DE69738074D1 - Reinigung von neurotrophinen - Google Patents

Reinigung von neurotrophinen

Info

Publication number
DE69738074D1
DE69738074D1 DE69738074T DE69738074T DE69738074D1 DE 69738074 D1 DE69738074 D1 DE 69738074D1 DE 69738074 T DE69738074 T DE 69738074T DE 69738074 T DE69738074 T DE 69738074T DE 69738074 D1 DE69738074 D1 DE 69738074D1
Authority
DE
Germany
Prior art keywords
neurotrophins
neurotrophines
cleaning
including mature
mature ngf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69738074T
Other languages
English (en)
Other versions
DE69738074T2 (de
Inventor
Louis E Burton
Charles H Schmelzer
Joanne T Beck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE69738074D1 publication Critical patent/DE69738074D1/de
Publication of DE69738074T2 publication Critical patent/DE69738074T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69738074T 1996-11-15 1997-11-14 Reinigung von neurotrophinen Expired - Lifetime DE69738074T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3083896P 1996-11-15 1996-11-15
US4785597P 1997-05-29 1997-05-29
US47855P 1997-05-29
PCT/US1997/021068 WO1998021234A2 (en) 1996-11-15 1997-11-14 Purification of neurotrophins
US30838P 2008-02-22

Publications (2)

Publication Number Publication Date
DE69738074D1 true DE69738074D1 (de) 2007-10-11
DE69738074T2 DE69738074T2 (de) 2008-05-21

Family

ID=26706516

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69738074T Expired - Lifetime DE69738074T2 (de) 1996-11-15 1997-11-14 Reinigung von neurotrophinen

Country Status (21)

Country Link
US (5) US6005081A (de)
EP (1) EP0942930B1 (de)
JP (3) JP4671372B2 (de)
KR (1) KR100554332B1 (de)
CN (1) CN1268639C (de)
AT (1) ATE371670T1 (de)
AU (1) AU729459B2 (de)
BR (1) BR9713055A (de)
CA (1) CA2268747A1 (de)
CZ (1) CZ300296B6 (de)
DE (1) DE69738074T2 (de)
EA (1) EA002349B1 (de)
ES (1) ES2293662T3 (de)
HU (1) HU222666B1 (de)
ID (1) ID26697A (de)
IL (2) IL129851A0 (de)
NO (1) NO327149B1 (de)
NZ (1) NZ335207A (de)
PL (1) PL191400B1 (de)
TR (1) TR199901734T2 (de)
WO (1) WO1998021234A2 (de)

