JP4718011B2 - 超臨界流体を用いる粒子の製法およびその装置 - Google Patents

超臨界流体を用いる粒子の製法およびその装置 Download PDF

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Publication number
JP4718011B2
JP4718011B2 JP2000589274A JP2000589274A JP4718011B2 JP 4718011 B2 JP4718011 B2 JP 4718011B2 JP 2000589274 A JP2000589274 A JP 2000589274A JP 2000589274 A JP2000589274 A JP 2000589274A JP 4718011 B2 JP4718011 B2 JP 4718011B2
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Japan
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conduit
mixture
pressure
solvent
flow
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Japanese (ja)
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JP2002532244A5 (https=
JP2002532244A (ja
Inventor
デイビッド・ロイ・メリフィード
クリストファー・エドモンド・バルダー
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SmithKline Beecham Ltd
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SmithKline Beecham Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicinal Preparation (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
JP2000589274A 1998-12-21 1999-12-21 超臨界流体を用いる粒子の製法およびその装置 Expired - Fee Related JP4718011B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9828204.9 1998-12-21
GBGB9828204.9A GB9828204D0 (en) 1998-12-21 1998-12-21 Process
PCT/GB1999/004355 WO2000037169A1 (en) 1998-12-21 1999-12-21 Process and apparatus for producing particles using a supercritical fluid

Publications (3)

Publication Number Publication Date
JP2002532244A JP2002532244A (ja) 2002-10-02
JP2002532244A5 JP2002532244A5 (https=) 2007-02-15
JP4718011B2 true JP4718011B2 (ja) 2011-07-06

Family

ID=10844704

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000589274A Expired - Fee Related JP4718011B2 (ja) 1998-12-21 1999-12-21 超臨界流体を用いる粒子の製法およびその装置

Country Status (11)

