DE69907166D1 - Zyklische aminoverbindungen - Google Patents

Zyklische aminoverbindungen

Info

Publication number
DE69907166D1
DE69907166D1 DE69907166T DE69907166T DE69907166D1 DE 69907166 D1 DE69907166 D1 DE 69907166D1 DE 69907166 T DE69907166 T DE 69907166T DE 69907166 T DE69907166 T DE 69907166T DE 69907166 D1 DE69907166 D1 DE 69907166D1
Authority
DE
Germany
Prior art keywords
cyclic amino
optionally substituted
connections
preventives
remedies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69907166T
Other languages
English (en)
Other versions
DE69907166T2 (de
Inventor
Fumitoshi Asai
Atsuhiro Sugidachi
Toshihiko Ikeda
Haruo Iwabuchi
Yoshiaki Kuroki
Teruhiko Inoue
Ryo Iwamura
Nobuhiko Shibakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Ube Corp
Original Assignee
Sankyo Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd, Ube Industries Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of DE69907166D1 publication Critical patent/DE69907166D1/de
Publication of DE69907166T2 publication Critical patent/DE69907166T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/52Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
  • Lubricants (AREA)
DE69907166T 1998-02-27 1999-02-26 Zyklische aminoverbindungen Expired - Lifetime DE69907166T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP4692198 1998-02-27
JP4692198 1998-02-27
PCT/JP1999/000924 WO1999043648A1 (fr) 1998-02-27 1999-02-26 Composes amino cycliques

Publications (2)

Publication Number Publication Date
DE69907166D1 true DE69907166D1 (de) 2003-05-28
DE69907166T2 DE69907166T2 (de) 2004-02-05

Family

ID=12760807

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69907166T Expired - Lifetime DE69907166T2 (de) 1998-02-27 1999-02-26 Zyklische aminoverbindungen

Country Status (23)

