DK0392376T3 - N-acylderivater af LL-E33288-antitumor-antibiotika - Google Patents

N-acylderivater af LL-E33288-antitumor-antibiotika

Info

Publication number
DK0392376T3
DK0392376T3 DK90106601T DK90106601T DK0392376T3 DK 0392376 T3 DK0392376 T3 DK 0392376T3 DK 90106601 T DK90106601 T DK 90106601T DK 90106601 T DK90106601 T DK 90106601T DK 0392376 T3 DK0392376 T3 DK 0392376T3
Authority
DK
Denmark
Prior art keywords
acyl derivatives
antitumor antibiotics
acyl
antitumor
antibiotics
Prior art date
Application number
DK90106601T
Other languages
Danish (da)
English (en)
Inventor
May Dean-Ming Lee
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DK0392376T3 publication Critical patent/DK0392376T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/29Micromonospora

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK90106601T 1989-04-14 1990-04-06 N-acylderivater af LL-E33288-antitumor-antibiotika DK0392376T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/338,928 US5079233A (en) 1987-01-30 1989-04-14 N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same

Publications (1)

Publication Number Publication Date
DK0392376T3 true DK0392376T3 (da) 2001-12-03

Family

ID=23326735

Family Applications (2)

Application Number Title Priority Date Filing Date
DK90106601T DK0392376T3 (da) 1989-04-14 1990-04-06 N-acylderivater af LL-E33288-antitumor-antibiotika
DK00128100T DK1097937T3 (da) 1989-04-14 1990-04-06 N-acylderivater af LL-E33288-antitumor-antibiotika

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK00128100T DK1097937T3 (da) 1989-04-14 1990-04-06 N-acylderivater af LL-E33288-antitumor-antibiotika

Country Status (23)

