anhydrase |
EP1985618A1 (en) * | 2007-04-27 | 2008-10-29 | Duke Chem, S. A. | Process for the preparation of brinzolamide and intermediates thereof |
EP2234608A2 (en) | 2007-12-11 | 2010-10-06 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties |
ITMI20081084A1 (it) * | 2008-06-16 | 2009-12-17 | Phf Sa | Processo per la preparazione di brinzolamide |
US8332007B2 (en) * | 2009-01-12 | 2012-12-11 | The Board Of Trustees Of The University Of Illinois | Quantitative three-dimensional mapping of oxygen tension |
JP2012520266A (ja) * | 2009-03-13 | 2012-09-06 | アザド ファーマスーティカル イングリーディエンツ アクチエンゲゼルシャフト | ブリンゾラミドの製造方法 |
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
EP2348026A1 (en) | 2009-12-22 | 2011-07-27 | Duke Chem, S. A. | Process for the preparation of brinzolamide and intermediates thereof |
EP2394637A1 (en) | 2010-05-21 | 2011-12-14 | Zaklady Farmaceutyczne Polpharma SA | Process for obtaining sterile brinzolamide suspensions |
TW201210584A (en) | 2010-08-18 | 2012-03-16 | Alcon Res Ltd | Bradykinin receptor agonists and uses thereof to treat ocular hypertension and glaucoma |
US20110021974A1 (en) * | 2010-10-05 | 2011-01-27 | Shantha Totada R | Retinitis pigmentosa treatment and prophalaxis |
WO2012053011A2 (en) | 2010-10-18 | 2012-04-26 | Usv Limited | Ophthalmic compositions comprising brinzolamide |
EP3659495B1 (en) | 2011-09-13 | 2022-12-14 | Dose Medical Corporation | Intraocular physiological sensor |
JP5836851B2 (ja) * | 2012-03-12 | 2015-12-24 | 株式会社トクヤマ | ブリンゾラミドの製造方法 |
EP2638909A1 (en) | 2012-03-15 | 2013-09-18 | Azad Pharmaceutical Ingredients AG | Process for preparing sterile Brinzolamide |
JP5881514B2 (ja) * | 2012-04-09 | 2016-03-09 | 株式会社トクヤマ | アミン誘導体の製造方法 |
JP5914246B2 (ja) * | 2012-08-10 | 2016-05-11 | 株式会社トクヤマ | ブリンゾラミドの精製方法 |
CN102936236A (zh) * | 2012-11-13 | 2013-02-20 | 江苏吉贝尔药业有限公司 | 一种布林佐胺中间体(3-乙酰基-5-氯-2-(苄基巯基)噻酚)的制备方法 |
US9730638B2 (en) | 2013-03-13 | 2017-08-15 | Glaukos Corporation | Intraocular physiological sensor |
EA030535B1 (ru) | 2013-10-17 | 2018-08-31 | Сентисс Фарма Прайвет Лимитед | Не содержащий консерванта офтальмологический фармацевтический состав |
WO2015068105A1 (en) | 2013-11-08 | 2015-05-14 | Sentiss Pharma Private Limited | An improved process for manufacturing sterile ophthalmic pharmaceutical suspensions |
US9820991B2 (en) | 2013-11-08 | 2017-11-21 | Sentiss Pharma Private Limited | Pharmaceutical composition comprising brinzolamide |
EP3096740B1 (en) * | 2014-01-24 | 2020-09-30 | Sentiss Pharma Private Limited | Pharmaceutical composition comprising brinzolamide |
JP6704400B2 (ja) | 2014-10-20 | 2020-06-03 | センティス・ファーマ・プライヴェート・リミテッド | 眼科用液剤 |
WO2017099207A1 (ja) * | 2015-12-10 | 2017-06-15 | 千寿製薬株式会社 | 眼科用医薬製品 |
CA3043938A1 (en) | 2016-12-21 | 2018-06-28 | Biotheryx, Inc. | Thienopyrrole derivatives for use in targeting proteins, compositions, methods, and uses thereof |
