DE69931518T2 - Chimäres Gen, das für die antigenischen Determinaten von vier Proteinen aus L. Infantum kodiert - Google Patents

Chimäres Gen, das für die antigenischen Determinaten von vier Proteinen aus L. Infantum kodiert Download PDF

Info

Publication number
DE69931518T2
DE69931518T2 DE69931518T DE69931518T DE69931518T2 DE 69931518 T2 DE69931518 T2 DE 69931518T2 DE 69931518 T DE69931518 T DE 69931518T DE 69931518 T DE69931518 T DE 69931518T DE 69931518 T2 DE69931518 T2 DE 69931518T2
Authority
DE
Germany
Prior art keywords
protein
leishmaniasis
pharmaceutical composition
proteins
animals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69931518T
Other languages
German (de)
English (en)
Other versions
DE69931518D1 (de
Inventor
Carlos Bedate Alonso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Leti SA
Original Assignee
Cbf Leti Sa Tres Cantos
Laboratorios Leti SA
CBF Leti SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA2256124A external-priority patent/CA2256124C/en
Application filed by Cbf Leti Sa Tres Cantos, Laboratorios Leti SA, CBF Leti SA filed Critical Cbf Leti Sa Tres Cantos
Application granted granted Critical
Publication of DE69931518D1 publication Critical patent/DE69931518D1/de
Publication of DE69931518T2 publication Critical patent/DE69931518T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69931518T 1998-12-23 1999-12-23 Chimäres Gen, das für die antigenischen Determinaten von vier Proteinen aus L. Infantum kodiert Expired - Lifetime DE69931518T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11382598P 1998-12-23 1998-12-23
US113825P 1998-12-23
CA2256124 1998-12-23
CA2256124A CA2256124C (en) 1998-12-23 1998-12-23 Chimeric gene formed of the dna sequences that encode the antigenic determinants of four proteins of l. infantum, and protein encoded by said gene, and pharmaceutical composition useful for preventing and/or treating leishmaniosis in animals or humans
PCT/EP1999/010441 WO2000039298A1 (en) 1998-12-23 1999-12-23 Chimeric gene encoding the antigenic determinants of four proteins of l. infantum

Publications (2)

Publication Number Publication Date
DE69931518D1 DE69931518D1 (de) 2006-06-29
DE69931518T2 true DE69931518T2 (de) 2006-12-21

Family

ID=25680668

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69931518T Expired - Lifetime DE69931518T2 (de) 1998-12-23 1999-12-23 Chimäres Gen, das für die antigenischen Determinaten von vier Proteinen aus L. Infantum kodiert
DE69940793T Expired - Lifetime DE69940793D1 (de) 1998-12-23 1999-12-23 Chimärisches Gen, dass für die antigenischen Determinanten von vier Proteinen aus L. Infantum kodiert

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69940793T Expired - Lifetime DE69940793D1 (de) 1998-12-23 1999-12-23 Chimärisches Gen, dass für die antigenischen Determinanten von vier Proteinen aus L. Infantum kodiert

Country Status (22)

