DE69133080D1 - Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide - Google Patents

Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide

Info

Publication number
DE69133080D1
DE69133080D1 DE69133080T DE69133080T DE69133080D1 DE 69133080 D1 DE69133080 D1 DE 69133080D1 DE 69133080 T DE69133080 T DE 69133080T DE 69133080 T DE69133080 T DE 69133080T DE 69133080 D1 DE69133080 D1 DE 69133080D1
Authority
DE
Germany
Prior art keywords
thiophene sulfonamides
sulfonamides used
carbohydrase
inhibitors
carbohydrase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69133080T
Other languages
English (en)
Other versions
DE69133080T2 (de
DE10299054I1 (de
Inventor
R Dean
Hwang-Hsing Chen
A May
Pathmaciri Dantanarayana
Daniel Kuzmich
Paul W Zinke
Eugene Conrow
E Deason
Thomas Dupriest
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Application granted granted Critical
Publication of DE69133080D1 publication Critical patent/DE69133080D1/de
Publication of DE69133080T2 publication Critical patent/DE69133080T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69133080T 1990-04-09 1991-04-03 Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide Expired - Lifetime DE69133080T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50673090A 1990-04-09 1990-04-09
US07/618,765 US5153192A (en) 1990-04-09 1990-11-27 Thiophene sulfonamides useful as carbonic anhydrase inhibitors
PCT/US1991/002262 WO1991015486A1 (en) 1990-04-09 1991-04-03 Thiophene sulfonamides useful as carbonic anydrase inhibitors

Publications (2)

Publication Number Publication Date
DE69133080D1 true DE69133080D1 (de) 2002-09-05
DE69133080T2 DE69133080T2 (de) 2003-03-27

Family

ID=27055558

Family Applications (3)

Application Number Title Priority Date Filing Date
DE1991633080 Pending DE10299054I1 (de) 1990-04-09 1991-04-03 Als Carbohydrase-Inhibitoren verwendbare Thiophen Sulfonamide
DE122009000026C Pending DE122009000026I1 (de) 1990-04-09 1991-04-03 Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide
DE69133080T Expired - Lifetime DE69133080T2 (de) 1990-04-09 1991-04-03 Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE1991633080 Pending DE10299054I1 (de) 1990-04-09 1991-04-03 Als Carbohydrase-Inhibitoren verwendbare Thiophen Sulfonamide
DE122009000026C Pending DE122009000026I1 (de) 1990-04-09 1991-04-03 Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide

Country Status (20)

