DE69831268T2 - Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses - Google Patents
Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses Download PDFInfo
- Publication number
- DE69831268T2 DE69831268T2 DE69831268T DE69831268T DE69831268T2 DE 69831268 T2 DE69831268 T2 DE 69831268T2 DE 69831268 T DE69831268 T DE 69831268T DE 69831268 T DE69831268 T DE 69831268T DE 69831268 T2 DE69831268 T2 DE 69831268T2
- Authority
- DE
- Germany
- Prior art keywords
- skin
- housing
- reservoir
- layer
- microprotrusions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012530 fluid Substances 0.000 title 1
- 239000000126 substance Substances 0.000 claims description 57
- 239000000463 material Substances 0.000 claims description 30
- 239000004744 fabric Substances 0.000 claims description 25
- 230000001070 adhesive effect Effects 0.000 claims description 18
- 239000000853 adhesive Substances 0.000 claims description 17
- 239000003814 drug Substances 0.000 claims description 16
- 239000006260 foam Substances 0.000 claims description 16
- 229910052751 metal Inorganic materials 0.000 claims description 14
- 239000002184 metal Substances 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 12
- 229920001903 high density polyethylene Polymers 0.000 claims description 12
- 239000004700 high-density polyethylene Substances 0.000 claims description 12
- 229920000642 polymer Polymers 0.000 claims description 9
- 241001465754 Metazoa Species 0.000 claims description 8
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 5
- 229910001220 stainless steel Inorganic materials 0.000 claims description 5
- 239000010935 stainless steel Substances 0.000 claims description 5
- 229910052719 titanium Inorganic materials 0.000 claims description 5
- 239000010936 titanium Substances 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 230000004044 response Effects 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 239000000919 ceramic Substances 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 229920005830 Polyurethane Foam Polymers 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims description 2
- 239000011496 polyurethane foam Substances 0.000 claims description 2
- 239000012491 analyte Substances 0.000 claims 3
- 239000004821 Contact adhesive Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000013583 drug formulation Substances 0.000 claims 1
- 230000000149 penetrating effect Effects 0.000 abstract description 14
- 210000003491 skin Anatomy 0.000 description 109
- 239000010410 layer Substances 0.000 description 78
- 239000011159 matrix material Substances 0.000 description 29
- 230000037317 transdermal delivery Effects 0.000 description 16
- 239000000499 gel Substances 0.000 description 11
- 238000000034 method Methods 0.000 description 10
- 210000000434 stratum corneum Anatomy 0.000 description 9
- 102000004196 processed proteins & peptides Human genes 0.000 description 8
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
- 230000035515 penetration Effects 0.000 description 7
- -1 polyethylene terephthalate Polymers 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 239000012790 adhesive layer Substances 0.000 description 6
- 230000002093 peripheral effect Effects 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 241000700198 Cavia Species 0.000 description 5
- 230000003204 osmotic effect Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 108091034117 Oligonucleotide Proteins 0.000 description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 150000002739 metals Chemical class 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 238000005070 sampling Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 238000011065 in-situ storage Methods 0.000 description 3
- 229910001092 metal group alloy Inorganic materials 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
- 229920000049 Carbon (fiber) Polymers 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000004873 anchoring Methods 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 239000004917 carbon fiber Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000005370 electroosmosis Methods 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 210000000282 nail Anatomy 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 229920001342 Bakelite® Polymers 0.000 description 1
- 101100494265 Caenorhabditis elegans best-15 gene Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 239000004637 bakelite Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 238000003486 chemical etching Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 239000012777 electrically insulating material Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 210000003811 finger Anatomy 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000002117 illicit drug Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052741 iridium Inorganic materials 0.000 description 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229960003299 ketamine Drugs 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 229910052703 rhodium Inorganic materials 0.000 description 1
- 239000010948 rhodium Substances 0.000 description 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000012056 semi-solid material Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 210000000498 stratum granulosum Anatomy 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
