ITFI920052A1 - Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico. - Google Patents

Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico.

Info

Publication number
ITFI920052A1
ITFI920052A1 IT000052A ITFI920052A ITFI920052A1 IT FI920052 A1 ITFI920052 A1 IT FI920052A1 IT 000052 A IT000052 A IT 000052A IT FI920052 A ITFI920052 A IT FI920052A IT FI920052 A1 ITFI920052 A1 IT FI920052A1
Authority
IT
Italy
Prior art keywords
antigen
helicobacter pylori
protein
vaccine
expresses
Prior art date
Application number
IT000052A
Other languages
English (en)
Inventor
Doretta Armellini
Massimo Bugnoli
Stefano Censini
Antonio Covacci
Natale Figura
Roberto Petracca
Rino Rappuoli
Original Assignee
Istituto Ricerche Immunobiologiche Siena S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Ricerche Immunobiologiche Siena S R L filed Critical Istituto Ricerche Immunobiologiche Siena S R L
Publication of ITFI920052A0 publication Critical patent/ITFI920052A0/it
Priority to ITFI920052A priority Critical patent/IT1262895B/it
Priority to DE69333110T priority patent/DE69333110T2/de
Priority to AU36300/93A priority patent/AU3630093A/en
Priority to EP93905285A priority patent/EP0643770B1/en
Priority to PCT/EP1993/000472 priority patent/WO1993018150A1/en
Priority to CA002383007A priority patent/CA2383007A1/en
Priority to EP99202698A priority patent/EP0967279B1/en
Priority to CA002131729A priority patent/CA2131729C/en
Priority to JP51530993A priority patent/JP3368902B2/ja
Priority to DE69334197T priority patent/DE69334197T2/de
Priority to AT93905285T priority patent/ATE245698T1/de
Priority to SG1996009100A priority patent/SG48353A1/en
Priority to AT99202698T priority patent/ATE382692T1/de
Publication of ITFI920052A1 publication Critical patent/ITFI920052A1/it
Priority to US08/471,491 priority patent/US6090611A/en
Priority to US08/466,662 priority patent/US6130059A/en
Priority to US08/470,260 priority patent/US6077706A/en
Priority to US08/477,451 priority patent/US5928865A/en
Application granted granted Critical
Publication of IT1262895B publication Critical patent/IT1262895B/it
Priority to US09/360,685 priority patent/US7141244B1/en
Priority to JP2000126695A priority patent/JP3408494B2/ja
Priority to JP2000126696A priority patent/JP2000333686A/ja
Priority to US09/921,157 priority patent/US20040048353A1/en
Priority to JP2003008806A priority patent/JP4271952B2/ja
Priority to US10/615,668 priority patent/US7700755B2/en
Priority to JP2005263068A priority patent/JP2006055168A/ja
Priority to US11/580,632 priority patent/US20070243204A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ITFI920052A 1992-03-02 1992-03-02 Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico. IT1262895B (it)

Priority Applications (25)

