DK0501821T3 - Antitrombinpolypeptider - Google Patents
AntitrombinpolypeptiderInfo
- Publication number
- DK0501821T3 DK0501821T3 DK92301721T DK92301721T DK0501821T3 DK 0501821 T3 DK0501821 T3 DK 0501821T3 DK 92301721 T DK92301721 T DK 92301721T DK 92301721 T DK92301721 T DK 92301721T DK 0501821 T3 DK0501821 T3 DK 0501821T3
- Authority
- DK
- Denmark
- Prior art keywords
- polypeptides
- thrombin
- preparation
- hirudinaria manillensis
- recombinant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919104260A GB9104260D0 (en) | 1991-02-28 | 1991-02-28 | Anti-thrombin polypeptides |
| GB919119954A GB9119954D0 (en) | 1991-09-18 | 1991-09-18 | Antithrombin polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0501821T3 true DK0501821T3 (da) | 1999-08-30 |
Family
ID=26298509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92301721T DK0501821T3 (da) | 1991-02-28 | 1992-02-28 | Antitrombinpolypeptider |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US5356875A (xx) |
| EP (1) | EP0501821B1 (xx) |
| JP (1) | JPH05247090A (xx) |
| KR (1) | KR100218818B1 (xx) |
| CN (1) | CN1044479C (xx) |
| AT (1) | ATE175236T1 (xx) |
| AU (1) | AU643876B2 (xx) |
| CA (1) | CA2061920A1 (xx) |
| CZ (1) | CZ283458B6 (xx) |
| DE (1) | DE69228015T2 (xx) |
| DK (1) | DK0501821T3 (xx) |
| ES (1) | ES2129426T3 (xx) |
| FI (1) | FI920861A (xx) |
| GR (1) | GR3029364T3 (xx) |
| HU (1) | HU215580B (xx) |
| IE (1) | IE920622A1 (xx) |
| IL (1) | IL101062A0 (xx) |
| MX (1) | MX9200795A (xx) |
| MY (1) | MY110327A (xx) |
| NO (1) | NO300138B1 (xx) |
| NZ (1) | NZ241715A (xx) |
| TW (1) | TW214556B (xx) |
| YU (1) | YU19792A (xx) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1266561B1 (it) * | 1993-07-22 | 1997-01-09 | Mini Ricerca Scient Tecnolog | Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione |
| CN1064968C (zh) * | 1996-07-10 | 2001-04-25 | 中国人民解放军第一军医大学 | 重组蛋白提取纯化方法 |
| NZ336793A (en) * | 1997-01-20 | 2000-08-25 | Japan Energy Corp | Method for stabilizing peptides by adding an organic acid and then lyophilizing the peptide mixture |
| US6077825A (en) | 1997-03-13 | 2000-06-20 | Auburn University | Antithrombin protein and DNA sequences from black fly |
| JP2000080046A (ja) * | 1998-09-03 | 2000-03-21 | Dai Ichi Seiyaku Co Ltd | 多臓器障害の予防・治療剤 |
| CN102876654A (zh) * | 2012-10-19 | 2013-01-16 | 广东海洋大学 | 一种桑蚕丝素固定化凝血酶的制备方法 |
| CN104193809B (zh) * | 2014-09-28 | 2016-08-17 | 顾玉奎 | 一种凝血酶抑制及其制备方法、应用 |
| CN104193807B (zh) * | 2014-09-28 | 2016-06-15 | 广州贝奥吉因生物科技有限公司 | 凝血酶抑制多肽及其制备方法、应用 |
| CN105646702B (zh) * | 2016-04-13 | 2019-03-01 | 中国科学院昆明动物研究所 | 菲牛蛭Kazal型胰蛋白酶抑制剂Bdellin-HM及其编码基因和应用 |
| CN108059672B (zh) * | 2016-11-08 | 2021-06-11 | 中国科学院昆明动物研究所 | 森林山蛭抗血栓肽Sylvestin及其基因和应用 |
| CN110468174A (zh) * | 2019-08-21 | 2019-11-19 | 北京中医药大学 | 一种水蛭活性寡肽的制备方法 |
| CN111454352B (zh) * | 2020-03-05 | 2021-07-23 | 中国科学院昆明动物研究所 | 一种活性蛋白hmei-a、活性蛋白hmei-a的编码基因及应用 |
| CN112114069B (zh) * | 2020-09-18 | 2023-05-16 | 江苏艾迪药业股份有限公司 | 凝血酶的亲和色谱柱、制备方法及应用 |
| CN112480210B (zh) * | 2020-11-25 | 2021-09-17 | 广东海洋大学 | 一种抗凝血活性肽及其用途 |
| KR102354461B1 (ko) * | 2021-02-19 | 2022-01-20 | 김건언 | 덕트 일체형 조명등기구 |
| CN115572329B (zh) * | 2021-06-21 | 2024-02-06 | 王大勇 | 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5268296A (en) * | 1988-06-11 | 1993-12-07 | Ciba-Geigy Corporation | DNA vector and recombinant host cell for production of hirullin P6 and P18 |