- A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Radiology & Medical Imaging (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicinal Preparation (AREA)
- Electrotherapy Devices (AREA)
- Paper (AREA)
- Detergent Compositions (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6934097P | 1997-12-11 | 1997-12-11 | |
| US6933997P | 1997-12-11 | 1997-12-11 | |
| US69339P | 1997-12-11 | ||
| US69340P | 1997-12-11 | ||
| PCT/US1998/026203 WO1999029365A1 (en) | 1997-12-11 | 1998-12-09 | Device for enhancing transdermal agent flux |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69831268D1 DE69831268D1 (de) | 2005-09-22 |
| DE69831268T2 true DE69831268T2 (de) | 2006-03-09 |
Family
ID=26749944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69831268T Expired - Lifetime DE69831268T2 (de) | 1997-12-11 | 1998-12-09 | Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6083196A (https=) |
| EP (1) | EP1037686B1 (https=) |
| JP (1) | JP2001525232A (https=) |
| KR (1) | KR100561892B1 (https=) |
| CN (1) | CN1170603C (https=) |
| AT (1) | ATE302041T1 (https=) |
| AU (1) | AU757192B2 (https=) |
| CA (1) | CA2313698C (https=) |
| DE (1) | DE69831268T2 (https=) |
| DK (1) | DK1037686T3 (https=) |
| ES (1) | ES2244106T3 (https=) |
| PT (1) | PT1037686E (https=) |
| WO (1) | WO1999029365A1 (https=) |
Families Citing this family (261)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2253549C (en) * | 1996-06-18 | 2005-10-25 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
| US6918901B1 (en) * | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
| US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
| US6532386B2 (en) * | 1998-08-31 | 2003-03-11 | Johnson & Johnson Consumer Companies, Inc. | Electrotransort device comprising blades |
| WO2000024455A1 (en) * | 1998-10-28 | 2000-05-04 | Cygnus, Inc. | Kit and method for quality control testing of an iontophoretic sampling system |
| US6597946B2 (en) * | 1998-11-09 | 2003-07-22 | Transpharma Ltd. | Electronic card for transdermal drug delivery and analyte extraction |
| US6148232A (en) | 1998-11-09 | 2000-11-14 | Elecsys Ltd. | Transdermal drug delivery and analyte extraction |
| US6611706B2 (en) | 1998-11-09 | 2003-08-26 | Transpharma Ltd. | Monopolar and bipolar current application for transdermal drug delivery and analyte extraction |
| US6708060B1 (en) | 1998-11-09 | 2004-03-16 | Transpharma Ltd. | Handheld apparatus and method for transdermal drug delivery and analyte extraction |
| US6660018B2 (en) * | 1999-03-08 | 2003-12-09 | Agilent Technologies, Inc. | Multiple lancet device |
| JP4180244B2 (ja) | 1999-04-16 | 2008-11-12 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | 内部センサを有する電気的な移動による送出装置系 |
| DK1189660T3 (da) * | 1999-06-08 | 2006-08-21 | Altea Therapeutics Corp | Apparat til mikroperforering af biologiske membraner ved hjælp af tyndfilms-vævsgrænseflade-anordninger samt fremgangsmåde til fremstilling deraf |
| US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
| US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
| US6890553B1 (en) | 1999-07-08 | 2005-05-10 | Johnson & Johnson Consumer Companies, Inc. | Exothermic topical delivery device |
| AU6076200A (en) | 1999-07-08 | 2001-01-30 | Johnson & Johnson Consumer Companies, Inc. | Exothermic bandage |
| US20030078499A1 (en) * | 1999-08-12 | 2003-04-24 | Eppstein Jonathan A. | Microporation of tissue for delivery of bioactive agents |
| US7133717B2 (en) * | 1999-08-25 | 2006-11-07 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery and diagnostic sampling |
| US7113821B1 (en) | 1999-08-25 | 2006-09-26 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery |
| US6251083B1 (en) * | 1999-09-07 | 2001-06-26 | Amira Medical | Interstitial fluid methods and devices for determination of an analyte in the body |
| US6536436B1 (en) * | 1999-10-26 | 2003-03-25 | Mcglothen Roberta | Strap for nasal cannula |
| US6197039B1 (en) * | 1999-12-09 | 2001-03-06 | Bahman Ashraf | Triple pointed micro knife |
| MXPA02005765A (es) * | 1999-12-10 | 2003-01-28 | Alza Corp | Aparato de tratamiento de piel para el suministro de farmaco transdermico sostenido. |
| ES2253278T3 (es) * | 1999-12-10 | 2006-06-01 | Alza Corporation | Dispositivo y procedimiento para mejorar la perforacion cutanea con microprotuberancias. |
| US7404815B2 (en) * | 2000-05-01 | 2008-07-29 | Lifescan, Inc. | Tissue ablation by shear force for sampling biological fluids and delivering active agents |
| US6629949B1 (en) * | 2000-05-08 | 2003-10-07 | Sterling Medivations, Inc. | Micro infusion drug delivery device |
| US6659982B2 (en) | 2000-05-08 | 2003-12-09 | Sterling Medivations, Inc. | Micro infusion drug delivery device |
| US6565532B1 (en) | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
| US7141034B2 (en) * | 2000-06-08 | 2006-11-28 | Altea Therapeutics Corporation | Transdermal drug delivery device, method of making same and method of using same |
| US6540675B2 (en) * | 2000-06-27 | 2003-04-01 | Rosedale Medical, Inc. | Analyte monitor |
| US6589202B1 (en) * | 2000-06-29 | 2003-07-08 | Becton Dickinson And Company | Method and apparatus for transdermally sampling or administering a substance to a patient |
| GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| JP5507030B2 (ja) * | 2000-09-08 | 2014-05-28 | アルザ・コーポレーシヨン | 経路閉鎖を阻害することによる経皮的薬物流動の減少の抑制方法 |