Country Link
EP (1) EP1141305B1 (enExample)
CN (1) CN1158387C (enExample)
AT (2) ATE327332T1 (enExample)
AU (1) AU759316B2 (enExample)
BE (1) BE2016C049I2 (enExample)
BG (1) BG65569B1 (enExample)
BR (1) BRPI9916549B8 (enExample)
CY (3) CY1105331T1 (enExample)
CZ (1) CZ20012360A3 (enExample)
DE (2) DE69931518T2 (enExample)
DK (1) DK1141305T3 (enExample)
ES (2) ES2273519T3 (enExample)
HR (1) HRP20010554A2 (enExample)
HU (1) HUP0104743A3 (enExample)
IL (2) IL143956A0 (enExample)
LU (1) LU93259I2 (enExample)
MX (1) MXPA01006548A (enExample)
NL (1) NL300830I2 (enExample)
PT (2) PT1624063E (enExample)
SI (1) SI1624063T1 (enExample)
TR (1) TR200102655T2 (enExample)
WO (1) WO2000039298A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613337B1 (en) * 1997-02-12 2003-09-02 Corixa Corporation Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
ES2169995B1 (es) * 2000-04-17 2003-12-01 Leti Lab Composicion a base de la proteina lip2a y su uso en la preparacion de un medicamento para suscitar una respuesta inmune contra un antigeno.
US6673351B1 (en) 2001-03-16 2004-01-06 Astralis, Llc Compositions and methods for the treatment and clinical remission of psoriasis
WO2006058243A2 (en) * 2004-11-24 2006-06-01 Yale University Leishmania antigens and related compositions and uses
AP3007A (en) * 2008-01-18 2014-10-31 Leti Sl Lab Vaccine comprising a ribosomal protein extract (RPE) and optionally a thi-promoting adjuvant
AP3516A (en) * 2009-07-13 2016-01-11 Leti Sl Lab Diagnosis of a parasitic disease such as leishmaniasis using ribosomal protein extract (rpe)
SA110310855B1 (ar) 2009-11-13 2014-09-16 Laboratories Leti S L Unipersonal استخدام مصدر l3 و/ أو l5 كلقاح أو كوسيلة تشخيصية لمرض طفيلي
BR102019003639A2 (pt) * 2019-02-22 2021-11-16 Fundação Oswaldo Cruz Proteína quimérica, seu método para produção e uso, bem como molécula de ácido nucleico, cassete de expressão, vetor de expressão, célula hospedeira, composição para diagnóstico de leishmaniose, kit de diagnóstico de leishmaniose e método de diagnóstico de leishmaniose in vitro
ES2795149B2 (es) 2020-06-08 2022-07-04 Univ Madrid Complutense Quimera sintetica multiepitopica como vacuna y tratamiento frente a leishmaniosis en mamiferos
CN112662694A (zh) * 2020-12-25 2021-04-16 康九生物科技(长春)有限公司 一种麦芽糖结合蛋白、麦芽糖结合蛋白表达载体、重组工程菌及其应用
WO2026115138A1 (en) * 2024-11-29 2026-06-04 Leti Pharma, S.L.U. Purification of protein q by ion exchange chromatography
WO2026115152A1 (en) 2024-11-29 2026-06-04 Leti Pharma, S.L.U. Lysate concentration
WO2026119906A1 (en) 2024-12-04 2026-06-11 Leti Pharma, S.L.U. New vaccine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0703295A1 (en) * 1994-09-26 1996-03-27 Institut Pasteur Vaccine composition comprising recombinant BCG expressing gp 63 fusion protein
US5912166A (en) * 1995-04-21 1999-06-15 Corixa Corporation Compounds and methods for diagnosis of leishmaniasis
ES2133236B1 (es) * 1997-06-27 2000-04-16 Leti Lab Gen quimerico formado por las secuencias de dna que codifican los determinantes antigenicos de cuatro proteinas de l. infantum, aplicable para el diagnostico serologico de leishmaniosis canina y proteina obtenida.

Also Published As

Publication number Publication date
BRPI9916549B8 (pt) 2022-08-30
BG105725A (en) 2002-06-28
BR9916549A (pt) 2005-01-04
EP1141305A1 (en) 2001-10-10
NL300830I2 (nl) 2020-08-31
IL143956A (en) 2010-11-30
BE2016C049I2 (enExample) 2019-03-05
DK1141305T3 (da) 2006-09-25
CN1335889A (zh) 2002-02-13
CN1158387C (zh) 2004-07-21
PT1141305E (pt) 2006-10-31
AU759316B2 (en) 2003-04-10
TR200102655T2 (tr) 2002-04-22
SI1624063T1 (sl) 2009-08-31
ES2326174T3 (es) 2009-10-02
BG65569B1 (bg) 2008-12-30
BRPI9916549B1 (pt) 2018-10-02
AU2434200A (en) 2000-07-31
CY1109221T1 (el) 2014-07-02
CZ20012360A3 (cs) 2001-10-17
CY1105331T1 (el) 2010-03-03
LU93259I2 (fr) 2016-12-06
EP1141305B1 (en) 2006-05-24
HUP0104743A2 (hu) 2002-03-28
ES2273519T3 (es) 2007-05-01
ATE327332T1 (de) 2006-06-15
PT1624063E (pt) 2009-06-19
WO2000039298A1 (en) 2000-07-06
HUP0104743A3 (en) 2004-10-28
CY2016033I1 (el) 2017-03-15
NL300830I1 (nl) 2016-09-28
DE69931518D1 (de) 2006-06-29
IL143956A0 (en) 2002-04-21
CY2016033I2 (el) 2017-03-15
HRP20010554A2 (en) 2002-08-31
DE69940793D1 (de) 2009-06-04
ATE429498T1 (de) 2009-05-15
MXPA01006548A (es) 2003-03-27