| ES2052062T3 (es) * | 1988-06-11 | 1994-07-01 | Ciba Geigy Ag | Nuevos polipeptidos con actividad anticoagulante. |
| GB8826428D0 (en) * | 1988-11-11 | 1988-12-14 | Biopharm Ltd | Antithrombin |
| IT1250689B (it) * | 1991-07-22 | 1995-04-21 | Marco Gerna | Analoghi dell'irudina e procedimento per la loro preparazione |
-
1992
- 1992-02-24 IL IL101062A patent/IL101062A0/xx unknown
- 1992-02-25 MX MX9200795A patent/MX9200795A/es not_active IP Right Cessation
- 1992-02-25 TW TW081101387A patent/TW214556B/zh active
- 1992-02-25 HU HU9200620A patent/HU215580B/hu not_active IP Right Cessation
- 1992-02-25 NZ NZ241715A patent/NZ241715A/en unknown
- 1992-02-25 AU AU11221/92A patent/AU643876B2/en not_active Ceased
- 1992-02-26 KR KR1019920002964A patent/KR100218818B1/ko not_active IP Right Cessation
- 1992-02-26 US US07/842,089 patent/US5356875A/en not_active Expired - Fee Related
- 1992-02-26 CA CA002061920A patent/CA2061920A1/en not_active Abandoned
- 1992-02-26 FI FI920861A patent/FI920861A/fi unknown
- 1992-02-26 YU YU19792A patent/YU19792A/sh unknown
- 1992-02-27 JP JP4075594A patent/JPH05247090A/ja active Pending
- 1992-02-27 MY MYPI92000321A patent/MY110327A/en unknown
- 1992-02-27 NO NO920777A patent/NO300138B1/no unknown
- 1992-02-27 CN CN92101143A patent/CN1044479C/zh not_active Expired - Fee Related
- 1992-02-27 IE IE062292A patent/IE920622A1/en not_active Application Discontinuation
- 1992-02-27 CZ CS92584A patent/CZ283458B6/cs not_active IP Right Cessation
- 1992-02-28 ES ES92301721T patent/ES2129426T3/es not_active Expired - Lifetime
- 1992-02-28 DE DE69228015T patent/DE69228015T2/de not_active Expired - Fee Related
- 1992-02-28 DK DK92301721T patent/DK0501821T3/da active
- 1992-02-28 AT AT92301721T patent/ATE175236T1/de not_active IP Right Cessation
- 1992-02-28 EP EP92301721A patent/EP0501821B1/en not_active Expired - Lifetime
-
1994
- 1994-06-23 US US08/264,485 patent/US5439820A/en not_active Expired - Fee Related
-
1999
- 1999-02-10 GR GR990400451T patent/GR3029364T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU643876B2 (en) | 1993-11-25 |
| NO920777D0 (no) | 1992-02-27 |
| DE69228015D1 (de) | 1999-02-11 |
| FI920861A0 (fi) | 1992-02-26 |
| HUT64592A (en) | 1994-01-28 |
| MX9200795A (es) | 1992-08-01 |
| US5356875A (en) | 1994-10-18 |
| KR920016468A (ko) | 1992-09-24 |
| KR100218818B1 (ko) | 1999-10-01 |
| ES2129426T3 (es) | 1999-06-16 |
| NZ241715A (en) | 1993-07-27 |
| NO300138B1 (no) | 1997-04-14 |
| EP0501821B1 (en) | 1998-12-30 |
| HU9200620D0 (en) | 1992-05-28 |
| CN1066272A (zh) | 1992-11-18 |
| YU19792A (sh) | 1994-06-10 |
| CA2061920A1 (en) | 1992-08-29 |
| FI920861A (fi) | 1992-08-29 |
| CZ283458B6 (cs) | 1998-04-15 |
| HU215580B (hu) | 1999-01-28 |
| CS58492A3 (en) | 1992-09-16 |
| IE920622A1 (en) | 1992-09-09 |
| AU1122192A (en) | 1992-09-03 |
| EP0501821A2 (en) | 1992-09-02 |
| IL101062A0 (en) | 1992-11-15 |
| NO920777L (no) | 1992-08-31 |
| DE69228015T2 (de) | 1999-06-02 |
| EP0501821A3 (en) | 1993-03-03 |
| GR3029364T3 (en) | 1999-05-28 |
| MY110327A (en) | 1998-04-30 |
| TW214556B (xx) | 1993-10-11 |
| CN1044479C (zh) | 1999-08-04 |
| US5439820A (en) | 1995-08-08 |
| ATE175236T1 (de) | 1999-01-15 |
| JPH05247090A (ja) | 1993-09-24 |
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