US11298360B2 (en) | 2018-04-25 | 2022-04-12 | Shilpa Medicare Limited | Ophthalmic compositions of brinzolamide |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA661731A (en) * | 1963-04-23 | Siedel Walter | Substituted thiophene-3,5-disulfonamides and a process for preparing them | |
DE1096916B (de) * | 1957-12-17 | 1961-01-12 | Hoechst Ag | Verfahren zur Herstellung von Thiophen-3, 5-disulfonamiden |
GB1516024A (en) * | 1977-04-20 | 1978-06-28 | Pfizer Ltd | Thiophene-2,5-disulphonamides |
US4746745A (en) * | 1980-07-09 | 1988-05-24 | Maren Thomas H | 1,3,4-thiadiazoline-5-sulfonamides |
US4797413A (en) * | 1986-05-14 | 1989-01-10 | Merck & Co., Inc. | Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use |
US4731368A (en) * | 1986-12-08 | 1988-03-15 | Merck & Co., Inc. | Thienopyridine sulfonamides and their ophthalmological formulation |
US4847289A (en) * | 1987-06-08 | 1989-07-11 | Merck & Co., Inc. | Thiophene sulfonamide antiglaucoma agents |
US5093332A (en) * | 1990-10-01 | 1992-03-03 | Merck & Co., Inc. | Substituted thieno(2,3-b)(1,4)thiazine-6-sulfonamides as antiglaucoma agents |
-
1990
- 1990-11-27 US US07/618,765 patent/US5153192A/en not_active Expired - Lifetime
-
1991
- 1991-04-03 KR KR1019920702476A patent/KR100196414B1/ko not_active IP Right Cessation
- 1991-04-03 EP EP91908317A patent/EP0527801B1/en not_active Expired - Lifetime
- 1991-04-03 ES ES91908317T patent/ES2180530T3/es not_active Expired - Lifetime
- 1991-04-03 JP JP3508001A patent/JP2562394B2/ja not_active Expired - Lifetime
- 1991-04-03 BR BR919106330A patent/BR9106330A/pt not_active Application Discontinuation
- 1991-04-03 DE DE122009000026C patent/DE122009000026I1/de active Pending
- 1991-04-03 DE DE1991633080 patent/DE10299054I1/de active Pending
- 1991-04-03 CA CA002080223A patent/CA2080223C/en not_active Expired - Lifetime
- 1991-04-03 WO PCT/US1991/002262 patent/WO1991015486A1/en active IP Right Grant
- 1991-04-03 DE DE69133080T patent/DE69133080T2/de not_active Expired - Lifetime
- 1991-04-03 AU AU77467/91A patent/AU655924B2/en not_active Expired
- 1991-04-03 DK DK91908317T patent/DK0527801T3/da active
- 1991-04-03 AT AT91908317T patent/ATE221527T1/de active
- 1991-04-08 ZA ZA912580A patent/ZA912580B/xx unknown
- 1991-04-09 NZ NZ237754A patent/NZ237754A/en unknown
- 1991-04-09 IL IL9780091A patent/IL97800A/xx not_active IP Right Cessation
- 1991-10-09 US US07/775,313 patent/US5240923A/en not_active Expired - Lifetime
-
1992
- 1992-10-08 FI FI924553A patent/FI924553A0/fi not_active Application Discontinuation
- 1992-10-09 NO NO92923948A patent/NO923948L/no unknown
-
1996
- 1996-09-02 FI FI963424A patent/FI963424A/fi not_active Application Discontinuation
-
1998
- 1998-12-24 HK HK98115497A patent/HK1014186A1/xx not_active IP Right Cessation
-
2002
- 2002-07-05 LU LU90935C patent/LU90935I2/fr unknown
- 2002-09-04 NL NL300098C patent/NL300098I2/nl unknown
-
2009
- 2009-04-22 LU LU91555C patent/LU91555I2/fr unknown
- 2009-05-11 NL NL300389C patent/NL300389I1/nl unknown
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