DE69831808T2 - Behandlung der diabetes mit thiazolidindione, insulinsekretionförderer und big uanide - Google Patents
Behandlung der diabetes mit thiazolidindione, insulinsekretionförderer und big uanide Download PDFInfo
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- DE69831808T2 DE69831808T2 DE69831808T DE69831808T DE69831808T2 DE 69831808 T2 DE69831808 T2 DE 69831808T2 DE 69831808 T DE69831808 T DE 69831808T DE 69831808 T DE69831808 T DE 69831808T DE 69831808 T2 DE69831808 T2 DE 69831808T2
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- diabetes mellitus
- insulin
- treatment
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- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 201000009925 nephrosclerosis Diseases 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 239000002687 nonaqueous vehicle Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229960005095 pioglitazone Drugs 0.000 description 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 description 1
- 201000009104 prediabetes syndrome Diseases 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940080313 sodium starch Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical compound OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 150000001467 thiazolidinediones Chemical class 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000759 toxicological effect Toxicity 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229960001641 troglitazone Drugs 0.000 description 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9715295 | 1997-07-18 | ||
| GB9715295A GB9715295D0 (en) | 1997-07-18 | 1997-07-18 | Novel method of treatment |
| PCT/GB1998/002110 WO1999003477A1 (en) | 1997-07-18 | 1998-07-16 | Treatment of diabetes with thiazolidinedione, insulin secretagogue and diguanide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69831808D1 DE69831808D1 (de) | 2006-02-16 |
| DE69831808T2 true DE69831808T2 (de) | 2006-07-06 |
Family
ID=10816167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69831808T Expired - Fee Related DE69831808T2 (de) | 1997-07-18 | 1998-07-16 | Behandlung der diabetes mit thiazolidindione, insulinsekretionförderer und big uanide |
Country Status (39)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6011049A (en) * | 1997-02-19 | 2000-01-04 | Warner-Lambert Company | Combinations for diabetes |
| US6099862A (en) * | 1998-08-31 | 2000-08-08 | Andrx Corporation | Oral dosage form for the controlled release of a biguanide and sulfonylurea |
| EA007610B1 (ru) * | 1998-11-12 | 2006-12-29 | Смитклайн Бичам Плс | Таблетка с энтеропокрытием, обеспечивающая отсроченное высвобождение |
| SE9902918D0 (sv) * | 1999-08-13 | 1999-08-13 | Pharmacia & Upjohn Ab | Methods for identification of compounds stimulating insulin secretion |
| MY125516A (en) * | 1999-11-16 | 2006-08-30 | Smithkline Beecham Plc | Novel composition based on thiazolidinedione and metformin and use |
| AU1403501A (en) * | 1999-11-16 | 2001-05-30 | Smithkline Beecham Plc | Novel composition and use |
| FR2812547B1 (fr) * | 2000-08-04 | 2002-10-31 | Lipha | Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete |
| WO2002055009A1 (en) | 2001-01-12 | 2002-07-18 | Sun Pharmaceutical Industries Limited | Spaced drug delivery system |
| ITFI20010126A1 (it) * | 2001-07-09 | 2003-01-09 | Molteni & C | Composizioni farmaceutiche per uso orale,contenenti,in combinazione,metformina e gliclazide |
| JP2004536843A (ja) * | 2001-07-10 | 2004-12-09 | エアロファーム テクノロジー インコーポレイテッド | ピオグリタゾンおよびビグアナイドを含むコア製剤 |
| WO2003105809A1 (en) | 2002-06-17 | 2003-12-24 | Themis Laboratories Private Limited | Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them |
| AU2003272504A1 (en) * | 2002-09-20 | 2004-04-08 | Andrx Labs Llc | Multistage formulation containing a biguanide and thiazolidindione derivatives |
| UA80991C2 (en) | 2002-10-07 | 2007-11-26 | Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes | |
| CN1874774B (zh) | 2003-10-31 | 2011-04-13 | 武田药品工业株式会社 | 包含胰岛素致敏剂、胰岛素促分泌素和聚氧乙烯脱水山梨醇脂肪酸酯的固体制剂 |
| MXPA05010977A (es) * | 2005-10-12 | 2007-04-11 | Abdala Leopoldo Espinosa | Composiciones farmaceuticas que comprenden sustancias antidiabeticas combinadas para su uso en diabetes mellitus. |
| KR100812538B1 (ko) * | 2006-10-23 | 2008-03-11 | 한올제약주식회사 | 약물 제어방출형 메트포르민-글리메피리드 복합제제 |
| CN101417130B (zh) * | 2007-10-22 | 2010-10-06 | 鲁南制药集团股份有限公司 | 一种治疗ⅱ型糖尿病及其并发症的药物组合物 |
| US11607441B2 (en) | 2017-10-20 | 2023-03-21 | Novmetapharma Co., Ltd. | Pharmaceutical composition for preventing or treating diabetes, containing zinc salt, cyclo-hispro and antidiabetic drug as active ingredients |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| JPS5697277A (en) * | 1980-01-07 | 1981-08-05 | Takeda Chem Ind Ltd | Thiazolidine derivative |
| JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
| US4582839A (en) * | 1984-03-21 | 1986-04-15 | Takeda Chemical Industries, Ltd. | 2,4-thiazolidinediones |
| CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| JPH06779B2 (ja) * | 1985-06-10 | 1994-01-05 | 武田薬品工業株式会社 | チアゾリジオン誘導体およびそれを含んでなる医薬組成物 |
| US4812570A (en) * | 1986-07-24 | 1989-03-14 | Takeda Chemical Industries, Ltd. | Method for producing thiazolidinedione derivatives |
| US4791125A (en) * | 1987-12-02 | 1988-12-13 | Pfizer Inc. | Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents |
| WO1989008651A1 (en) * | 1988-03-08 | 1989-09-21 | Pfizer Inc. | Hypoglycemic thiazolidinedione derivatives |
| US5061717A (en) * | 1988-03-08 | 1991-10-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| WO1991007107A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
| JPH04210683A (ja) * | 1990-12-06 | 1992-07-31 | Terumo Corp | チアゾリジン−２，４−ジオン誘導体およびこれを含有する糖尿病合併症治療薬 |
| US5900435A (en) * | 1991-08-26 | 1999-05-04 | Pharmacia & Upjohn Company | Composition, food product and uses of 3-guanidinopropionic acid |
| US5917052A (en) * | 1994-09-28 | 1999-06-29 | Shaman Pharmaceuticals, Inc. | Hypoglycemic agent from cryptolepis |
| TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| CN1168451C (zh) * | 1997-06-18 | 2004-09-29 | 史密丝克莱恩比彻姆有限公司 | 噻唑烷二酮和磺酰脲组合物在制备治疗糖尿病的药物中的用途 |
-
1997
- 1997-07-18 GB GB9715295A patent/GB9715295D0/en active Pending
-
1998
- 1998-07-15 DZ DZ980172A patent/DZ2562A1/xx active
- 1998-07-16 NZ NZ511608A patent/NZ511608A/xx unknown
- 1998-07-16 PL PL338126A patent/PL197844B1/pl not_active IP Right Cessation
- 1998-07-16 NZ NZ501164A patent/NZ501164A/en unknown
- 1998-07-16 DE DE69831808T patent/DE69831808T2/de not_active Expired - Fee Related
- 1998-07-16 IL IL13404698A patent/IL134046A0/xx unknown
- 1998-07-16 MA MA25171A patent/MA24607A1/fr unknown
- 1998-07-16 PL PL378474A patent/PL198017B1/pl not_active IP Right Cessation
- 1998-07-16 TR TR2000/00134T patent/TR200000134T2/xx unknown
- 1998-07-16 JP JP2000502776A patent/JP2001510159A/ja not_active Withdrawn
- 1998-07-16 SI SI9830804T patent/SI1001783T1/sl unknown
- 1998-07-16 CN CN98807319A patent/CN1264303A/zh active Pending
- 1998-07-16 EP EP98935127A patent/EP1001783B1/en not_active Expired - Lifetime
- 1998-07-16 UA UA2000010261A patent/UA70303C2/uk unknown
- 1998-07-16 DK DK98935127T patent/DK1001783T3/da active
- 1998-07-16 KR KR1020007000512A patent/KR100671918B1/ko not_active Expired - Fee Related
- 1998-07-16 SK SK59-2000A patent/SK285484B6/sk not_active IP Right Cessation
- 1998-07-16 AU AU84488/98A patent/AU8448898A/en not_active Abandoned
- 1998-07-16 AP APAP/P/2000/001733A patent/AP1352A/en active
- 1998-07-16 AR ARP980103481A patent/AR016349A1/es unknown
- 1998-07-16 HU HU0003629A patent/HUP0003629A3/hu unknown
- 1998-07-16 AT AT98935127T patent/ATE305790T1/de not_active IP Right Cessation
- 1998-07-16 WO PCT/GB1998/002110 patent/WO1999003477A1/en not_active Ceased
- 1998-07-16 ID IDW20000075A patent/ID24211A/id unknown
- 1998-07-16 ES ES98935127T patent/ES2251093T3/es not_active Expired - Lifetime
- 1998-07-16 CA CA002296653A patent/CA2296653C/en not_active Expired - Fee Related
- 1998-07-16 PE PE1998000629A patent/PE99599A1/es not_active Application Discontinuation
- 1998-07-16 EA EA200000139A patent/EA003021B1/ru not_active IP Right Cessation
- 1998-07-16 BR BR9810445-4A patent/BR9810445A/pt not_active Application Discontinuation
- 1998-07-17 TW TW087111770A patent/TW505516B/zh active
- 1998-07-17 CO CO98040747A patent/CO4940420A1/es unknown
- 1998-07-17 MY MYPI98003288A patent/MY155219A/en unknown
- 1998-07-17 ZA ZA9806363A patent/ZA986363B/xx unknown
- 1998-07-17 UY UY25102A patent/UY25102A1/es not_active IP Right Cessation
- 1998-07-20 IN IN2087DE1998 patent/IN189275B/en unknown
- 1998-08-29 SA SA98190468A patent/SA98190468B1/ar unknown
-
2000
- 2000-01-17 NO NO20000228A patent/NO325727B1/no not_active IP Right Cessation
- 2000-01-18 OA OA1200000012A patent/OA11279A/en unknown
- 2000-02-07 BG BG104135A patent/BG64785B1/bg unknown
-
2005
- 2005-04-21 JP JP2005123562A patent/JP2005213273A/ja active Pending
- 2005-12-07 CY CY20051101486T patent/CY1105254T1/el unknown
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Legal Events
| Date | Code | Title | Description |
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| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |