FI924553A0 - Tiofensulfonamider anvaendbara som kolanhydrasinhibitorer - Google Patents

Tiofensulfonamider anvaendbara som kolanhydrasinhibitorer

Info

Publication number
FI924553A0
FI924553A0 FI924553A FI924553A FI924553A0 FI 924553 A0 FI924553 A0 FI 924553A0 FI 924553 A FI924553 A FI 924553A FI 924553 A FI924553 A FI 924553A FI 924553 A0 FI924553 A0 FI 924553A0
Authority
FI
Finland
Prior art keywords
thiofensulphonamider
cololhydrasinhibitorer
anvaendbara som
anvaendbara
som
Prior art date
Application number
FI924553A
Other languages
English (en)
Other versions
FI924553A (fi
Inventor
Thomas R Dean
Hwang-Hsing Chen
Jesse A May
Anura Pathmaciri Dantanarayana
Daniel Kuzmich
Paul W Zinke
Raymond Eugene Conrow
Michael E Deason
Mark Thomas Dupriest
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Publication of FI924553A publication Critical patent/FI924553A/fi
Publication of FI924553A0 publication Critical patent/FI924553A0/fi
Priority to FI963424A priority Critical patent/FI963424A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
FI924553A 1990-04-09 1992-10-08 Tiofensulfonamider anvaendbara som kolanhydrasinhibitorer FI924553A0 (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI963424A FI963424A (fi) 1990-04-09 1996-09-02 Menetelmä terapeuttisesti aktiivisten tiofeenisulfonamidien valmistamiseksi

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50673090A 1990-04-09 1990-04-09
US07/618,765 US5153192A (en) 1990-04-09 1990-11-27 Thiophene sulfonamides useful as carbonic anhydrase inhibitors
PCT/US1991/002262 WO1991015486A1 (en) 1990-04-09 1991-04-03 Thiophene sulfonamides useful as carbonic anydrase inhibitors

Publications (2)

Publication Number Publication Date
FI924553A FI924553A (fi) 1992-10-08
FI924553A0 true FI924553A0 (fi) 1992-10-08

Family

ID=27055558

Family Applications (2)

Application Number Title Priority Date Filing Date
FI924553A FI924553A0 (fi) 1990-04-09 1992-10-08 Tiofensulfonamider anvaendbara som kolanhydrasinhibitorer
FI963424A FI963424A (fi) 1990-04-09 1996-09-02 Menetelmä terapeuttisesti aktiivisten tiofeenisulfonamidien valmistamiseksi

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI963424A FI963424A (fi) 1990-04-09 1996-09-02 Menetelmä terapeuttisesti aktiivisten tiofeenisulfonamidien valmistamiseksi

Country Status (20)

Country Link
US (2) US5153192A (fi)
EP (1) EP0527801B1 (fi)
JP (1) JP2562394B2 (fi)
KR (1) KR100196414B1 (fi)
AT (1) ATE221527T1 (fi)
AU (1) AU655924B2 (fi)
BR (1) BR9106330A (fi)
CA (1) CA2080223C (fi)
DE (3) DE122009000026I1 (fi)
DK (1) DK0527801T3 (fi)
ES (1) ES2180530T3 (fi)
FI (2) FI924553A0 (fi)
HK (1) HK1014186A1 (fi)
IL (1) IL97800A (fi)
LU (2) LU90935I2 (fi)
NL (2) NL300098I2 (fi)
NO (1) NO923948L (fi)
NZ (1) NZ237754A (fi)
WO (1) WO1991015486A1 (fi)
ZA (1) ZA912580B (fi)