Country Link
US (1) US6830714B1 (https=)
EP (1) EP1169117B2 (https=)
JP (1) JP4718011B2 (https=)
AT (1) ATE306314T1 (https=)
AU (1) AU1876100A (https=)
CY (1) CY1105172T1 (https=)
DE (1) DE69932948T3 (https=)
DK (1) DK1169117T4 (https=)
ES (1) ES2251250T5 (https=)
GB (1) GB9828204D0 (https=)
WO (1) WO2000037169A1 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE555773T1 (de) * 1999-06-09 2012-05-15 Sievers Robert E Überkritische fluidgestützte verneblung und blasen trochnen
GB9920148D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel composition
CH694686A5 (it) * 2000-03-04 2005-06-15 Eco2 Sa Prodotto di micronizzazione di sostanze farmaceutiche.
AU2002221320B2 (en) * 2000-12-08 2006-06-15 The University Of Sydney Synthesis of small particles
GB0102075D0 (en) 2001-01-26 2001-03-14 Astrazeneca Ab Process
RU2296002C2 (ru) 2001-02-26 2007-03-27 ДОМПЕ ФА.Р.МА С.п.А. Способ получения микронных и субмикронных частиц и предназначенное для этого устройство
DE10109829A1 (de) * 2001-03-01 2002-09-05 Celanese Ventures Gmbh Polymermembran, Verfahren zu deren Herstellung sowie deren Verwendung
US6596206B2 (en) 2001-03-30 2003-07-22 Picoliter Inc. Generation of pharmaceutical agent particles using focused acoustic energy
US6869551B2 (en) 2001-03-30 2005-03-22 Picoliter Inc. Precipitation of solid particles from droplets formed using focused acoustic energy
US6610223B2 (en) 2001-03-30 2003-08-26 Picoliter Inc. Focused acoustic energy in the generation of solid particles
ES2261469T5 (es) * 2001-07-02 2015-12-22 Micro & Nano Materials Sagl Proceso para producir micro y/o nanopartículas
US7641823B2 (en) 2001-12-07 2010-01-05 Map Pharmaceuticals, Inc. Synthesis of small particles
AU2002365617B2 (en) * 2001-12-07 2008-04-03 Map Pharmaceuticals, Inc. Synthesis of small particles
CA2484052C (en) * 2002-04-11 2011-06-14 Medimmune Vaccines, Inc. Preservation of bioactive materials by spray drying
EP1494796B1 (en) * 2002-04-12 2014-06-04 Feyecon B.V. Process for small particle formation
DE10248619A1 (de) * 2002-10-18 2004-04-29 Bayer Ag Verfahren zur Herstellung pulverförmiger Wirkstoff-Formulierungen mit kompressiblen Fluiden
JP2004148174A (ja) * 2002-10-29 2004-05-27 Kobe Steel Ltd 超臨界流体を利用して微粒子を製造する方法および装置
JP3663408B2 (ja) * 2003-06-30 2005-06-22 株式会社アイテック 高温高圧水を用いる微粒子製造方法および微粒子製造装置
KR100603974B1 (ko) 2003-12-05 2006-07-25 김갑식 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법
CN100432124C (zh) * 2004-01-28 2008-11-12 独立行政法人科学技术振兴机构 采用从超临界流体向不良溶剂中快速膨胀的方法的微粒制备方法
AU2006272438B2 (en) * 2005-07-15 2011-08-04 Map Pharmaceuticals, Inc. Method of particle formation
ES2444703T3 (es) 2007-06-29 2014-02-26 Cellutech Ab Métodos para preparar superficies superhidrofóbicas sobre cuerpos sólidos mediante soluciones de expansión rápida
CA2706684C (en) * 2007-12-07 2016-01-12 Xspray Microparticles Ab Method and arrangement for the production of particles
US20100294986A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Supercritical fluid facilitated particle formation in microfluidic systems
US20100298602A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Systems and methods for microfluidic crystallization
GB0915106D0 (en) 2009-08-28 2009-10-07 Glaxo Group Ltd Process
WO2011118960A2 (ko) 2010-03-22 2011-09-29 (주)바이오시네틱스 나노입자 제조방법
US9138705B2 (en) 2010-11-22 2015-09-22 Hong Kong Polytechnic University Method for precipitating a solute from a solution
DE102011105201A1 (de) * 2011-04-11 2012-10-11 Martin Ruda Luftkappe, Anordnung aus Haltering und Luftkappe und Farbleiteinrich-tung für eine Farbspritzpistole
WO2013136974A1 (ja) * 2012-03-12 2013-09-19 シャープ株式会社 修飾微粒子の精製方法および製造方法、修飾微粒子、機能性材料、光学部材、熱伝部材、ならびに、被覆率分析装置および被覆率分析方法
US8778181B1 (en) 2013-03-14 2014-07-15 Crititech, Inc. Equipment assembly for and method of processing particles
US10239009B2 (en) 2013-03-14 2019-03-26 Lawrence Livermore National Security, Llc Continuously-operable flow stream processing system and method
US20170050337A1 (en) * 2013-05-02 2017-02-23 Melior Innovations, Inc. Formation apparatus, systems and methods for manufacturing polymer derived ceramic structures
JP6429949B2 (ja) * 2017-01-26 2018-11-28 タナベウィルテック株式会社 微粒子製造装置および微粒子製造方法
BR112018072382A2 (pt) 2017-04-21 2019-02-12 Bio-Synectics Inc. método para preparar nanopartícula de ingrediente ativo
CN112007584A (zh) * 2020-08-31 2020-12-01 胡勇刚 一种油脂的超临界颗粒制备工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01176437A (ja) * 1987-12-29 1989-07-12 Ono Pharmaceut Co Ltd 有機物質の微粒化方法
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
EP0885038B1 (en) * 1996-03-01 2011-06-15 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
GB9622173D0 (en) * 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
GB9703673D0 (en) † 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles

Also Published As

Publication number Publication date
US6830714B1 (en) 2004-12-14
DE69932948D1 (de) 2006-10-05
DE69932948T3 (de) 2009-08-13
DK1169117T4 (da) 2009-06-15
ES2251250T3 (es) 2006-04-16
DK1169117T3 (da) 2006-02-20
JP2002532244A (ja) 2002-10-02
DE69932948T2 (de) 2007-01-11
WO2000037169A1 (en) 2000-06-29
CY1105172T1 (el) 2010-03-03
GB9828204D0 (en) 1999-02-17
EP1169117B2 (en) 2009-03-18
ES2251250T5 (es) 2009-07-06
EP1169117A1 (en) 2002-01-09
AU1876100A (en) 2000-07-12
ATE306314T1 (de) 2005-10-15
EP1169117B1 (en) 2005-10-12

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