ES2169995B1 - Composicion a base de la proteina lip2a y su uso en la preparacion de un medicamento para suscitar una respuesta inmune contra un antigeno. - Google Patents
Composicion a base de la proteina lip2a y su uso en la preparacion de un medicamento para suscitar una respuesta inmune contra un antigeno.Info
- Publication number
- ES2169995B1 ES2169995B1 ES200000999A ES200000999A ES2169995B1 ES 2169995 B1 ES2169995 B1 ES 2169995B1 ES 200000999 A ES200000999 A ES 200000999A ES 200000999 A ES200000999 A ES 200000999A ES 2169995 B1 ES2169995 B1 ES 2169995B1
- Authority
- ES
- Spain
- Prior art keywords
- lip2a
- antigen
- protein
- preparation
- immune response
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 230000028993 immune response Effects 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 241000222722 Leishmania <genus> Species 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Abstract
Composición a base de la proteína Lip2a y su uso en la preparación de un medicamento para suscitar una respuesta inmune contra un antígeno en individuos inmunizados o en grupos celulares. La composición comprende una proteína llamada Lip2a Leishmania formada por una secuencia de aminoácidos codificada por una secuencia de DNA que comprende los nucleótidos: 1-1 de los Nos. 778 a 1231 de la SEQ. ID NO 1 1-2 o formada por una secuencia de nucleótidos capaces de hibridar con la secuencia descrita en 1-1 bajo condiciones de hibridación moderadamente astringentes y que codificaría por lo tanto una proteína similar a la Lip2a. El método comprende incubar dichas células con dicha proteína Lip2a en presencia o no de un antígeno específico de una enfermedad o infección.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200000999A ES2169995B1 (es) | 2000-04-17 | 2000-04-17 | Composicion a base de la proteina lip2a y su uso en la preparacion de un medicamento para suscitar una respuesta inmune contra un antigeno. |
| AU95175/01A AU9517501A (en) | 2000-04-17 | 2001-04-11 | Composition containing leishmania LIP2A |
| PT1971447T PT1279679E (pt) | 2000-04-17 | 2001-04-11 | Composição contendo leishmânia lip2a |
| EP01971447.6A EP1279679B1 (en) | 2000-04-17 | 2001-04-11 | Composition containing leishmania lip2a |
| DK01971447.6T DK1279679T3 (en) | 2000-04-17 | 2001-04-11 | A composition containing Leishmania LiP2a |
| US10/258,165 US20030157125A1 (en) | 2000-04-17 | 2001-04-11 | Composition containing leishmania lip2a |
| ES01971447.6T ES2546301T3 (es) | 2000-04-17 | 2001-04-11 | Composición que contiene Leishmania Lip2a |
| PCT/ES2001/000147 WO2001081388A1 (es) | 2000-04-17 | 2001-04-11 | Composición que contiene leishmania lip2a |
| US11/282,328 US20060127418A1 (en) | 2000-04-17 | 2005-11-18 | Composition containing Leishmania Lip2a |
| CY20151100892T CY1116774T1 (el) | 2000-04-17 | 2015-10-06 | Συνθεση η οποια περιεχει lip2a leishmania |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200000999A ES2169995B1 (es) | 2000-04-17 | 2000-04-17 | Composicion a base de la proteina lip2a y su uso en la preparacion de un medicamento para suscitar una respuesta inmune contra un antigeno. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2169995A1 ES2169995A1 (es) | 2002-07-16 |
| ES2169995B1 true ES2169995B1 (es) | 2003-12-01 |
Family
ID=8493222
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200000999A Expired - Fee Related ES2169995B1 (es) | 2000-04-17 | 2000-04-17 | Composicion a base de la proteina lip2a y su uso en la preparacion de un medicamento para suscitar una respuesta inmune contra un antigeno. |
| ES01971447.6T Expired - Lifetime ES2546301T3 (es) | 2000-04-17 | 2001-04-11 | Composición que contiene Leishmania Lip2a |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01971447.6T Expired - Lifetime ES2546301T3 (es) | 2000-04-17 | 2001-04-11 | Composición que contiene Leishmania Lip2a |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20030157125A1 (es) |