| DE60138411D1 (de) * | 2000-10-13 | 2009-05-28 | Alza Corp | Vorrichtung und verfahren zum durchstechen der haut mit micronadeln |
| ATE416692T1 (de) * | 2000-10-13 | 2008-12-15 | Alza Corp | Mikronadelelementhalter für schlagapplikator |
| US7419481B2 (en) * | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
| US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
| US7131987B2 (en) | 2000-10-16 | 2006-11-07 | Corium International, Inc. | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
| US7108681B2 (en) | 2000-10-16 | 2006-09-19 | Corium International, Inc. | Microstructures for delivering a composition cutaneously to skin |
| NZ525551A (en) | 2000-10-26 | 2005-09-30 | Alza Corp | Transdermal drug delivery devices having coated microprotrusions |
| US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
| GB0030929D0 (en) | 2000-12-19 | 2001-01-31 | Inverness Medical Ltd | Analyte measurement |
| DE10102817B4 (de) * | 2001-01-23 | 2006-01-12 | Lts Lohmann Therapie-Systeme Ag | Vorrichtung und Verfahren zur Hitzepulsgestützten transdermalen Applikation von Wirkstoffen |
| US6663820B2 (en) | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
| WO2002074173A1 (en) * | 2001-03-16 | 2002-09-26 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
| AU2007203302B2 (en) * | 2001-04-20 | 2010-07-01 | Alza Corporation | Microprojection array immunization patch and method |
| EP3251722B1 (en) | 2001-04-20 | 2020-06-17 | ALZA Corporation | Microprojection array having a beneficial agent containing coating and method of forming the coating thereon |
| US20020193729A1 (en) * | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
| ATE444773T1 (de) * | 2001-04-20 | 2009-10-15 | Alza Corp | Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält |
| US6591124B2 (en) | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
| US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
| ATE485766T1 (de) | 2001-06-12 | 2010-11-15 | Pelikan Technologies Inc | Elektrisches betätigungselement für eine lanzette |
| US6875613B2 (en) | 2001-06-12 | 2005-04-05 | Lifescan, Inc. | Biological fluid constituent sampling and measurement devices and methods |
| AU2002348683A1 (en) | 2001-06-12 | 2002-12-23 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
| US6721586B2 (en) | 2001-06-12 | 2004-04-13 | Lifescan, Inc. | Percutaneous biological fluid sampling and analyte measurement devices and methods |
| US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US6501976B1 (en) | 2001-06-12 | 2002-12-31 | Lifescan, Inc. | Percutaneous biological fluid sampling and analyte measurement devices and methods |
| US6793632B2 (en) | 2001-06-12 | 2004-09-21 | Lifescan, Inc. | Percutaneous biological fluid constituent sampling and measurement devices and methods |
| US6837988B2 (en) | 2001-06-12 | 2005-01-04 | Lifescan, Inc. | Biological fluid sampling and analyte measurement devices and methods |
| ES2336081T3 (es) | 2001-06-12 | 2010-04-08 | Pelikan Technologies Inc. | Dispositivo de puncion de auto-optimizacion con medios de adaptacion a variaciones temporales en las propiedades cutaneas. |
| US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
| US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
| US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
| US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US20040087992A1 (en) * | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
| JP4647863B2 (ja) * | 2001-09-26 | 2011-03-09 | テルモ株式会社 | 薬剤投与具及び薬剤投与装置 |
| US6689100B2 (en) * | 2001-10-05 | 2004-02-10 | Becton, Dickinson And Company | Microdevice and method of delivering or withdrawing a substance through the skin of an animal |
| US7429258B2 (en) * | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
| EP1450876B1 (en) | 2001-11-07 | 2016-08-17 | Syneron Medical Ltd. | Integrated transdermal drug delivery system |
| US20030199810A1 (en) * | 2001-11-30 | 2003-10-23 | Trautman Joseph Creagan | Methods and apparatuses for forming microprojection arrays |
| WO2003053258A1 (en) * | 2001-12-20 | 2003-07-03 | Alza Corporation | Skin-piercing microprojections having piercing depth control |
| US6908453B2 (en) * | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
| US7004928B2 (en) | 2002-02-08 | 2006-02-28 | Rosedale Medical, Inc. | Autonomous, ambulatory analyte monitor or drug delivery device |
| US9918665B2 (en) | 2002-03-11 | 2018-03-20 | Nitto Denko Corporation | Transdermal porator and patch system and method for using same |
| US8116860B2 (en) | 2002-03-11 | 2012-02-14 | Altea Therapeutics Corporation | Transdermal porator and patch system and method for using same |
| US7115108B2 (en) * | 2002-04-02 | 2006-10-03 | Becton, Dickinson And Company | Method and device for intradermally delivering a substance |
| US6780171B2 (en) | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
| US7047070B2 (en) * | 2002-04-02 | 2006-05-16 | Becton, Dickinson And Company | Valved intradermal delivery device and method of intradermally delivering a substance to a patient |
| US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
| US8372016B2 (en) | 2002-04-19 | 2013-02-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
| US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
| US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