Country Link
US (2) US5153192A (de)
EP (1) EP0527801B1 (de)
JP (1) JP2562394B2 (de)
KR (1) KR100196414B1 (de)
AT (1) ATE221527T1 (de)
AU (1) AU655924B2 (de)
BR (1) BR9106330A (de)
CA (1) CA2080223C (de)
DE (3) DE10299054I1 (de)
DK (1) DK0527801T3 (de)
ES (1) ES2180530T3 (de)
FI (2) FI924553A0 (de)
HK (1) HK1014186A1 (de)
IL (1) IL97800A (de)
LU (2) LU90935I2 (de)
NL (2) NL300098I2 (de)
NO (1) NO923948L (de)
NZ (1) NZ237754A (de)
WO (1) WO1991015486A1 (de)
ZA (1) ZA912580B (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585377A (en) * 1990-04-09 1996-12-17 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
FR2662439B1 (fr) * 1990-05-23 1993-11-19 Rhone Poulenc Chimie Reactif et procede de perfluoroalkylation de substrats nucleophiles par les perfluoroalcanesulfinates de sodium en milieu oxydant.
SG84487A1 (en) 1991-04-17 2001-11-20 Merck & Co Inc Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist
AU677577B2 (en) * 1992-02-21 1997-05-01 Alcon Laboratories, Inc. Topical antiglaucoma compositions comprising carbonic anhydrase inhibitors and beta-blockers
US5932572A (en) * 1992-02-21 1999-08-03 Alcon Laboratories, Inc. Topical anti-glaucoma compositions
US5276025A (en) * 1992-09-09 1994-01-04 Merck & Co., Inc. Heterobicyclic sulfonamides
US5308842A (en) * 1992-09-09 1994-05-03 Merck & Co., Inc. Tricyclic derivatives of the thienodiazocine and thienothiadiazocine classes of compounds
CA2141879A1 (en) * 1992-09-17 1994-03-31 Thomas Robert Dean Topical carbonic anhydrase inhibitor composition
US5344929A (en) * 1993-02-18 1994-09-06 Alcon Laboratories, Inc. Preparation of carbonic anhydrase inhibitors
US5538966A (en) * 1994-01-21 1996-07-23 Alcon Laboratories, Inc. Carbonic anhydrase inhibitors
AU1684895A (en) * 1994-01-21 1995-08-08 Alcon Laboratories, Inc. Thienothiazine sulfonamide derivatives process and intermediates for their preparation and their use as carbonic anhydrase inhibitors
US5646142A (en) * 1994-07-08 1997-07-08 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US6316443B1 (en) 1994-08-04 2001-11-13 Merck & Co., Inc. Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
US5464831A (en) * 1994-09-09 1995-11-07 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5510347A (en) * 1994-09-09 1996-04-23 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5470973A (en) * 1994-10-03 1995-11-28 Alcon Laboratories, Inc. Synthesis of sulfonamide intermediates
US5620970A (en) * 1995-06-05 1997-04-15 Alcon Laboratories, Inc. Topical ophthalmic carbonic anhydrase inhibitor formulations
US6172054B1 (en) 1995-06-15 2001-01-09 Alcon Laboratories, Inc. Combination therapy for lowering and controlling intraocular pressure
WO1997002825A1 (en) * 1995-07-12 1997-01-30 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
EP1057486A1 (de) * 1995-11-17 2000-12-06 Alcon Laboratories, Inc. Verwendung einer Medikamentenkombination zur Behandlung von Glaukom
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
TR199801665T2 (xx) * 1996-02-26 1998-12-21 Advanced Research & Technology Institute Makular �demin engellenmesi i�in karbonik anhidraz inhibit�rlerinin kullan�m�.
US5900427A (en) * 1996-05-03 1999-05-04 Wisconsin Alumni Research Foundation N-heteroarenesulfonyl-protected amino acid reagents for peptide synthesis
AUPO227896A0 (en) 1996-09-13 1996-10-03 Fujisawa Pharmaceutical Co., Ltd. Novel compounds and their preparation
BR9814497A (pt) 1997-12-23 2000-10-10 Alcon Lab Inc Processo para prevenir ou retardar perda de campo visual associada com glaucoma ou hipertensão ocular
US6156785A (en) * 1998-01-23 2000-12-05 Merck Sharp & Dohme B.V. Method for increasing oxygen tension in the optic nerve and retina
EP1058546A4 (de) * 1998-03-06 2004-07-28 Univ Texas Zusammenstellungen und methoden zur behandlung von erkrankungen der macula
US5948801A (en) * 1998-03-09 1999-09-07 Alcon Laboratories, Inc. Treatment of retinal edema with brinzolamide
US6960579B1 (en) * 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
US6548535B2 (en) * 2000-01-18 2003-04-15 Merck & Co., Inc. Method for treating ocular hypertension
EP1251862B1 (de) 2000-01-18 2008-10-01 Merck & Co., Inc. Orhthalmologische zusammenstellungen zur behandlung von ocularer hypertension
US6903081B2 (en) * 2000-03-31 2005-06-07 Purdue Research Foundation Phosphoramidates and methods therefor
AU1770901A (en) * 2000-11-16 2002-05-27 Alcon Lab Inc Combination therapy for lowering and controlling intraocular pressure
US20040067992A1 (en) * 2001-08-10 2004-04-08 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a carbonic anhydrase inhibitor for the treatment of neoplasia
US20040254230A1 (en) * 2001-12-03 2004-12-16 Ogidigben Miller J. Method for treating ocular hypertension