Application Number Priority Date Filing Date Title
ITFI920052A IT1262895B (it) 1992-03-02 1992-03-02 Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico.
AT99202698T ATE382692T1 (de) 1992-03-02 1993-03-02 Helicobacter pylori cytotoxin verwendbar in impfstoffe und diagnostik
AU36300/93A AU3630093A (en) 1992-03-02 1993-03-02 Helicobacter pylori proteins useful for vaccines and diagnostics
EP93905285A EP0643770B1 (en) 1992-03-02 1993-03-02 Helicobacter pylori cytotoxin associated immunodominant antigen useful for vaccines and diagnostics
PCT/EP1993/000472 WO1993018150A1 (en) 1992-03-02 1993-03-02 Helicobacter pylori proteins useful for vaccines and diagnostics
CA002383007A CA2383007A1 (en) 1992-03-02 1993-03-02 Helicobacter pylori proteins useful for vaccines and diagnostics
EP99202698A EP0967279B1 (en) 1992-03-02 1993-03-02 Helicobacter pylori cytotoxin useful for vaccines and diagnostics
CA002131729A CA2131729C (en) 1992-03-02 1993-03-02 Helicobacter pylori proteins useful for vaccines and diagnostics
JP51530993A JP3368902B2 (ja) 1992-03-02 1993-03-02 ワクチンおよび診断に有用なＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉタンパク質
DE69334197T DE69334197T2 (de) 1992-03-02 1993-03-02 Helicobacter pylori Cytotoxin verwendbar in Impfstoffe und Diagnostik
AT93905285T ATE245698T1 (de) 1992-03-02 1993-03-02 Mit dem cytotoxin von helicobacter pylori assoziiertes, immunodominantes antigen verwendbar in impfstoffen und zur diagnose
SG1996009100A SG48353A1 (en) 1992-03-02 1993-03-02 Helicobacter pylori proteins useful for vaccines and diagnostics
DE69333110T DE69333110T2 (de) 1992-03-02 1993-03-02 Mit dem cytotoxin von helicobacter pylori assoziiertes, immunodominantes antigen verwendbar in impfstoffen und zur diagnose
US08/470,260 US6077706A (en) 1992-03-02 1995-06-06 Helicobacter pylori proteins useful for vaccines and diagnostics
US08/471,491 US6090611A (en) 1992-03-02 1995-06-06 Helicobacter pylori proteins useful for vaccines and diagnostics
US08/466,662 US6130059A (en) 1992-03-02 1995-06-06 Helicobacter pylori proteins useful for vaccines and diagnostics
US08/477,451 US5928865A (en) 1992-03-02 1995-06-07 Compositions comprising isolated Helicobacter pylori CagI polynucleotides and method of preparation thereof
US09/360,685 US7141244B1 (en) 1992-03-02 1999-07-26 Helicobacter pylori proteins useful for vaccines and diagnostics
JP2000126695A JP3408494B2 (ja) 1992-03-02 2000-04-26 ワクチンおよび診断に有用なＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉタンパク質
JP2000126696A JP2000333686A (ja) 1992-03-02 2000-04-26 ワクチンおよび診断に有用なＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉタンパク質
US09/921,157 US20040048353A1 (en) 1992-03-02 2001-08-02 Helicobacter pylori proteins useful for vaccines and diagnostics
JP2003008806A JP4271952B2 (ja) 1992-03-02 2003-01-16 ワクチンおよび診断に有用なＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉタンパク質
US10/615,668 US7700755B2 (en) 1992-03-02 2003-07-08 Helicobacter pylori CAI antigen
JP2005263068A JP2006055168A (ja) 1992-03-02 2005-09-09 ワクチンおよび診断に有用なＨｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉタンパク質
US11/580,632 US20070243204A1 (en) 1992-03-02 2006-10-12 Helicobacter pylori proteins useful for vaccines and diagnostics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITFI920052A IT1262895B (it) 1992-03-02 1992-03-02 Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico.

Publications (3)

Publication Number Publication Date
ITFI920052A0 ITFI920052A0 (it) 1992-03-02
ITFI920052A1 true ITFI920052A1 (it) 1993-09-02
IT1262895B IT1262895B (it) 1996-07-22

Family

ID=11349982

Family Applications (1)

Application Number Title Priority Date Filing Date
ITFI920052A IT1262895B (it) 1992-03-02 1992-03-02 Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico.

Country Status (6)

Country Link
US (1) US6090611A (it)
EP (1) EP0643770B1 (it)
JP (1) JP4271952B2 (it)
AT (2) ATE245698T1 (it)
IT (1) IT1262895B (it)
SG (1) SG48353A1 (it)