| US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
| US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
| US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
| US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| AU2003226605A1 (en) * | 2002-04-19 | 2003-11-03 | Transpharma Medical Ltd. | Handheld transdermal drug delivery and analyte extraction |
| US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
| US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
| US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US6945952B2 (en) * | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
| AU2003243750A1 (en) | 2002-06-25 | 2004-01-06 | Sung-Yun Kwon | Rapidly dissolving micro-perforator for drug delivery and other applications |
| AU2003279641B2 (en) * | 2002-06-28 | 2009-06-18 | Alza Corporation | Transdermal drug delivery devices having coated microprotrusions |
| AR040819A1 (es) * | 2002-08-08 | 2005-04-20 | Alza Corp | Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas |
| US7422567B2 (en) * | 2002-08-29 | 2008-09-09 | Becton, Dickinson And Company | Microabrader with controlled abrasion features |
| US8062573B2 (en) * | 2002-09-16 | 2011-11-22 | Theraject, Inc. | Solid micro-perforators and methods of use |
| EP1590033A2 (en) * | 2002-09-30 | 2005-11-02 | Alza Corporation | Drug delivery device having coated microprojections incorporating vasoconstrictors |
| EP1590034B1 (en) * | 2002-10-07 | 2014-05-14 | Biovalve Technologies, Inc. | Microneedle array patch |
| FR2845267B1 (fr) * | 2002-10-08 | 2004-12-31 | Antialis | Kit cutane de diagnostic de l'atopie |
| IL152575A (en) * | 2002-10-31 | 2008-12-29 | Transpharma Medical Ltd | A skin-to-skin transmission system of water-insoluble drugs |
| US8133505B2 (en) * | 2002-10-31 | 2012-03-13 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized medications |
| IL152573A (en) * | 2002-10-31 | 2009-11-18 | Transpharma Medical Ltd | A system for the transmission through the skin of a medical preparation against vomiting and nausea |
| US7045069B2 (en) | 2002-11-14 | 2006-05-16 | Gennady Ozeryansky | Microfabrication method based on metal matrix composite technology |
| AR042815A1 (es) * | 2002-12-26 | 2005-07-06 | Alza Corp | Dispositivo de suministro de agente activo que tiene miembros compuestos |
| US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
| US7578954B2 (en) * | 2003-02-24 | 2009-08-25 | Corium International, Inc. | Method for manufacturing microstructures having multiple microelements with through-holes |
| US7052652B2 (en) | 2003-03-24 | 2006-05-30 | Rosedale Medical, Inc. | Analyte concentration detection devices and methods |
| WO2004098683A1 (en) * | 2003-05-08 | 2004-11-18 | Novo Nordisk A/S | Internal needle inserter |
| EP1475113A1 (en) * | 2003-05-08 | 2004-11-10 | Novo Nordisk A/S | External needle inserter |
| WO2004098684A2 (en) * | 2003-05-08 | 2004-11-18 | Novo Nordisk A/S | Skin mountable injection device with a detachable needle insertion actuation |
| JP2004343275A (ja) * | 2003-05-14 | 2004-12-02 | Murata Mach Ltd | 画像処理システム及びスキャナ装置 |
| EP1628567B1 (en) | 2003-05-30 | 2010-08-04 | Pelikan Technologies Inc. | Method and apparatus for fluid injection |
| EP1633235B1 (en) | 2003-06-06 | 2014-05-21 | Sanofi-Aventis Deutschland GmbH | Apparatus for body fluid sampling and analyte sensing |
| WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
| US20050123507A1 (en) | 2003-06-30 | 2005-06-09 | Mahmoud Ameri | Formulations for coated microprojections having controlled solubility |
| PL1638468T3 (pl) * | 2003-06-30 | 2008-01-31 | Alza Corp | Sposób powlekania mikrowystępów do przekłuwania skóry |
| KR20060038407A (ko) | 2003-06-30 | 2006-05-03 | 알자 코포레이션 | 비휘발성 반대이온을 포함하는 코팅된 미세돌출부용 제제 |
| CN1845708A (zh) * | 2003-07-02 | 2006-10-11 | 阿尔扎公司 | 微突出物阵列免疫贴剂和方法 |
| EP1502613A1 (en) * | 2003-08-01 | 2005-02-02 | Novo Nordisk A/S | Needle device with retraction means |
| JP2007501071A (ja) * | 2003-08-04 | 2007-01-25 | アルザ・コーポレーシヨン | 経皮作用剤流率を向上させる方法および装置 |
| CA2536443A1 (en) * | 2003-08-26 | 2005-03-03 | Alza Corporation | Device and method for intradermal cell implantation |
| EP1671096A4 (en) | 2003-09-29 | 2009-09-16 | Pelikan Technologies Inc | METHOD AND APPARATUS FOR PROVIDING IMPROVED SAMPLE CAPTURING DEVICE |
| US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
| KR20060099520A (ko) * | 2003-10-21 | 2006-09-19 | 노보 노르디스크 에이/에스 | 의료용 피부 장착 장치 |
| US8016811B2 (en) * | 2003-10-24 | 2011-09-13 | Altea Therapeutics Corporation | Method for transdermal delivery of permeant substances |
| BRPI0415466A (pt) * | 2003-10-24 | 2006-12-19 | Alza Corp | método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos |
| AU2004285481A1 (en) * | 2003-10-24 | 2005-05-12 | Alza Corporation | Apparatus and method for enhancing transdermal drug delivery |
| JP2007535337A (ja) * | 2003-10-28 | 2007-12-06 | アルザ・コーポレーシヨン | 被覆された微小突起による治療用ペプチドおよびタンパクのポリマー接合体の送達 |
| AU2004287412A1 (en) * | 2003-10-28 | 2005-05-19 | Alza Corporation | Method and apparatus for reducing the incidence of tobacco use |
| ES2377647T3 (es) | 2003-10-31 | 2012-03-29 | Alza Corporation | Aplicador auto-actuado para ordenamiento de microproyecciones |
| KR20070010115A (ko) * | 2003-11-13 | 2007-01-22 | 알자 코포레이션 | 경피전달용 조성물 및 장치 |
| DE10353629A1 (de) * | 2003-11-17 | 2005-06-16 | Lts Lohmann Therapie-Systeme Ag | Vorrichtung zur transdermalen Verabreichung von Wirkstoffen |