Country Link
US (1) US6610708B1 (de)
EP (1) EP1063230B1 (de)
KR (1) KR100567950B1 (de)
CN (1) CN100369896C (de)
AT (1) ATE238279T1 (de)
AU (1) AU737303B2 (de)
BR (1) BRPI9908319B8 (de)
CA (1) CA2322171C (de)
CZ (1) CZ300821B6 (de)
DE (1) DE69907166T2 (de)
DK (1) DK1063230T3 (de)
ES (1) ES2196772T3 (de)
HU (1) HU225741B1 (de)
ID (1) ID25589A (de)
IL (1) IL138068A (de)
MX (1) MXPA00008439A (de)
NO (1) NO317882B1 (de)
NZ (1) NZ506574A (de)
PL (1) PL200666B1 (de)
PT (1) PT1063230E (de)
RU (1) RU2203887C2 (de)
TR (1) TR200002505T2 (de)
WO (1) WO1999043648A1 (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ547401A (en) * 2003-11-28 2008-06-30 Sankyo Co Cyclic amine derivative having heteroaryl ring
JP2008504279A (ja) * 2004-06-24 2008-02-14 インサイト・コーポレイション アミド化合物およびその医薬としての使用
MXPA06014574A (es) 2004-06-24 2007-03-12 Incyte Corp Piperidinas n-sustituidas y su uso como farmaceuticos.
TW200720252A (en) * 2005-05-27 2007-06-01 Sankyo Co Cyclic amine derivative having substituted alkyl group
WO2014037832A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment of epilepsy and neurological diseases
CA2872975A1 (en) 2012-05-07 2013-11-14 Cellixbio Private Limited Compositions and methods for the treatment of neurological disorders
EP2847158A4 (de) 2012-05-07 2015-12-30 Cellix Bio Private Ltd Zusammensetzungen und verfahren zur behandlung neuromuskulärer erkrankungen und neurodegenerativer erkrankungen
US9399634B2 (en) 2012-05-07 2016-07-26 Cellix Bio Private Limited Compositions and methods for the treatment of depression
US9522884B2 (en) 2012-05-08 2016-12-20 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic disorders
US9403826B2 (en) 2012-05-08 2016-08-02 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory disorders
WO2013168025A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for treatment of blood clotting disorders
US9434704B2 (en) 2012-05-08 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of neurological degenerative disorders
WO2013168022A1 (en) * 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for treating atherothrombosis
US9266823B2 (en) 2012-05-08 2016-02-23 Cellix Bio Private Limited Compositions and methods for the treatment of parkinson's disease
US9315461B2 (en) 2012-05-10 2016-04-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurologic diseases
WO2013168011A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of chronic pain
WO2013168000A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of severe pain
US9233161B2 (en) 2012-05-10 2016-01-12 Cellix Bio Private Limited Compositions and methods for the treatment of neurological conditions
WO2013168012A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of respiratory disorders
US9346742B2 (en) 2012-05-10 2016-05-24 Cellix Bio Private Limited Compositions and methods for the treatment of fibromyalgia pain
SG11201407318UA (en) 2012-05-10 2014-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of metabolic syndrome
US9339484B2 (en) 2012-05-10 2016-05-17 Cellix Bio Private Limited Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
WO2013167997A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of metabolic syndrome
US9499527B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of familial amyloid polyneuropathy
WO2013168001A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
WO2013168033A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for treatment of neurologic diseases
WO2013168015A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of asthma and allergy
JP6202287B2 (ja) 2012-05-23 2017-09-27 セリックスビオ プライヴェート リミテッド 炎症性腸疾患の治療のための組成物及び方法
WO2013175347A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of respiratory disorders
JP2015518854A (ja) 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 多発性硬化症の治療のための組成物および方法
US9492409B2 (en) 2012-05-23 2016-11-15 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9434729B2 (en) 2012-05-23 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
JP2015518855A (ja) 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 粘膜炎の治療のための組成物および方法
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
WO2014020480A2 (en) 2012-08-03 2014-02-06 Mahesh Kandula Compositions and methods for the treatment migraine and neurologic diseases
US9624168B2 (en) 2012-09-06 2017-04-18 Cellix Bio Private Limited Compositions and methods for the treatment inflammation and lipid disorders
SG11201407325YA (en) 2012-09-08 2014-12-30 Cellix Bio Private Ltd Compositions and methods for treatment of inflammation and lipid disorders
NZ709744A (en) 2013-01-09 2016-10-28 Univ Michigan Mixed disulfide conjugates of thienopyridine compounds and uses thereof
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
EP3004049B1 (de) 2013-06-04 2018-09-05 Cellixbio Private Limited Zusammensetzungen und verfahren zur behandlung von diabetes und prädiabetes
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
EP3240779B1 (de) 2014-09-26 2020-10-28 Cellixbio Private Limited Zusammensetzungen und verfahren zur behandlung von epilepsie- und lipidstörungen
EP3201168B1 (de) 2014-09-29 2020-03-18 Cellix Bio Private Limited Verbindungen und zusammensetzungen zur behandlung multipler sklerose
CA2965449C (en) 2014-10-27 2020-11-10 Cellix Bio Private Limited Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis
US9150557B1 (en) 2014-11-05 2015-10-06 Cellix Bio Private Limited Compositions and methods for the treatment of hyperglycemia
US9321716B1 (en) 2014-11-05 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9284287B1 (en) 2014-11-05 2016-03-15 Cellix Bio Private Limited Compositions and methods for the suppression of carbonic anhydrase activity
US9175008B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Prodrugs of anti-platelet agents
US10208014B2 (en) 2014-11-05 2019-02-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
US9173877B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9290486B1 (en) 2014-11-05 2016-03-22 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
EP3242869B1 (de) 2015-01-06 2021-10-27 Cellixbio Private Limited Zusammensetzungen und verfahren zur behandlung von entzündungen und schmerzen
EA201792085A1 (ru) * 2015-04-30 2018-05-31 Зе Реджентс Оф Зе Юниверсити Оф Мичиган Смешанные дисульфидные конъюгаты тиенопиридиновых соединений и их применение
CN106554368A (zh) * 2015-09-25 2017-04-05 陕西合成药业股份有限公司 噻吩并吡啶类衍生物及其制备方法和用途
CN106554369A (zh) * 2015-09-25 2017-04-05 陕西合成药业股份有限公司 噻吩并吡啶类衍生物及其制备方法和用途
CN106554302A (zh) * 2015-09-25 2017-04-05 陕西合成药业股份有限公司 噻吩并吡啶类衍生物及其制备方法和用途
US11642335B2 (en) * 2019-09-26 2023-05-09 Board Of Regents, The University Of Texas System Chemical synthesis of clopidogrel active metabolites and disulfide conjugate prodrugs
CN111484446A (zh) * 2020-04-02 2020-08-04 北京翼方生物科技有限责任公司 氯吡格雷代谢活性体二硫衍生物、其制备方法及医药用途
CN111848497A (zh) * 2020-07-28 2020-10-30 内蒙古医科大学 氯吡格雷活性代谢物衍生物、其前药及其制备方法与应用
CN112851570A (zh) * 2021-01-13 2021-05-28 北京沃邦医药科技有限公司 不饱和环胺半胱氨酸二硫衍生物制备方法及其医药用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US555854A (en) * 1896-03-03 Brush-handle attachment
US3647796A (en) * 1968-12-23 1972-03-07 Parke Davis & Co Cyclicamino alkylaminothioacridine
FR2215948B1 (de) 1973-02-01 1976-05-14 Centre Etd Ind Pharma
FR2530247B1 (fr) 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2576901B1 (fr) 1985-01-31 1987-03-20 Sanofi Sa Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique
FI101150B (fi) 1991-09-09 1998-04-30 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
EP0623120A1 (de) * 1992-01-21 1994-11-09 Glaxo Group Limited Piperidinessigsäure-Derivate, als Inhibitoren der fibrinogen-abhängigen Blutplättchen-Aggregation
DE59408453D1 (de) 1993-04-23 1999-08-12 Hoechst Ag Pyrido-pyrimidindione, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO1995007691A1 (en) 1993-09-17 1995-03-23 Brigham And Women's Hospital Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces
NZ334389A (en) * 1996-08-28 2001-05-25 Ube Industries Cyclic amine derivatives