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FR2662439B1 (fr) * 1990-05-23 1993-11-19 Rhone Poulenc Chimie Reactif et procede de perfluoroalkylation de substrats nucleophiles par les perfluoroalcanesulfinates de sodium en milieu oxydant.
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US5932572A (en) * 1992-02-21 1999-08-03 Alcon Laboratories, Inc. Topical anti-glaucoma compositions
AU677577B2 (en) * 1992-02-21 1997-05-01 Alcon Laboratories, Inc. Topical antiglaucoma compositions comprising carbonic anhydrase inhibitors and beta-blockers
US5308842A (en) * 1992-09-09 1994-05-03 Merck & Co., Inc. Tricyclic derivatives of the thienodiazocine and thienothiadiazocine classes of compounds
US5276025A (en) * 1992-09-09 1994-01-04 Merck & Co., Inc. Heterobicyclic sulfonamides
CA2141879A1 (en) * 1992-09-17 1994-03-31 Thomas Robert Dean Topical carbonic anhydrase inhibitor composition
US5344929A (en) * 1993-02-18 1994-09-06 Alcon Laboratories, Inc. Preparation of carbonic anhydrase inhibitors
US5538966A (en) * 1994-01-21 1996-07-23 Alcon Laboratories, Inc. Carbonic anhydrase inhibitors
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US6316443B1 (en) 1994-08-04 2001-11-13 Merck & Co., Inc. Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
US5464831A (en) * 1994-09-09 1995-11-07 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5510347A (en) * 1994-09-09 1996-04-23 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5470973A (en) * 1994-10-03 1995-11-28 Alcon Laboratories, Inc. Synthesis of sulfonamide intermediates
US5620970A (en) * 1995-06-05 1997-04-15 Alcon Laboratories, Inc. Topical ophthalmic carbonic anhydrase inhibitor formulations
US6172054B1 (en) 1995-06-15 2001-01-09 Alcon Laboratories, Inc. Combination therapy for lowering and controlling intraocular pressure
AU2998995A (en) * 1995-07-12 1997-02-10 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
WO1997018812A1 (en) * 1995-11-17 1997-05-29 Alcon Laboratories, Inc. Combination therapy for treating glaucoma
DK0954305T3 (da) * 1996-02-26 2003-08-25 Advanced Res & Tech Inst Anvendelse af carbonanhydraseinhibitorer til behandling af maculaødem
US5900427A (en) * 1996-05-03 1999-05-04 Wisconsin Alumni Research Foundation N-heteroarenesulfonyl-protected amino acid reagents for peptide synthesis
AUPO227896A0 (en) * 1996-09-13 1996-10-03 Fujisawa Pharmaceutical Co., Ltd. Novel compounds and their preparation
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US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
US6548535B2 (en) * 2000-01-18 2003-04-15 Merck & Co., Inc. Method for treating ocular hypertension
ATE409491T1 (de) 2000-01-18 2008-10-15 Merck & Co Inc Orhthalmologische zusammenstellungen zur behandlung von ocularer hypertension
DE60117247D1 (de) * 2000-03-31 2006-04-20 Purdue Research Foundation West Lafayette Phosphoramidat-prodrugs
WO2002040030A1 (en) * 2000-11-16 2002-05-23 Alcon Manufacturing, Ltd. Combination therapy for lowering and controlling intraocular pressure
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WO2003077845A2 (en) * 2002-03-15 2003-09-25 Merck & Co., Inc. Compositions and methods for treating glaucoma and ocular hypertension
JP2005534653A (ja) * 2002-06-06 2005-11-17 メルク フロスト カナダ アンド カンパニー 眼及び骨疾患の治療に於いてｅｐ４受容体作動薬として使用するための１，５−二置換イミダゾリジン−２−オン誘導体
AU2003239972B2 (en) * 2002-06-14 2008-02-28 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
JP2005533055A (ja) * 2002-06-17 2005-11-04 メルク　エンド　カムパニー　インコーポレーテッド 新規マキシｋチャンネルブロッカー、その使用方法および製造方法
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US20050239787A1 (en) * 2002-06-17 2005-10-27 Goetz Michael A Novel maxi-k channel blockers, methods of use and process for making the same
WO2004019938A1 (en) * 2002-08-28 2004-03-11 Merck Frosst Canada & Co. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
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DE1096916B (de) * 1957-12-17 1961-01-12 Hoechst Ag Verfahren zur Herstellung von Thiophen-3, 5-disulfonamiden
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Also Published As

Publication number Publication date
FI963424A0 (fi) 1996-09-02
EP0527801A1 (en) 1993-02-24
NL300098I2 (nl) 2003-01-06
KR930700490A (ko) 1993-03-15
HK1014186A1 (en) 1999-09-24
LU90935I2 (en) 2002-09-05
EP0527801A4 (en) 1993-03-10
ATE221527T1 (de) 2002-08-15
LU91555I2 (fr) 2009-06-22
NO923948L (no) 1992-12-08
EP0527801B1 (en) 2002-07-31
AU7746791A (en) 1991-10-30
NL300098I1 (nl) 2002-11-01
CA2080223C (en) 2000-11-07
NO923948D0 (no) 1992-10-09
DE69133080T2 (de) 2003-03-27
AU655924B2 (en) 1995-01-19
US5240923A (en) 1993-08-31
JPH05508832A (ja) 1993-12-09
NZ237754A (en) 1992-08-26
CA2080223A1 (en) 1991-10-10
DE122009000026I1 (de) 2010-01-28
BR9106330A (pt) 1993-04-20
FI963424A (fi) 1996-09-02
DE10299054I1 (de) 2006-06-08
US5153192A (en) 1992-10-06
DE69133080D1 (de) 2002-09-05
IL97800A (en) 1997-08-14
NL300389I1 (nl) 2009-07-01
FI924553A (fi) 1992-10-08
ES2180530T3 (es) 2003-02-16
ZA912580B (en) 1992-01-29
JP2562394B2 (ja) 1996-12-11
IL97800A0 (en) 1992-06-21
WO1991015486A1 (en) 1991-10-17
DK0527801T3 (da) 2002-11-25
KR100196414B1 (ko) 1999-06-15

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