| AU2004292953A1 (en) * | 2003-11-21 | 2005-06-09 | Alza Corporation | Ultrasound assisted transdermal vaccine delivery method and system |
| US8017145B2 (en) * | 2003-12-22 | 2011-09-13 | Conopco, Inc. | Exfoliating personal care wipe article containing an array of projections |
| US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
| EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
| WO2005094526A2 (en) | 2004-03-24 | 2005-10-13 | Corium International, Inc. | Transdermal delivery device |
| WO2005094920A1 (en) * | 2004-03-30 | 2005-10-13 | Novo Nordisk A/S | Actuator system comprising lever mechanism |
| CA2579146C (en) * | 2004-04-01 | 2016-06-21 | The General Hospital Corporation | Method and apparatus for dermatological treatment |
| CN101120101A (zh) * | 2004-04-13 | 2008-02-06 | 阿尔扎公司 | 多联疫苗透皮释放的装置和方法 |
| CA2562731A1 (en) * | 2004-04-13 | 2005-11-03 | Alza Corporation | Apparatus and method for transdermal delivery of fentanyl-based agents |
| US7556821B2 (en) | 2004-05-13 | 2009-07-07 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents |
| MXPA06013490A (es) * | 2004-05-19 | 2007-06-12 | Johnson & Johnson | Metodo y formulacion para el suministro transdermico de agentes inmunologicamente activos. |
| WO2006011062A2 (en) | 2004-05-20 | 2006-02-02 | Albatros Technologies Gmbh & Co. Kg | Printable hydrogel for biosensors |
| WO2005120365A1 (en) | 2004-06-03 | 2005-12-22 | Pelikan Technologies, Inc. | Method and apparatus for a fluid sampling device |
| US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
| US20050273075A1 (en) * | 2004-06-08 | 2005-12-08 | Peter Krulevitch | Method for delivering drugs to the adventitia using device having microprojections |
| JP2005349202A (ja) * | 2004-06-08 | 2005-12-22 | Cordis Corp | 治療薬を組織内へ導入する器具および方法 |
| US20050273049A1 (en) * | 2004-06-08 | 2005-12-08 | Peter Krulevitch | Drug delivery device using microprojections |
| US20060030811A1 (en) * | 2004-08-03 | 2006-02-09 | Wong Patrick S | Method and device for enhancing transdermal agent flux |
| AR054300A1 (es) * | 2004-08-10 | 2007-06-20 | Alza Corp | Aparato y sistema de microproyeccion con escaso potencial infeccioso |
| US20060058602A1 (en) * | 2004-08-17 | 2006-03-16 | Kwiatkowski Krzysztof C | Interstitial fluid analyzer |
| AR050608A1 (es) * | 2004-08-19 | 2006-11-08 | Alza Corp | Aparato y metodo para administracion transdermica de factores de crecimiento endotelial vascular |
| CA2579509A1 (en) * | 2004-09-08 | 2006-03-16 | Alza Corporation | Microprojection array with improved skin adhesion and compliance |
| WO2006032692A1 (en) * | 2004-09-22 | 2006-03-30 | Novo Nordisk A/S | Medical device with cannula inserter |
| CN101027095B (zh) * | 2004-09-22 | 2010-09-29 | 诺和诺德公司 | 带插管插入器的医疗器械 |
| US20060093658A1 (en) * | 2004-10-26 | 2006-05-04 | Gayatri Sathyan | Apparatus and method for transdermal delivery of desmopressin |
| DE602005016298D1 (de) * | 2004-12-06 | 2009-10-08 | Novo Nordisk As | Belüftete an der haut befestigbare vorrichtung |
| DE602005024038D1 (de) * | 2004-12-10 | 2010-11-18 | 3M Innovative Properties Co | Medizinische vorrichtung |
| US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
| JP2008528086A (ja) * | 2005-01-24 | 2008-07-31 | ノボ・ノルデイスク・エー/エス | 保護された穿刺装置を有する医療用装置 |
| JP2008530230A (ja) * | 2005-02-16 | 2008-08-07 | アルザ・コーポレーシヨン | エリスロポエチンに基づく剤の経皮送達のための装置および方法 |
| WO2006120253A2 (en) * | 2005-05-13 | 2006-11-16 | Novo Nordisk A/S | Medical device adapted to detect disengagement of a transcutaneous device |
| US20060275170A1 (en) * | 2005-06-02 | 2006-12-07 | Mahmoud Ameri | Method for terminal sterilization of transdermal delivery devices |
| WO2006130869A1 (en) * | 2005-06-02 | 2006-12-07 | Alza Corporation | Method for terminal sterilization of transdermal delivery devices |
| US20060281187A1 (en) | 2005-06-13 | 2006-12-14 | Rosedale Medical, Inc. | Analyte detection devices and methods with hematocrit/volume correction and feedback control |
| EP1898989A2 (en) * | 2005-06-21 | 2008-03-19 | Alza Corporation | Method and device for coating a continuous strip of microprojection members |
| WO2007008824A2 (en) * | 2005-07-11 | 2007-01-18 | Infotonics Technology Center, Inc. | Minimally invasive allergy testing system |
| US20070014728A1 (en) * | 2005-07-18 | 2007-01-18 | Imbert Delphine C | Device and method for increasing the throughput of irritation testing of transdermal formulations |
| AU2006274530B2 (en) * | 2005-08-01 | 2009-03-12 | Hawk Medical Technologies Ltd. | Eradication of pigmentation and scar tissue |
| US20070078414A1 (en) * | 2005-08-05 | 2007-04-05 | Mcallister Devin V | Methods and devices for delivering agents across biological barriers |
| CN101687094B (zh) * | 2005-09-06 | 2012-09-26 | 谢拉杰克特股份有限公司 | 含有药物颗粒和/或药物吸附颗粒的固体溶液穿孔器 |
| AU2006291157A1 (en) * | 2005-09-12 | 2007-03-22 | Alza Corporation | Coatable transdermal delivery microprojection assembly |
| US8801631B2 (en) | 2005-09-30 | 2014-08-12 | Intuity Medical, Inc. | Devices and methods for facilitating fluid transport |
| WO2007041355A2 (en) | 2005-09-30 | 2007-04-12 | Intuity Medical, Inc. | Catalysts for body fluid sample extraction |
| US7658728B2 (en) * | 2006-01-10 | 2010-02-09 | Yuzhakov Vadim V | Microneedle array, patch, and applicator for transdermal drug delivery |