Also Published As

Publication number Publication date
NO317882B1 (no) 2004-12-27
PL200666B1 (pl) 2009-01-30
KR20010041367A (ko) 2001-05-15
EP1063230A1 (de) 2000-12-27
IL138068A0 (en) 2001-10-31
EP1063230A4 (de) 2001-12-12
DK1063230T3 (da) 2003-07-14
WO1999043648A1 (fr) 1999-09-02
ES2196772T3 (es) 2003-12-16
ID25589A (id) 2000-10-19
CA2322171C (en) 2009-10-27
BRPI9908319B1 (pt) 2012-01-10
US6610708B1 (en) 2003-08-26
NO20004279D0 (no) 2000-08-25
CN1298389A (zh) 2001-06-06
BRPI9908319B8 (pt) 2021-07-06
CN100369896C (zh) 2008-02-20
ATE238279T1 (de) 2003-05-15
EP1063230B1 (de) 2003-04-23
NO20004279L (no) 2000-10-26
RU2203887C2 (ru) 2003-05-10
AU737303B2 (en) 2001-08-16
TR200002505T2 (tr) 2000-12-21
NZ506574A (en) 2003-06-30
HU225741B1 (en) 2007-07-30
HUP0100950A3 (en) 2002-12-28
CZ20003119A3 (cs) 2001-01-17
CA2322171A1 (en) 1999-09-02
MXPA00008439A (es) 2002-04-24
PT1063230E (pt) 2003-07-31
DE69907166T2 (de) 2004-02-05
CZ300821B6 (cs) 2009-08-19
IL138068A (en) 2005-11-20
KR100567950B1 (ko) 2006-04-05
BRPI9908319A (pt) 2000-11-07
AU2641399A (en) 1999-09-15
HUP0100950A2 (hu) 2001-08-28
PL342573A1 (en) 2001-06-18

Similar Documents

Publication Publication Date Title
DE69907166D1 (de) Zyklische aminoverbindungen
EA200100411A1 (ru) Замещенные 3-цианохинолины в качестве ингибиторов протеинтирозинкиназ
CA2263983A1 (en) Cyclic amine derivatives for inhibiting blood platelet aggregation
ES2182234T3 (es) Inhibidores de metaloproteasa.
RS51776B (en) MACROCYCLIC HEPATITIS VIRUS INHIBITORS C
NO2011026I2 (no) Eribulin eller et farmasøytisk akseptabelt salt derav
NO20024766D0 (no) Etyldiaminderivater
SE0100902D0 (sv) Compounds
ATE114670T1 (de) Phenylamidinderivate als plättchenaggregationsinhibitoren.
DK0698606T3 (da) Azolylaminderivat
DE69820248D1 (de) Pyrrolidin-derivate die eine phospholipase-a2-hemmende wirkung haben
DK1673338T3 (da) Forbindelser afledt af fedtsyrer, fremstilling og anvendelse
DE60329918D1 (de) Amidderivat
DE60025856D1 (de) Neue Pseudoerythromycin Derivate
EA200000826A1 (ru) Галоидированные производные амидиноаминокислот, применимые в качестве ингибиторов no-синтазы
DE69920923D1 (de) Anthranilsäurederivate
ATE237612T1 (de) Benzofuranderivate
DK0903347T3 (da) Hidtil ukendte cyclodepsipeptid PF1022-derivater
ATE368645T1 (de) Aminosäurederivate als hiv-protease-inhibitoren
ATE311106T1 (de) Insektizide amide mit stickstoffhaltigen kondensierten bizyklischen ringsystemen
ES2169220T3 (es) Derivados de vitamina d3 con sustituyentes en la posicion 2.
EA200200041A1 (ru) Новые четвертичные соединения аммония, способ их получения и фармацевтическое применение
DK1156058T3 (da) Fremgangsmåde til fremstilling af (E,Z) 3-(2-aminoethoxyimino)-androstan-6,17-dion og analoger deraf
BR9902096A (pt) Pitazóis.
ATE462689T1 (de) Vitamin-d-derivate mit substituenten an der 2- alpha-position

Legal Events

Date Code Title Description
8364 No opposition during term of opposition