EP1487438A4 (de) * 2002-03-15 2007-08-15 Merck & Co Inc Zusammensetzungen und verfahren zur behandlung von glaukom und okularer hypertonie
EP1513523A1 (de) * 2002-06-06 2005-03-16 Merck Frosst Canada & Co. 1,5-disubstituierte imidazolidin-2-on derivate zur verwendung als ep4 rezeptor agonisten zur behandlung von augen- und knochen-krankheiten
US20050256117A1 (en) * 2002-06-14 2005-11-17 Meng Hsin Chen Ophthalmic compositions for treating ocular hypertension
WO2003105781A2 (en) * 2002-06-17 2003-12-24 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
CA2488752A1 (en) * 2002-06-17 2003-12-24 Merck & Co., Inc. Novel maxi-k channel blockers, methods of use and process for making the same
AU2003245531A1 (en) * 2002-06-17 2003-12-31 Merck & Co., Inc. Novel maxi-k channel blockers, methods of use and process for making the same
AU2003258433A1 (en) * 2002-08-28 2004-03-19 Merck Frosst Canada Ltd Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
US20060167081A1 (en) * 2002-10-25 2006-07-27 Xavier Billot Ep4 receptor agonists
KR100503618B1 (ko) * 2002-11-07 2005-07-26 안헌상 케이크용 장식용품
US20040216749A1 (en) * 2003-01-23 2004-11-04 Hosheng Tu Vasomodulation during glaucoma surgery
CA2519899A1 (en) * 2003-03-27 2004-10-14 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
US6949518B1 (en) 2003-06-25 2005-09-27 Pao-Hsien Chu Methods for treating macular degeneration with topiramate
US20050119262A1 (en) * 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
KR100537781B1 (ko) * 2004-06-02 2005-12-20 안헌상 케이크 장식용품의 제조방법 및 그 물품
US8193193B2 (en) 2005-07-12 2012-06-05 Kowa Co., Ltd. Agent for prevention or treatment of glaucoma
JP4831668B2 (ja) * 2006-02-16 2011-12-07 独立行政法人産業技術総合研究所 新規なチアジノインドール化合物およびその製造方法
LT5504B (lt) 2006-08-02 2008-06-25 Biotechnologijos Institutas Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti
NZ579229A (en) 2007-01-25 2011-07-29 Verva Pharmaceuticals Ltd Insulin sensitisers and methods of treatment
WO2008120099A1 (en) * 2007-03-30 2008-10-09 Pfizer Inc. Thieno [3, 2-e] [1, 2] thiazine derivative as inhibitor of carbonic anhydrase
EP1985618A1 (de) * 2007-04-27 2008-10-29 Duke Chem, S. A. Herstellungsverfahren für Brinzolamid und Zwischenprodukte dafür
EP2543368A1 (de) 2007-12-11 2013-01-09 Viamet Pharmaceuticals, Inc. Metalloenzymhemmer mit metallbindenden Teilen in Kombination mit Targeting-Teilen
ITMI20081084A1 (it) * 2008-06-16 2009-12-17 Phf Sa Processo per la preparazione di brinzolamide
US8332007B2 (en) * 2009-01-12 2012-12-11 The Board Of Trustees Of The University Of Illinois Quantitative three-dimensional mapping of oxygen tension
CN102414192A (zh) * 2009-03-13 2012-04-11 Azad药物成分股份公司 制备布林唑胺的方法
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
EP2348026A1 (de) * 2009-12-22 2011-07-27 Duke Chem, S. A. Verfahren zur Herstellung von Brinzolamid und Zwischenprodukte dafür
EP2394637A1 (de) 2010-05-21 2011-12-14 Zaklady Farmaceutyczne Polpharma SA Verfahren zum Erhalt von sterilen Brinzolamidsuspensionen
TW201210584A (en) 2010-08-18 2012-03-16 Alcon Res Ltd Bradykinin receptor agonists and uses thereof to treat ocular hypertension and glaucoma
US20110021974A1 (en) * 2010-10-05 2011-01-27 Shantha Totada R Retinitis pigmentosa treatment and prophalaxis
WO2012053011A2 (en) 2010-10-18 2012-04-26 Usv Limited Ophthalmic compositions comprising brinzolamide
US11363951B2 (en) 2011-09-13 2022-06-21 Glaukos Corporation Intraocular physiological sensor
JP5836851B2 (ja) * 2012-03-12 2015-12-24 株式会社トクヤマ ブリンゾラミドの製造方法
EP2638909A1 (de) 2012-03-15 2013-09-18 Azad Pharmaceutical Ingredients AG Verfahren zur Herstellung steriler Brinzolamid
JP5881514B2 (ja) * 2012-04-09 2016-03-09 株式会社トクヤマ アミン誘導体の製造方法
JP5914246B2 (ja) * 2012-08-10 2016-05-11 株式会社トクヤマ ブリンゾラミドの精製方法
CN102936236A (zh) * 2012-11-13 2013-02-20 江苏吉贝尔药业有限公司 一种布林佐胺中间体(3-乙酰基-5-氯-2-(苄基巯基)噻酚)的制备方法
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
UA116273C2 (uk) 2013-10-17 2018-02-26 Сентісс Фарма Прайвет Лімітед Офтальмологічний фармацевтичний склад, що не містить консерванта
US9820991B2 (en) 2013-11-08 2017-11-21 Sentiss Pharma Private Limited Pharmaceutical composition comprising brinzolamide
US10463674B2 (en) 2013-11-08 2019-11-05 Sentiss Pharma Private Limited Process for manufacturing sterile ophthalmic pharmaceutical suspensions
UA118576C2 (uk) 2014-01-24 2019-02-11 Сентис Фарма Прайвет Лімітед Фармацевтична композиція, яка містить бринзоламід
EP3209331B1 (de) * 2014-10-20 2023-07-12 Sentiss Pharma Private Limited Augenlösung
WO2017099207A1 (ja) * 2015-12-10 2017-06-15 千寿製薬株式会社 眼科用医薬製品
JP2020504711A (ja) 2016-12-21 2020-02-13 バイオセリックス， インコーポレイテッド タンパク質を標的とすることにおいて使用するための、チエノピロール誘導体、その組成物、方法、および使用
US11298360B2 (en) 2018-04-25 2022-04-12 Shilpa Medicare Limited Ophthalmic compositions of brinzolamide