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SI1308455T1 (sl) * 1998-05-06 2006-08-31 Genentech Inc Sestavek, ki obsega protitelesa anti-HER2
ES2266188T3 (es) 2000-03-27 2007-03-01 Genetics Institute, Llc Procedimientos de purificacion de proteinas altamente anionicas.
DK1714982T3 (da) * 2001-06-05 2009-05-04 Genetics Inst Llc Fremgangsmåde til rensning af stærkt anioniske proteiner
EP1456233A4 (de) * 2001-06-15 2006-06-21 Queensland Bioproc Technology Hämocyanin aus abalonen und verfahren zu dessen aufreinigung
WO2004002417A2 (en) 2002-06-28 2004-01-08 Centocor, Inc. Mammalian ch1 deleted mimetibodies, compositions, methods and uses
US7998705B2 (en) * 2002-08-06 2011-08-16 FUJIFILM Diosynth Biotechnologies U.S.A., Inc Increased dynamic binding capacity in ion exchange chromatography by addition of polyethylene glycol
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EP1538201A1 (de) * 2003-12-02 2005-06-08 F.Hoffmann-La Roche Ag Verfahren zur Herstellung und Reinigung von rekombinanten Proteinkinasen
US20050209148A1 (en) * 2004-02-20 2005-09-22 Arnon Rosenthal Methods of treating obesity or diabetes using NT-4/5
DE602005022239D1 (de) * 2004-04-23 2010-08-19 Conjuchem Biotechnologies Inc Festphase zur Verwendung in einem Verfahren zur Reinigung von Albuminkonjugaten
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EP1888118B1 (de) 2005-05-25 2016-08-17 Novo Nordisk A/S Polypeptidformulierungen stabilisiert mittels ethylendiamin
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CN102898514B (zh) * 2011-07-28 2015-04-29 中国人民解放军军事医学科学院生物工程研究所 重组人神经生长因子缺失突变体及其制备方法和用途
EP2594295A1 (de) 2011-11-16 2013-05-22 Servicio Andaluz De Salud Nervenimplantat basierend auf einem kompaktierten, zellhaltigen Biomaterial
US9266370B2 (en) 2012-10-10 2016-02-23 Apdn (B.V.I) Inc. DNA marking of previously undistinguished items for traceability
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CN103880943A (zh) * 2014-01-20 2014-06-25 厦门北大之路生物工程有限公司 一种rhNGF成熟肽的制备方法
CN106103121B (zh) 2014-03-18 2019-12-06 亚普蒂恩(B.V.I.)公司 用于安全应用的加密光学标记物
US10745825B2 (en) 2014-03-18 2020-08-18 Apdn (B.V.I.) Inc. Encrypted optical markers for security applications
CN104195160A (zh) * 2014-08-08 2014-12-10 厦门北大之路生物工程有限公司 一种以Pro-BDNF的形式制备人脑源性神经营养因子的方法
US10760182B2 (en) 2014-12-16 2020-09-01 Apdn (B.V.I.) Inc. Method and device for marking fibrous materials
CN106279397A (zh) * 2015-06-09 2017-01-04 舒泰神（北京）生物制药股份有限公司 一种神经生长因子的提取方法
CN109070130B (zh) 2016-04-11 2022-03-22 亚普蒂恩（B V I）公司 用于标记纤维素产品的方法
CN106478801A (zh) * 2016-10-10 2017-03-08 未名生物医药有限公司 一种从哺乳动物细胞培养物中分离重组人神经生长因子的方法
US10995371B2 (en) 2016-10-13 2021-05-04 Apdn (B.V.I.) Inc. Composition and method of DNA marking elastomeric material
US10920274B2 (en) 2017-02-21 2021-02-16 Apdn (B.V.I.) Inc. Nucleic acid coated submicron particles for authentication
GB201705955D0 (en) * 2017-04-13 2017-05-31 Cell Guidance Systems Ltd Delivery method
CN107973848B (zh) * 2017-12-28 2020-10-16 未名生物医药有限公司 一种从混合物中分离天然序列神经生长因子的方法
CN108467429A (zh) * 2018-03-26 2018-08-31 江苏中新医药有限公司 疏水层析动态清除重组人神经生长因子前体的方法
CN108467428A (zh) * 2018-03-26 2018-08-31 江苏中新医药有限公司 一种清除rhNGF中N端截短及异常变异体的方法
CN108239146A (zh) * 2018-03-26 2018-07-03 江苏中新医药有限公司 一种高纯度rhNGF的制备方法
US20210079053A1 (en) * 2018-04-27 2021-03-18 Chiesi Farmaceutici Spa Production of nerve growth factor (ngf) and of muteins thereof
CN114252519B (zh) * 2020-09-23 2023-11-24 舒泰神（北京）生物制药股份有限公司 一种测定神经生长因子纯度的方法
CN114380901A (zh) * 2021-12-31 2022-04-22 华东理工大学 蛋白纳米粒子的制备方法、所得蛋白纳米粒子及其应用

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Also Published As

Publication number Publication date
DE69738074T2 (de) 2008-05-21
IL129851A0 (en) 2000-02-29
TR199901734T2 (xx) 2000-01-21
ES2293662T3 (es) 2008-03-16
ATE371670T1 (de) 2007-09-15
AU5444898A (en) 1998-06-03
PL191400B1 (pl) 2006-05-31
WO1998021234A3 (en) 1998-07-23
NO992353L (no) 1999-07-09
KR20000053297A (ko) 2000-08-25
IL129851A (en) 2006-12-10
JP2009040786A (ja) 2009-02-26
KR100554332B1 (ko) 2006-02-24
US20040138431A1 (en) 2004-07-15
US6953844B2 (en) 2005-10-11
ID26697A (id) 2001-02-01
JP4671372B2 (ja) 2011-04-13
EA002349B1 (ru) 2002-04-25
NO327149B1 (no) 2009-05-04
EP0942930B1 (de) 2007-08-29
WO1998021234A2 (en) 1998-05-22
US6005081A (en) 1999-12-21
PL333460A1 (en) 1999-12-20
NZ335207A (en) 2000-09-29
JP2001503779A (ja) 2001-03-21
HUP9903947A2 (hu) 2000-03-28
HUP9903947A3 (en) 2001-03-28
CN1268639C (zh) 2006-08-09
US6812330B2 (en) 2004-11-02
JP4881234B2 (ja) 2012-02-22
CN1237184A (zh) 1999-12-01
EA199900436A1 (ru) 2000-02-28
BR9713055A (pt) 2000-04-04
HU222666B1 (hu) 2003-09-29
CZ300296B6 (cs) 2009-04-15
AU729459B2 (en) 2001-02-01
US6184360B1 (en) 2001-02-06
EP0942930A2 (de) 1999-09-22
US6423831B1 (en) 2002-07-23
NO992353D0 (no) 1999-05-14
CZ166699A3 (cs) 1999-10-13
CA2268747A1 (en) 1998-05-22
JP2007302679A (ja) 2007-11-22
US20020137893A1 (en) 2002-09-26

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