DE69932948T3 - Verfahren zur Herstellung von Teilchen unter Verwendung eines überkritischen Fluids - Google Patents
Verfahren zur Herstellung von Teilchen unter Verwendung eines überkritischen Fluids Download PDFInfo
- Publication number
- DE69932948T3 DE69932948T3 DE69932948T DE69932948T DE69932948T3 DE 69932948 T3 DE69932948 T3 DE 69932948T3 DE 69932948 T DE69932948 T DE 69932948T DE 69932948 T DE69932948 T DE 69932948T DE 69932948 T3 DE69932948 T3 DE 69932948T3
- Authority
- DE
- Germany
- Prior art keywords
- substance
- mixture
- pressure
- compressible fluid
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012530 fluid Substances 0.000 title claims abstract description 208
- 238000000034 method Methods 0.000 title claims abstract description 102
- 239000002245 particle Substances 0.000 title claims abstract description 44
- 230000008569 process Effects 0.000 title claims abstract description 27
- 239000000126 substance Substances 0.000 claims abstract description 91
- 239000000203 mixture Substances 0.000 claims abstract description 71
- 239000000463 material Substances 0.000 claims abstract description 67
- 239000012296 anti-solvent Substances 0.000 claims abstract description 60
- 239000000654 additive Substances 0.000 claims abstract description 50
- 239000002904 solvent Substances 0.000 claims abstract description 37
- 239000006185 dispersion Substances 0.000 claims abstract description 8
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 77
- 230000000996 additive effect Effects 0.000 claims description 42
- 239000001569 carbon dioxide Substances 0.000 claims description 37
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 37
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 18
- 238000011144 upstream manufacturing Methods 0.000 claims description 14
- 230000015572 biosynthetic process Effects 0.000 claims description 13
- 239000003607 modifier Substances 0.000 claims description 13
- 239000007787 solid Substances 0.000 claims description 13
- -1 alkyl ketones Chemical class 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000003960 organic solvent Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 239000008365 aqueous carrier Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000013529 heat transfer fluid Substances 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000011236 particulate material Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 238000009472 formulation Methods 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 47
- 239000007789 gas Substances 0.000 description 44
- 230000007704 transition Effects 0.000 description 21
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 239000007921 spray Substances 0.000 description 13
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
- 239000007788 liquid Substances 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 230000001105 regulatory effect Effects 0.000 description 10
- 239000003570 air Substances 0.000 description 8
- 238000002156 mixing Methods 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000009833 condensation Methods 0.000 description 5
- 230000005494 condensation Effects 0.000 description 5
- 239000010419 fine particle Substances 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- XPDWGBQVDMORPB-UHFFFAOYSA-N Fluoroform Chemical compound FC(F)F XPDWGBQVDMORPB-UHFFFAOYSA-N 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- BLXXJMDCKKHMKV-UHFFFAOYSA-N Nabumetone Chemical compound C1=C(CCC(C)=O)C=CC2=CC(OC)=CC=C21 BLXXJMDCKKHMKV-UHFFFAOYSA-N 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 229960004270 nabumetone Drugs 0.000 description 4
- 238000007711 solidification Methods 0.000 description 4
- 230000008023 solidification Effects 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 235000011089 carbon dioxide Nutrition 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000002466 solution-enhanced dispersion by supercritical fluid Methods 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- XWCDCDSDNJVCLO-UHFFFAOYSA-N Chlorofluoromethane Chemical class FCCl XWCDCDSDNJVCLO-UHFFFAOYSA-N 0.000 description 2
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- 229910018503 SF6 Inorganic materials 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- AFYPFACVUDMOHA-UHFFFAOYSA-N chlorotrifluoromethane Chemical compound FC(F)(F)Cl AFYPFACVUDMOHA-UHFFFAOYSA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 150000008282 halocarbons Chemical class 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- NIQQIJXGUZVEBB-UHFFFAOYSA-N methanol;propan-2-one Chemical compound OC.CC(C)=O NIQQIJXGUZVEBB-UHFFFAOYSA-N 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000001046 rapid expansion of supercritical solution Methods 0.000 description 2