Similar Documents

Publication Publication Date Title
DE3586853T2 (de) Immunologisch aktive Peptide, geeignet zur Einführung von Immunisierung gegen Malaria und deren Kodierung von Genen.
EP0418827B1 (de) Impfstoff gegen die Lyme-Krankheit
DE69417541T2 (de) Diagnose der leishmaniose
DE69231837T2 (de) Antigen praesentierende ms2-huelle
DE69328489T2 (de) Stress-proteine epitopen
DE69333468T2 (de) Schützende antikörper induzierende antigene aus plasmodium falciparum
DE3881204T2 (de) Moleküle mit mindestens einer peptidsequenz einer oder mehrerer epitopen eines p.falciparum-produzierten proteins in hepatozyten und zusammensetzungen davon.
DE69835682T2 (de) Oberflächenantigene und proteine für zusammensetzungen zu diagnose und vorbeugung der lyme-kkrankheit
DE60131858T2 (de) Borrelia burgdorferi rekombinante genkonstrukte
DE60301944T2 (de) Verfahren zur Vorbereitung von hypoallergenen Mosaikproteinen#
DE69111880T2 (de) Immunogenes Protein und cDNA-Klon.
DE3885365T2 (de) Spezifische Sekretions-Exkretions-Antigene von Toxoplasma gondii, deren Expressionsprodukte, Verfahren zu deren Herstellung und deren diagnostische und prophylaktische Anwendungen.
DE69635077T2 (de) Gegen malaria polypeptidische molekulen von vorerythrozytären stadium
EP1141305B1 (en) Chimeric gene encoding the antigenic determinants of four proteins of l. infantum
DE68918712T2 (de) Rekombinante Eimeria tenella-Vakzine.
DE3751777T2 (de) Impfstoff, der zecken-antigene enthält
DE60220988T2 (de) Herstellung und verwendung eines plasmodiumfusionsantigen
DE4419264B4 (de) Antigen, um Menschen und Tieren eine schützende Immunität gegen Wurminfektionen zu verleihen
AU676828B2 (en) Antigens protective against (echinococcus granulosus) infection and vaccines containing such antigens
EP1399549B1 (en) Anticomplement polypeptide from salivary glands of the tick ixodes ricinus
DE60307987T2 (de) Galectin aus milben
DE60320425T2 (de) Ostertagia-impfstoff
DE69615685T2 (de) Impstoff gegen krankheitserreger, zusammensetzung zur behandlung und vorbeugung von hiv infektionen
US6962704B2 (en) Chimeric gene formed by the dna sequences that encode the antigenic determinants of four proteins of l. infantum and protein encoded by said gene, and pharmaceutical composition useful for preventing and/or treating leishmaniosis in animals or humans
EP1624063B1 (en) Chimeric gene encoding the antigenic determinants of four proteins of L. infantum

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LABORATORIOS LETI, S.L., TRES CANTONS, ES

R065 Request for grant of supplementary protection certificate validly filed

Free format text: PRODUCT NAME: PROTEIN Q, EIN REKOMBINANTES, CHIMAERES PROTEIN, BESTEHEND AUS FUENF ANTIGENISCHEN FRAGMENTEN VON VIER VERSCHIEDENEN LEISHMANIA INFANTUM (ZYMODEME MON-1) PROTEINEN, ODER EIN THERAPEUTISCH AEQUIVALENTES, REKOMBINANTES, CHIMAERES DURCH DAS PATENT GESCHUETZTES PROTEIN; REGISTRATION NO/DATE: EU/2/16/195 20160420

Spc suppl protection certif: 122016000068

Filing date: 20160824

Expiry date: 20191224

Free format text: PRODUCT NAME: PROTEIN Q, EIN REKOMBINANTES, CHIMAERES PROTEIN, BESTEHEND AUS FUENF ANTIGENISCHEN FRAGMENTEN VON VIER VERSCHIEDENEN LEISHMANIA INFANTUM (ZYMODEME MON-1) PROTEINEN, ODER EIN THERAPEUTISCH AEQUIVALENTES, REKOMBINANTES, CHIMAERES DURCH DAS PATENT GESCHUETZTES PROTEIN; AUTHORISATION NO/DATE: EU/2/16/195 20160420

Spc suppl protection certif: 122016000068