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US7141244B1 (en) * 1992-03-02 2006-11-28 Chiron Srl Helicobacter pylori proteins useful for vaccines and diagnostics
DE69333110T2 (de) * 1992-03-02 2004-05-06 Chiron S.P.A. Mit dem cytotoxin von helicobacter pylori assoziiertes, immunodominantes antigen verwendbar in impfstoffen und zur diagnose
ATE229978T1 (de) * 1994-07-01 2003-01-15 Chiron Corp Helicobacter proteine und impstoffe
DK0909323T3 (da) * 1996-01-04 2007-05-21 Novartis Vaccines & Diagnostic Helicobacter pylori-bakterioferritin
US20060269532A1 (en) * 1997-02-25 2006-11-30 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US7517952B1 (en) * 1997-02-25 2009-04-14 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US20060024301A1 (en) * 1997-02-25 2006-02-02 Corixa Corporation Prostate-specific polypeptides and fusion polypeptides thereof
US20030185830A1 (en) * 1997-02-25 2003-10-02 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US6841155B1 (en) 1998-04-30 2005-01-11 Chiron S.R.L. Immunization against and treatment for infection by H. pylori
US6764687B1 (en) * 1999-06-09 2004-07-20 Akzo Nobel N.V. Live attenuated bacteria for use in a vaccine
US7179609B1 (en) 2000-10-04 2007-02-20 Atrophus Ab Screening method for gastritis
US7048931B1 (en) 2000-11-09 2006-05-23 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US20020107368A1 (en) * 2000-12-07 2002-08-08 Jing-Hui Tian Helicobacter proteins, gene sequences and uses thereof
CA2458854A1 (en) * 2001-08-31 2003-03-06 Chiron Srl Helicobacter pylori vaccination
SE0200974D0 (sv) 2002-03-27 2002-03-27 Phagen Ab Screening method for gastritis
US20060078919A1 (en) * 2004-09-08 2006-04-13 Harry C. Gurney Janice Gurney Diagnostic test kit and methods of diagnosis and treatment of helicobacter SPP. associated infections
US8809494B2 (en) 2004-11-17 2014-08-19 Drexel University Method and compositions for prevention and treatment of malaria infections
EP1853914B1 (en) * 2005-01-25 2015-04-22 The Johns Hopkins University Plasmodium diagnostic assay
SI1991263T1 (sl) 2006-03-01 2015-03-31 Aduro Biotech Listeria spremenjena z inĹľeniringom ter postopki za njenjo uporabo
PL2640842T3 (pl) 2010-11-17 2018-11-30 Aduro Biotech, Inc. Sposoby i kompozycje do indukowania odpowiedzi immunologicznej na EGFRVIII
KR101998431B1 (ko) 2011-04-26 2019-07-09 몰레큘라 익스프레스 인코포레이티드 리포솜 제제
SG11201407875UA (en) 2012-06-08 2014-12-30 Aduro Biotech Compostions and methods for cancer immunotherapy
EP2916854A4 (en) 2012-11-06 2016-06-22 Aduro Biotech Inc BACTERIAL SPECIES WHICH CAN BE MISSED AND METHODS OF PREPARATION AND USE THEREOF
WO2014093936A1 (en) 2012-12-13 2014-06-19 Aduro Biotech, Inc. Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
BR112015015076A2 (pt) 2012-12-27 2018-10-30 Aduro Biotech Inc parceiros de fusão de peptídeo sinal que facilitam a expressão listerial de sequências antigênicas e métodos de preparação e uso dos mesmos.
CN105358158A (zh) 2013-04-29 2016-02-24 纪念斯隆-凯特琳癌症中心 用于改变第二信使信号传导的组合物和方法
JP2016518140A (ja) 2013-05-03 2016-06-23 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｉ型インターフェロンの環状ジヌクレオチド誘導法
RS59500B1 (sr) 2013-05-18 2019-12-31 Aduro Biotech Inc Sastavi i metode za aktiviranje signaliziranja koje je zavisno od „stimulatora gena za interferon“
US9549944B2 (en) 2013-05-18 2017-01-24 Aduro Biotech, Inc. Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
WO2015017652A1 (en) 2013-07-31 2015-02-05 Memorial Sloan-Kettering Cancer Center Sting crystals and modulators
WO2016061115A1 (en) 2014-10-13 2016-04-21 Providence Health & Services-Oregon D/B/A Providence Portland Medical Center Bacterial vaccines deficient in the 2-c-methyl-d-erythritol-4-phosphate pathway and methods of preparation and use thereof
WO2016073381A1 (en) 2014-11-03 2016-05-12 Cerus Corporation Compositions and methods for improved car-t cell therapies

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US5459041A (en) * 1988-02-18 1995-10-17 Enteric Research Laboratories, Inc. Campylobacter pylori antigens and uses thereof for detection of Campylobacter pylori infection
US4882271A (en) * 1988-03-10 1989-11-21 Baylor College Of Medicine Process for preparation of high molecular weight cell-associated protein of campylobacter pylori and use for serological detection of campylobacter pylori infection
FR2637612B1 (fr) * 1988-10-06 1993-09-10 Pasteur Institut Sequences de nucleotides codant pour une proteine a activite ureasique
GB8928625D0 (en) * 1989-12-19 1990-02-21 3I Res Expl Ltd H.pylori dna probes
US5292658A (en) * 1989-12-29 1994-03-08 University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center Cloning and expressions of Renilla luciferase
US5354854A (en) * 1991-11-07 1994-10-11 The Curators Of The University Of Missouri Expression system for use in plants to suppress foreign expression and method
US5403924A (en) * 1992-10-13 1995-04-04 Vanderbilt University Taga gene and methods for detecting predisposition to peptic ulceration

Also Published As

Publication number Publication date
US6090611A (en) 2000-07-18
EP0643770B1 (en) 2003-07-23
IT1262895B (it) 1996-07-22
JP2003199567A (ja) 2003-07-15
ATE382692T1 (de) 2008-01-15
SG48353A1 (en) 1998-04-17
ATE245698T1 (de) 2003-08-15
ITFI920052A0 (it) 1992-03-02
EP0643770A1 (en) 1995-03-22
JP4271952B2 (ja) 2009-06-03

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19980327