- 239000013557 residual solvent Substances 0.000 description 2
- 239000011343 solid material Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- SFZCNBIFKDRMGX-UHFFFAOYSA-N sulfur hexafluoride Chemical compound FS(F)(F)(F)(F)F SFZCNBIFKDRMGX-UHFFFAOYSA-N 0.000 description 2
- 229960000909 sulfur hexafluoride Drugs 0.000 description 2
- 230000003319 supportive effect Effects 0.000 description 2
- 229910052724 xenon Inorganic materials 0.000 description 2
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- 229960000878 docusate sodium Drugs 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 239000011551 heat transfer agent Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 235000020030 perry Nutrition 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Medicinal Preparation (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9828204 | 1998-12-21 | ||
| GBGB9828204.9A GB9828204D0 (en) | 1998-12-21 | 1998-12-21 | Process |
| PCT/GB1999/004355 WO2000037169A1 (en) | 1998-12-21 | 1999-12-21 | Process and apparatus for producing particles using a supercritical fluid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE69932948D1 DE69932948D1 (de) | 2006-10-05 |
| DE69932948T2 DE69932948T2 (de) | 2007-01-11 |
| DE69932948T3 true DE69932948T3 (de) | 2009-08-13 |
Family
ID=10844704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69932948T Expired - Lifetime DE69932948T3 (de) | 1998-12-21 | 1999-12-21 | Verfahren zur Herstellung von Teilchen unter Verwendung eines überkritischen Fluids |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6830714B1 (https=) |
| EP (1) | EP1169117B2 (https=) |
| JP (1) | JP4718011B2 (https=) |
| AT (1) | ATE306314T1 (https=) |
| AU (1) | AU1876100A (https=) |
| CY (1) | CY1105172T1 (https=) |
| DE (1) | DE69932948T3 (https=) |
| DK (1) | DK1169117T4 (https=) |
| ES (1) | ES2251250T5 (https=) |
| GB (1) | GB9828204D0 (https=) |
| WO (1) | WO2000037169A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE555773T1 (de) * | 1999-06-09 | 2012-05-15 | Sievers Robert E | Überkritische fluidgestützte verneblung und blasen trochnen |
| GB9920148D0 (en) * | 1999-08-25 | 1999-10-27 | Smithkline Beecham Plc | Novel composition |
| CH694686A5 (it) * | 2000-03-04 | 2005-06-15 | Eco2 Sa | Prodotto di micronizzazione di sostanze farmaceutiche. |
| AU2002221320B2 (en) * | 2000-12-08 | 2006-06-15 | The University Of Sydney | Synthesis of small particles |
| GB0102075D0 (en) | 2001-01-26 | 2001-03-14 | Astrazeneca Ab | Process |
| RU2296002C2 (ru) | 2001-02-26 | 2007-03-27 | ДОМПЕ ФА.Р.МА С.п.А. | Способ получения микронных и субмикронных частиц и предназначенное для этого устройство |
| DE10109829A1 (de) * | 2001-03-01 | 2002-09-05 | Celanese Ventures Gmbh | Polymermembran, Verfahren zu deren Herstellung sowie deren Verwendung |
| US6596206B2 (en) | 2001-03-30 | 2003-07-22 | Picoliter Inc. | Generation of pharmaceutical agent particles using focused acoustic energy |
| US6869551B2 (en) | 2001-03-30 | 2005-03-22 | Picoliter Inc. | Precipitation of solid particles from droplets formed using focused acoustic energy |
| US6610223B2 (en) | 2001-03-30 | 2003-08-26 | Picoliter Inc. | Focused acoustic energy in the generation of solid particles |
| ES2261469T5 (es) * | 2001-07-02 | 2015-12-22 | Micro & Nano Materials Sagl | Proceso para producir micro y/o nanopartículas |
| US7641823B2 (en) | 2001-12-07 | 2010-01-05 | Map Pharmaceuticals, Inc. | Synthesis of small particles |
| AU2002365617B2 (en) * | 2001-12-07 | 2008-04-03 | Map Pharmaceuticals, Inc. | Synthesis of small particles |
| CA2484052C (en) * | 2002-04-11 | 2011-06-14 | Medimmune Vaccines, Inc. | Preservation of bioactive materials by spray drying |
| EP1494796B1 (en) * | 2002-04-12 | 2014-06-04 | Feyecon B.V. | Process for small particle formation |
| DE10248619A1 (de) * | 2002-10-18 | 2004-04-29 | Bayer Ag | Verfahren zur Herstellung pulverförmiger Wirkstoff-Formulierungen mit kompressiblen Fluiden |
| JP2004148174A (ja) * | 2002-10-29 | 2004-05-27 | Kobe Steel Ltd | 超臨界流体を利用して微粒子を製造する方法および装置 |
| JP3663408B2 (ja) * | 2003-06-30 | 2005-06-22 | 株式会社アイテック | 高温高圧水を用いる微粒子製造方法および微粒子製造装置 |