| EP (1) | EP1279679B1 (es) |
| AU (1) | AU9517501A (es) |
| CY (1) | CY1116774T1 (es) |
| DK (1) | DK1279679T3 (es) |
| ES (2) | ES2169995B1 (es) |
| PT (1) | PT1279679E (es) |
| WO (1) | WO2001081388A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2863272B1 (fr) * | 2003-11-19 | 2006-06-09 | Inst Rech Developpement Ird | Nouveaux moyens pour la prevention des leishmanioses |
| FR2881752B1 (fr) * | 2005-02-10 | 2009-07-31 | Inst Rech Pour Le Dev I R D Et | Moyens pour l'obtention de promastigotes de leishmanies avirulents, promastigotes obtenus et leurs applications |
| RU2521499C2 (ru) * | 2008-01-18 | 2014-06-27 | Лабораториос Лети, С.Л. Униперсональ | ВАКЦИНА, СОДЕРЖАЩАЯ ЭКСТРАКТ РИБОСОМНОГО БЕЛКА (RPE) И Th1- АКТИВИРУЮЩИЙ АДЪЮВАНТ |
| WO2010010577A1 (en) | 2008-07-25 | 2010-01-28 | Department Of Biotechnology | Constructing a dna chimera for vaccine development against leishmaniasis and tuberculosis |
| MX2012000675A (es) | 2009-07-13 | 2012-06-08 | Leti Sl Lab | Diagnostico de una parasitosis tal como la leishmaniasis usando un extracto de proteinas ribosomicas (rpe). |
| US9804158B2 (en) * | 2013-07-02 | 2017-10-31 | Institut De Recherche Pour Le Développement | Peptides and methods for the detection of Leishmaniasis |
| US10973897B2 (en) * | 2016-04-14 | 2021-04-13 | Peptcell Limited | Chagas antigens and antibodies and compositions, methods and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2133236B1 (es) * | 1997-06-27 | 2000-04-16 | Leti Lab | Gen quimerico formado por las secuencias de dna que codifican los determinantes antigenicos de cuatro proteinas de l. infantum, aplicable para el diagnostico serologico de leishmaniosis canina y proteina obtenida. |
| US6525186B2 (en) * | 1998-12-23 | 2003-02-25 | C.B.F. Leti S.A. | Chimeric gene formed of the DNA sequences that encode the antigenic determinants of four proteins of L. infantum, useful of serologic diagnosis of canine leishmaniosis and protein obtained |
| US6458359B1 (en) * | 1998-12-23 | 2002-10-01 | C.B.F. Leti S.A. | Chimeric gene formed by the dna sequences that encode the antigenic determinants of four proteins of l. infantum and protein encoded by said gene, and pharmacuetical composition useful for preventing and/or treating leishmaniosis in animals or humans |
| SI1624063T1 (sl) * | 1998-12-23 | 2009-08-31 | Leti Sl Lab | Himerni gen, ki kodira antigenske determinante štirih beljakovin iz L. infantuma |
-
2000
- 2000-04-17 ES ES200000999A patent/ES2169995B1/es not_active Expired - Fee Related
-
2001
- 2001-04-11 AU AU95175/01A patent/AU9517501A/en not_active Abandoned
- 2001-04-11 ES ES01971447.6T patent/ES2546301T3/es not_active Expired - Lifetime
- 2001-04-11 PT PT1971447T patent/PT1279679E/pt unknown
- 2001-04-11 WO PCT/ES2001/000147 patent/WO2001081388A1/es active Application Filing
- 2001-04-11 EP EP01971447.6A patent/EP1279679B1/en not_active Expired - Lifetime
- 2001-04-11 DK DK01971447.6T patent/DK1279679T3/en active
- 2001-04-11 US US10/258,165 patent/US20030157125A1/en not_active Abandoned
-
2005
- 2005-11-18 US US11/282,328 patent/US20060127418A1/en not_active Abandoned
-
2015
- 2015-10-06 CY CY20151100892T patent/CY1116774T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2546301T3 (es) | 2015-09-22 |
| CY1116774T1 (el) | 2017-03-15 |
| ES2169995A1 (es) | 2002-07-16 |
| US20030157125A1 (en) | 2003-08-21 |
| EP1279679A1 (en) | 2003-01-29 |
| US20060127418A1 (en) | 2006-06-15 |
| WO2001081388A1 (es) | 2001-11-01 |
| EP1279679B1 (en) | 2015-07-08 |
| DK1279679T3 (en) | 2015-08-24 |
| PT1279679E (pt) | 2015-12-24 |
| AU9517501A (en) | 2001-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20020716 Kind code of ref document: A1 Effective date: 20020716 |
|
| PC2A | Transfer of patent | ||
| FD2A | Announcement of lapse in spain |
Effective date: 20211117 |