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA661731A (en) * 1963-04-23 Siedel Walter Substituted thiophene-3,5-disulfonamides and a process for preparing them
DE1096916B (de) * 1957-12-17 1961-01-12 Hoechst Ag Verfahren zur Herstellung von Thiophen-3, 5-disulfonamiden
GB1516024A (en) * 1977-04-20 1978-06-28 Pfizer Ltd Thiophene-2,5-disulphonamides
US4746745A (en) * 1980-07-09 1988-05-24 Maren Thomas H 1,3,4-thiadiazoline-5-sulfonamides
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4731368A (en) * 1986-12-08 1988-03-15 Merck & Co., Inc. Thienopyridine sulfonamides and their ophthalmological formulation
US4847289A (en) * 1987-06-08 1989-07-11 Merck & Co., Inc. Thiophene sulfonamide antiglaucoma agents
US5093332A (en) * 1990-10-01 1992-03-03 Merck & Co., Inc. Substituted thieno(2,3-b)(1,4)thiazine-6-sulfonamides as antiglaucoma agents

Also Published As

Publication number Publication date
IL97800A (en) 1997-08-14
NZ237754A (en) 1992-08-26
KR930700490A (ko) 1993-03-15
HK1014186A1 (en) 1999-09-24
US5153192A (en) 1992-10-06
CA2080223C (en) 2000-11-07
LU91555I2 (fr) 2009-06-22
ZA912580B (en) 1992-01-29
IL97800A0 (en) 1992-06-21
DE69133080T2 (de) 2003-03-27
EP0527801B1 (de) 2002-07-31
CA2080223A1 (en) 1991-10-10
DK0527801T3 (da) 2002-11-25
NL300098I1 (nl) 2002-11-01
FI924553A (fi) 1992-10-08
JPH05508832A (ja) 1993-12-09
US5240923A (en) 1993-08-31
EP0527801A4 (en) 1993-03-10
AU655924B2 (en) 1995-01-19
NO923948D0 (no) 1992-10-09
DE122009000026I1 (de) 2010-01-28
WO1991015486A1 (en) 1991-10-17
EP0527801A1 (de) 1993-02-24
ES2180530T3 (es) 2003-02-16
NO923948L (no) 1992-12-08
BR9106330A (pt) 1993-04-20
ATE221527T1 (de) 2002-08-15
FI963424A0 (fi) 1996-09-02
FI963424A (fi) 1996-09-02
NL300098I2 (nl) 2003-01-06
FI924553A0 (fi) 1992-10-08
DE10299054I1 (de) 2006-06-08
NL300389I1 (nl) 2009-07-01
LU90935I2 (en) 2002-09-05
JP2562394B2 (ja) 1996-12-11
KR100196414B1 (ko) 1999-06-15
AU7746791A (en) 1991-10-30

Similar Documents

Publication Publication Date Title
DE69133080D1 (de) Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide
DK0833839T3 (da) Heterocykliske peptidylforbindelser, der er nyttige til behandling af thrombinrelaterede sygdomme
ATE86998T1 (de) Substituierte aromatische sulfonamide als mittel gegen glaukom.
SE8700499D0 (sv) Novel pharmacologically active compounds
MA26901A1 (fr) Nouvelle composition pharmaceutique
NO972391L (no) 2-substituerte 1,2,5-tiadiazolidin-3-on 1,1-dioksider og preparater og metoder for anvendelse derav
SE8804628D0 (sv) New compounds
DK0471718T3 (da) Paracetamolholdigt farmaceutisk præparat
DE69129126D1 (de) Neue pharmazeutische formulierungen von 5-(2-chlor-1-hydroxyethyl)-4-methylthiazol
DE69230644D1 (de) Verwendung von protease nexin-i als mittel gegen entzündungen
ES2087534T3 (es) Nuevas composiciones liquidas a base de derivados de la piperidina substituidos en 1,4.
SE8206217D0 (sv) N-substituerade ergolin- och 9,10-didehydro-ergolin-8-karboxamid- och -8-aminometyl-derivat, deras framstellning och farmaceutiska kompositioner derav