Country Link
US (1) US5079233A (ko)
EP (2) EP0392376B1 (ko)
JP (1) JP3083309B2 (ko)
KR (1) KR0149493B1 (ko)
CN (1) CN1027267C (ko)
AT (2) ATE297405T1 (ko)
AU (1) AU627863B2 (ko)
CA (1) CA2014472C (ko)
CZ (2) CZ284618B6 (ko)
DE (2) DE69034194T2 (ko)
DK (2) DK0392376T3 (ko)
ES (2) ES2162783T3 (ko)
FI (1) FI97889C (ko)
HK (2) HK1035540A1 (ko)
IE (1) IE20011013A1 (ko)
IL (1) IL93732A (ko)
NO (1) NO172938C (ko)
NZ (1) NZ233149A (ko)
PH (1) PH27361A (ko)
PT (1) PT93715B (ko)
SG (1) SG47857A1 (ko)
SK (1) SK188390A3 (ko)
ZA (1) ZA902839B (ko)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
EP0855911A4 (en) * 1995-10-20 1998-10-14 Univ Utah Res Found NAME AMICIN, AN ENDIYN ANTITUMOR ANTIBIOTIC FROM THE SEA ASCIDIACEA POLYSYNCRATON LITHOSTROTUM
ATE338120T2 (de) 1998-11-27 2006-09-15 Ucb Sa Zusammensetzungen und verfahren zur erhöhung der knochenmineralisierung
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
US20050287153A1 (en) * 2002-06-28 2005-12-29 Genentech, Inc. Serum albumin binding peptides for tumor targeting
WO2001045746A2 (en) * 1999-12-24 2001-06-28 Genentech, Inc. Methods and compositions for prolonging elimination half-times of bioactive compounds
US20060228364A1 (en) * 1999-12-24 2006-10-12 Genentech, Inc. Serum albumin binding peptides for tumor targeting
US20040001827A1 (en) * 2002-06-28 2004-01-01 Dennis Mark S. Serum albumin binding peptides for tumor targeting
US20040023910A1 (en) * 2001-09-28 2004-02-05 Zhiming Zhang Use of cyr61 in the treatment and diagnosis of human uterine leiomyomas
US20110045005A1 (en) 2001-10-19 2011-02-24 Craig Crowley Compositions and methods for the treatment of tumor of hematopoietic origin
PT3127553T (pt) 2002-05-02 2022-01-24 Wyeth Holdings Llc Conjugados de derivado da caliqueamicina - transportador
US7381409B2 (en) 2003-06-16 2008-06-03 Celltech R&D, Inc. Antibodies specific for sclerostin and methods of screening and use therefor
JP2007501011A (ja) * 2003-08-01 2007-01-25 ジェネンテック・インコーポレーテッド 制限多様性配列を有する結合型ポリペプチド
US20050282168A1 (en) * 2003-09-29 2005-12-22 Wyeth Cell surface molecules as markers and therapeutic agents against kidney cancers
DK2489364T3 (en) 2003-11-06 2015-03-02 Seattle Genetics Inc Monomethylvaline compounds conjugated to antibodies
NZ547438A (en) 2003-12-19 2010-01-29 Genentech Inc Monovalent antibody fragments useful as therapeutics
AR048098A1 (es) * 2004-03-15 2006-03-29 Wyeth Corp Conjugados de caliqueamicina
AU2005249490B2 (en) 2004-06-01 2010-07-29 Genentech, Inc. Antibody drug conjugates and methods
US20060222850A1 (en) * 2005-04-01 2006-10-05 The University Of Chicago Synthesis of a self assembled hybrid of ultrananocrystalline diamond and carbon nanotubes
ES2377979T3 (es) * 2004-09-03 2012-04-03 Genentech, Inc. Antagonistas anti-beta7 humanizados y utilizaciones para los mismos
WO2006031653A2 (en) * 2004-09-10 2006-03-23 Wyeth Humanized anti-5t4 antibodies and anti-5t4 antibody / calicheamicin conjugates
AU2005286607B2 (en) 2004-09-23 2011-01-27 Genentech, Inc. Cysteine engineered antibodies and conjugates
EP1796718A2 (en) * 2004-10-05 2007-06-20 Genentech, Inc. Therapeutic agents with decreased toxicity
EP1817059A2 (en) 2004-12-01 2007-08-15 Genentech, Inc. Conjugates of 1,8-bis-naphthalimides with an antibody
US20070003559A1 (en) * 2005-07-01 2007-01-04 Wyeth Methods of determining pharmacokinetics of targeted therapies
EP1957531B1 (en) 2005-11-07 2016-04-13 Genentech, Inc. Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