| WO2007104755A1 (en) | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Secure pairing of electronic devices using dual means of communication |
| AU2007225056A1 (en) * | 2006-03-15 | 2007-09-20 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia |
| WO2007124393A2 (en) * | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Molded articles comprising microneedle arrays |
| US20070299388A1 (en) * | 2006-04-25 | 2007-12-27 | Alza Corporation | Microprojection array application with multilayered microprojection member for high drug loading |
| US20070293816A1 (en) * | 2006-04-25 | 2007-12-20 | Alza Corporation | Microprojection Array Application with Grouped Microprojections for High Drug Loading |
| EP2012852A1 (en) * | 2006-04-26 | 2009-01-14 | Novo Nordisk A/S | Skin-mountable device in packaging comprising coated seal member |
| WO2007141210A1 (en) | 2006-06-06 | 2007-12-13 | Novo Nordisk A/S | Assembly comprising skin-mountable device and packaging therefore |
| US20100100005A1 (en) * | 2006-07-11 | 2010-04-22 | Infotonics Technology Center, Inc. | Minimally invasive allergy testing system with coated allergens |
| US7785301B2 (en) * | 2006-11-28 | 2010-08-31 | Vadim V Yuzhakov | Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection |
| US8821446B2 (en) | 2007-01-22 | 2014-09-02 | Corium International, Inc. | Applicators for microneedles |
| JP2010520409A (ja) * | 2007-03-06 | 2010-06-10 | ノボ・ノルデイスク・エー/エス | アクチュエータシステムを備えるポンプ組立体 |
| GB2448493B (en) * | 2007-04-16 | 2009-10-14 | Dewan Fazlul Hoque Chowdhury | Microneedle transdermal delivery device |
| ES2817249T3 (es) | 2007-04-16 | 2021-04-06 | Corium Inc | Matrices de microagujas obtenidas mediante disolución y colada que contienen un principio activo |
| WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| CA2701772A1 (en) * | 2007-10-31 | 2009-05-07 | Novo Nordisk A/S | Non-porous material as sterilization barrier |
| WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
| JP5584202B2 (ja) * | 2008-05-21 | 2014-09-03 | セラジェクト, インコーポレイテッド | 固溶体穿孔器パッチの製造方法及びその使用 |
| US9833183B2 (en) | 2008-05-30 | 2017-12-05 | Intuity Medical, Inc. | Body fluid sampling device—sampling site interface |
| EP3639744B1 (en) | 2008-06-06 | 2021-11-24 | Intuity Medical, Inc. | Blood glucose meter and method of operating |
| WO2009148624A1 (en) | 2008-06-06 | 2009-12-10 | Intuity Medical, Inc. | Detection meter and mode of operation |
| JP4955634B2 (ja) * | 2008-09-24 | 2012-06-20 | テルモ株式会社 | 薬剤投与具 |
| US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
| US8606366B2 (en) | 2009-02-18 | 2013-12-10 | Syneron Medical Ltd. | Skin treatment apparatus for personal use and method for using same |
| US9033898B2 (en) * | 2010-06-23 | 2015-05-19 | Seventh Sense Biosystems, Inc. | Sampling devices and methods involving relatively little pain |
| US9295417B2 (en) | 2011-04-29 | 2016-03-29 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
| US9041541B2 (en) | 2010-01-28 | 2015-05-26 | Seventh Sense Biosystems, Inc. | Monitoring or feedback systems and methods |
| WO2010101626A1 (en) | 2009-03-02 | 2010-09-10 | Seventh Sense Biosystems, Inc. | Techniques and devices associated with blood sampling |
| EP2429627B1 (en) * | 2009-04-24 | 2017-06-14 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
| US8764712B2 (en) * | 2009-08-04 | 2014-07-01 | Cook Medical Technologies Llc | Micro-needle array and method of use thereof |
| US8919605B2 (en) | 2009-11-30 | 2014-12-30 | Intuity Medical, Inc. | Calibration material delivery devices and methods |
| US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| EP2566501B1 (en) | 2010-05-04 | 2019-03-13 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| US10330667B2 (en) | 2010-06-25 | 2019-06-25 | Intuity Medical, Inc. | Analyte monitoring methods and systems |
| US20120016308A1 (en) | 2010-07-16 | 2012-01-19 | Seventh Sense Biosystems, Inc. | Low-pressure packaging for fluid devices |
| US20130158482A1 (en) | 2010-07-26 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
| US20120039809A1 (en) | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Systems and techniques for monitoring subjects |
| US9017289B2 (en) | 2010-11-03 | 2015-04-28 | Covidien Lp | Transdermal fluid delivery device |
| WO2012064802A1 (en) | 2010-11-09 | 2012-05-18 | Seventh Sense Biosystems, Inc. | Systems and interfaces for blood sampling |
| US10244981B2 (en) * | 2011-03-30 | 2019-04-02 | SensiVida Medical Technologies, Inc. | Skin test image analysis apparatuses and methods thereof |
| EP2699252B1 (en) * | 2011-04-22 | 2017-10-25 | Radius Health, Inc. | Method of drug delivery for pth, pthrp and related peptides |
| JP6121400B2 (ja) | 2011-04-29 | 2017-04-26 | セブンス センス バイオシステムズ,インコーポレーテッド | 流体の送達および/または受け取り |
| EP3236259A1 (en) | 2011-04-29 | 2017-10-25 | Seventh Sense Biosystems, Inc. | Plasma or serum production and removal of fluids under reduced pressure |
| US20130158468A1 (en) | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
| WO2013020103A1 (en) | 2011-08-03 | 2013-02-07 | Intuity Medical, Inc. | Devices and methods for body fluid sampling and analysis |
| EP2934660B1 (en) | 2012-12-21 | 2019-07-17 | Corium, Inc. | Microarray for delivery of therapeutic agent and method of making same |