| KR100603974B1 (ko) | 2003-12-05 | 2006-07-25 | 김갑식 | 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법 |
| CN100432124C (zh) * | 2004-01-28 | 2008-11-12 | 独立行政法人科学技术振兴机构 | 采用从超临界流体向不良溶剂中快速膨胀的方法的微粒制备方法 |
| AU2006272438B2 (en) * | 2005-07-15 | 2011-08-04 | Map Pharmaceuticals, Inc. | Method of particle formation |
| ES2444703T3 (es) | 2007-06-29 | 2014-02-26 | Cellutech Ab | Métodos para preparar superficies superhidrofóbicas sobre cuerpos sólidos mediante soluciones de expansión rápida |
| CA2706684C (en) * | 2007-12-07 | 2016-01-12 | Xspray Microparticles Ab | Method and arrangement for the production of particles |
| US20100294986A1 (en) * | 2009-05-19 | 2010-11-25 | Massachusetts Institute Of Technology | Supercritical fluid facilitated particle formation in microfluidic systems |
| US20100298602A1 (en) * | 2009-05-19 | 2010-11-25 | Massachusetts Institute Of Technology | Systems and methods for microfluidic crystallization |
| GB0915106D0 (en) | 2009-08-28 | 2009-10-07 | Glaxo Group Ltd | Process |
| WO2011118960A2 (ko) | 2010-03-22 | 2011-09-29 | (주)바이오시네틱스 | 나노입자 제조방법 |
| US9138705B2 (en) | 2010-11-22 | 2015-09-22 | Hong Kong Polytechnic University | Method for precipitating a solute from a solution |
| DE102011105201A1 (de) * | 2011-04-11 | 2012-10-11 | Martin Ruda | Luftkappe, Anordnung aus Haltering und Luftkappe und Farbleiteinrich-tung für eine Farbspritzpistole |
| WO2013136974A1 (ja) * | 2012-03-12 | 2013-09-19 | シャープ株式会社 | 修飾微粒子の精製方法および製造方法、修飾微粒子、機能性材料、光学部材、熱伝部材、ならびに、被覆率分析装置および被覆率分析方法 |
| US8778181B1 (en) | 2013-03-14 | 2014-07-15 | Crititech, Inc. | Equipment assembly for and method of processing particles |
| US10239009B2 (en) | 2013-03-14 | 2019-03-26 | Lawrence Livermore National Security, Llc | Continuously-operable flow stream processing system and method |
| US20170050337A1 (en) * | 2013-05-02 | 2017-02-23 | Melior Innovations, Inc. | Formation apparatus, systems and methods for manufacturing polymer derived ceramic structures |
| JP6429949B2 (ja) * | 2017-01-26 | 2018-11-28 | タナベウィルテック株式会社 | 微粒子製造装置および微粒子製造方法 |
| BR112018072382A2 (pt) | 2017-04-21 | 2019-02-12 | Bio-Synectics Inc. | método para preparar nanopartícula de ingrediente ativo |
| CN112007584A (zh) * | 2020-08-31 | 2020-12-01 | 胡勇刚 | 一种油脂的超临界颗粒制备工艺 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01176437A (ja) * | 1987-12-29 | 1989-07-12 | Ono Pharmaceut Co Ltd | 有機物質の微粒化方法 |
| US5639441A (en) * | 1992-03-06 | 1997-06-17 | Board Of Regents Of University Of Colorado | Methods for fine particle formation |
| GB9313642D0 (en) * | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| GB9413202D0 (en) * | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
| EP0885038B1 (en) * | 1996-03-01 | 2011-06-15 | The University Of Kansas | Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents |
| GB9622173D0 (en) * | 1996-10-24 | 1996-12-18 | Glaxo Group Ltd | Particulate Products |
| GB9703673D0 (en) † | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
-
1998
- 1998-12-21 GB GBGB9828204.9A patent/GB9828204D0/en not_active Ceased
-
1999
- 1999-12-21 AU AU18761/00A patent/AU1876100A/en not_active Abandoned
- 1999-12-21 ES ES99962400T patent/ES2251250T5/es not_active Expired - Lifetime
- 1999-12-21 AT AT99962400T patent/ATE306314T1/de active
- 1999-12-21 DE DE69932948T patent/DE69932948T3/de not_active Expired - Lifetime
- 1999-12-21 DK DK99962400T patent/DK1169117T4/da active
- 1999-12-21 EP EP99962400A patent/EP1169117B2/en not_active Expired - Lifetime
- 1999-12-21 JP JP2000589274A patent/JP4718011B2/ja not_active Expired - Fee Related
- 1999-12-21 WO PCT/GB1999/004355 patent/WO2000037169A1/en not_active Ceased
- 1999-12-21 US US09/868,581 patent/US6830714B1/en not_active Expired - Lifetime
-
2006
- 2006-01-03 CY CY20061100001T patent/CY1105172T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6830714B1 (en) | 2004-12-14 |
| DE69932948D1 (de) | 2006-10-05 |
| JP4718011B2 (ja) | 2011-07-06 |
| DK1169117T4 (da) | 2009-06-15 |
| ES2251250T3 (es) | 2006-04-16 |
| DK1169117T3 (da) | 2006-02-20 |
| JP2002532244A (ja) | 2002-10-02 |
| DE69932948T2 (de) | 2007-01-11 |
| WO2000037169A1 (en) | 2000-06-29 |
| CY1105172T1 (el) | 2010-03-03 |
| GB9828204D0 (en) | 1999-02-17 |
| EP1169117B2 (en) | 2009-03-18 |
| ES2251250T5 (es) | 2009-07-06 |
| EP1169117A1 (en) | 2002-01-09 |
| AU1876100A (en) | 2000-07-12 |
| ATE306314T1 (de) | 2005-10-15 |
| EP1169117B1 (en) | 2005-10-12 |
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