JP5808070B2 (ja) * 2005-12-02 2015-11-10 ジェネンテック, インコーポレイテッド 結合ポリペプチド及びその使用
WO2007064919A2 (en) * 2005-12-02 2007-06-07 Genentech, Inc. Binding polypeptides with restricted diversity sequences
WO2007067602A1 (en) * 2005-12-06 2007-06-14 Wyeth Interleukin-11 compositions and methods of use
EP1973948B1 (en) 2005-12-15 2015-02-11 Genentech, Inc. Methods and compositions for targeting polyubiquitin
ES2526204T3 (es) 2006-01-05 2015-01-08 Genentech, Inc. Anticuerpos anti-EphB4 y métodos para usar los mismos
TW200806685A (en) * 2006-02-21 2008-02-01 Wyeth Corp Processes for the convergent synthesis of calicheamicin derivatives
MX2008011492A (es) 2006-03-10 2008-09-22 Wyeth Corp Anticuerpos anti-5t4 y usos de los mismos.
AR059851A1 (es) 2006-03-16 2008-04-30 Genentech Inc Anticuerpos de la egfl7 y metodos de uso
TWI523864B (zh) * 2006-05-30 2016-03-01 建南德克公司 抗體及免疫接合物及其用途
PT2061814E (pt) 2006-10-27 2012-09-10 Genentech Inc Anticorpos e imunoconjugados e suas utilizações
RU2009133784A (ru) 2007-02-09 2011-03-20 Дженентек, Инк. (Us) АНТИ-Robo4-АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
MX2009012587A (es) 2007-05-22 2010-05-14 Wyeth Llc Proceso mejorado para la elaboracion de hidrazidas.
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
PE20090309A1 (es) * 2007-06-04 2009-04-18 Wyeth Corp Conjugado portador-caliqueamicina y un metodo de deteccion de caliqueamicina
TWI580694B (zh) 2007-11-30 2017-05-01 建南德克公司 抗-vegf抗體
AU2009205995B2 (en) 2008-01-18 2014-04-03 Medimmune, Llc Cysteine engineered antibodies for site-specific conjugation
CA2719189C (en) 2008-04-09 2020-08-04 Genentech, Inc. Novel compositions and methods for the treatment of immune related diseases
BRPI0908665A2 (pt) * 2008-05-16 2020-08-18 Genentech Inc método para a determinação da eficácia de um antagonista de integrina beta7 para o tratamento de um distúrbio inflamatório gastrointestinal, método de predição da responsividade de um paciente, método para a determinaçao da dosagem de um antagonista de integrina beta7, método para determinaçao do regime terapêutico de um antagonista de integrina beta7, método para predição de prognóstico de uma doença inflamatória intestinal, método de elaboração de um tratamento e método de identificação de uma população de linfócitos
ES2442024T3 (es) 2008-07-15 2014-02-07 Academia Sinica Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados
MY152068A (en) 2009-03-20 2014-08-15 Genentech Inc Bispecific anti-her antibodies
BRPI1006448B1 (pt) 2009-03-25 2021-08-17 Genentech, Inc Anticorpo antagonista anti-fgfr3, anticorpo monoclonal, polinucleotídeo, vetor, micro­organismo transgênico, método para produção de um anticorpo anti-fgfr3, formulação farmacêutica e usos do anticorpo antagonista anti-fgfr3
EP2445520A4 (en) 2009-06-22 2013-03-06 Medimmune Llc MANIPULATED FC REGIONS FOR LOCAL SPECIFIC CONJUGATION
DK2473522T3 (en) 2009-09-02 2016-11-28 Genentech Inc Smoothened MUTANT AND METHODS OF USING THE SAME
JP5889794B2 (ja) 2009-10-19 2016-03-22 ジェネンテック, インコーポレイテッド 肝細胞増殖因子アクチベーターの調節
KR20120105446A (ko) 2009-10-22 2012-09-25 제넨테크, 인크. 대식세포-자극 단백질의 헵신 활성화를 조정하기 위한 방법 및 조성물
EP2491059B1 (en) 2009-10-22 2015-02-25 F.Hoffmann-La Roche Ag Anti-hepsin antibodies and methods using same
WO2011056497A1 (en) 2009-10-26 2011-05-12 Genentech, Inc. Activin receptor type iib compositions and methods of use
WO2011056502A1 (en) 2009-10-26 2011-05-12 Genentech, Inc. Bone morphogenetic protein receptor type ii compositions and methods of use