| BR112015020328B1 (pt) * | 2013-02-28 | 2022-05-31 | Sorrento Therapeutics, Inc | Dispositivo de aplicação transdérmica de droga |
| EP4094799A1 (en) | 2013-03-12 | 2022-11-30 | Corium, Inc. | Microprojection applicators |
| WO2014152717A2 (en) | 2013-03-14 | 2014-09-25 | Sano Intelligence, Inc. | On-body microsensor for biomonitoring |
| US10820860B2 (en) | 2013-03-14 | 2020-11-03 | One Drop Biosensor Technologies, Llc | On-body microsensor for biomonitoring |
| WO2014150285A2 (en) | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| EP2968119B1 (en) | 2013-03-15 | 2019-09-18 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| US10384045B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| CN103263727B (zh) * | 2013-05-22 | 2015-09-30 | 清华大学 | 金属微针阵列、经皮给药贴片、微针滚轮及微针电极阵列 |
| US10729386B2 (en) | 2013-06-21 | 2020-08-04 | Intuity Medical, Inc. | Analyte monitoring system with audible feedback |
| CN106061546A (zh) * | 2014-02-10 | 2016-10-26 | Lts勒曼治疗系统股份公司 | 微针系统及其制造方法 |
| ES3055185T3 (en) | 2014-03-28 | 2026-02-10 | Univ Duke | Treatment of an estrogen receptor positive breast cancer using a selective estrogen receptor modulator |
| US10624843B2 (en) | 2014-09-04 | 2020-04-21 | Corium, Inc. | Microstructure array, methods of making, and methods of use |
| KR20250152679A (ko) | 2015-04-29 | 2025-10-23 | 래디어스 파마슈티컬스, 인코포레이티드 | 암을 치료하는 방법 |
| US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| EP3326683B1 (en) * | 2015-07-17 | 2023-03-15 | Toppan Printing Co., Ltd. | Percutaneous administration device |
| WO2017130793A1 (ja) * | 2016-01-28 | 2017-08-03 | 株式会社リコー | マイクロニードルアレイ、マイクロニードルシート |
| WO2017143345A1 (en) | 2016-02-19 | 2017-08-24 | Zp Opco, Inc. | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines |
| JP2018086071A (ja) * | 2016-11-28 | 2018-06-07 | 株式会社リコー | 経皮吸収デバイス及び経皮吸収パッチ |
| JP7481115B2 (ja) | 2017-01-05 | 2024-05-10 | ラジウス ファーマシューティカルズ,インコーポレイテッド | Rad1901-2hclの多形性形態 |
| US11660264B2 (en) | 2017-08-23 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
| EP3672570A1 (en) | 2017-08-23 | 2020-07-01 | Zosano Pharma Corporation | Method of rapidly achieving therapeutic concentrations of zolmitriptan for treatment of migraines and cluster headaches |
| US11660265B2 (en) | 2018-06-28 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
| MX2020013713A (es) | 2018-07-04 | 2021-03-02 | Radius Pharmaceuticals Inc | Formas polimorficas de rad1901-2hcl. |
| KR102187439B1 (ko) * | 2019-01-30 | 2020-12-07 | 주식회사 라파스 | 마이크로니들 패취를 이용한 최소 침습적 피부 생체 검사 방법 |
| EP3924328A1 (en) | 2019-02-12 | 2021-12-22 | Radius Pharmaceuticals, Inc. | Processes and compounds |
| JP2024117288A (ja) * | 2023-02-17 | 2024-08-29 | 能美防災株式会社 | 防護対象物に付着した延焼防止剤の除去方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE25637E (en) | 1964-09-08 | Means for vaccinating | ||
| US25637A (en) * | 1859-10-04 | Cooking-stove | ||
| US2893392A (en) * | 1958-01-08 | 1959-07-07 | American Cyanamid Co | Article of manufacture for intracutaneous injections |
| US3072122A (en) * | 1959-01-15 | 1963-01-08 | Rosenthal Sol Roy | Package for transcutaneous injection |
| US3675766A (en) * | 1970-02-04 | 1972-07-11 | Sol Roy Rosenthal | Multiple puncture injector device |
| US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| BE795384A (fr) * | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
| US4379454A (en) * | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
| US4340048A (en) * | 1981-03-28 | 1982-07-20 | Alza Corporation | Self-driven hypodermic injector |
| US4753651A (en) * | 1982-08-30 | 1988-06-28 | Alza Corporation | Self-driven pump |
| US4725439A (en) * | 1984-06-29 | 1988-02-16 | Alza Corporation | Transdermal drug delivery device |
| US4588580B2 (en) * | 1984-07-23 | 1999-02-16 | Alaz Corp | Transdermal administration of fentanyl and device therefor |
| US4655766A (en) * | 1985-08-01 | 1987-04-07 | Alza Corporation | Fluid imbibing pump with self-regulating skin patch |
| US4756314A (en) * | 1985-10-28 | 1988-07-12 | Alza Corporation | Sweat collection patch |
| US4698062A (en) * | 1985-10-30 | 1987-10-06 | Alza Corporation | Medical device for pulsatile transdermal delivery of biologically active agents |
| US5080646A (en) * | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| US4832953A (en) * | 1987-08-13 | 1989-05-23 | Alza Corporation | Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix |
| US5362307A (en) * | 1989-01-24 | 1994-11-08 | The Regents Of The University Of California | Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance |
| WO1989006989A1 (en) * | 1988-01-29 | 1989-08-10 | The Regents Of The University Of California | Iontophoretic non-invasive sampling or delivery device |
| GB2221394B (en) * | 1988-08-05 | 1992-03-04 | Eilert Eilertsen | An injection device |
| US5438984A (en) * | 1988-09-08 | 1995-08-08 | Sudor Partners | Apparatus and method for the collection of analytes on a dermal patch |
| US5147296A (en) * | 1988-10-03 | 1992-09-15 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| US5169382A (en) * | 1988-10-03 | 1992-12-08 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| EP0429842B1 (en) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
| US5077104A (en) * | 1989-12-21 | 1991-12-31 | Alza Corporation | Nicotine packaging materials |
| AU657681B2 (en) * | 1990-03-30 | 1995-03-23 | Alza Corporation | Device and method for iontophoretic drug delivery |
