DE10299054I1 - Als Carbohydrase-Inhibitoren verwendbare Thiophen Sulfonamide - Google Patents

Als Carbohydrase-Inhibitoren verwendbare Thiophen Sulfonamide

Info

Publication number
DE10299054I1
DE10299054I1 DE1991633080 DE69133080C DE10299054I1 DE 10299054 I1 DE10299054 I1 DE 10299054I1 DE 1991633080 DE1991633080 DE 1991633080 DE 69133080 C DE69133080 C DE 69133080C DE 10299054 I1 DE10299054 I1 DE 10299054I1
Authority
DE
Germany
Prior art keywords
sulfonamides useful
thiophene sulfonamides
carbohydrase
inhibitors
carbohydrase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE1991633080
Other languages
English (en)
Other versions
DE69133080T2 (de
DE69133080D1 (de
Inventor
R Dean
A May
Paul Zinke
E Deason
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Application granted granted Critical
Publication of DE10299054I1 publication Critical patent/DE10299054I1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE1991633080 1990-04-09 1991-04-03 Als Carbohydrase-Inhibitoren verwendbare Thiophen Sulfonamide Pending DE10299054I1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50673090A 1990-04-09 1990-04-09
US07/618,765 US5153192A (en) 1990-04-09 1990-11-27 Thiophene sulfonamides useful as carbonic anhydrase inhibitors
PCT/US1991/002262 WO1991015486A1 (en) 1990-04-09 1991-04-03 Thiophene sulfonamides useful as carbonic anydrase inhibitors

Publications (1)

Publication Number Publication Date
DE10299054I1 true DE10299054I1 (de) 2006-06-08

Family

ID=27055558

Family Applications (3)

Application Number Title Priority Date Filing Date
DE1991633080 Pending DE10299054I1 (de) 1990-04-09 1991-04-03 Als Carbohydrase-Inhibitoren verwendbare Thiophen Sulfonamide
DE122009000026C Pending DE122009000026I1 (de) 1990-04-09 1991-04-03 Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide
DE69133080T Expired - Lifetime DE69133080T2 (de) 1990-04-09 1991-04-03 Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE122009000026C Pending DE122009000026I1 (de) 1990-04-09 1991-04-03 Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide
DE69133080T Expired - Lifetime DE69133080T2 (de) 1990-04-09 1991-04-03 Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide

Country Status (20)

Country Link
US (2) US5153192A (de)
EP (1) EP0527801B1 (de)
JP (1) JP2562394B2 (de)
KR (1) KR100196414B1 (de)
AT (1) ATE221527T1 (de)
AU (1) AU655924B2 (de)
BR (1) BR9106330A (de)
CA (1) CA2080223C (de)
DE (3) DE10299054I1 (de)
DK (1) DK0527801T3 (de)
ES (1) ES2180530T3 (de)
FI (2) FI924553A0 (de)
HK (1) HK1014186A1 (de)
IL (1) IL97800A (de)
LU (2) LU90935I2 (de)
NL (2) NL300098I2 (de)
NO (1) NO923948L (de)
NZ (1) NZ237754A (de)
WO (1) WO1991015486A1 (de)
ZA (1) ZA912580B (de)

Families Citing this family (80)

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AU677577B2 (en) * 1992-02-21 1997-05-01 Alcon Laboratories, Inc. Topical antiglaucoma compositions comprising carbonic anhydrase inhibitors and beta-blockers
US5932572A (en) * 1992-02-21 1999-08-03 Alcon Laboratories, Inc. Topical anti-glaucoma compositions
US5276025A (en) * 1992-09-09 1994-01-04 Merck & Co., Inc. Heterobicyclic sulfonamides
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US5344929A (en) * 1993-02-18 1994-09-06 Alcon Laboratories, Inc. Preparation of carbonic anhydrase inhibitors
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US5470973A (en) * 1994-10-03 1995-11-28 Alcon Laboratories, Inc. Synthesis of sulfonamide intermediates
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Also Published As

Publication number Publication date
WO1991015486A1 (en) 1991-10-17
NL300389I1 (nl) 2009-07-01
FI963424A (fi) 1996-09-02
AU7746791A (en) 1991-10-30
EP0527801B1 (de) 2002-07-31
NO923948D0 (no) 1992-10-09
DE69133080T2 (de) 2003-03-27
LU90935I2 (en) 2002-09-05
US5153192A (en) 1992-10-06
KR100196414B1 (ko) 1999-06-15
DE122009000026I1 (de) 2010-01-28
IL97800A0 (en) 1992-06-21
KR930700490A (ko) 1993-03-15
US5240923A (en) 1993-08-31
JP2562394B2 (ja) 1996-12-11
FI924553A (fi) 1992-10-08
LU91555I2 (fr) 2009-06-22
NL300098I2 (nl) 2003-01-06
NZ237754A (en) 1992-08-26
HK1014186A1 (en) 1999-09-24
NL300098I1 (nl) 2002-11-01
FI924553A0 (fi) 1992-10-08
IL97800A (en) 1997-08-14
DK0527801T3 (da) 2002-11-25
AU655924B2 (en) 1995-01-19
ATE221527T1 (de) 2002-08-15
CA2080223A1 (en) 1991-10-10
NO923948L (no) 1992-12-08
JPH05508832A (ja) 1993-12-09
DE69133080D1 (de) 2002-09-05
CA2080223C (en) 2000-11-07
BR9106330A (pt) 1993-04-20
FI963424A0 (fi) 1996-09-02
EP0527801A4 (en) 1993-03-10
ES2180530T3 (es) 2003-02-16
EP0527801A1 (de) 1993-02-24
ZA912580B (en) 1992-01-29

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