WO2011056494A1 (en) 2009-10-26 2011-05-12 Genentech, Inc. Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations
US8361744B2 (en) 2009-11-05 2013-01-29 Genentech, Inc. Methods and composition for secretion of heterologous polypeptides
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
TWI505836B (zh) 2009-12-11 2015-11-01 Genentech Inc 抗-vegf-c抗體及其使用方法
AR079704A1 (es) 2009-12-23 2012-02-15 Genentech Inc Anticuerpos anti-bv8 y sus usos
KR101723615B1 (ko) 2010-01-12 2017-04-06 한상선 천연 한약재를 이용한 샴푸 조성물
WO2011097627A1 (en) 2010-02-08 2011-08-11 Agensys, Inc. Antibody drug conjugates (adc) that bind to 161p2f10b proteins
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
NZ602840A (en) 2010-06-03 2014-11-28 Genentech Inc Immuno-pet imaging of antibodies and immunoconjugates and uses therefor
IL290591B2 (en) 2010-09-29 2024-08-01 Seagen Inc Antibody drug preparations (ADC) that bind to 191P4D12 proteins
US8481680B2 (en) 2010-10-05 2013-07-09 Genentech, Inc. Mutant smoothened and methods of using the same
WO2012092539A2 (en) 2010-12-31 2012-07-05 Takeda Pharmaceutical Company Limited Antibodies to dll4 and uses thereof
DK2668210T3 (da) 2011-01-26 2020-08-24 Celldex Therapeutics Inc Anti-kit antistoffer og anvendelser deraf
AU2012328980A1 (en) 2011-10-28 2014-04-24 Genentech, Inc. Therapeutic combinations and methods of treating melanoma
EP2589609A1 (en) 2011-11-03 2013-05-08 Pierre Fabre Medicament Antigen binding protein and its use as addressing product for the treatment of cancer
CN102584915B (zh) * 2011-12-31 2014-07-23 沈阳药科大学 一种芳香酸类化合物及其用途
EP2802601B1 (en) 2012-01-09 2019-11-13 The Scripps Research Institute Humanized antibodies with ultralong cdr3s
CN104520321A (zh) 2012-01-09 2015-04-15 斯克利普斯研究所 超长互补决定区及其用途
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
EP2875051B1 (en) 2012-07-19 2019-02-20 Daiichi Sankyo Company, Limited Anti-siglec-15 antibodies
US9334332B2 (en) 2012-07-25 2016-05-10 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies
AU2013306098A1 (en) 2012-08-18 2015-02-12 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
US8968742B2 (en) 2012-08-23 2015-03-03 Agensys, Inc. Antibody drug conjugates (ADC) that bind to 158P1D7 proteins
TWI609887B (zh) 2012-11-05 2018-01-01 皮爾法伯製藥公司 新穎的抗原結合蛋白及其作爲治療癌症之定址產物的用途
US10086054B2 (en) 2013-06-26 2018-10-02 Academia Sinica RM2 antigens and use thereof
WO2014210564A1 (en) 2013-06-27 2014-12-31 Academia Sinica Glycan conjugates and use thereof
AU2014290361B2 (en) 2013-07-18 2019-04-18 Taurus Biosciences, Llc Humanized antibodies with ultralong complementarity determining regions
EP3022224A2 (en) 2013-07-18 2016-05-25 Fabrus, Inc. Antibodies with ultralong complementarity determining regions
WO2015017552A1 (en) 2013-08-01 2015-02-05 Agensys, Inc. Antibody drug conjugates (adc) that bind to cd37 proteins
JP6486368B2 (ja) 2013-09-06 2019-03-20 アカデミア シニカAcademia Sinica 改変されたグリコシル基を含む糖脂質を用いたヒトiNKT細胞の活性化
WO2015065954A1 (en) 2013-11-04 2015-05-07 Pfizer, Inc. Anti-efna4 antibody-drug conjugates
US9982041B2 (en) 2014-01-16 2018-05-29 Academia Sinica Compositions and methods for treatment and detection of cancers
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
RU2685728C2 (ru) 2014-01-29 2019-04-23 Шанхай Хэнжуй Фармасьютикал Ко., Лтд. Конъюгат лиганд - цитотоксическое лекарственное средство, способ его получения и его применения
ES2694857T3 (es) 2014-02-04 2018-12-27 Genentech, Inc. Smoothened mutante y métodos de uso de la misma
EP3129767B1 (en) 2014-03-27 2021-09-01 Academia Sinica Reactive labelling compounds and uses thereof
JP6835591B2 (ja) 2014-04-25 2021-02-24 ピエール、ファーブル、メディカマン Igf−1r抗体および癌処置のためのアドレッシングビヒクルとしてのその使用
ES2856927T3 (es) 2014-04-30 2021-09-28 Pfizer Conjugados de fármaco-anticuerpo anti-PTK7
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
CA2950423A1 (en) 2014-05-27 2015-12-03 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
CN106661099A (zh) 2014-05-27 2017-05-10 中央研究院 抗her2醣抗体及其用途
KR20240096599A (ko) 2014-05-27 2024-06-26 아카데미아 시니카 항-cd20 글리코항체 및 이의 용도
WO2015184001A1 (en) 2014-05-28 2015-12-03 Academia Sinica Anti-tnf-alpha glycoantibodies and uses thereof
WO2016034968A1 (en) 2014-09-02 2016-03-10 Pfizer Inc. Therapeutic antibody
KR102422375B1 (ko) 2014-09-08 2022-07-18 아카데미아 시니카 당지질을 사용한 인간 iNKT 세포 활성화
RU2017119185A (ru) 2014-11-05 2018-12-05 Дженентек, Инк. Антитела против fgfr2/3 и способы их применения
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
CN107430127B (zh) 2015-01-24 2020-08-28 中央研究院 癌症标记及其使用方法
AU2015378564A1 (en) 2015-01-24 2017-07-13 Academia Sinica Novel glycan conjugates and methods of use thereof
JP2018512597A (ja) 2015-02-04 2018-05-17 ジェネンテック, インコーポレイテッド 突然変異体スムースンド及びその使用方法
MA45326A (fr) 2015-10-20 2018-08-29 Genentech Inc Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation
PT3383920T (pt) 2015-11-30 2024-04-15 Univ California Entrega de carga útil específica para tumores e ativação imune utilizando um anticorpo humano que tem como alvo um antigénio altamente específico da superfície das células tumorais
CA3019952A1 (en) 2016-02-04 2017-08-10 Curis, Inc. Mutant smoothened and methods of using the same
WO2017153432A1 (en) 2016-03-07 2017-09-14 Pierre Fabre Medicament A new universal method to capture and analyze adcs for characterization of drug distribution and the drug-to-antibody ratio in biological samples
JP2019515876A (ja) 2016-03-08 2019-06-13 アカデミア シニカAcademia Sinica N−グリカンおよびそのアレイのモジュール合成のための方法
JP2019524706A (ja) 2016-07-08 2019-09-05 ジェネンテック, インコーポレイテッド Muc16陽性癌治療の応答性を評価するためのヒト精巣上体タンパク質4(he4)の使用
CA3034057A1 (en) 2016-08-22 2018-03-01 CHO Pharma Inc. Antibodies, binding fragments, and methods of use
US20190048073A1 (en) 2017-07-20 2019-02-14 Pfizer Inc. Anti-gd3 antibodies and antibody-drug conjugates
WO2019110725A1 (en) 2017-12-06 2019-06-13 Synaffix B.V. Enediyne conjugates
CN112739340A (zh) 2018-07-23 2021-04-30 美真达治疗公司 抗cd5抗体药物缀合物(adc)在同种异体细胞疗法中的用途
CN112512591B (zh) 2018-09-26 2024-08-16 江苏恒瑞医药股份有限公司 依喜替康类似物的配体-药物偶联物及其制备方法和应用
JPWO2021010326A1 (ko) 2019-07-12 2021-01-21
BR112022003635A2 (pt) 2019-09-04 2022-05-24 Pf Medicament Anticorpo anti-vsig4 ou fragmento de ligação ao antígeno e seu uso
CA3168654A1 (en) 2020-01-22 2021-07-29 Shanghai Senhui Medicine Co., Ltd. Drug conjugate of eribulin derivative, preparation method therefor and application thereof in medicine
EP4129345A4 (en) 2020-03-25 2023-11-29 Jiangsu Hengrui Pharmaceuticals Co., Ltd. PHARMACEUTICAL COMPOSITION COMPRISING AN ANTIBODY-DRUG CONJUGATE AND USE THEREOF
AU2021243080A1 (en) 2020-03-25 2022-09-22 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Preparation method for antibody medicament conjugate
EP4301786A1 (en) 2021-03-03 2024-01-10 Pierre Fabre Medicament Anti-vsig4 antibody or antigen binding fragment and uses thereof
IL308106A (en) 2021-04-30 2023-12-01 Pf Medicament A new antibody against VISTA

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5644076B2 (ko) * 1973-07-12 1981-10-16
EP1215212A3 (en) * 1987-01-30 2003-05-21 Wyeth Holdings Corporation Dihydro derivatives of LL-E33288 antibiotics
US4837206A (en) * 1987-04-29 1989-06-06 Bristol-Myers Company Esperamicin derivatives
ATE112172T1 (de) * 1987-10-30 1994-10-15 American Cyanamid Co Targetformer von antitumor-methyltrithioagenzien.
IL115770A (en) * 1989-04-14 1999-03-12 American Cyanamid Co Substituted disulfides of formula q-sp-ss-w their preparation and use for inhibiting the growth of tumours and for treating bacterial infections

Also Published As

Publication number Publication date
CN1048390A (zh) 1991-01-09
NO172938B (no) 1993-06-21
EP0392376A3 (en) 1991-08-14
AU5324890A (en) 1990-10-18
DK1097937T3 (da) 2005-09-19
FI97889C (fi) 1997-03-10
PT93715B (pt) 1996-08-30
ATE297405T1 (de) 2005-06-15
JP3083309B2 (ja) 2000-09-04
ES2162783T3 (es) 2002-01-16
DE69034194D1 (de) 2005-07-14
CA2014472C (en) 2000-03-28
HK1035540A1 (en) 2001-11-30
CA2014472A1 (en) 1990-10-14
KR900016242A (ko) 1990-11-13
SK281179B6 (sk) 2000-12-11
DE69033839D1 (de) 2001-12-06
FI97889B (fi) 1996-11-29
IL93732A (en) 1994-11-28
KR0149493B1 (ko) 1998-08-17
NO901654L (no) 1990-10-15
US5079233A (en) 1992-01-07
EP1097937A1 (en) 2001-05-09
ES2240000T3 (es) 2005-10-16
DE69034194T2 (de) 2005-11-03
CZ188390A3 (cs) 1998-10-14
CZ53598A3 (cs) 1998-09-16
CZ284618B6 (cs) 1999-01-13
NO172938C (no) 1993-12-29
PH27361A (en) 1993-06-21
DE69033839T2 (de) 2002-06-06
JPH032192A (ja) 1991-01-08
ATE207926T1 (de) 2001-11-15
IL93732A0 (en) 1990-12-23
EP0392376A2 (en) 1990-10-17
CN1027267C (zh) 1995-01-04
PT93715A (pt) 1990-11-20
IE20011013A1 (en) 2002-12-30
AU627863B2 (en) 1992-09-03
FI901865A0 (fi) 1990-05-12
HK1011368A1 (en) 1999-07-09
NO901654D0 (no) 1990-04-11
ZA902839B (en) 1991-12-24
SK188390A3 (en) 2000-12-11
EP1097937B1 (en) 2005-06-08
NZ233149A (en) 1996-02-27
SG47857A1 (en) 1998-04-17
CZ297668B6 (cs) 2007-02-28
EP0392376B1 (en) 2001-10-31

Similar Documents

Publication Publication Date Title
DK1097937T3 (da) N-acylderivater af LL-E33288-antitumor-antibiotika
ES2119831T3 (es) 7-(sustituido)-9-((glicil sustituido)amido)-6-desmetil-6-desoxitetraciclinas.
ES2162617T3 (es) Nuevas 7-(sustituido)-8-(sustituido)-9-((glicilo sustituido)amido)-6-desmetil-6-desoxitetraciclinas.
FI933567A (fi) Nya 7-(substituerad)-8-(substituerad)-9-(substituerad amino)-6-demetyl-6-deoxitetracykliner
ES2161220T3 (es) 9-((glicil sustituido)amido)-6-desmetil-6-desoxitetraciclinas como agentes antibioticos.
FI904851A0 (fi) Radiomaerkta antikoagulantpeptider.
BR8801905A (pt) Composicoes elastomericas de halobutila
DE69123312D1 (de) Kalziumphosphat Glaskeramik
MX9205003A (es) Derivados novedosos de benzopirano.
FI892222A (fi) Peptidalkoholer med antikoagulantverkan.
DK652887D0 (da) Beta-lactam-antibiotika
MX9102079A (es) Plemezcla de semduramicina
FR2597105B1 (fr) Derives antibiotiques de la famille des 20-0-acyl-19,20-enolmacrolides
MX9202911A (es) Compuestos pseudoagliconas de los antibioticos del complejo ll-e33288.
MX9202870A (es) Conjugados acarreador-farmaco de la familia de los agentes antitumorales y antibioticos del metiltritio.
ES1019673Y (es) Prenda de vestir interior de efectos luminosos.
ES1014062Y (es) Conjunto porta-esfera de farola.
KR920013544U (ko) 스위치의 고정장치
BR6902067U (pt) Aperfeicoamento de dispositivo de contorneamento
MX19365A (es) Derivados de tetrahidrobencimidazol.