| US5242406A (en) * | 1990-10-19 | 1993-09-07 | Sil Medics Ltd. | Liquid delivery device particularly useful for delivering drugs |
| MX9101782A (es) * | 1990-10-29 | 1992-06-05 | Alza Corp | Dispositivo de suministro iontoforetico y metodo para hidratar el mismo |
| US5279544A (en) * | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
| US5312456A (en) * | 1991-01-31 | 1994-05-17 | Carnegie Mellon University | Micromechanical barb and method for making the same |
| US5310404A (en) * | 1992-06-01 | 1994-05-10 | Alza Corporation | Iontophoretic delivery device and method of hydrating same |
| JPH10510175A (ja) * | 1994-12-09 | 1998-10-06 | ノバルティス アクチェンゲゼルシャフト | 経皮システム |
| AU5869796A (en) * | 1995-05-22 | 1996-12-11 | Ned A. Godshall | Micromechanical patch for enhancing the delivery of compound s through the skin |
| WO1996037155A1 (en) | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical device and method for enhancing delivery of compounds through the skin |
| DE19525607A1 (de) * | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
| ES2536459T3 (es) * | 1995-08-29 | 2015-05-25 | Nitto Denko Corporation | Microporación de piel humana para administración de fármacos y aplicaciones de supervisión |
| CA2253549C (en) | 1996-06-18 | 2005-10-25 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
| EP0957972B1 (en) * | 1996-12-20 | 2003-03-19 | Alza Corporation | Device and method for enhancing transdermal agent flux |
-
1998
- 1998-12-09 CA CA002313698A patent/CA2313698C/en not_active Expired - Fee Related
- 1998-12-09 AU AU19068/99A patent/AU757192B2/en not_active Ceased
- 1998-12-09 CN CNB988119897A patent/CN1170603C/zh not_active Expired - Fee Related
- 1998-12-09 DE DE69831268T patent/DE69831268T2/de not_active Expired - Lifetime
- 1998-12-09 JP JP2000524033A patent/JP2001525232A/ja active Pending
- 1998-12-09 AT AT98963824T patent/ATE302041T1/de not_active IP Right Cessation
- 1998-12-09 US US09/208,812 patent/US6083196A/en not_active Expired - Lifetime
- 1998-12-09 DK DK98963824T patent/DK1037686T3/da active
- 1998-12-09 KR KR1020007006269A patent/KR100561892B1/ko not_active Expired - Fee Related
- 1998-12-09 ES ES98963824T patent/ES2244106T3/es not_active Expired - Lifetime
- 1998-12-09 EP EP98963824A patent/EP1037686B1/en not_active Expired - Lifetime
- 1998-12-09 PT PT98963824T patent/PT1037686E/pt unknown
- 1998-12-09 WO PCT/US1998/026203 patent/WO1999029365A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU1906899A (en) | 1999-06-28 |
| US6083196A (en) | 2000-07-04 |
| CN1170603C (zh) | 2004-10-13 |
| EP1037686A1 (en) | 2000-09-27 |
| ES2244106T3 (es) | 2005-12-01 |
| CA2313698A1 (en) | 1999-06-17 |
| ATE302041T1 (de) | 2005-09-15 |
| KR20010032925A (ko) | 2001-04-25 |
| DE69831268D1 (de) | 2005-09-22 |
| PT1037686E (pt) | 2005-10-31 |
| WO1999029365A1 (en) | 1999-06-17 |
| DK1037686T3 (da) | 2006-01-02 |
| EP1037686B1 (en) | 2005-08-17 |
| KR100561892B1 (ko) | 2006-03-16 |
| JP2001525232A (ja) | 2001-12-11 |
| CA2313698C (en) | 2008-04-15 |
| CN1281376A (zh) | 2001-01-24 |
| AU757192B2 (en) | 2003-02-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69831268T2 (de) | Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses | |
| DE69806963T2 (de) | Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses | |
| DE60020159T2 (de) | Hautbehandlungsvorrichtung zur verlängerten transdermalen verabreichung von medikamenten | |
| DE69730971T2 (de) | Vorrichtung für die transdermale verabrecihung von medikamenten oder der abnahme von körperflüssigkeiten | |
| DE60024312T2 (de) | Transdermale Wirkstoffabgabe von makromolekularen Wirkstoffen und Vorrichtung hierfür | |
| DE60018865T2 (de) | Vorrichtung zum Abscheuern der Haut | |
| DE60027720T2 (de) | Vorrichtung zur mikroporation eines biologischen gewebes mittels einer filmgewebe schnittstellenvorrichtung und verfahren | |
| DE69720057T2 (de) | Vorrichtung und verfahren zur erhöhung des transdermalen wirkstoffeflusses | |
| DE60018796T2 (de) | Vorrichtung zur erhöhung des transdermalen flusses von probenwirkstoffen | |
| DE60106261T2 (de) | Abgabevorrichtung mit mikronadeln zur transdermalen verabreichung von einer substanz | |
| DE69922353T2 (de) | Vorrichtung zur elektroporation durch gewebemikroporen | |
| DE60213976T2 (de) | Vorrichtung zur manipulation von nadeln oder polierarray | |
| DE60124917T2 (de) | Mikrovorrichtung und verfahren zur herstellung | |
| EP3280484B1 (de) | Mikronadelsystem zur applikation von flüssigen formulierungen | |
| DE602005004782T2 (de) | Transdermale arzneimittelabgabevorrichtung durch dehnung/lockerung | |
| JP2001525227A (ja) | 経皮的薬剤流量を高めるための装置 | |
| DE102013219432A1 (de) | Blutentnahmevorrichtung und Verfahren zum Entnehmen von Blut | |
| DE10353629A1 (de) | Vorrichtung zur transdermalen Verabreichung von Wirkstoffen | |
| WO2015024816A1 (de) | Transdermales therapeutisches system mit druckerzeugungsvorrichtung | |
| EP2636424A1 (de) | Therapeutisches System mit hohlen Mikronadeln | |
| DE102023101977A1 (de) | Applikationsvorrichtung für Mikronadeln, System zur Mikronadelapplikation und Verfahren zur Bereitstellung eines Systems zur Mikronadelapplikation | |
| MXPA00005765A (en) | Device for enhancing transdermal agent flux | |
| MXPA00005725A (es) | Dispositivo para aumentar el flujo transdermico de agentes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |