DE69133080T2 - Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide - Google Patents

Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide

Info

Publication number
DE69133080T2
DE69133080T2 DE69133080T DE69133080T DE69133080T2 DE 69133080 T2 DE69133080 T2 DE 69133080T2 DE 69133080 T DE69133080 T DE 69133080T DE 69133080 T DE69133080 T DE 69133080T DE 69133080 T2 DE69133080 T2 DE 69133080T2
Authority
DE
Germany
Prior art keywords
thiophene sulfonamides
sulfonamides used
carbohydrase
inhibitors
carbohydrase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69133080T
Other languages
English (en)
Other versions
DE10299054I1 (de
DE69133080D1 (de
Inventor
R Dean
Hwang-Hsing Chen
A May
Pathmaciri Dantanarayana
Daniel Kuzmich
Paul W Zinke
Eugene Conrow
E Deason
Thomas Dupriest
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Application granted granted Critical
Publication of DE69133080D1 publication Critical patent/DE69133080D1/de
Publication of DE69133080T2 publication Critical patent/DE69133080T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
DE69133080T 1990-04-09 1991-04-03 Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide Expired - Lifetime DE69133080T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50673090A 1990-04-09 1990-04-09
US07/618,765 US5153192A (en) 1990-04-09 1990-11-27 Thiophene sulfonamides useful as carbonic anhydrase inhibitors
PCT/US1991/002262 WO1991015486A1 (en) 1990-04-09 1991-04-03 Thiophene sulfonamides useful as carbonic anydrase inhibitors

Publications (2)

Publication Number Publication Date
DE69133080D1 DE69133080D1 (de) 2002-09-05
DE69133080T2 true DE69133080T2 (de) 2003-03-27

Family

ID=27055558

Family Applications (3)

Application Number Title Priority Date Filing Date
DE1991633080 Pending DE10299054I1 (de) 1990-04-09 1991-04-03 Als Carbohydrase-Inhibitoren verwendbare Thiophen Sulfonamide
DE122009000026C Pending DE122009000026I1 (de) 1990-04-09 1991-04-03 Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide
DE69133080T Expired - Lifetime DE69133080T2 (de) 1990-04-09 1991-04-03 Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE1991633080 Pending DE10299054I1 (de) 1990-04-09 1991-04-03 Als Carbohydrase-Inhibitoren verwendbare Thiophen Sulfonamide
DE122009000026C Pending DE122009000026I1 (de) 1990-04-09 1991-04-03 Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide

Country Status (20)

Country Link
US (2) US5153192A (de)
EP (1) EP0527801B1 (de)
JP (1) JP2562394B2 (de)
KR (1) KR100196414B1 (de)
AT (1) ATE221527T1 (de)
AU (1) AU655924B2 (de)
BR (1) BR9106330A (de)
CA (1) CA2080223C (de)
DE (3) DE10299054I1 (de)
DK (1) DK0527801T3 (de)
ES (1) ES2180530T3 (de)
FI (2) FI924553A0 (de)
HK (1) HK1014186A1 (de)
IL (1) IL97800A (de)
LU (2) LU90935I2 (de)
NL (2) NL300098I2 (de)
NO (1) NO923948L (de)
NZ (1) NZ237754A (de)
WO (1) WO1991015486A1 (de)
ZA (1) ZA912580B (de)

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US5510347A (en) * 1994-09-09 1996-04-23 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
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US5620970A (en) * 1995-06-05 1997-04-15 Alcon Laboratories, Inc. Topical ophthalmic carbonic anhydrase inhibitor formulations
US6172054B1 (en) 1995-06-15 2001-01-09 Alcon Laboratories, Inc. Combination therapy for lowering and controlling intraocular pressure
WO1997002825A1 (en) * 1995-07-12 1997-01-30 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
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US5948801A (en) * 1998-03-09 1999-09-07 Alcon Laboratories, Inc. Treatment of retinal edema with brinzolamide
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CN102936236A (zh) * 2012-11-13 2013-02-20 江苏吉贝尔药业有限公司 一种布林佐胺中间体(3-乙酰基-5-氯-2-(苄基巯基)噻酚)的制备方法
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Also Published As

Publication number Publication date
FI924553A (fi) 1992-10-08
JP2562394B2 (ja) 1996-12-11
DE122009000026I1 (de) 2010-01-28
CA2080223C (en) 2000-11-07
EP0527801A4 (en) 1993-03-10
KR100196414B1 (ko) 1999-06-15
FI924553A0 (fi) 1992-10-08
LU91555I2 (fr) 2009-06-22
EP0527801A1 (de) 1993-02-24
IL97800A (en) 1997-08-14
DK0527801T3 (da) 2002-11-25
DE10299054I1 (de) 2006-06-08
NL300098I2 (nl) 2003-01-06
ZA912580B (en) 1992-01-29
US5240923A (en) 1993-08-31
EP0527801B1 (de) 2002-07-31
WO1991015486A1 (en) 1991-10-17
NL300098I1 (nl) 2002-11-01
JPH05508832A (ja) 1993-12-09
NL300389I1 (nl) 2009-07-01
IL97800A0 (en) 1992-06-21
ES2180530T3 (es) 2003-02-16
NZ237754A (en) 1992-08-26
HK1014186A1 (en) 1999-09-24
NO923948D0 (no) 1992-10-09
NO923948L (no) 1992-12-08
ATE221527T1 (de) 2002-08-15
CA2080223A1 (en) 1991-10-10
AU655924B2 (en) 1995-01-19
DE69133080D1 (de) 2002-09-05
FI963424A (fi) 1996-09-02
KR930700490A (ko) 1993-03-15
US5153192A (en) 1992-10-06
BR9106330A (pt) 1993-04-20
AU7746791A (en) 1991-10-30
FI963424A0 (fi) 1996-09-02
LU90935I2 (en) 2002-09-05

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